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O00871 (PGK_TETPY) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:PGK
OrganismTetrahymena pyriformis
Taxonomic identifier5908 [NCBI]
Taxonomic lineageEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

Protein attributes

Sequence length375 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›375›375Phosphoglycerate kinase
PRO_0000145860

Regions

Nucleotide binding350 – 3534ATP By similarity
Region2 – 43Substrate binding By similarity
Region41 – 444Substrate binding By similarity

Sites

Binding site171Substrate By similarity
Binding site1001Substrate By similarity
Binding site1481Substrate By similarity
Binding site1971ATP By similarity
Binding site2901ATP; via carbonyl oxygen By similarity
Binding site3211ATP By similarity

Experimental info

Non-terminal residue11
Non-terminal residue3751

Sequences

Sequence LengthMass (Da)Tools
O00871 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 141D0ED9620C34DB

FASTA37540,673
        10         20         30         40         50         60 
VDFNVPLKDG QVKDPTRIQG SIPSIKKILE QNPKGLVLMS HLGRPDGNRV EKHSMKPVVP 

        70         80         90        100        110        120 
KLEQLLGTKV KFLNDCVGKD VEEAVKSSRN GEIILLENLR FHAEEEGKSI DAAGNKVKAD 

       130        140        150        160        170        180 
PKAVKEFRKS LTSLGDLYVN DAFGTAHRAH SSMVGVDHKI RAAGYLLKKE LDYFSKALES 

       190        200        210        220        230        240 
PNRPFLVVLG GAKVKDKIQL IESMIDKVDE MIIGGGMAFT FLKRIHNMEI GNSLFDEEGY 

       250        260        270        280        290        300 
KIVDQLLEKA KAKGVKIHLP VDFLCGDSLE ANANTQIHDL ISGIPKGWIG LDAGPKTIAL 

       310        320        330        340        350        360 
NADAVARANT IVWNGPQGRF EVDKFRQGSA DLLKRVSART AAGATSIIGG GDTVNLVQQE 

       370 
KATDKVSHVS TGGGE 

« Hide

References

[1]Pearlman R.E.
Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF001851 Genomic DNA. Translation: AAB58243.1.

3D structure databases

ProteinModelPortalO00871.
SMRO00871. Positions 1-374.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEO00871.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
ProtoNetSearch...

Entry information

Entry namePGK_TETPY
AccessionPrimary (citable) accession number: O00871
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: June 11, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways