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Protein

Tubulin gamma chain

Gene

GTU

Organism
Tetrahymena thermophila
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin gamma chainUniRule annotation
Gene namesi
Name:GTUImported
OrganismiTetrahymena thermophilaImported
Taxonomic identifieri5911 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MicrotubuleUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi5911.EAR95547.

Structurei

3D structure databases

ProteinModelPortaliO00849.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 246199TubulinInterPro annotationAdd
BLAST
Domaini248 – 389142Tubulin_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the tubulin family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1374. Eukaryota.
COG5023. LUCA.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002454. Gamma_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PTHR11588:SF7. PTHR11588:SF7. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01164. GAMMATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00849-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRDIITLQV GQCGNQIGME FWKQLCLEHG INQEGILQEY ATNTDDRKEV
60 70 80 90 100
FFYQADDQHY IPRACLIDLE DRVLKRIVKQ SDYSSLYNPE NIFYGTDGSG
110 120 130 140 150
AGNVWAYGYQ EANKIQDDLL DMIDREADTS DSFEAFLLIH SIAGGTGSGV
160 170 180 190 200
GSYLLEKLND RFPKKIIKTY SVFPSGHTDG VVHPYNSLLT LKRLALNADA
210 220 230 240 250
TTVLDNNALE KIAQDRLKLE NPTIETTNSL VSTVMAACTT TLRYPGYMNN
260 270 280 290 300
DLVGLLASLV PTPKCHFLMT GYTPISIDRH IKTIRKTTVL DVMRRLLQTK
310 320 330 340 350
NIMVSASTKK GQYISIMNVI QGEVDASQIH KSLQRIRERK LANFINWGPA
360 370 380 390 400
SIQVALSKKS PYIETSHKVS GLMLANHTSI HTLFEKIISN FDIMRKKNAY
410 420 430 440
IEQFKKVDSF NLEEFDDSKE VVQQLIEEYK AAEEPNYLDY FDDGLEDEN
Length:449
Mass (Da):50,885
Last modified:July 1, 1997 - v1
Checksum:iEAE9B352996A11A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96076 Genomic DNA. Translation: AAB65830.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96076 Genomic DNA. Translation: AAB65830.1.

3D structure databases

ProteinModelPortaliO00849.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5911.EAR95547.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1374. Eukaryota.
COG5023. LUCA.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002454. Gamma_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PTHR11588:SF7. PTHR11588:SF7. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01164. GAMMATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO00849_TETTH
AccessioniPrimary (citable) accession number: O00849
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.