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Protein

Signal transducing adapter molecule 1

Gene

stam-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1.2 Publications

GO - Molecular functioni

  • protein C-terminus binding Source: WormBase
  • ubiquitin binding Source: WormBase

GO - Biological processi

  • endosome to lysosome transport Source: WormBase
  • ephrin receptor signaling pathway Source: UniProtKB
  • intracellular protein transport Source: InterPro
  • multicellular organism development Source: UniProtKB-KW
  • negative regulation of MAPK cascade Source: UniProtKB
  • protein localization to non-motile cilium Source: WormBase
  • response to hermaphrodite contact Source: WormBase

Keywordsi

Molecular functionDevelopmental protein
Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-6807004. Negative regulation of MET activity.
R-CEL-917729. Endosomal Sorting Complex Required For Transport (ESCRT).
SignaLinkiO01498.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducing adapter molecule 1By similarity
Short name:
STAM-1By similarity
Alternative name(s):
Prion-like-(Q/N-rich) domain-bearing protein 19
Gene namesi
Name:stam-1
Synonyms:pqn-19
ORF Names:C34G6.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiC34G6.7a; CE29700; WBGene00004109; stam-1.
C34G6.7b; CE32816; WBGene00004109; stam-1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003472841 – 457Signal transducing adapter molecule 1Add BLAST457

Proteomic databases

EPDiO01498.
PaxDbiO01498.
PeptideAtlasiO01498.
PRIDEiO01498.

Expressioni

Tissue specificityi

Widely expressed, including the pharyngeal intestinal valve, several head neurons, and phasmids in both males and hermaphrodites throughout development. In males, also expressed in the gonad and sensory neurons in the tail. Expressed in the male-specific ciliate CEM, ray B-type and hook HOB sensory neurons.1 Publication

Gene expression databases

BgeeiWBGene00004109.

Interactioni

Subunit structurei

Isoform a, but not isoform b, interacts (via C-terminus) with lov-1 (via C-terminus).1 Publication

GO - Molecular functioni

  • protein C-terminus binding Source: WormBase
  • ubiquitin binding Source: WormBase

Protein-protein interaction databases

BioGridi37718. 8 interactors.
DIPiDIP-26020N.
IntActiO01498. 16 interactors.
MINTiMINT-1124360.
STRINGi6239.C34G6.7a.2.

Structurei

3D structure databases

ProteinModelPortaliO01498.
SMRiO01498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 147VHSPROSITE-ProRule annotationAdd BLAST129
Domaini173 – 192UIMPROSITE-ProRule annotationAdd BLAST20
Domaini219 – 278SH3PROSITE-ProRule annotationAdd BLAST60
Domaini366 – 383ITAMSequence analysisAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi372 – 456Gln-richSequence analysisAdd BLAST85

Sequence similaritiesi

Belongs to the STAM family.Sequence analysis

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG2199. Eukaryota.
ENOG410XTSY. LUCA.
GeneTreeiENSGT00870000136415.
HOGENOMiHOG000017280.
InParanoidiO01498.
KOiK04705.
OMAiMYAKLQS.
OrthoDBiEOG091G0H1Y.
PhylomeDBiO01498.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiView protein in InterPro
IPR008942. ENTH_VHS.
IPR001452. SH3_domain.
IPR003903. UIM_dom.
IPR002014. VHS_dom.
PfamiView protein in Pfam
PF00018. SH3_1. 1 hit.
PF00790. VHS. 1 hit.
PRINTSiPR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00326. SH3. 1 hit.
SM00288. VHS. 1 hit.
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiView protein in PROSITE
PS50002. SH3. 1 hit.
PS50330. UIM. 1 hit.
PS50179. VHS. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a1 Publication (identifier: O01498-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKQKSFPMS AYEDLLGKIT APTITVENWE GILAFCDMIN NDFEGSKTGI
60 70 80 90 100
KSLRKRLNNR DPHVVLLAIS VLDSCWANCE ERFRKEVSSA QFINELKALC
110 120 130 140 150
TSSQRQVAEK MRLTVQKWVD TECKTEQSLS LIVTLHKNLV ADGYSFVVDD
160 170 180 190 200
PKSKTKAIDA KFANDPNYVG SAQEEEAIAK AIAASLADAE KQEKAKKSTS
210 220 230 240 250
TMYPSAKASS PAVQTNSNIP EKNVRALYDF EAAESNELSF VAGDIITITD
260 270 280 290 300
ESNPHWWTGR IGTQQGLFPS SFVTNQLDDL KSKETDSSQK APEVVASINE
310 320 330 340 350
AILVRCLQVL HECDPTGERQ DPEDLAQLEA ASYAQGNLID AHLASIDRQS
360 370 380 390 400
NSLAQIDVAI RDVLALYDDA IQKGGFQHQS QGMYQQPMQQ YNYQQPPNRA
410 420 430 440 450
YYPPTGPVQQ QQPQQYPPQH YPAPGAQPQY ACPPNSVPQP QQQQQQWPAP

SSQPQQY
Note: No experimental confirmation available.Curated
Length:457
Mass (Da):50,830
Last modified:December 1, 2001 - v2
Checksum:i1AD9B1D83EBE2E16
GO
Isoform b1 Publication (identifier: O01498-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: Missing.
     397-405: PNRAYYPPT → VSFYSEKNI
     406-457: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:397
Mass (Da):44,017
Checksum:i5CFD4FE172B63E75
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0528961 – 8Missing in isoform b. 1 Publication8
Alternative sequenceiVSP_052897397 – 405PNRAYYPPT → VSFYSEKNI in isoform b. 1 Publication9
Alternative sequenceiVSP_052898406 – 457Missing in isoform b. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080778 Genomic DNA. Translation: CCD66687.1.
FO080778 Genomic DNA. Translation: CCD66688.1.
PIRiG87789.
RefSeqiNP_491710.2. NM_059309.6. [O01498-1]
NP_871813.1. NM_182013.6. [O01498-2]
UniGeneiCel.7418.

Genome annotation databases

EnsemblMetazoaiC34G6.7a; C34G6.7a; WBGene00004109. [O01498-1]
GeneIDi172264.
KEGGicel:CELE_C34G6.7.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSTAM1_CAEEL
AccessioniPrimary (citable) accession number: O01498
Secondary accession number(s): Q8I7I2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families