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Protein

Innexin-12

Gene

inx-12

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Structural component of the gap junctions (By similarity). Plays a role in oocyte directional transit in the spermatheca during ovulation by facilitating the directional propagation of the calcium signal in the spermatheca (PubMed:23671426).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Innexin-12
Alternative name(s):
Protein opu-12
Gene namesi
Name:inx-12
Synonyms:opu-12
ORF Names:ZK770.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiZK770.3 ; CE15413 ; WBGene00002134 ; inx-12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei113 – 133HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei197 – 217HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei284 – 304HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown causes defective oocyte transit through the spermatheca. Calcium oscillations triggered during ovulation are random resulting in uncoordinated spermatheca constrictions. Oocytes enter the spermatheca normally but change direction several times before returning into the gonad or proceeding into the uterus.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002085131 – 408Innexin-12Add BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO01634
PaxDbiO01634
PeptideAtlasiO01634
PRIDEiO01634

PTM databases

iPTMnetiO01634

Expressioni

Gene expression databases

BgeeiWBGene00002134

Interactioni

Protein-protein interaction databases

BioGridi37418, 1 interactor
DIPiDIP-26804N
IntActiO01634, 1 interactor
STRINGi6239.ZK770.3.1

Family & Domainsi

Sequence similaritiesi

Belongs to the pannexin family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410K7PX Eukaryota
ENOG4110M6V LUCA
GeneTreeiENSGT00530000064205
HOGENOMiHOG000017412
InParanoidiO01634
KOiK22037
OMAiCWFPAYY
OrthoDBiEOG091G06YS
PhylomeDBiO01634

Family and domain databases

InterProiView protein in InterPro
IPR000990 Innexin
PANTHERiPTHR11893 PTHR11893, 1 hit
PfamiView protein in Pfam
PF00876 Innexin, 1 hit
PRINTSiPR01262 INNEXIN
PROSITEiView protein in PROSITE
PS51013 PANNEXIN, 1 hit

Sequencei

Sequence statusi: Complete.

O01634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVIQNLLSA VSPQPDGDFV DKLNYCATTI GLVLASAFIT GWSFVGSPID
60 70 80 90 100
CWFPAYYKGW WAEYALDYCY VQNTFFVPFS EDKAERSYNW EQLVADKQNT
110 120 130 140 150
TSLKQTNQIG YYQWVPFILA LQAMLFYFPV VIWRLFYGMA GQNVTSLCNT
160 170 180 190 200
CTATEGNEES RKGTITTIAG YISQKRHRNL IVKQLSGFQN RANGSAVITS
210 220 230 240 250
YLFMKALFLI NVLFQFVLLK RMLGVDSYFW GAEVTSDLWS GNEWPETGNF
260 270 280 290 300
PRVTMCEYEV RNLDNIHKHS VQCVLMINMF NEKIFVALWW WLCFLTVVTI
310 320 330 340 350
TNTIYWFWRA SGTSVSKNFI RPYVEDIDPK VKNNRGKLQQ FVSEFLSPDT
360 370 380 390 400
VFILRLIELN NGKTPVVELI RDMWRRFNTA VPPPYSAPPL LVKDGAPLLK

NFQDESEM
Length:408
Mass (Da):47,091
Last modified:July 1, 1997 - v1
Checksum:iE3EDFF80FE7C41A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080751 Genomic DNA Translation: CCD66426.1
PIRiT34467
RefSeqiNP_491213.1, NM_058812.5
UniGeneiCel.16136

Genome annotation databases

EnsemblMetazoaiZK770.3.1; ZK770.3.1; WBGene00002134
ZK770.3.2; ZK770.3.2; WBGene00002134
GeneIDi171944
KEGGicel:CELE_ZK770.3
UCSCiZK770.3.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiINX12_CAEEL
AccessioniPrimary (citable) accession number: O01634
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health