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Protein
Submitted name:

CREB-binding protein homolog

Gene

nej

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cAMP response element binding protein binding Source: FlyBase
  • histone acetyltransferase activity Source: FlyBase
  • histone acetyltransferase activity (H3-K18 specific) Source: FlyBase
  • histone acetyltransferase activity (H3-K27 specific) Source: FlyBase
  • histone methyltransferase binding Source: FlyBase
  • transcription coactivator activity Source: FlyBase
  • transcription factor binding Source: FlyBase
  • zinc ion binding Source: InterPro

GO - Biological processi

  • circadian regulation of gene expression Source: FlyBase
  • compound eye development Source: FlyBase
  • compound eye morphogenesis Source: FlyBase
  • DNA replication checkpoint Source: FlyBase
  • glial cell migration Source: FlyBase
  • hemopoiesis Source: FlyBase
  • histone acetylation Source: FlyBase
  • histone H3-K18 acetylation Source: FlyBase
  • histone H3-K27 acetylation Source: FlyBase
  • histone H3-K4 methylation Source: FlyBase
  • histone H4-K12 acetylation Source: FlyBase
  • histone H4-K8 acetylation Source: FlyBase
  • locomotor rhythm Source: FlyBase
  • neurogenesis Source: FlyBase
  • neurotransmitter secretion Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • R3/R4 cell fate commitment Source: FlyBase
  • R7 cell differentiation Source: FlyBase
  • regulation of glucose metabolic process Source: FlyBase
  • regulation of mitotic nuclear division Source: FlyBase
  • sensory perception of pain Source: FlyBase
  • smoothened signaling pathway Source: FlyBase
  • synapse assembly Source: FlyBase
  • thermosensory behavior Source: FlyBase
  • Wnt signaling pathway Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-1234158. Regulation of gene expression by Hypoxia-inducible Factor.
R-DME-201722. Formation of the beta-catenin:TCF transactivating complex.
R-DME-3371568. Attenuation phase.
R-DME-5621575. CD209 (DC-SIGN) signaling.
R-DME-6781823. Formation of TC-NER Pre-Incision Complex.
R-DME-6782135. Dual incision in TC-NER.
R-DME-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
SignaLinkiO01368.

Names & Taxonomyi

Protein namesi
Submitted name:
CREB-binding protein homologImported
Gene namesi
Name:nejImported
ORF Names:CG15319Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0261617. nej.

Subcellular locationi

GO - Cellular componenti

  • histone acetyltransferase complex Source: FlyBase
  • histone methyltransferase complex Source: FlyBase
  • nucleoplasm Source: FlyBase
  • nucleus Source: FlyBase
  • polytene chromosome Source: FlyBase
  • presynapse Source: GOC
  • protein complex Source: FlyBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiO01368.
PRIDEiO01368.

Expressioni

Gene expression databases

BgeeiO01368.
ExpressionAtlasiO01368. differential.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
armP188243EBI-868028,EBI-216128

GO - Molecular functioni

  • cAMP response element binding protein binding Source: FlyBase
  • histone methyltransferase binding Source: FlyBase
  • transcription factor binding Source: FlyBase

Protein-protein interaction databases

DIPiDIP-41329N.
IntActiO01368. 1 interaction.
MINTiMINT-232637.
STRINGi7227.FBpp0291862.

Structurei

3D structure databases

ProteinModelPortaliO01368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini508 – 59487TAZ-typeInterPro annotationAdd
BLAST
Domaini938 – 101780KIXInterPro annotationAdd
BLAST
Domaini1715 – 178773BromoInterPro annotationAdd
BLAST
Domaini1945 – 2328384CBP/p300-type HAT (histone acetyltransferase)InterPro annotationAdd
BLAST
Domaini2329 – 237244ZZ-typeInterPro annotationAdd
BLAST
Domaini2392 – 247382TAZ-typeInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili2170 – 219728Sequence analysisAdd
BLAST

Keywords - Domaini

BromodomainSAAS annotation, Coiled coilSequence analysis, Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG1778. Eukaryota.
COG5076. LUCA.
OrthoDBiEOG75B84F.

Family and domain databases

Gene3Di1.10.246.20. 1 hit.
1.20.1020.10. 2 hits.
1.20.920.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR031162. CBP_P300_HAT.
IPR013178. Histone_AcTrfase_Rtt109/CBP.
IPR003101. KIX_dom.
IPR010303. RING_CBP-p300.
IPR019786. Zinc_finger_PHD-type_CS.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF06001. DUF902. 1 hit.
PF08214. HAT_KAT11. 1 hit.
PF02172. KIX. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM01250. KAT11. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF47040. SSF47040. 1 hit.
SSF47370. SSF47370. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51727. CBP_P300_HAT. 1 hit.
PS50952. KIX. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O01368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMADHLDEPP QKRVKMDPTD ISYFLEENLP DELVSSNSGW SDQLTGGAGG
60 70 80 90 100
GNGGGGASGV TTNPTSGPNP GGGPNKPAAQ GPGSGTGGVG VGVNVGVGGV
110 120 130 140 150
VGVGVVPSQM NGAGGGNGSG TGGDDGSGNG SGAGNRISQM QHQQLQHLLQ
160 170 180 190 200
QQQQGQKGAM VVPGMQQLGS KSPNLQSPNQ GGMQQVVGTQ MGMVNSMPMS
210 220 230 240 250
ISNNGNNGMN AIPGMNTIAQ GNLGNMVLTN SVGGGMGGMV NHLKQQPGGG
260 270 280 290 300
GGGMINSVSV PGGPGAGAGG VGAGGGGAVA ANQGMHMQNG PMMGRMVGQQ
310 320 330 340 350
HMLRGPHLMG ASGGAGGPGN GPGGGGPRMQ NPNMQMTQLN SLPYGVGQYG
360 370 380 390 400
GPGGGNNPQQ QQQQQQQQLL AQQMAQRGGV VPGMPRGNRP VGTVVPMSTL
410 420 430 440 450
GGDGSGPAGQ LVSGNPQQQQ MLAQQQTGAM GPRPPQPNQL LGHPGQQQQQ
460 470 480 490 500
QQQPGTSQQQ QQQQGVGIGG AGVVANAGTV AGVPAVAGGG AGGAVQSSGP
510 520 530 540 550
GGANRDVPDD RKRQIQQQLM LLLHAHKCNR RENLNPNREV CNVNYCKAMK
560 570 580 590 600
SVLAHMGTCK QSKDCTMQHC ASSRQILLHY KTCQNSGCVI CYPFRQNHSV
610 620 630 640 650
FQNANVPPGG GPAGIGGAPP GGGGAGGGAA GAGGNLQQQQ QQQQQQQQNQ
660 670 680 690 700
QPNLTGLVVG GKQGQQVAPG GGQNTAIVLP QQQGAGGAPG APKTPADMVQ
710 720 730 740 750
QLTQQQQQQQ QQVHQQQVQQ QELRRFDGMS QQVVAGGMQQ QQQQGLPPVI
760 770 780 790 800
RIQGAQPAVR VLGPGGPGGP SGPNVLPNDV NSLHQQQQQM LQQQQQQGQN
810 820 830 840 850
RRRGGLATMV EQQQQHQQQQ QQPNPAQLGG NIPAPLSVNV GGFGNTNFGG
860 870 880 890 900
AAAGGAVGAN DKQQLKVAQV HPQSHGVGAG GASAGAGASG GQVAAGSSVL
910 920 930 940 950
MPADTTGSGN AGNPNQNAGG VAGGAGGGNG GNTGPPGDNE KDWRESVTAD
960 970 980 990 1000
LRNHLVHKLV QAIFPTSDPT TMQDKRMHNL VSYAEKVEKD MYEMAKSRSE
1010 1020 1030 1040 1050
YYHLLAEKIY KIQKELEEKR LKRKEQHQQM LMQQQGVANP VAGGAAGGAG
1060 1070 1080 1090 1100
SAAGVAGGVV LPQQQQQQQQ QQQQQGQQPL QSCIHPSISP MGGVMPPQQL
1110 1120 1130 1140 1150
RPQGPPGILG QQTAAGLGVG VGVTNNMVTM RSHSPGGNML ALQQQQRMQF
1160 1170 1180 1190 1200
PQQQQQQPPG SGAGKMLVGP PGPSPGGMVV NPALSPYQTT NVLTSPVPGQ
1210 1220 1230 1240 1250
QQQQQFINAN GGTGANPQLS EIMKQRHIHQ QQQQQQQQQQ QQGMLLPQSP
1260 1270 1280 1290 1300
FSNSTPLQQQ QQQQQQQQQQ QATSNSFSSP MQQQQQGQQQ QQQKPGSVLN
1310 1320 1330 1340 1350
NMPPTPTSLE ALNAGAGAPG TGGSASNVTV SAPSPSPGFL SNGPSIGTPS
1360 1370 1380 1390 1400
NNNNSSSANN NPPSVSSLMQ QPLSNRPGTP PYIPASPVPA TSASGLAASS
1410 1420 1430 1440 1450
TPASAAATCA SSGSGSNSSS GATAAGASST SSSSSAGSGT PLSSVSTPTS
1460 1470 1480 1490 1500
ATMATSSGGG GGGGGNAGGG SSTTPASNPL LLMSGGTAGG GTGATTTTST
1510 1520 1530 1540 1550
SSSSRMMSSS SSLSSQMAAL EAAARDNDDE TPSPSGENTN GSGGSGNAGG
1560 1570 1580 1590 1600
MASKGKLDSI KQDDDIKKEF MDDSCGGNND SSQMDCSTGG GKGKNVNNDG
1610 1620 1630 1640 1650
TSMIKMEIKT EDGLDGEVKI KTEAMDVDEA GGSTAGEHHG EGGGGSGVGG
1660 1670 1680 1690 1700
GKDNINGAHD GGATGGAVDI KPKTETKPLV PEPLAPNAGD KKKKCQFNPE
1710 1720 1730 1740 1750
ELRTALLPTL EKLYRQEPES VPFRYPVDPQ ALGIPDYFEI VKKPMDLGTI
1760 1770 1780 1790 1800
RTNIQNGKYS DPWEYVDDVW LMFDNAWLYN PKTSRVYRYC TKLSEVFEAE
1810 1820 1830 1840 1850
IDPVMQALGY CCGRKYTFNP QVLCCYGKQL CTIPRDAKYY SYQNSLKEYG
1860 1870 1880 1890 1900
VASNRYTYCQ KCFNDIQGDT VTLGDDPLQS QTQIKKDQFK EMKNDHLELE
1910 1920 1930 1940 1950
PFVNCQECGR KQHQICVLWL DSIWPGGFVC DNCLKKKNSK RKENKFNAKR
1960 1970 1980 1990 2000
LPTTKLGVYI ETRVNNFLKK KEAGAGEVHI RVVSSSDKCV EVKPGMRRRF
2010 2020 2030 2040 2050
VEQGEMMNEF PYRAKALFAF EEVDGIDVCF FGMHVQEYGS ECPAPNTRRV
2060 2070 2080 2090 2100
YIAYLDSVHF FRPRQYRTAV YHEILLGYMD YVKQLGYTMA HIWACPPSEG
2110 2120 2130 2140 2150
DDYIFHCHPT DQKIPKPKRL QEWYKKMLDK GMIERIIQDY KDILKQAMED
2160 2170 2180 2190 2200
KLGSAAELPY FEGDFWPNVL EESIKELDQE EEEKRKQAEA AEAAAAANLF
2210 2220 2230 2240 2250
SIEENEVSGD GKKKGQKKAK KSNKSKAAQR KNSKKSNEHQ SGNDLSTKIY
2260 2270 2280 2290 2300
ATMEKHKEVF FVIRLHSAQS AASLAPIQDP DPLLTCDLMD GRDAFLTLAR
2310 2320 2330 2340 2350
DKHFEFSSLR RAQFSTLSML YELHNQGQDK FVYTCNHCKT AVETRYHCTV
2360 2370 2380 2390 2400
CDDFDLCIVC KEKVGHQHKM EKLGFDIDDG SALADHKQAN PQEARKQSIQ
2410 2420 2430 2440 2450
RCIQSLAHAC QCRDANCRLP SCQKMKLVVQ HTKNCKRKPN GGCPICKQLI
2460 2470 2480 2490 2500
ALCCYHAKNC EEQKCPVPFC PNIKHKLKQQ QSQQKFQQQQ LLRRRVALMS
2510 2520 2530 2540 2550
RTAAPAALQG PAAVSGPTVV SGGVPVVGMS GVAVSQQVIP GQAGILPPGA
2560 2570 2580 2590 2600
GGMSPSTVAV PSPVSGGAGA GGMGGMTSPH PHQPGIGMKP GGGHSPSPNV
2610 2620 2630 2640 2650
LQVVKQVQEE AARQQVSHGG GFGKGVPMAP PVMNRPMGGA GPNQNVVNQL
2660 2670 2680 2690 2700
GGMGVGVGGV GGVGVGGVGG VGVNQLNSGG GNTPGAPISG PGMNVNHLMS
2710 2720 2730 2740 2750
MDQWGGGGAG GGGANPGGGN PQARYANNTG GMRQPTHVMQ TNLIPPQQQQ
2760 2770 2780 2790 2800
QMMGGLGGPN QLGGGQMPVG GQHGGMGMGM GAPPMAGTVG GVRPSPGAGG
2810 2820 2830 2840 2850
GGGSATGGGL NTQQLALIMQ KIKNNPTNES NQHILAILKQ NPQIMAAIIK
2860 2870 2880 2890 2900
QRQQSQNNAA AGGGAPGPGG ALQQQQAGNG PQNPQQQQQQ QQQQQVMQQQ
2910 2920 2930 2940 2950
QMQHMMNQQQ GGGGPQQMNP NQQQQQQQVN LMQQQQQGGP GGPGSGLPTR
2960 2970 2980 2990 3000
MPNMPNALGM LQSLPPNMSP GVSTQGGMVP NQNWNKMRYM QMSQYPPPYP
3010 3020 3030 3040 3050
QRQRGPHMGG AGPGPGQQQF PGGGGGAGNF NAGGAGGAGG VVGVGGVPGG
3060 3070 3080 3090 3100
AGTVPGGDQY SMANAAAASN MLQQQQGQVG VGVGVGVKPG PGQQQQQMGV
3110 3120 3130 3140 3150
GMPPGMQQQQ QQQQPLQQQQ MMQVAMPNAN AQNPSAVVGG PNAQVMVRRR
3160 3170 3180 3190
RISAAAADAI GPLVAAYSLP AANAIATFGS IATCCSIRLA
Length:3,190
Mass (Da):331,878
Last modified:July 1, 1997 - v1
Checksum:iE53526F78BC055A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88570 mRNA. Translation: AAB53050.1.
PIRiT13828.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88570 mRNA. Translation: AAB53050.1.
PIRiT13828.

3D structure databases

ProteinModelPortaliO01368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-41329N.
IntActiO01368. 1 interaction.
MINTiMINT-232637.
STRINGi7227.FBpp0291862.

Proteomic databases

PaxDbiO01368.
PRIDEiO01368.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0261617. nej.

Phylogenomic databases

eggNOGiKOG1778. Eukaryota.
COG5076. LUCA.
OrthoDBiEOG75B84F.

Enzyme and pathway databases

ReactomeiR-DME-1234158. Regulation of gene expression by Hypoxia-inducible Factor.
R-DME-201722. Formation of the beta-catenin:TCF transactivating complex.
R-DME-3371568. Attenuation phase.
R-DME-5621575. CD209 (DC-SIGN) signaling.
R-DME-6781823. Formation of TC-NER Pre-Incision Complex.
R-DME-6782135. Dual incision in TC-NER.
R-DME-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
SignaLinkiO01368.

Gene expression databases

BgeeiO01368.
ExpressionAtlasiO01368. differential.

Family and domain databases

Gene3Di1.10.246.20. 1 hit.
1.20.1020.10. 2 hits.
1.20.920.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR031162. CBP_P300_HAT.
IPR013178. Histone_AcTrfase_Rtt109/CBP.
IPR003101. KIX_dom.
IPR010303. RING_CBP-p300.
IPR019786. Zinc_finger_PHD-type_CS.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF06001. DUF902. 1 hit.
PF08214. HAT_KAT11. 1 hit.
PF02172. KIX. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM01250. KAT11. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF47040. SSF47040. 1 hit.
SSF47370. SSF47370. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51727. CBP_P300_HAT. 1 hit.
PS50952. KIX. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling."
    Akimaru H., Chen Y., Dai P., Hou D.X., Nonaka M., Smolik S.M., Armstrong S., Goodman R.H., Ishii S.
    Nature 386:735-738(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO01368_DROME
AccessioniPrimary (citable) accession number: O01368
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: July 6, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.