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O00852

- PGK_GLACH

UniProt

O00852 - PGK_GLACH

Protein

Phosphoglycerate kinase

Gene

PGK

Organism
Glaucoma chattoni
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei17 – 171SubstrateBy similarity
    Binding sitei100 – 1001SubstrateBy similarity
    Binding sitei148 – 1481SubstrateBy similarity
    Binding sitei197 – 1971ATPBy similarity
    Binding sitei290 – 2901ATP; via carbonyl oxygenBy similarity
    Binding sitei321 – 3211ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi350 – 3534ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase (EC:2.7.2.3)
    Gene namesi
    Name:PGK
    OrganismiGlaucoma chattoni
    Taxonomic identifieri5883 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaGlaucomidaeGlaucoma

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›376›376Phosphoglycerate kinasePRO_0000145852Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO00852.
    SMRiO00852. Positions 1-376.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 43Substrate bindingBy similarity
    Regioni41 – 444Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    O00852-1 [UniParc]FASTAAdd to Basket

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    VDFNVPLKEG VVKDPTRIAG SIPSIKKILE TNPRGLVLMS HLGRPDGQRV    50
    EKHSLKPVLP KLEELLGTKV TFLNDCVGKD VEEAVKSSRN GEIILLENLR 100
    FHIEEEGKAV DAAGNKVKAD PKAVKEFRKS LTNLGDLFFN DAFGTAHRAH 150
    SSMVGVDHKI RVAGYLLKKE LEYFSKALES PTLPFCVVLG GAKVKDKIQL 200
    INSMLDNVNE MIIGGGMAFT FLKRLHNLEI GNSLFDEEGY KIVDELLEKA 250
    KKKNVKIHLP VDFLCGDSLE ANANTAIHDL QSGIPKGWIG LDAGPKTIAL 300
    NAEVIARANT IVWNGPQGRF EVDKFRNGSS DLLKKVIERT KTGATSIIGG 350
    GDTVNLVQQE KASNKVSHVS TGGGAS 376
    Length:376
    Mass (Da):40,873
    Last modified:July 1, 1997 - v1
    Checksum:iA25D27DC6173DDA9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei376 – 3761

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF001850 Genomic DNA. Translation: AAB58242.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF001850 Genomic DNA. Translation: AAB58242.1 .

    3D structure databases

    ProteinModelPortali O00852.
    SMRi O00852. Positions 1-376.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Pearlman R.E.
      Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiPGK_GLACH
    AccessioniPrimary (citable) accession number: O00852
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3