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Protein

Lysosomal acid alpha-glucosidase

Gene
N/A
Organism
Tetrahymena pyriformis
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the degradation of glygogen to glucose in lysosomes. Has both alpha-1,4 and alpha-1,6-glucosidase activity.

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

pH dependencei

Optimum pH is 4.0.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei455NucleophilePROSITE-ProRule annotation1
Active sitei458By similarity1
Active sitei585Proton donorBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH31 Glycoside Hydrolase Family 31

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal acid alpha-glucosidase (EC:3.2.1.20)
Alternative name(s):
Acid maltase
OrganismiTetrahymena pyriformis
Taxonomic identifieri5908 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000001857418 – 36Add BLAST19
ChainiPRO_000001857537 – 923Lysosomal acid alpha-glucosidaseAdd BLAST887

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi405N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi440N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi586N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi621N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi646N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi848N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi908N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi912N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiO00906

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 31 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.40.1180, 1 hit
InterProiView protein in InterPro
IPR031727 Gal_mutarotase_N
IPR011013 Gal_mutarotase_sf_dom
IPR000322 Glyco_hydro_31
IPR030458 Glyco_hydro_31_AS
IPR030459 Glyco_hydro_31_CS
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF01055 Glyco_hydro_31, 1 hit
PF16863 NtCtMGAM_N, 1 hit
SUPFAMiSSF51445 SSF51445, 2 hits
SSF74650 SSF74650, 1 hit
PROSITEiView protein in PROSITE
PS00129 GLYCOSYL_HYDROL_F31_1, 1 hit
PS00707 GLYCOSYL_HYDROL_F31_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00906-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHQVLLPLL VTTAIIAGSV GVYTHSKPLL GQSQDQVLPP FTPPLQNGHI
60 70 80 90 100
DLQGKYIVST LDQVNATHIN IYANYNGPEA SYAMPKNKLI THILVSIVIN
110 120 130 140 150
DVNQLGIKIT DRTYRHFEVP YSNLFPHDKV FNFPANNQFD ITLPKRGEAF
160 170 180 190 200
YLTIKRKDTG EVVFDTNNQF FVYSDLYHEF TVAMQNEFIY GLGERRNKQF
210 220 230 240 250
LYDSGEYTFL NKDQYESVAD GHPDQQTYGT HPMYLRRENS GNFHVVFLRN
260 270 280 290 300
YNSIQAVYSK GKSLTYKVVG GLLEFKIFLG DKSPETSLKL YHSYVNGFNL
310 320 330 340 350
HPFWAHGFHQ CRWGYKTSEM MTTVWDTFNT NGLPFDTIWS DIDYMKDLTD
360 370 380 390 400
FTIDTSRYDK AQMNTMLDRS VAAGVHWVPI IDAGIALGDV SNERGKELGV
410 420 430 440 450
YQKSNKTGED LIGCVWPGKV NYPDFNHPLS QEFWAEGLMN LTKNYGITPS
460 470 480 490 500
GFWIDMNEFS NFINGEISED QNCIMPGDTT TNPNYLGNSV EDFYTRIPFE
510 520 530 540 550
VGGADHPQQE KTMSYDAPKY NYADAKTVYI PNYELREFDF HNLNGFSEGI
560 570 580 590 600
ATNYALKKMG NKLPFIISRS QIAGSGQFVQ HWTGDNGSQW DFLQYSLGEI
610 620 630 640 650
FNFNMYGIPM TGADICGFAQ NTTAELCARW MQVGAFYPFS RNHNSNDTIP
660 670 680 690 700
QEPYAFPDST YVLDSSKKSL RLRYALLKQY YSHFVSSNGV GTVFRPTFFN
710 720 730 740 750
FPDDASLLTN DQQFMIGDSL LGQPVLVQSA TPARFSHSSY LTFPSSGAFY
760 770 780 790 800
DFVTDVATLN AQRYTNANNG QIKNVKFDDI MPLYIREGYT VFTQLASTAL
810 820 830 840 850
RSRLLDSNFE LHVALAKSGT SYTAKGKFIT IQDYSDDNLI QKCIGANNCS
860 870 880 890 900
FDIQVTGVVN GANLDLTIQI AGESAQTNFE TINVNKIIPY AADLKFAAST
910 920
ATFTISKNGT INASIPLQAA QQE
Length:923
Mass (Da):104,117
Last modified:July 1, 1997 - v1
Checksum:i6294809F43EA54C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83384 mRNA Translation: BAA20462.1

Similar proteinsi

Entry informationi

Entry nameiAGLU_TETPY
AccessioniPrimary (citable) accession number: O00906
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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