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Protein

Myosin-B/C

Gene
N/A
Organism
Toxoplasma gondii
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Plays a role in proper daughter cell budding and separation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi199 – 2068ATPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-B/C
Short name:
MyoB/C
Alternative name(s):
TgM-B
OrganismiToxoplasma gondiiImported
Taxonomic identifieri5811 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11711171Myosin-B/CPRO_0000123378Add
BLAST

Proteomic databases

PRIDEiO00936.

Expressioni

Developmental stagei

Both isoforms are expressed at higher levels in bradyzoites than in tachyzoites. Isoform MyoC is the predominant isoform in tachyzoites.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi5811.TGME49_055190.

Structurei

3D structure databases

ProteinModelPortaliO00936.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini105 – 780676Myosin motorAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni671 – 68111Actin-bindingSequence analysisAdd
BLAST
Regioni810 – 1171362TailAdd
BLAST

Sequence similaritiesi

Contains 1 myosin motor domain.Curated

Phylogenomic databases

eggNOGiKOG0160. Eukaryota.
COG5022. LUCA.

Family and domain databases

InterProiIPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Myosin B (identifier: O00936-1) [UniParc]FASTAAdd to basket
Also known as: MyoB

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERKQTQMIL GRRLAKDSPE VKHFQRKSSV VPFGRDGRAA TNFTCWTADC
60 70 80 90 100
PAVKADPTLV FAKCIVVGGS MDTQLELEQV DPPARGTFTV APTDVFNANE
110 120 130 140 150
LIEPETVDDI GYLPHTNVAC VLDVLKSRFL RSIIYTTAEP LLVAINPFKD
160 170 180 190 200
LGNTTDAWIS TYRNASKPEM LPPHVFKTAR AALEDLEGYK KNQSIIVSGE
210 220 230 240 250
SGAGKTEATK QIMRFFASAS SEVRTTIQDT IMAGNPILEA FGNAKTIRNN
260 270 280 290 300
NSSRFGRFMM LDVSSHRGIQ HGSISNFLLE KVRVVSQEAN ERSYHIFYQL
310 320 330 340 350
LKGATSEMRA KYHLRSLKEY AYLNGKNGGC YDVPGIDDKA DFEEVLQSLD
360 370 380 390 400
AMQITGSKRH SVFSILSGLL LIGNVSIEGK DAQGVPDAAY ISPQSEEILE
410 420 430 440 450
EACQLLSVDD AALKKEILVK STKVGPQVIE GVRTKDEAKT SVLSLSKNVY
460 470 480 490 500
DKLFDWLVRQ LNSLIDAPDG MPNFIGILDI FGFEVLEVNS LEQVLINITN
510 520 530 540 550
EYLQKHFIDV VFDMETKLYQ AEGVPTEALE YTDNLALVGA LCGKNDSFFA
560 570 580 590 600
LLEDACLGIR STDEGFCGTI LRRLEPSGFF LESRRDKRLK FIIRHTIADI
610 620 630 640 650
EYTCEGMLEK NKDFLRKEVM DVMKASTDPV TKALFEGIEI EAGKIGKGTL
660 670 680 690 700
IASRFLKNLE EMIGIVAQTE AHFIRCLKPN EEKKPLGWNG SKVLNQLFSL
710 720 730 740 750
SILEALQLRQ VGYAYRRNFS EFCSHFRWLD LGLVNSDRDR KEVAQLLLEQ
760 770 780 790 800
SGIPESSWVI GKTMVFVKPD AAKELSILQR EKLMCFQPLI AVLGPMWRKV
810 820 830 840 850
LLRKKMARVI HFLTRLESNA RRHLEPDSIN ISPEEREALL SGMERPRNPC
860 870 880 890 900
VVVKKRVEPE RAPPTKVLSL SRARLSLSKE LPRNYAASNE ALDVDDTMSV
910 920 930 940 950
DTDAFLRLKM KRSPNENYLR QTALARLKER RPSHVCMEEA YHVWRSVELL
960 970 980 990 1000
FREPLSDKRL QNICTVIRND MDQHYGFFWQ VIINRTPNFG MAATHIHGSL
1010 1020 1030 1040 1050
HVVEQEGMYR DGRQFLFHLI MYKTRKPRKE EIRLHERAAE KTYGICRKRD
1060 1070 1080 1090 1100
FSGIVRVMNS KVPPYMQKDV SYLIGMLFQR YQYTRDWTNF ATCIQSYLIG
1110 1120 1130 1140 1150
RYSEPFGGAW NVVAQEGAFF LSRLWTKHSR FLRVEIDFPA LAEQASSEPC
1160 1170
PGCPTPVLTV VCFEACAPDR P
Length:1,171
Mass (Da):132,672
Last modified:December 1, 2001 - v4
Checksum:i2A5D98FA96C44D3A
GO
Isoform Myosin C (identifier: O00936-2) [UniParc]FASTAAdd to basket
Also known as: Myoc

The sequence of this isoform differs from the canonical sequence as follows:
     1054-1074: IVRVMNSKVPPYMQKDVSYLI → NAPTQEFVIFSLTWKHNQKHS
     1075-1171: Missing.

Show »
Length:1,074
Mass (Da):121,706
Checksum:iFD230965439B4EAC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti791 – 7911A → G in AAL30895 (PubMed:11706051).Curated
Sequence conflicti791 – 7911A → G in AAL30896 (PubMed:11706051).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1054 – 107421IVRVM…VSYLI → NAPTQEFVIFSLTWKHNQKH S in isoform Myosin C. 2 PublicationsVSP_050203Add
BLAST
Alternative sequencei1075 – 117197Missing in isoform Myosin C. 2 PublicationsVSP_050204Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF438183 mRNA. Translation: AAL30895.1.
AF438184 mRNA. Translation: AAL30896.1.
AF006627 mRNA. Translation: AAC47725.3.
AF006628 mRNA. Translation: AAC47726.3.
AF202585 Genomic DNA. Translation: AAF09586.2.
PIRiT29105.
T29106.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF438183 mRNA. Translation: AAL30895.1.
AF438184 mRNA. Translation: AAL30896.1.
AF006627 mRNA. Translation: AAC47725.3.
AF006628 mRNA. Translation: AAC47726.3.
AF202585 Genomic DNA. Translation: AAF09586.2.
PIRiT29105.
T29106.

3D structure databases

ProteinModelPortaliO00936.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5811.TGME49_055190.

Proteomic databases

PRIDEiO00936.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0160. Eukaryota.
COG5022. LUCA.

Family and domain databases

InterProiIPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYOB_TOXGO
AccessioniPrimary (citable) accession number: O00936
Secondary accession number(s): O00935
, Q8WRF8, Q8WRF9, Q9U618
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: November 11, 2015
This is version 70 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.