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Protein
Submitted name:

Kinesin-73

Gene

Khc-73

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • microtubule motor activity Source: FlyBase
  • protein homodimerization activity Source: FlyBase

GO - Biological processi

  • establishment of spindle orientation Source: FlyBase
  • microtubule-based movement Source: FlyBase
  • plus-end-directed vesicle transport along microtubule Source: InterPro
  • regulation of synapse structure or activity Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiO01349.

Names & Taxonomyi

Protein namesi
Submitted name:
Kinesin-73Imported
Gene namesi
Name:Khc-73Imported
ORF Names:CG8183Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0019968. Khc-73.

Subcellular locationi

GO - Cellular componenti

  • early endosome Source: FlyBase
  • kinesin complex Source: FlyBase
  • microtubule plus-end Source: FlyBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiO01349.
PRIDEiO01349.

Expressioni

Gene expression databases

BgeeiO01349.
ExpressionAtlasiO01349. differential.

Interactioni

GO - Molecular functioni

  • protein homodimerization activity Source: FlyBase

Protein-protein interaction databases

STRINGi7227.FBpp0302989.

Structurei

3D structure databases

ProteinModelPortaliO01349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 352348Kinesin motorInterPro annotationAdd
BLAST
Domaini1826 – 186843CAP-GlyInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili589 – 62133Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.SAAS annotation
Contains kinesin motor domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0245. Eukaryota.
COG5059. LUCA.
COG5244. LUCA.

Family and domain databases

Gene3Di2.30.30.190. 1 hit.
2.60.200.20. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR000938. CAP-Gly_domain.
IPR000253. FHA_dom.
IPR032923. KIF13A.
IPR022164. Kinesin-like.
IPR027640. Kinesin-like_fam.
IPR022140. Kinesin-like_KIF1-typ.
IPR032405. Kinesin_assoc.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PTHR24115:SF458. PTHR24115:SF458. 3 hits.
PfamiPF01302. CAP_GLY. 1 hit.
PF12473. DUF3694. 1 hit.
PF00498. FHA. 1 hit.
PF12423. KIF1B. 1 hit.
PF00225. Kinesin. 1 hit.
PF16183. Kinesin_assoc. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM01052. CAP_GLY. 1 hit.
SM00240. FHA. 1 hit.
SM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF74924. SSF74924. 1 hit.
PROSITEiPS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 1 hit.
PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O01349-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASDKIKVAV RVRPFNRREI ELDTKCIVEM EKQQTILQNP PPLEKIERKQ
60 70 80 90 100
PKTFAFDHCF YSLNPEDENF ASQETVFDCV GRGILDNAFQ GYNACIFAYG
110 120 130 140 150
QTGSGKSYTM MGTQESKGII PRLCDQLFSA IANKSTPELM YKVEVSYMEI
160 170 180 190 200
YNEKVHDLLD PKPNKQSLKV REHNVMGPYV DGLSQLAVTS YQDIDNLMTE
210 220 230 240 250
GNKSRTVAAT NMNAESSRSH AVFSVVLTQI LTDQATGVSG EKVSRMSLVD
260 270 280 290 300
LAGSERAVKT GAVGDRLKEG SNINKSLTTL GLVISKLADQ SNGKKSGNDK
310 320 330 340 350
FVPYRDSVLT WLLKDNLGGN SRTVMVATIS PSADNYEETL STLRYADRAK
360 370 380 390 400
RIVNHAVVNE DPNARIIREL RHEVETLRSM LKHATGSPVG DVQDKLAESE
410 420 430 440 450
NLMKQISQTW EEKLVKTERI QNERQQALEK MGISVQASGI KVEKNKYYLV
460 470 480 490 500
NLNADPSLNE LLVYYLKDRT LIGGRTISGQ QPDIQLSGLG IQPEHCVITI
510 520 530 540 550
EDSGLYMEPV QGARCFVNGS AAVEKTPLQN GDRILWGNHH FFRVNSPKSN
560 570 580 590 600
NTSMCASEPQ TPAQLIDYNF ARDEIMQNEL SNDPIQTAIA RLERQHEEDK
610 620 630 640 650
QVALEKQRQE YERQFQQLRN ILSPSTPYAP YAPYDPLRMG KITPNTPTSQ
660 670 680 690 700
MRVEKWAQER DEMFRRSLGQ LKTDIMRANS LVQEANFLAE EMEKKTKFSV
710 720 730 740 750
TLQIPPANLS PNRRRGAFVS EPAILAKRTN SGSQIWTMEK LENKLIDMRE
760 770 780 790 800
MYQEHKERVL NGLPLIEPFS EDEFDDKDED NAKPQDPFYE SQENHNLIGV
810 820 830 840 850
ANIFLEVLFH DVKLDYHTPI ISQQGEVAGR LQVEIERIAG QMPQDRMCES
860 870 880 890 900
VSESSGDSRD EYDDPVDPTS NQITCRVTIK CASGLPLSLS NFVFCQYTFW
910 920 930 940 950
GHQEMVVPVI NAESTAHDQN MVFKFEHTQD FTVTINEEFL EHCIEGALSI
960 970 980 990 1000
EVWGHRSAGF SKTKGWEVEQ QQAKARSLVD RWAELSRKIE LWVEIHELND
1010 1020 1030 1040 1050
NGEYSPVEVT NRNEVLTGGI YQLRQGQQRR VNVRVKPVQN SGTLPIICQS
1060 1070 1080 1090 1100
IVNVAIGSVT VRSRLQRPLD SYQEEDLTVL REKWSEALGR RRQYLDQQIQ
1110 1120 1130 1140 1150
MLIKKEEKNE QERERELSLV HQWVSLTEER NAVLVPAPGS GIPGAPASWE
1160 1170 1180 1190 1200
PPSGMEPHVP VLFLNLNGDD LSAQNTNDEL SVAGINSILS KEHGHKFYTL
1210 1220 1230 1240 1250
QILQHLDKDV CCVASWDSSM HDSQALNRVT EANERVYLIL RTTVRLSHPA
1260 1270 1280 1290 1300
PMDLVLRKRL SINIKKGQTL TDRLKKFRLV RGENAIWQSG VTYEVVSNIP
1310 1320 1330 1340 1350
KASEELEDRE SLAQLAASGD DCSASDGETY IEKYTRGVSA VESILTLDRL
1360 1370 1380 1390 1400
RQNVAVKELE TAHGQPLSMR KTVSVPNFSQ QLINKLTQIM RFDASMESLL
1410 1420 1430 1440 1450
NVGRSESFAD LNNSALGNKF TPAGHSPAGA GGVIRSRHSF GGKGSSDDSP
1460 1470 1480 1490 1500
GKAFGIASPA TSKLLGMRMT TLHEEPLGGH RSLDEEPEDS YSDSEYAAEY
1510 1520 1530 1540 1550
EQERQQNKSM ATRSRLTASK TMDSFMDVSS HSNQSYLSYT SSANANMKHL
1560 1570 1580 1590 1600
TGLATLSMSS STSSGYGSQA VSCNNLSNED IASMRSMSID ETPDFDRVNS
1610 1620 1630 1640 1650
NSPPNRQARV NPFLKDMPKA KIQEQPEPQA KKLQEAFTHP LEQLESRENA
1660 1670 1680 1690 1700
QSDDDECAQL PKNNNNNVDL VNEPKPLSGQ MELEEPMSQP ESQTEFATDN
1710 1720 1730 1740 1750
QNGNRSSDEL SHSSEDLLEG DGIVREELPA GKVVRRKKSN TQPPSNGNSI
1760 1770 1780 1790 1800
NNNNNGTTQV PRINHRASVA KMEGLAAYLD SSIMTSSTEV DEESKDVELV
1810 1820 1830 1840 1850
LPEWLVVGES VLIRPYNTSG VIRFVGTTEF QPGAWIGVEL DTPTGKNDGS
1860 1870 1880 1890 1900
VKGVQYFQCK PKHGMFVRSD KLMLDKRGKA MRAYKAAEKS NSISKEMSTS
1910 1920
MTGSMTRSKS RGDSLNLSAR K
Length:1,921
Mass (Da):215,048
Last modified:July 1, 1997 - v1
Checksum:i4643F6F9783E99D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81788 mRNA. Translation: AAB50404.1.
PIRiT13827.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81788 mRNA. Translation: AAB50404.1.
PIRiT13827.

3D structure databases

ProteinModelPortaliO01349.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0302989.

Proteomic databases

PaxDbiO01349.
PRIDEiO01349.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0019968. Khc-73.

Phylogenomic databases

eggNOGiKOG0245. Eukaryota.
COG5059. LUCA.
COG5244. LUCA.

Enzyme and pathway databases

SignaLinkiO01349.

Gene expression databases

BgeeiO01349.
ExpressionAtlasiO01349. differential.

Family and domain databases

Gene3Di2.30.30.190. 1 hit.
2.60.200.20. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR000938. CAP-Gly_domain.
IPR000253. FHA_dom.
IPR032923. KIF13A.
IPR022164. Kinesin-like.
IPR027640. Kinesin-like_fam.
IPR022140. Kinesin-like_KIF1-typ.
IPR032405. Kinesin_assoc.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PTHR24115:SF458. PTHR24115:SF458. 3 hits.
PfamiPF01302. CAP_GLY. 1 hit.
PF12473. DUF3694. 1 hit.
PF00498. FHA. 1 hit.
PF12423. KIF1B. 1 hit.
PF00225. Kinesin. 1 hit.
PF16183. Kinesin_assoc. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM01052. CAP_GLY. 1 hit.
SM00240. FHA. 1 hit.
SM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF74924. SSF74924. 1 hit.
PROSITEiPS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 1 hit.
PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Kinesin-73 in the nervous system of Drosophila embryos."
    Li H.P., Liu Z.M., Nirenberg M.
    Proc. Natl. Acad. Sci. U.S.A. 94:1086-1091(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO01349_DROME
AccessioniPrimary (citable) accession number: O01349
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: May 11, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.