O01393 (UNC9_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Innexin unc-9

Alternative name(s):
Uncoordinated protein 9

Gene names

Name:	unc-9
ORF Names:	R12H7.1

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	386 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Structural components of the gap junctions.
Subunit structure	Heterooligomer of unc-7 and unc-9 Probable.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential. Cell junction › gap junction.
Sequence similarities	Belongs to the pannexin family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Gap junction Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Ion channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ion transmembrane transport Inferred from direct assay PubMed 19432959. Source: WormBase
Cellular_component	gap junction Inferred from sequence or structural similarity. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	gap junction hemi-channel activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 386	386	Innexin unc-9		PRO_0000208518
Regions
	Transmembrane	33 – 53	21	Helical; Potential
	Transmembrane	103 – 123	21	Helical; Potential
	Transmembrane	197 – 217	21	Helical; Potential
	Transmembrane	282 – 302	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O01393 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: D7126726B74B7CAB	FASTA	386	45,192
	10 20 30 40 50 60 MSMLLYYFAS AVKSIQFHVD DDIIDKLNYY YTTAIITVFA ILVSAKQYVG FPIQCWVPAT 70 80 90 100 110 120 FTEPMEQYTE NYCWVQNTYF LPLHDYIPHN YAERENRQIG YYQWVPFVLA LEALLFYVPT 130 140 150 160 170 180 IVWRLLSWQS GIHVQSLVQM ACDSRLLDLE SRNRALQTIA TNVEEALHVK HQVMSGNRLK 190 200 210 220 230 240 LLNLIICTRS SGAAVTFLYI SVKILYTVNI VGQIFLLNTF LGNRSKWYGL QVLNDLMNGR 250 260 270 280 290 300 EWEESGHFPR VTLCDFEVKV LGNVHRHTVQ CVLMINMFNE KIFLFLWFWY FLLAGATLCS 310 320 330 340 350 360 LFYWIYISVV PSRQLNFVGK YLTGIEGYKM VDSQSLRRFV FHFLRQDGVF LLRMVATHAG 370 380 ELPCYELAKT LWNNYCDNKE GKMHDV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The C. elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family implicated in electrical coupling of excitable cells." Barnes T.M., Hekimi S. J. Neurochem. 69:2251-2260(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U93195 mRNA. Translation: AAB51534.1. Z50755 Genomic DNA. Translation: CAB61030.2.
RefSeq	NP_741917.1. NM_171790.3.
UniGene	Cel.19695.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	6239.R12H7.1.
Proteomic databases
PaxDb	O01393.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	R12H7.1; R12H7.1; R12H7.1.
GeneID	181443.
KEGG	cel:CELE_R12H7.1.
UCSC	R12H7.1. c. elegans.
Organism-specific databases
CTD	181443.
WormBase	R12H7.1; CE28246; WBGene00006749; unc-9.
Phylogenomic databases
eggNOG	NOG80783.
GeneTree	ENSGT00530000064205.
HOGENOM	HOG000017412.
InParanoid	O01393.
OMA	PSTLEMA.
Family and domain databases
InterPro	IPR000990. Innexin. [Graphical view]
PANTHER	PTHR11893. PTHR11893. 1 hit.
Pfam	PF00876. Innexin. 1 hit. [Graphical view]
PRINTS	PR01262. INNEXIN.
PROSITE	PS51013. PANNEXIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	913966.

Entry information

Entry name

UNC9_CAEEL

Accession

Primary (citable) accession number: O01393
Secondary accession number(s): Q9NAN6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	July 1, 1997
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project