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Protein

Myosin-B/C

Gene
N/A
Organism
Toxoplasma gondii
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Plays a role in proper daughter cell budding and separation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi199 – 206ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-B/C
Short name:
MyoB/C
Alternative name(s):
TgM-B
OrganismiToxoplasma gondiiImported
Taxonomic identifieri5811 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001233781 – 1171Myosin-B/CAdd BLAST1171

Proteomic databases

PRIDEiO00936

Expressioni

Developmental stagei

Both isoforms are expressed at higher levels in bradyzoites than in tachyzoites. Isoform MyoC is the predominant isoform in tachyzoites.1 Publication

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliO00936
SMRiO00936
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini105 – 780Myosin motorPROSITE-ProRule annotationAdd BLAST676

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni671 – 681Actin-bindingSequence analysisAdd BLAST11
Regioni810 – 1171TailAdd BLAST362

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0160 Eukaryota
COG5022 LUCA

Family and domain databases

CDDicd14876 MYSc_Myo14, 1 hit
Gene3Di3.40.850.10, 3 hits
InterProiView protein in InterPro
IPR037177 DLC_sf
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR036044 MYSc_Myo14
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF54648 SSF54648, 1 hit
PROSITEiView protein in PROSITE
PS51456 MYOSIN_MOTOR, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Myosin B (identifier: O00936-1) [UniParc]FASTAAdd to basket
Also known as: MyoB

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERKQTQMIL GRRLAKDSPE VKHFQRKSSV VPFGRDGRAA TNFTCWTADC
60 70 80 90 100
PAVKADPTLV FAKCIVVGGS MDTQLELEQV DPPARGTFTV APTDVFNANE
110 120 130 140 150
LIEPETVDDI GYLPHTNVAC VLDVLKSRFL RSIIYTTAEP LLVAINPFKD
160 170 180 190 200
LGNTTDAWIS TYRNASKPEM LPPHVFKTAR AALEDLEGYK KNQSIIVSGE
210 220 230 240 250
SGAGKTEATK QIMRFFASAS SEVRTTIQDT IMAGNPILEA FGNAKTIRNN
260 270 280 290 300
NSSRFGRFMM LDVSSHRGIQ HGSISNFLLE KVRVVSQEAN ERSYHIFYQL
310 320 330 340 350
LKGATSEMRA KYHLRSLKEY AYLNGKNGGC YDVPGIDDKA DFEEVLQSLD
360 370 380 390 400
AMQITGSKRH SVFSILSGLL LIGNVSIEGK DAQGVPDAAY ISPQSEEILE
410 420 430 440 450
EACQLLSVDD AALKKEILVK STKVGPQVIE GVRTKDEAKT SVLSLSKNVY
460 470 480 490 500
DKLFDWLVRQ LNSLIDAPDG MPNFIGILDI FGFEVLEVNS LEQVLINITN
510 520 530 540 550
EYLQKHFIDV VFDMETKLYQ AEGVPTEALE YTDNLALVGA LCGKNDSFFA
560 570 580 590 600
LLEDACLGIR STDEGFCGTI LRRLEPSGFF LESRRDKRLK FIIRHTIADI
610 620 630 640 650
EYTCEGMLEK NKDFLRKEVM DVMKASTDPV TKALFEGIEI EAGKIGKGTL
660 670 680 690 700
IASRFLKNLE EMIGIVAQTE AHFIRCLKPN EEKKPLGWNG SKVLNQLFSL
710 720 730 740 750
SILEALQLRQ VGYAYRRNFS EFCSHFRWLD LGLVNSDRDR KEVAQLLLEQ
760 770 780 790 800
SGIPESSWVI GKTMVFVKPD AAKELSILQR EKLMCFQPLI AVLGPMWRKV
810 820 830 840 850
LLRKKMARVI HFLTRLESNA RRHLEPDSIN ISPEEREALL SGMERPRNPC
860 870 880 890 900
VVVKKRVEPE RAPPTKVLSL SRARLSLSKE LPRNYAASNE ALDVDDTMSV
910 920 930 940 950
DTDAFLRLKM KRSPNENYLR QTALARLKER RPSHVCMEEA YHVWRSVELL
960 970 980 990 1000
FREPLSDKRL QNICTVIRND MDQHYGFFWQ VIINRTPNFG MAATHIHGSL
1010 1020 1030 1040 1050
HVVEQEGMYR DGRQFLFHLI MYKTRKPRKE EIRLHERAAE KTYGICRKRD
1060 1070 1080 1090 1100
FSGIVRVMNS KVPPYMQKDV SYLIGMLFQR YQYTRDWTNF ATCIQSYLIG
1110 1120 1130 1140 1150
RYSEPFGGAW NVVAQEGAFF LSRLWTKHSR FLRVEIDFPA LAEQASSEPC
1160 1170
PGCPTPVLTV VCFEACAPDR P
Length:1,171
Mass (Da):132,672
Last modified:December 1, 2001 - v4
Checksum:i2A5D98FA96C44D3A
GO
Isoform Myosin C (identifier: O00936-2) [UniParc]FASTAAdd to basket
Also known as: Myoc

The sequence of this isoform differs from the canonical sequence as follows:
     1054-1074: IVRVMNSKVPPYMQKDVSYLI → NAPTQEFVIFSLTWKHNQKHS
     1075-1171: Missing.

Show »
Length:1,074
Mass (Da):121,706
Checksum:iFD230965439B4EAC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti791A → G in AAL30895 (PubMed:11706051).Curated1
Sequence conflicti791A → G in AAL30896 (PubMed:11706051).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0502031054 – 1074IVRVM…VSYLI → NAPTQEFVIFSLTWKHNQKH S in isoform Myosin C. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_0502041075 – 1171Missing in isoform Myosin C. 2 PublicationsAdd BLAST97

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF438183 mRNA Translation: AAL30895.1
AF438184 mRNA Translation: AAL30896.1
AF006627 mRNA Translation: AAC47725.3
AF006628 mRNA Translation: AAC47726.3
AF202585 Genomic DNA Translation: AAF09586.2
PIRiT29105
T29106

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMYOB_TOXGO
AccessioniPrimary (citable) accession number: O00936
Secondary accession number(s): O00935
, Q8WRF8, Q8WRF9, Q9U618
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 79 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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