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Protein

Sex-lethal homolog

Gene

SXL

Organism
Megaselia scalaris (Humpbacked fly) (Phora scalaris)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Unknown; apparently not involved in somatic sex determination.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sex-lethal homolog
Gene namesi
Name:SXL
Synonyms:SXL2
OrganismiMegaselia scalaris (Humpbacked fly) (Phora scalaris)
Taxonomic identifieri36166 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaPlatypezoideaPhoridaeMegaseliiniMegaselia
Proteomesi
  • UP000015102 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000819691 – 321Sex-lethal homologAdd BLAST321

Expressioni

Tissue specificityi

Expressed in gonads and somatic tissues of both sexes. In the ovary, expressed in the last egg chamber of each ovariole. Highly expressed in nurse cells with low expression found in oocytes. Highly expressed in testis with lower expression in testis sheath and vas deferentia.1 Publication

Structurei

3D structure databases

ProteinModelPortaliO01671.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 156RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini164 – 244RRM 2PROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR006546. Sxl.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
TIGRFAMsiTIGR01659. sex-lethal. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist. The event occurs in a sex-independent manner.
Isoform 1 (identifier: O01671-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYRGGRMWGM SHSLPSGMSS YAFSPQDTDF SSYPSTIGRQ HSQQSQRYYQ
60 70 80 90 100
NNNCGLGSVG NMANSTNSLN SGTNNSGTNL IVNYLPQDMQ DRELYSLFRT
110 120 130 140 150
IGPINTCRIM RDYKTGYSYG YGFVDFGSEA DALRAINNLN GITVRNKRIK
160 170 180 190 200
VSFARPGGEQ LRDTNLYVTN LSRSITDEQL ETIFGKYGQI VQKNILRDKH
210 220 230 240 250
TGTPRGVAFI RFNKREEAQE AISALNNVIP EGGTQPLTVR VAEEHGKSKG
260 270 280 290 300
HVYMAPNQPP HGNMGHGNMG NMGHGNMGMA GGSGMNLNNM NAFNGMNQMV
310 320
HRGRQKHSYQ RKIHPYNPNF L
Length:321
Mass (Da):35,738
Last modified:April 23, 2003 - v3
Checksum:iE2F18FC8AA0B68C0
GO
Isoform 2 (identifier: O01671-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.
     19-26: Missing.

Show »
Length:307
Mass (Da):34,149
Checksum:i2370A3904A2EE872
GO
Isoform 3 (identifier: O01671-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.

Show »
Length:260
Mass (Da):28,955
Checksum:i3647C516A4C59CE8
GO
Isoform 4 (identifier: O01671-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-26: Missing.

Show »
Length:313
Mass (Da):34,870
Checksum:i149AB6756BCC5402
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0071891 – 61Missing in isoform 3. CuratedAdd BLAST61
Alternative sequenceiVSP_0071881 – 6Missing in isoform 2. Curated6
Alternative sequenceiVSP_00719019 – 26Missing in isoform 2 and isoform 4. Curated8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110846 Genomic DNA. Translation: AAF15091.1.
AF110846 Genomic DNA. Translation: AAF15092.1.
AJ000546 mRNA. Translation: CAA04179.2.
AJ245662 mRNA. Translation: CAC01696.1.
X98769 mRNA. Translation: CAB61832.1.
X98770 mRNA. Translation: CAB61830.1.
X98771 mRNA. Translation: CAB61831.1.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110846 Genomic DNA. Translation: AAF15091.1.
AF110846 Genomic DNA. Translation: AAF15092.1.
AJ000546 mRNA. Translation: CAA04179.2.
AJ245662 mRNA. Translation: CAC01696.1.
X98769 mRNA. Translation: CAB61832.1.
X98770 mRNA. Translation: CAB61830.1.
X98771 mRNA. Translation: CAB61831.1.

3D structure databases

ProteinModelPortaliO01671.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR006546. Sxl.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
TIGRFAMsiTIGR01659. sex-lethal. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSXL_MEGSC
AccessioniPrimary (citable) accession number: O01671
Secondary accession number(s): O96931
, Q9GVB9, Q9U536, Q9U537, Q9U5M7, Q9U5M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 23, 2003
Last modified: October 5, 2016
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.