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Protein

Caspase

Gene

Drice

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the activation cascade of caspases responsible for apoptosis execution. Acts downstream of rpr. Cleaves baculovirus p35 and lamin DmO in vitro.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei169By similarity1
Active sitei211By similarity1

GO - Molecular functioni

  • BIR domain binding Source: FlyBase
  • cysteine-type endopeptidase activity Source: FlyBase
  • cysteine-type endopeptidase activity involved in apoptotic process Source: FlyBase
  • cysteine-type endopeptidase activity involved in execution phase of apoptosis Source: FlyBase

GO - Biological processi

  • apoptotic process Source: FlyBase
  • neuron remodeling Source: FlyBase
  • nurse cell apoptotic process Source: FlyBase
  • positive regulation of compound eye retinal cell programmed cell death Source: FlyBase
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: FlyBase
  • programmed cell death Source: FlyBase
  • programmed cell death involved in cell development Source: FlyBase
  • proteolysis Source: FlyBase
  • regulation of retinal cell programmed cell death Source: FlyBase
  • response to X-ray Source: FlyBase
  • salivary gland histolysis Source: FlyBase
  • spermatid differentiation Source: FlyBase
  • sterol regulatory element binding protein cleavage Source: FlyBase

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-DME-111465 Apoptotic cleavage of cellular proteins
R-DME-2028269 Signaling by Hippo
R-DME-211227 Activation of DNA fragmentation factor
R-DME-264870 Caspase-mediated cleavage of cytoskeletal proteins
R-DME-351906 Apoptotic cleavage of cell adhesion proteins
R-DME-418889 Ligand-independent caspase activation via DCC

Protein family/group databases

MEROPSiC14.015

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase (EC:3.4.22.-)
Alternative name(s):
drICE
Cleaved into the following 2 chains:
Gene namesi
Name:Drice
Synonyms:ICE
ORF Names:CG7788
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0019972 Drice

Subcellular locationi

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi29A → V: Abolishes binding to Diap2 but has no effect on Drice processing or activity. 1 Publication1
Mutagenesisi211C → A: No effect on binding to Diap2 but may effect stability of complex formed with Diap2. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000046661 – 28By similarityAdd BLAST28
ChainiPRO_000000466729 – 217Caspase subunit p21By similarityAdd BLAST189
PropeptideiPRO_0000004668218 – 230By similarityAdd BLAST13
ChainiPRO_0000004669231 – 339Caspase subunit p12By similarityAdd BLAST109

Keywords - PTMi

Zymogen

Proteomic databases

PaxDbiO01382
PRIDEiO01382

Expressioni

Developmental stagei

Expressed at all stages where apoptosis occurs.

Gene expression databases

BgeeiFBgn0019972
GenevisibleiO01382 DM

Interactioni

Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 21 kDa (p21) and a 12 kDa (p12) subunit. Inactive pro-form can homodimerize. Dronc and Drice can form a stable complex (PubMed:10675329). Interacts with Diap2 (via BIR3 domain) to form a stable complex (PubMed:18166655).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DroncQ9XYF43EBI-91422,EBI-108311

GO - Molecular functioni

  • BIR domain binding Source: FlyBase

Protein-protein interaction databases

BioGridi68378, 25 interactors
DIPiDIP-21838N
ELMiO01382
IntActiO01382, 2 interactors
MINTiO01382
STRINGi7227.FBpp0084848

Structurei

Secondary structure

1339
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi90 – 101Combined sources12
Beta strandi105 – 108Combined sources4
Helixi118 – 128Combined sources11
Beta strandi132 – 138Combined sources7
Helixi141 – 152Combined sources12
Helixi156 – 158Combined sources3
Beta strandi159 – 168Combined sources10
Helixi180 – 186Combined sources7
Helixi189 – 191Combined sources3
Turni193 – 195Combined sources3
Helixi197 – 199Combined sources3
Beta strandi200 – 202Combined sources3
Beta strandi204 – 211Combined sources8
Beta strandi245 – 252Combined sources8
Turni261 – 263Combined sources3
Helixi266 – 278Combined sources13
Turni279 – 281Combined sources3
Helixi284 – 296Combined sources13
Helixi307 – 309Combined sources3
Beta strandi317 – 320Combined sources4
Beta strandi323 – 325Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SIPX-ray3.50A/C78-230[»]
B/D231-339[»]
3SIRX-ray2.68A/B/C/D78-332[»]
ProteinModelPortaliO01382
SMRiO01382
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C14A family.Curated

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00760000118912
InParanoidiO01382
KOiK04397
OMAiSGSWFVQ
OrthoDBiEOG091G05YD
PhylomeDBiO01382

Family and domain databases

CDDicd00032 CASc, 1 hit
InterProiView protein in InterPro
IPR029030 Caspase-like_dom_sf
IPR033139 Caspase_cys_AS
IPR016129 Caspase_his_AS
IPR002138 Pept_C14_p10
IPR001309 Pept_C14_p20
IPR015917 Pept_C14A
PRINTSiPR00376 IL1BCENZYME
SMARTiView protein in SMART
SM00115 CASc, 1 hit
SUPFAMiSSF52129 SSF52129, 1 hit
PROSITEiView protein in PROSITE
PS01122 CASPASE_CYS, 1 hit
PS01121 CASPASE_HIS, 1 hit
PS50207 CASPASE_P10, 1 hit
PS50208 CASPASE_P20, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O01382-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDATNNGESA DQVGIRVGNP EQPNDHTDAL GSVGSGGAGS SGLVAGSSHP
60 70 80 90 100
YGSGAIGQLA NGYSSPSSSY RKNVAKMVTD RHAAEYNMRH KNRGMALIFN
110 120 130 140 150
HEHFEVPTLK SRAGTNVDCE NLTRVLKQLD FEVTVYKDCR YKDILRTIEY
160 170 180 190 200
AASQNHSDSD CILVAILSHG EMGYIYAKDT QYKLDNIWSF FTANHCPSLA
210 220 230 240 250
GKPKLFFIQA CQGDRLDGGV TMQRSQTETD GDSSMSYKIP VHADFLIAYS
260 270 280 290 300
TVPGFYSWRN TTRGSWFMQS LCAELAANGK RLDILTLLTF VCQRVAVDFE
310 320 330
SCTPDTPEMH QQKQIPCITT MLTRILRFSD KQLAPAGRV
Length:339
Mass (Da):37,363
Last modified:December 1, 2000 - v2
Checksum:iE105ED29518507EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151A → S in CAA72937 (PubMed:9184225).Curated1
Sequence conflicti265S → T in CAA72937 (PubMed:9184225).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12261 mRNA Translation: CAA72937.1
AE014297 Genomic DNA Translation: AAF56939.1
AY058451 mRNA Translation: AAL13680.1
RefSeqiNP_524551.2, NM_079827.3
UniGeneiDm.2333

Genome annotation databases

EnsemblMetazoaiFBtr0085482; FBpp0084848; FBgn0019972
GeneIDi43514
KEGGidme:Dmel_CG7788

Similar proteinsi

Entry informationi

Entry nameiDRICE_DROME
AccessioniPrimary (citable) accession number: O01382
Secondary accession number(s): Q9VAH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

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