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Protein

Tyrosine-protein kinase

Gene

CELE_F26E4.5

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiO01325.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
ORF Names:CELE_F26E4.5Imported, F26E4.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF26E4.5; CE32638; WBGene00009160.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiO01325.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.F26E4.5.

Structurei

3D structure databases

ProteinModelPortaliO01325.
SMRiO01325. Positions 86-455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini91 – 18393SH2InterPro annotationAdd
BLAST
Domaini195 – 453259Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation
Contains 1 SH2 domain.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0194. Eukaryota.
ENOG410Y6RP. LUCA.
GeneTreeiENSGT00760000119011.
HOGENOMiHOG000017388.
InParanoidiO01325.
OMAiWNGIANK.
OrthoDBiEOG708VXW.
PhylomeDBiO01325.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O01325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSASRGNRR HKDRSEVETA VRGPDLLLKA TDETSSDGAS TSLSKSVEES
60 70 80 90 100
APNKDKSNSS LVKSHHVLKI KLKKITNWSG CSGALLDDEP FYHGYMSREE
110 120 130 140 150
SEKLVRSQGE FLLRKTELTK RGEVVVLSVF WDEGVHHLVV EKANNGLYYL
160 170 180 190 200
KEFCFENISD LVRYHHQTRA SVYKSGIKLF SWVVREEWQL YHEQINLGKK
210 220 230 240 250
LGNGEFGEVF QGVLSVGIFT NDVEVAVKTM KGSKVTADER ITFLREANLM
260 270 280 290 300
LKLNHKYVVR LYGVATQQEP IMIVMELCSG GCLKSRIEKK DEQLSDVLKR
310 320 330 340 350
KYCKQIAKGM RYLEKKQVIH RDLAARNVLL DKSDNCKISD FGLSLFGKLH
360 370 380 390 400
KEQKLMKVPI RWLAPETLLK GIYSSKSDVW SFGVVMFEVF SGEYPYADVK
410 420 430 440 450
VLKELRRKVA HENLRLKPPS DMPTDDAKVM EMCFEPVDNR ATFVQVCNRY
460 470
KDLTSPLPTW NGIANKLIGI GSAV
Length:474
Mass (Da):53,922
Last modified:March 1, 2003 - v2
Checksum:i9767670DFFE8A63A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB03003.2.
PIRiT21417.
RefSeqiNP_492594.2. NM_060193.4.
UniGeneiCel.39072.

Genome annotation databases

EnsemblMetazoaiF26E4.5; F26E4.5; WBGene00009160.
GeneIDi172828.
KEGGicel:CELE_F26E4.5.
UCSCiF26E4.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB03003.2.
PIRiT21417.
RefSeqiNP_492594.2. NM_060193.4.
UniGeneiCel.39072.

3D structure databases

ProteinModelPortaliO01325.
SMRiO01325. Positions 86-455.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F26E4.5.

Proteomic databases

PaxDbiO01325.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF26E4.5; F26E4.5; WBGene00009160.
GeneIDi172828.
KEGGicel:CELE_F26E4.5.
UCSCiF26E4.5. c. elegans.

Organism-specific databases

CTDi172828.
WormBaseiF26E4.5; CE32638; WBGene00009160.

Phylogenomic databases

eggNOGiKOG0194. Eukaryota.
ENOG410Y6RP. LUCA.
GeneTreeiENSGT00760000119011.
HOGENOMiHOG000017388.
InParanoidiO01325.
OMAiWNGIANK.
OrthoDBiEOG708VXW.
PhylomeDBiO01325.

Enzyme and pathway databases

SignaLinkiO01325.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO01325_CAEEL
AccessioniPrimary (citable) accession number: O01325
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.