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Protein

Phosphoglycerate kinase

Gene

PGK

Organism
Paramecium primaurelia
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathway:iglycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (PGK)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei17 – 171SubstrateBy similarity
Binding sitei99 – 991SubstrateBy similarity
Binding sitei147 – 1471SubstrateBy similarity
Binding sitei196 – 1961ATPBy similarity
Binding sitei289 – 2891ATP; via carbonyl oxygenBy similarity
Binding sitei320 – 3201ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi349 – 3524ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:PGK
OrganismiParamecium primaurelia
Taxonomic identifieri5886 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›367›367Phosphoglycerate kinasePRO_0000145858Add
BLAST

Proteomic databases

PRIDEiO00869.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO00869.
SMRiO00869. Positions 1-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 43Substrate bindingBy similarity
Regioni41 – 444Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.

Sequencei

Sequence statusi: Fragment.

O00869-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VDFNVPIKEG KVKNTTRIQG AIPTLKKILE QNPKNVTLMS HMGRPDGKRV
60 70 80 90 100
EKDSLKIVVP KLEELLGTKV NFVNDCVGSE ALEASNAGNG QINLLENLRF
110 120 130 140 150
HIQEEGKGLD ANGAKIKADK ESVKKFRKEL SSLGDIYVND AFGTAHRAHS
160 170 180 190 200
SMVGIDHKIR VAGYLMKKEL DYFAKALETP QRPFLVILGG AKVADKIQLI
210 220 230 240 250
KSMLDKVDEM IIGGGMAFTF LKKYIMFPIG KSLFDEEGYK IVDEIIAKAK
260 270 280 290 300
EKNVKIHLPT DFVCGTGLDA SSPVALHDLK SGIPDGWLGL DAGQLTQREN
310 320 330 340 350
ADAIGRAKTI VWNGPQGAFE IEQFKNGSVS MLNALVKQTQ NGATTIVGGG
360
DTVNLVGANK ANDKLSH
Length:367
Mass (Da):39,876
Last modified:July 1, 1997 - v1
Checksum:iDEF64500127DE460
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei367 – 3671

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001849 Genomic DNA. Translation: AAB58241.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001849 Genomic DNA. Translation: AAB58241.1.

3D structure databases

ProteinModelPortaliO00869.
SMRiO00869. Positions 1-367.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO00869.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Pearlman R.E.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPGK_PARPR
AccessioniPrimary (citable) accession number: O00869
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: April 1, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.