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Protein

Aspartic protease 6

Gene

asp-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89PROSITE-ProRule annotation1
Active sitei277PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.A71.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartic protease 6 (EC:3.4.23.-)
Gene namesi
Name:asp-6
ORF Names:F21F8.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF21F8.7; CE09542; WBGene00000219; asp-6.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000030786416 – 389Aspartic protease 6Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi102 ↔ 106By similarity
Disulfide bondi312 ↔ 344By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO01530.
PaxDbiO01530.
PeptideAtlasiO01530.
PRIDEiO01530.

Expressioni

Gene expression databases

BgeeiWBGene00000219.

Interactioni

Protein-protein interaction databases

BioGridi44250. 4 interactors.
DIPiDIP-24896N.
IntActiO01530. 3 interactors.
MINTiMINT-227516.
STRINGi6239.F21F8.7.2.

Structurei

3D structure databases

ProteinModelPortaliO01530.
SMRiO01530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 384Peptidase A1PROSITE-ProRule annotationAdd BLAST314

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
InParanoidiO01530.
OMAiCKTKSKF.
OrthoDBiEOG091G0CWN.
PhylomeDBiO01530.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 1 hit.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O01530-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTFILLAVL GLASASVHQH KIVWRESKKM GMIRTGQYPA YLEYQRNLRA
60 70 80 90 100
VSPNVLANLP QNVNDFGDFE YLGNITIGTP DQGFIVVLDT GSSNLWIPGP
110 120 130 140 150
TCKTNCKTKS KFDSTASSTF VKNGKSWTIQ YGSGDAAGIL GQDTVRFGAK
160 170 180 190 200
GDSQLSVPTT TFGIASKISA DFKNDATDGI LGLAFTSLAV DGVVPPLINA
210 220 230 240 250
INQGILDQPL FSVWLEHRGA ANNVGGGVFT YGAIDTTNCG ALVAYQPLSS
260 270 280 290 300
ATYYQFKAAG FKLGSYSNTK TVDVISDTGT SFLGGPQSVV DGLAKAAGAT
310 320 330 340 350
YDDFNEVYFI DCAAQPGTLD ITIGTNTYSI QPVNYIVDAG NGQCLFAAFP
360 370 380
FDFGGFGPSW ILGDPFIRQY CNIYDIGNKR MGFAPSLQK
Length:389
Mass (Da):41,520
Last modified:July 1, 1997 - v1
Checksum:i38B1DC51910FBF84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080569 Genomic DNA. Translation: CCD64751.1.
PIRiT29410.
RefSeqiNP_505133.1. NM_072732.7.
UniGeneiCel.18329.

Genome annotation databases

EnsemblMetazoaiF21F8.7; F21F8.7; WBGene00000219.
GeneIDi179209.
KEGGicel:CELE_F21F8.7.
UCSCiF21F8.7.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080569 Genomic DNA. Translation: CCD64751.1.
PIRiT29410.
RefSeqiNP_505133.1. NM_072732.7.
UniGeneiCel.18329.

3D structure databases

ProteinModelPortaliO01530.
SMRiO01530.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44250. 4 interactors.
DIPiDIP-24896N.
IntActiO01530. 3 interactors.
MINTiMINT-227516.
STRINGi6239.F21F8.7.2.

Protein family/group databases

MEROPSiA01.A71.

Proteomic databases

EPDiO01530.
PaxDbiO01530.
PeptideAtlasiO01530.
PRIDEiO01530.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF21F8.7; F21F8.7; WBGene00000219.
GeneIDi179209.
KEGGicel:CELE_F21F8.7.
UCSCiF21F8.7.1. c. elegans.

Organism-specific databases

CTDi179209.
WormBaseiF21F8.7; CE09542; WBGene00000219; asp-6.

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
InParanoidiO01530.
OMAiCKTKSKF.
OrthoDBiEOG091G0CWN.
PhylomeDBiO01530.

Miscellaneous databases

PROiO01530.

Gene expression databases

BgeeiWBGene00000219.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 1 hit.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASP6_CAEEL
AccessioniPrimary (citable) accession number: O01530
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 1, 1997
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.