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Protein

FACT complex subunit ssrp1-B

Gene

hmg-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to double-stranded DNA (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi561 – 627HMG boxPROSITE-ProRule annotationAdd BLAST67

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair, DNA replication, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-CEL-674695 RNA Polymerase II Pre-transcription Events
R-CEL-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-CEL-75955 RNA Polymerase II Transcription Elongation

Names & Taxonomyi

Protein namesi
Recommended name:
FACT complex subunit ssrp1-B
Alternative name(s):
Facilitates chromatin transcription complex subunit ssrp1-B
HMG box-containing protein 3
Structure-specific recognition protein 1-B
Gene namesi
Name:hmg-3
ORF Names:C32F10.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiC32F10.5 ; CE08542 ; WBGene00001973 ; hmg-3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002451931 – 689FACT complex subunit ssrp1-BAdd BLAST689

Proteomic databases

EPDiO01683
PaxDbiO01683
PeptideAtlasiO01683
PRIDEiO01683

PTM databases

iPTMnetiO01683

Expressioni

Gene expression databases

BgeeiWBGene00001973

Interactioni

Subunit structurei

Component of the FACT complex, a stable heterodimer of hmg-3 and spt-16. The FACT complex may also include hmg-4 instead of hmg-3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi377051 interactor.
IntActiO01683 1 interactor.
STRINGi6239.C32F10.5

Structurei

3D structure databases

ProteinModelPortaliO01683
SMRiO01683
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi444 – 519Asp-rich (acidic)Add BLAST76
Compositional biasi526 – 656Lys-rich (basic)Add BLAST131

Sequence similaritiesi

Belongs to the SSRP1 family.Curated

Phylogenomic databases

eggNOGiKOG0526 Eukaryota
COG5165 LUCA
GeneTreeiENSGT00560000076898
HOGENOMiHOG000180790
InParanoidiO01683
KOiK09272
OMAiKPVMYIR
OrthoDBiEOG091G04JP
PhylomeDBiO01683

Family and domain databases

Gene3Di1.10.30.101 hit
2.30.29.2201 hit
2.30.29.302 hits
InterProiView protein in InterPro
IPR013719 DUF1747
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR011993 PH-like_dom_sf
IPR035417 POB3_N
IPR000969 SSrcognition
IPR024954 SSRP1_dom
IPR038167 SSRP1_sf
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF17292 POB3_N, 1 hit
PF08512 Rtt106, 1 hit
PF03531 SSrecog, 1 hit
PRINTSiPR00887 SSRCOGNITION
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SM01287 Rtt106, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O01683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTELKFKGVY VEDIGHLTCG TLTLTENSIN FIGDKGGKSV YITGTDVDKL
60 70 80 90 100
KWQKLGNKPG LRVGLSDGGA HRFGGFLDDD LQKIQSFTSS NWSKSINQSN
110 120 130 140 150
LFINGWNYGQ ADVKGKNIEF SWENEPIFEI PCTNVSNVIA NKNEAILEFH
160 170 180 190 200
QNEQSKVQLM EMRFHMPVDL ENEEDTDKVE EFKKAVLAYA GLEAETEQPI
210 220 230 240 250
CLLTDILCTT PRGRYDIKVY PTSIALHGKT YDYKIPVKTI NRLFLVPHKD
260 270 280 290 300
GRQVYFVLSL NPPIRQGQTH YSYLIFEFGK DEEEDLELSL TDEQLDYFNG
310 320 330 340 350
NLQREMTGPI YETISILFKS ICNLKVTVPG RFLGSSGTPA IQCTHRQNLG
360 370 380 390 400
LLYPMEKGFL FIQKPVMYIR FEEISSCHFA RSDSGTVTRT FDFEIDLKTG
410 420 430 440 450
SSLTFSAMDK EENNKLFDYL NKKEIKIRNS HRIDNKSAGY GSSDEDDIDP
460 470 480 490 500
YKSTVKAEGR EQDDDSDDES TDEDYDLDKD MKKQKNDKDS SEGSGSEPDD
510 520 530 540 550
EYDSGSEKDA SGTGESDPDE ENIEPKKKES KEKKNKREKK EKPVKEKAVK
560 570 580 590 600
KGKKTKDPNE PKRATTAYII WFNANRNSMK EDGDTLGDVA KKAGAKWKSM
610 620 630 640 650
SADDKKEWND KAAQDKARYE AEMKEYKKNG GGVEKASGPS TKKSSDQSPG
660 670 680
KQFKSKEHIS DTDDSDDDEP LKAKKDESDA ASESSGESD
Length:689
Mass (Da):77,752
Last modified:July 1, 1997 - v1
Checksum:iD1F3057CF09880FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080198 Genomic DNA Translation: CCD61910.1
PIRiT34025
RefSeqiNP_491688.1, NM_059287.3
UniGeneiCel.18541

Genome annotation databases

EnsemblMetazoaiC32F10.5; C32F10.5; WBGene00001973
GeneIDi172250
KEGGicel:CELE_C32F10.5
UCSCiC32F10.5 c. elegans

Similar proteinsi

Entry informationi

Entry nameiSSP1B_CAEEL
AccessioniPrimary (citable) accession number: O01683
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome