Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myosin-A

Gene
N/A
Organism
Toxoplasma gondii
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi193 – 2008ATPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-A
Short name:
MyoA
Alternative name(s):
TgM-A
OrganismiToxoplasma gondii
Taxonomic identifieri5811 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi814 – 8152RR → AA: Complete loss of membrane localization. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 831831Myosin-APRO_0000123377Add
BLAST

PTM databases

SwissPalmiO00934.

Interactioni

Protein-protein interaction databases

STRINGi5811.TGME49_035470.

Structurei

3D structure databases

ProteinModelPortaliO00934.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini99 – 773675Myosin motorAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni663 – 67311Actin-bindingSequence analysisAdd
BLAST
Regioni775 – 83157TailAdd
BLAST

Domaini

This protein differs from the typical myosin heavy chain structure in having head and tail domains but no discernible neck domain.

Sequence similaritiesi

Contains 1 myosin motor domain.Curated

Phylogenomic databases

eggNOGiKOG0160. Eukaryota.
COG5022. LUCA.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00934-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKTTSEEL KTATALKKRS SDVHAVDHSG NVYKGFQIWT DLAPSVKEEP
60 70 80 90 100
DLMFAKCIVQ AGTDKGNLTC VQIDPPGFDE PFEVPQANAW NVNSLIDPMT
110 120 130 140 150
YGDIGMLPHT NIPCVLDFLK VRFMKNQIYT TADPLVVAIN PFRDLGNTTL
160 170 180 190 200
DWIVRYRDTF DLSKLAPHVF YTARRALDNL HAVNKSQTII VSGESGAGKT
210 220 230 240 250
EATKQIMRYF AAAKTGSMDL RIQNAIMAAN PVLEAFGNAK TIRNNNSSRF
260 270 280 290 300
GRFMQLDVGR EGGIKFGSVV AFLLEKSRVL TQDEQERSYH IFYQMCKGAD
310 320 330 340 350
AAMKERFHIL PLSEYKYINP LCLDAPGIDD VAEFHEVCES FRSMNLTEDE
360 370 380 390 400
VASVWSIVSG VLLLGNVEVT ATKDGGIDDA AAIEGKNLEV FKKACGLLFL
410 420 430 440 450
DAERIREELT VKVSYAGNQE IRGRWKQEDG DMLKSSLAKA MYDKLFMWII
460 470 480 490 500
AVLNRSIKPP GGFKIFMGML DIFGFEVFKN NSLEQFFINI TNEMLQKNFV
510 520 530 540 550
DIVFDRESKL YRDEGVSSKE LIFTSNAEVI KILTAKNNSV LAALEDQCLA
560 570 580 590 600
PGGSDEKFLS TCKNALKGTT KFKPAKVSPN INFLISHTVG DIQYNAEGFL
610 620 630 640 650
FKNKDVLRAE IMEIVQQSKN PVVAQLFAGI VMEKGKMAKG QLIGSQFLSQ
660 670 680 690 700
LQSLMELINS TEPHFIRCIK PNDTKKPLDW VPSKMLIQLH ALSVLEALQL
710 720 730 740 750
RQLGYSYRRP FKEFLFQFKF IDLSASENPN LDPKEAALRL LKSSKLPSEE
760 770 780 790 800
YQLGKTMVFL KQTGAKELTQ IQRECLSSWE PLVSVLEAYY AGRRHKKQLL
810 820 830
KKTPFIIRAQ AHIRRHLVDN NVSPATVQPA F
Length:831
Mass (Da):93,334
Last modified:July 1, 1997 - v1
Checksum:i56C4ED1D50C2FB74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006626 mRNA. Translation: AAC47724.1.
PIRiA59283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006626 mRNA. Translation: AAC47724.1.
PIRiA59283.

3D structure databases

ProteinModelPortaliO00934.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5811.TGME49_035470.

PTM databases

SwissPalmiO00934.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0160. Eukaryota.
COG5022. LUCA.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYOA_TOXGO
AccessioniPrimary (citable) accession number: O00934
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 1, 1997
Last modified: February 17, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.