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Protein

FACT complex subunit ssrp1-B

Gene

hmg-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to double-stranded DNA (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi561 – 62767HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, DNA replication, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
FACT complex subunit ssrp1-B
Alternative name(s):
Facilitates chromatin transcription complex subunit ssrp1-B
HMG box-containing protein 3
Structure-specific recognition protein 1-B
Gene namesi
Name:hmg-3
ORF Names:C32F10.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiC32F10.5; CE08542; WBGene00001973; hmg-3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation
  • Chromosome By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 689689FACT complex subunit ssrp1-BPRO_0000245193Add
BLAST

Proteomic databases

EPDiO01683.
PaxDbiO01683.
PRIDEiO01683.

PTM databases

iPTMnetiO01683.

Interactioni

Subunit structurei

Component of the FACT complex, a stable heterodimer of hmg-3 and spt-16. The FACT complex may also include hmg-4 instead of hmg-3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi37705. 1 interaction.
IntActiO01683. 1 interaction.
STRINGi6239.C32F10.5.

Structurei

3D structure databases

ProteinModelPortaliO01683.
SMRiO01683. Positions 20-167, 200-429, 530-630.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi444 – 51976Asp-rich (acidic)Add
BLAST
Compositional biasi526 – 656131Lys-rich (basic)Add
BLAST

Sequence similaritiesi

Belongs to the SSRP1 family.Curated
Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0526. Eukaryota.
COG5165. LUCA.
GeneTreeiENSGT00560000076898.
HOGENOMiHOG000180790.
InParanoidiO01683.
KOiK09272.
OMAiKFDGFRE.
OrthoDBiEOG7B31MG.
PhylomeDBiO01683.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR013719. DUF1747.
IPR009071. HMG_box_dom.
IPR011993. PH_dom-like.
IPR000969. SSrcognition.
IPR024954. SSRP1_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF08512. Rtt106. 1 hit.
PF03531. SSrecog. 1 hit.
[Graphical view]
PRINTSiPR00887. SSRCOGNITION.
SMARTiSM00398. HMG. 1 hit.
SM01287. Rtt106. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O01683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTELKFKGVY VEDIGHLTCG TLTLTENSIN FIGDKGGKSV YITGTDVDKL
60 70 80 90 100
KWQKLGNKPG LRVGLSDGGA HRFGGFLDDD LQKIQSFTSS NWSKSINQSN
110 120 130 140 150
LFINGWNYGQ ADVKGKNIEF SWENEPIFEI PCTNVSNVIA NKNEAILEFH
160 170 180 190 200
QNEQSKVQLM EMRFHMPVDL ENEEDTDKVE EFKKAVLAYA GLEAETEQPI
210 220 230 240 250
CLLTDILCTT PRGRYDIKVY PTSIALHGKT YDYKIPVKTI NRLFLVPHKD
260 270 280 290 300
GRQVYFVLSL NPPIRQGQTH YSYLIFEFGK DEEEDLELSL TDEQLDYFNG
310 320 330 340 350
NLQREMTGPI YETISILFKS ICNLKVTVPG RFLGSSGTPA IQCTHRQNLG
360 370 380 390 400
LLYPMEKGFL FIQKPVMYIR FEEISSCHFA RSDSGTVTRT FDFEIDLKTG
410 420 430 440 450
SSLTFSAMDK EENNKLFDYL NKKEIKIRNS HRIDNKSAGY GSSDEDDIDP
460 470 480 490 500
YKSTVKAEGR EQDDDSDDES TDEDYDLDKD MKKQKNDKDS SEGSGSEPDD
510 520 530 540 550
EYDSGSEKDA SGTGESDPDE ENIEPKKKES KEKKNKREKK EKPVKEKAVK
560 570 580 590 600
KGKKTKDPNE PKRATTAYII WFNANRNSMK EDGDTLGDVA KKAGAKWKSM
610 620 630 640 650
SADDKKEWND KAAQDKARYE AEMKEYKKNG GGVEKASGPS TKKSSDQSPG
660 670 680
KQFKSKEHIS DTDDSDDDEP LKAKKDESDA ASESSGESD
Length:689
Mass (Da):77,752
Last modified:July 1, 1997 - v1
Checksum:iD1F3057CF09880FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080198 Genomic DNA. Translation: CCD61910.1.
PIRiT34025.
RefSeqiNP_491688.1. NM_059287.3.
UniGeneiCel.18541.

Genome annotation databases

EnsemblMetazoaiC32F10.5; C32F10.5; WBGene00001973.
GeneIDi172250.
KEGGicel:CELE_C32F10.5.
UCSCiC32F10.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080198 Genomic DNA. Translation: CCD61910.1.
PIRiT34025.
RefSeqiNP_491688.1. NM_059287.3.
UniGeneiCel.18541.

3D structure databases

ProteinModelPortaliO01683.
SMRiO01683. Positions 20-167, 200-429, 530-630.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi37705. 1 interaction.
IntActiO01683. 1 interaction.
STRINGi6239.C32F10.5.

PTM databases

iPTMnetiO01683.

Proteomic databases

EPDiO01683.
PaxDbiO01683.
PRIDEiO01683.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC32F10.5; C32F10.5; WBGene00001973.
GeneIDi172250.
KEGGicel:CELE_C32F10.5.
UCSCiC32F10.5. c. elegans.

Organism-specific databases

CTDi172250.
WormBaseiC32F10.5; CE08542; WBGene00001973; hmg-3.

Phylogenomic databases

eggNOGiKOG0526. Eukaryota.
COG5165. LUCA.
GeneTreeiENSGT00560000076898.
HOGENOMiHOG000180790.
InParanoidiO01683.
KOiK09272.
OMAiKFDGFRE.
OrthoDBiEOG7B31MG.
PhylomeDBiO01683.

Miscellaneous databases

PROiO01683.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR013719. DUF1747.
IPR009071. HMG_box_dom.
IPR011993. PH_dom-like.
IPR000969. SSrcognition.
IPR024954. SSRP1_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF08512. Rtt106. 1 hit.
PF03531. SSrecog. 1 hit.
[Graphical view]
PRINTSiPR00887. SSRCOGNITION.
SMARTiSM00398. HMG. 1 hit.
SM01287. Rtt106. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiSSP1B_CAEEL
AccessioniPrimary (citable) accession number: O01683
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 1, 1997
Last modified: June 8, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.