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Protein

Innexin-12

Gene

inx-12

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Structural components of the gap junctions.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Innexin-12
Alternative name(s):
Protein opu-12
Gene namesi
Name:inx-12
Synonyms:opu-12
ORF Names:ZK770.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiZK770.3; CE15413; WBGene00002134; inx-12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4921HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei113 – 13321HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei197 – 21721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei284 – 30421HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Innexin-12PRO_0000208513Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi99 – 991N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO01634.
PaxDbiO01634.

Expressioni

Gene expression databases

BgeeiWBGene00002134.

Interactioni

Protein-protein interaction databases

BioGridi37418. 1 interaction.
DIPiDIP-26804N.
MINTiMINT-1070991.
STRINGi6239.ZK770.3.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the pannexin family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410K7PX. Eukaryota.
ENOG4110M6V. LUCA.
GeneTreeiENSGT00530000064205.
HOGENOMiHOG000017412.
InParanoidiO01634.
OMAiNTCTATE.
OrthoDBiEOG091G06YS.
PhylomeDBiO01634.

Family and domain databases

InterProiIPR000990. Innexin.
[Graphical view]
PANTHERiPTHR11893. PTHR11893. 1 hit.
PfamiPF00876. Innexin. 1 hit.
[Graphical view]
PRINTSiPR01262. INNEXIN.
PROSITEiPS51013. PANNEXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O01634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVIQNLLSA VSPQPDGDFV DKLNYCATTI GLVLASAFIT GWSFVGSPID
60 70 80 90 100
CWFPAYYKGW WAEYALDYCY VQNTFFVPFS EDKAERSYNW EQLVADKQNT
110 120 130 140 150
TSLKQTNQIG YYQWVPFILA LQAMLFYFPV VIWRLFYGMA GQNVTSLCNT
160 170 180 190 200
CTATEGNEES RKGTITTIAG YISQKRHRNL IVKQLSGFQN RANGSAVITS
210 220 230 240 250
YLFMKALFLI NVLFQFVLLK RMLGVDSYFW GAEVTSDLWS GNEWPETGNF
260 270 280 290 300
PRVTMCEYEV RNLDNIHKHS VQCVLMINMF NEKIFVALWW WLCFLTVVTI
310 320 330 340 350
TNTIYWFWRA SGTSVSKNFI RPYVEDIDPK VKNNRGKLQQ FVSEFLSPDT
360 370 380 390 400
VFILRLIELN NGKTPVVELI RDMWRRFNTA VPPPYSAPPL LVKDGAPLLK

NFQDESEM
Length:408
Mass (Da):47,091
Last modified:July 1, 1997 - v1
Checksum:iE3EDFF80FE7C41A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080751 Genomic DNA. Translation: CCD66426.1.
PIRiT34467.
RefSeqiNP_491213.1. NM_058812.5.
UniGeneiCel.16136.

Genome annotation databases

EnsemblMetazoaiZK770.3.1; ZK770.3.1; WBGene00002134.
ZK770.3.2; ZK770.3.2; WBGene00002134.
GeneIDi171944.
KEGGicel:CELE_ZK770.3.
UCSCiZK770.3.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080751 Genomic DNA. Translation: CCD66426.1.
PIRiT34467.
RefSeqiNP_491213.1. NM_058812.5.
UniGeneiCel.16136.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi37418. 1 interaction.
DIPiDIP-26804N.
MINTiMINT-1070991.
STRINGi6239.ZK770.3.1.

Proteomic databases

EPDiO01634.
PaxDbiO01634.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK770.3.1; ZK770.3.1; WBGene00002134.
ZK770.3.2; ZK770.3.2; WBGene00002134.
GeneIDi171944.
KEGGicel:CELE_ZK770.3.
UCSCiZK770.3.1. c. elegans.

Organism-specific databases

CTDi171944.
WormBaseiZK770.3; CE15413; WBGene00002134; inx-12.

Phylogenomic databases

eggNOGiENOG410K7PX. Eukaryota.
ENOG4110M6V. LUCA.
GeneTreeiENSGT00530000064205.
HOGENOMiHOG000017412.
InParanoidiO01634.
OMAiNTCTATE.
OrthoDBiEOG091G06YS.
PhylomeDBiO01634.

Miscellaneous databases

PROiO01634.

Gene expression databases

BgeeiWBGene00002134.

Family and domain databases

InterProiIPR000990. Innexin.
[Graphical view]
PANTHERiPTHR11893. PTHR11893. 1 hit.
PfamiPF00876. Innexin. 1 hit.
[Graphical view]
PRINTSiPR01262. INNEXIN.
PROSITEiPS51013. PANNEXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINX12_CAEEL
AccessioniPrimary (citable) accession number: O01634
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.