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O01391

- UCHL_APLCA

UniProt

O01391 - UCHL_APLCA

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Protein
Ubiquitin carboxyl-terminal hydrolase
Gene
UCH
Organism
Aplysia californica (California sea hare)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei90 – 901Nucleophile By similarity
Active sitei164 – 1641Proton donor By similarity
Sitei179 – 1791Important for enzyme activity By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC12.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase (EC:3.4.19.12)
Alternative name(s):
Ubiquitin thioesterase
Gene namesi
Name:UCH
OrganismiAplysia californica (California sea hare)
Taxonomic identifieri6500 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiomorphaAplysioideaAplysiidaeAplysia

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Ubiquitin carboxyl-terminal hydrolase
PRO_0000211068Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO01391.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C12 family.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.
PROSITEiPS00140. UCH_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O01391-1 [UniParc]FASTAAdd to Basket

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MASEQRWIPL ESNPKVLNKY VHNLGMDAGW NFVDVFGLDP ELLAMVPRPA    50
AALVLLFPDD KETVNQLIGE YQSDYPDSLY YTKQTIGNAC GTVAIVHALA 100
NNENVIPFDA AKHFKTFLEK TKPLNPEERA KHLEQDNLMG AAHGDCAQEG 150
DTQAPSQDEH VKSHFVALVH CNGTLYELDG RKEAPVVHGT TSADTFLEDA 200
AEVVKKFMAR DPEI 214
Length:214
Mass (Da):23,703
Last modified:July 1, 1997 - v1
Checksum:i07ACDEDAADB05D6E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U90177 mRNA. Translation: AAB52410.1.
RefSeqiNP_001191493.1. NM_001204564.1.
UniGeneiAcl.28.

Genome annotation databases

GeneIDi100533253.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U90177 mRNA. Translation: AAB52410.1 .
RefSeqi NP_001191493.1. NM_001204564.1.
UniGenei Acl.28.

3D structure databases

ProteinModelPortali O01391.
ModBasei Search...

Protein family/group databases

MEROPSi C12.003.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100533253.

Organism-specific databases

CTDi 100533253.

Family and domain databases

Gene3Di 3.40.532.10. 1 hit.
InterProi IPR001578. Peptidase_C12_UCH.
[Graphical view ]
PANTHERi PTHR10589. PTHR10589. 1 hit.
Pfami PF01088. Peptidase_C12. 1 hit.
[Graphical view ]
PRINTSi PR00707. UBCTHYDRLASE.
PROSITEi PS00140. UCH_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in Aplysia."
    Hegde A.N., Inokuchi K., Pei W., Casadio A., Ghirardi M., Chain D.G., Martin K.C., Kandel E.R., Schwartz J.H.
    Cell 89:115-126(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiUCHL_APLCA
AccessioniPrimary (citable) accession number: O01391
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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