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Protein

Myosin-A

Gene
N/A
Organism
Toxoplasma gondii
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi193 – 200ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-A
Short name:
MyoA
Alternative name(s):
TgM-A
OrganismiToxoplasma gondii
Taxonomic identifieri5811 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi814 – 815RR → AA: Complete loss of membrane localization. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001233771 – 831Myosin-AAdd BLAST831

Proteomic databases

PRIDEiO00934

PTM databases

SwissPalmiO00934

Interactioni

GO - Molecular functioni

Structurei

Secondary structure

1831
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi803 – 816Combined sources14
Helixi818 – 820Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VT9X-ray1.85C/D801-831[»]
ProteinModelPortaliO00934
SMRiO00934
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 773Myosin motorPROSITE-ProRule annotationAdd BLAST675

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni663 – 673Actin-bindingSequence analysisAdd BLAST11
Regioni775 – 831TailAdd BLAST57

Domaini

This protein differs from the typical myosin heavy chain structure in having head and tail domains but no discernible neck domain.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0160 Eukaryota
COG5022 LUCA

Family and domain databases

CDDicd14876 MYSc_Myo14, 1 hit
Gene3Di3.40.850.10, 3 hits
InterProiView protein in InterPro
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR036044 MYSc_Myo14
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51456 MYOSIN_MOTOR, 1 hit

Sequencei

Sequence statusi: Complete.

O00934-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKTTSEEL KTATALKKRS SDVHAVDHSG NVYKGFQIWT DLAPSVKEEP
60 70 80 90 100
DLMFAKCIVQ AGTDKGNLTC VQIDPPGFDE PFEVPQANAW NVNSLIDPMT
110 120 130 140 150
YGDIGMLPHT NIPCVLDFLK VRFMKNQIYT TADPLVVAIN PFRDLGNTTL
160 170 180 190 200
DWIVRYRDTF DLSKLAPHVF YTARRALDNL HAVNKSQTII VSGESGAGKT
210 220 230 240 250
EATKQIMRYF AAAKTGSMDL RIQNAIMAAN PVLEAFGNAK TIRNNNSSRF
260 270 280 290 300
GRFMQLDVGR EGGIKFGSVV AFLLEKSRVL TQDEQERSYH IFYQMCKGAD
310 320 330 340 350
AAMKERFHIL PLSEYKYINP LCLDAPGIDD VAEFHEVCES FRSMNLTEDE
360 370 380 390 400
VASVWSIVSG VLLLGNVEVT ATKDGGIDDA AAIEGKNLEV FKKACGLLFL
410 420 430 440 450
DAERIREELT VKVSYAGNQE IRGRWKQEDG DMLKSSLAKA MYDKLFMWII
460 470 480 490 500
AVLNRSIKPP GGFKIFMGML DIFGFEVFKN NSLEQFFINI TNEMLQKNFV
510 520 530 540 550
DIVFDRESKL YRDEGVSSKE LIFTSNAEVI KILTAKNNSV LAALEDQCLA
560 570 580 590 600
PGGSDEKFLS TCKNALKGTT KFKPAKVSPN INFLISHTVG DIQYNAEGFL
610 620 630 640 650
FKNKDVLRAE IMEIVQQSKN PVVAQLFAGI VMEKGKMAKG QLIGSQFLSQ
660 670 680 690 700
LQSLMELINS TEPHFIRCIK PNDTKKPLDW VPSKMLIQLH ALSVLEALQL
710 720 730 740 750
RQLGYSYRRP FKEFLFQFKF IDLSASENPN LDPKEAALRL LKSSKLPSEE
760 770 780 790 800
YQLGKTMVFL KQTGAKELTQ IQRECLSSWE PLVSVLEAYY AGRRHKKQLL
810 820 830
KKTPFIIRAQ AHIRRHLVDN NVSPATVQPA F
Length:831
Mass (Da):93,334
Last modified:July 1, 1997 - v1
Checksum:i56C4ED1D50C2FB74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006626 mRNA Translation: AAC47724.1
PIRiA59283

Similar proteinsi

Entry informationi

Entry nameiMYOA_TOXGO
AccessioniPrimary (citable) accession number: O00934
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

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