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Protein

Tropomyosin

Gene
N/A
Organism
Acanthocheilonema viteae (Filarial nematode worm) (Dipetalonema viteae)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin
OrganismiAcanthocheilonema viteae (Filarial nematode worm) (Dipetalonema viteae)
Taxonomic identifieri6277 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaFilarioideaOnchocercidaeAcanthocheilonema

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284TropomyosinPRO_0000205644Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO01673.
SMRiO01673. Positions 1-282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 284284Add
BLAST

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil, Repeat

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O01673-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAIKKKMQA MKIEKDTALD RADAAKEKVR QMTDKLERIE EELRDTQKKM
60 70 80 90 100
MQTENDLNKA QEDLAVANTN LEDKEKKVQK AEAEVPPLNR RMTLLEEELE
110 120 130 140 150
RAEERLKIAT DKLEKATHTA DESDRVRKVM ENRSFQDEER ANTVESQLKE
160 170 180 190 200
AQLLAEEADR KYDEVARKLA MVEADLERAE ERAEAGENKI VELEEELRVV
210 220 230 240 250
GNNLKFLEVS EEKALQREDS YEEQIRTVSA RLKEAETRAE FAERSVQKLQ
260 270 280
KEVDRLEDEL VHEKGRYKNI SEELDQTFQE LFGY
Length:284
Mass (Da):33,247
Last modified:July 1, 1997 - v1
Checksum:i885714CB0DF62BAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000607 mRNA. Translation: AAB53807.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000607 mRNA. Translation: AAB53807.1.

3D structure databases

ProteinModelPortaliO01673.
SMRiO01673. Positions 1-282.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and characterization of tropomyosin, a protective antigen of Acanthocheilonema viteae."
    Adam R., Hartmann S., von Nickisch-Rosenegk E., Lucius R.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Muscle.

Entry informationi

Entry nameiTPM_ACAVI
AccessioniPrimary (citable) accession number: O01673
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: July 1, 1997
Last modified: October 1, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.