O00754 (MA2B1_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 134.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Lysosomal alpha-mannosidase Short name=Laman EC=3.2.1.24 Alternative name(s): Lysosomal acid alpha-mannosidase Mannosidase alpha class 2B member 1 Mannosidase alpha-B | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Reference proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 1011 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages. |
| Catalytic activity | Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. |
| Cofactor | Binds 1 zinc ion per subunit By similarity. |
| Subcellular location | |
| Post-translational modification | First processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). The 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Heavily glycosylated. Ref.7 |
| Involvement in disease | Mannosidosis, alpha B, lysosomal (MANSA) [MIM:248500]: A lysosomal storage disease characterized by accumulation of unbranched oligosaccharide chains. This accumulation is expressed histologically as cytoplasmic vacuolation predominantly in the CNS and parenchymatous organs. Depending on the clinical findings at the age of onset, a severe infantile (type I) and a mild juvenile (type II) form of alpha-mannosidosis are recognized. There is considerable variation in the clinical expression with mental retardation, recurrent infections, impaired hearing and Hurler-like skeletal changes being the most consistent abnormalities. |
| Sequence similarities | Belongs to the glycosyl hydrolase 38 family. |
| Sequence caution | The sequence AAB03816.1 differs from that shown. Reason: Erroneous initiation. The sequence AAC50812.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Lysosome |
| Coding sequence diversity | Polymorphism |
| Disease | Disease mutation |
| Domain | Signal |
| Ligand | Metal-binding Zinc |
| Molecular function | Glycosidase Hydrolase |
| PTM | Disulfide bond Glycoprotein Zymogen |
| Technical term | Complete proteome Direct protein sequencing Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | mannose metabolic process Inferred from electronic annotation. Source: InterPro protein deglycosylationTraceable author statement Ref.5. Source: ProtInc |
| Cellular_component | lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | alpha-mannosidase activity Traceable author statement Ref.5. Source: ProtInc carbohydrate bindingInferred from electronic annotation. Source: InterPro zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 49 | 49 | |||||||||
| Chain | 50 – 1011 | 962 | Lysosomal alpha-mannosidase | PRO_0000012069 | |||||||
| Chain | 50 – 345 | 296 | Lysosomal alpha-mannosidase A peptide | PRO_0000012070 | |||||||
| Chain | 346 – 429 | 84 | Lysosomal alpha-mannosidase B peptide | PRO_0000012071 | |||||||
| Chain | 430 – 601 | 172 | Lysosomal alpha-mannosidase C peptide | PRO_0000012072 | |||||||
| Chain | 602 – 882 | 281 | Lysosomal alpha-mannosidase D peptide | PRO_0000012073 | |||||||
| Chain | 883 – 1011 | 129 | Lysosomal alpha-mannosidase E peptide | PRO_0000012074 | |||||||
Sites | |||||||||||
| Active site | 196 | 1 | Nucleophile By similarity | ||||||||
| Metal binding | 72 | 1 | Zinc By similarity | ||||||||
| Metal binding | 74 | 1 | Zinc By similarity | ||||||||
| Metal binding | 196 | 1 | Zinc By similarity | ||||||||
| Metal binding | 446 | 1 | Zinc By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 133 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 310 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 367 | 1 | N-linked (GlcNAc...) Ref.8 | ||||||||
| Glycosylation | 497 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 645 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 651 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 692 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 766 | 1 | N-linked (GlcNAc...) Ref.8 | ||||||||
| Glycosylation | 832 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 930 | 1 | N-linked (GlcNAc...) Ref.7 | ||||||||
| Glycosylation | 989 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 55 ↔ 358 | By similarity | |||||||||
| Disulfide bond | 268 ↔ 273 | By similarity | |||||||||
| Disulfide bond | 412 ↔ 472 | By similarity | |||||||||
| Disulfide bond | 493 ↔ 501 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 55 | 1 | C → F in MANSA; results in less than 20% of wild-type enzyme activity. Ref.15 | VAR_068034 | |||||||
| Natural variant | 72 | 1 | H → L in MANSA; type II. Ref.2 Ref.11 | VAR_003338 | |||||||
| Natural variant | 74 | 1 | D → E in MANSA; results in less than 20% of wild-type enzyme activity. Ref.15 | VAR_068035 | |||||||
| Natural variant | 95 | 1 | A → P in MANSA; results in less than 20% of wild-type enzyme activity. Ref.15 | VAR_068036 | |||||||
| Natural variant | 99 | 1 | Y → H in MANSA; results in less than 20% of wild-type enzyme activity. Ref.15 | VAR_068037 | |||||||
| Natural variant | 159 | 1 | D → N in MANSA; results in less than 20% of wild-type enzyme activity. Ref.15 | VAR_068038 | |||||||
| Natural variant | 197 | 1 | P → R in MANSA; results in less than 20% of wild-type enzyme activity. Ref.15 | VAR_068039 | |||||||
| Natural variant | 200 | 1 | H → L in MANSA; no residual enzyme activity. Ref.14 Ref.15 | VAR_026412 | |||||||
| Natural variant | 200 | 1 | H → N in MANSA; reduced enzyme activity. Ref.15 | VAR_068040 | |||||||
| Natural variant | 202 | 1 | R → P in MANSA; reduced enzyme activity. Ref.15 | VAR_068041 | |||||||
| Natural variant | 229 | 1 | R → W in MANSA; reduced enzyme activity. Ref.15 | VAR_068042 | |||||||
| Natural variant | 248 | 1 | P → L. Ref.15 Corresponds to variant rs117843968 [ dbSNP | Ensembl ]. | VAR_068043 | |||||||
| Natural variant | 250 | 1 | A → S. Corresponds to variant rs3745650 [ dbSNP | Ensembl ]. | VAR_049209 | |||||||
| Natural variant | 263 | 1 | P → L in MANSA; results in less than 20% of wild-type enzyme activity. Ref.15 | VAR_068044 | |||||||
| Natural variant | 278 | 1 | L → V. Ref.12 Ref.15 Corresponds to variant rs1054486 [ dbSNP | Ensembl ]. | VAR_003339 | |||||||
| Natural variant | 282 | 1 | P → S. Ref.15 Corresponds to variant rs45576136 [ dbSNP | Ensembl ]. | VAR_068045 | |||||||
| Natural variant | 312 | 1 | T → I. Ref.12 Ref.15 Corresponds to variant rs1054487 [ dbSNP | Ensembl ]. | VAR_003340 | |||||||
| Natural variant | 318 | 1 | S → L in MANSA; reduced enzyme activity. Ref.15 | VAR_068046 | |||||||
| Natural variant | 337 | 1 | R → Q. Ref.12 Ref.15 Corresponds to variant rs1133330 [ dbSNP | Ensembl ]. | VAR_003341 | |||||||
| Natural variant | 339 – 342 | 4 | Missing in MANSA. | VAR_068047 | |||||||
| Natural variant | 352 | 1 | L → P in MANSA; results in less than 20% of wild-type enzyme activity. Ref.15 | VAR_068048 | |||||||
| Natural variant | 355 | 1 | T → P in MANSA. Ref.12 | VAR_003342 | |||||||
| Natural variant | 356 | 1 | P → R in MANSA; type I. Ref.11 | VAR_003343 | |||||||
| Natural variant | 379 | 1 | P → L in MANSA; reduced enzyme activity. Ref.15 | VAR_068049 | |||||||
| Natural variant | 390 | 1 | G → C in MANSA; results in less than 20% of wild-type enzyme activity. Ref.15 | VAR_068050 | |||||||
| Natural variant | 402 | 1 | E → K in MANSA; unknown pathological significance. Ref.12 Ref.15 | VAR_003344 | |||||||
| Natural variant | 413 | 1 | N → S. Ref.12 Ref.15 Corresponds to variant rs35836657 [ dbSNP | Ensembl ]. | VAR_003345 | |||||||
| Natural variant | 420 | 1 | G → V in MANSA; results in less than 20% of wild-type enzyme activity. Ref.15 | VAR_068051 | |||||||
| Natural variant | 445 | 1 | H → Y in MANSA; results in less than 20% of wild-type enzyme activity. Ref.15 | VAR_068052 | |||||||
| Natural variant | 451 | 1 | G → C in MANSA; reduced enzyme activity. Ref.15 | VAR_068053 | |||||||
| Natural variant | 453 | 1 | S → F in MANSA; reduced enzyme activity. Ref.15 | VAR_068054 | |||||||
| Natural variant | 453 | 1 | S → Y in MANSA. Ref.13 Ref.15 | VAR_026413 | |||||||
| Natural variant | 457 | 1 | V → E in MANSA; reduced enzyme activity. Ref.15 | VAR_068055 | |||||||
| Natural variant | 481 | 1 | A → S. Ref.15 Corresponds to variant rs34544747 [ dbSNP | Ensembl ]. | VAR_049210 | |||||||
| Natural variant | 501 | 1 | C → S in MANSA; reduced enzyme activity. Ref.15 | VAR_068056 | |||||||
| Natural variant | 565 | 1 | L → P in MANSA; results in less than 20% of wild-type enzyme activity. Ref.15 | VAR_068057 | |||||||
| Natural variant | 669 | 1 | P → L. Ref.15 Corresponds to variant rs75029862 [ dbSNP | Ensembl ]. | VAR_068058 | |||||||
| Natural variant | 714 | 1 | W → R in MANSA. Ref.12 | VAR_003346 | |||||||
| Natural variant | 745 | 1 | T → R in MANSA; results in less than 20% of wild-type enzyme activity. Ref.15 | VAR_068059 | |||||||
| Natural variant | 750 | 1 | R → W in MANSA; type II. Ref.11 | VAR_003347 | |||||||
| Natural variant | 800 | 1 | G → R in MANSA; results in less than 20% of wild-type enzyme activity. Ref.15 | VAR_068060 | |||||||
| Natural variant | 800 | 1 | G → W in MANSA; results in less than 20% of wild-type enzyme activity. Ref.15 | VAR_068061 | |||||||
| Natural variant | 801 | 1 | G → D in MANSA; no residual enzyme activity. Ref.14 | VAR_026414 | |||||||
| Natural variant | 809 | 1 | L → P in MANSA. Ref.12 | VAR_003348 | |||||||
| Natural variant | 815 | 1 | R → RHR in MANSA; results in less than 20% of wild-type enzyme activity. | VAR_068062 | |||||||
| Natural variant | 891 | 1 | G → R in MANSA; results in less than 20% of wild-type enzyme activity. Ref.15 | VAR_068063 | |||||||
| Natural variant | 892 | 1 | L → P in MANSA; results in less than 20% of wild-type enzyme activity. Ref.15 | VAR_068064 | |||||||
| Natural variant | 916 | 1 | R → C in MANSA; results in less than 20% of wild-type enzyme activity. Ref.15 | VAR_068065 | |||||||
| Natural variant | 916 | 1 | R → H in MANSA; results in less than 20% of wild-type enzyme activity. Ref.15 | VAR_068066 | |||||||
| Natural variant | 950 | 1 | R → P in MANSA; results in less than 20% of wild-type enzyme activity. Ref.15 | VAR_068067 | |||||||
| Natural variant | 956 | 1 | L → R in MANSA; results in less than 20% of wild-type enzyme activity. Ref.15 | VAR_068068 | |||||||
| Natural variant | 1000 | 1 | F → S in MANSA; results in less than 20% of wild-type enzyme activity. Ref.15 | VAR_068069 | |||||||
Experimental info | |||||||||||
| Sequence conflict | 3 | 1 | Missing in AAC51362. Ref.3 | ||||||||
| Sequence conflict | 186 | 1 | D → V in AAC34130. Ref.2 | ||||||||
| Sequence conflict | 343 | 1 | Missing in AAB03816. Ref.1 | ||||||||
| Sequence conflict | 384 | 1 | P → H in AAC50812. Ref.5 | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Human lysosomal alpha-mannosidase: isolation and nucleotide sequence of the full-length cDNA." Nebes V.L., Schmidt M.C. Biochem. Biophys. Res. Commun. 200:239-245(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Alpha-mannosidosis: functional cloning of the lysosomal alpha-mannosidase cDNA and identification of a mutation in two affected siblings." Nilssen O., Berg T., Riise H.M.F., Ramachandran U., Evjen G., Hansen G.M., Malm D., Tranebjaerg L., Tollersrud O.-K. Hum. Mol. Genet. 6:717-726(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, VARIANT MANSA LEU-72. Tissue: Lung and Skin. |
| [3] | "Genomic structure of the human lysosomal alpha-mannosidase gene (MANB)." Riise H.M.F., Berg T., Nilssen O., Romeo G., Tollersrud O.-K., Ceccherini I. Genomics 42:200-207(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta. |
| [5] | "Cloning, expression, purification, and characterization of the human broad specificity lysosomal acid alpha-mannosidase." Liao Y.-F., Lal A., Moremen K.W. J. Biol. Chem. 271:28348-28358(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-1010. Tissue: Spleen. |
| [6] | "Partial sequence of the purified protein confirms the identity of cDNA coding for human lysosomal alpha-mannosidase B." Emiliani C., Martino S., Stirling J.L., Maras B., Orlacchio A. Biochem. J. 305:363-366(1995) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE. |
| [7] | "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry." Zhang H., Li X.-J., Martin D.B., Aebersold R. Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION AT ASN-930. |
| [8] | "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-367 AND ASN-766, MASS SPECTROMETRY. Tissue: Liver. |
| [9] | "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell. |
| [10] | "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
| [11] | "Missense and nonsense mutations in the lysosomal alpha-mannosidase gene (MANB) in severe and mild forms of alpha-mannosidosis." Gotoda Y., Wakamatsu N., Kawai H., Nishida Y., Matsumoto T. Am. J. Hum. Genet. 63:1015-1024(1998) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MANSA LEU-72; ARG-356 AND TRP-750. |
| [12] | "Spectrum of mutations in alpha-mannosidosis." Berg T., Riise H.M.F., Hansen G.M., Malm D., Tranebjaerg L., Tollersrud O.-K., Nilssen O. Am. J. Hum. Genet. 64:77-88(1999) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MANSA PRO-355; LYS-402; ARG-714 AND PRO-809, VARIANTS VAL-278; ILE-312; GLN-337 AND SER-413. |
| [13] | "Alpha-mannosidosis and mutational analysis in a Turkish patient." Oelmez A., Nilssen O., Coskun T., Klenow H. Turk. J. Pediatr. 45:46-50(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT MANSA TYR-453. |
| [14] | "Identification and characterization of five novel MAN2B1 mutations in Italian patients with alpha-mannosidosis." Sbaragli M., Bibi L., Pittis M.G., Balducci C., Heikinheimo P., Ricci R., Antuzzi D., Parini R., Spaccini L., Bembi B., Beccari T. Hum. Mutat. 25:320-320(2005) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MANSA LEU-200 AND ASP-801, CHARACTERIZATION OF VARIANTS MANSA LEU-200 AND ASP-801. |
| [15] | "Identification of 83 novel alpha-mannosidosis-associated sequence variants: functional analysis of MAN2B1 missense mutations." Riise Stensland H.M., Klenow H.B., Van Nguyen L., Hansen G.M., Malm D., Nilssen O. Hum. Mutat. 33:511-520(2012) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MANSA PHE-55; GLU-74; PRO-95; HIS-99; ASN-159; ARG-197; ASN-200; LEU-200; PRO-202; TRP-229; LEU-263; LEU-318; 339-VAL--GLN-342 DEL; PRO-352; LEU-379; CYS-390; LYS-402; VAL-420; TYR-445; CYS-451; TYR-453; PHE-453; GLU-457; SER-501; PRO-565; ARG-745; ARG-800; TRP-800; HIS-ARG-815 INS; ARG-891; PRO-892; CYS-916; HIS-916; PRO-950; ARG-956 AND SER-1000, VARIANTS LEU-248; VAL-278; SER-282; ILE-312; GLN-337; SER-413; SER-481 AND LEU-669, CHARACTERIZATION OF VARIANTS MANSA PHE-55; GLU-74; PRO-95; HIS-99; ASN-159; ARG-197; ASN-200; LEU-200; PRO-202; TRP-229; LEU-263; LEU-318; PRO-352; LEU-379; CYS-390; LYS-402; VAL-420; TYR-445; CYS-451; TYR-453; PHE-453; GLU-457; SER-501; PRO-565; ARG-745; ARG-800; TRP-800; HIS-ARG-815 INS; ARG-891; PRO-892; CYS-916; HIS-916; PRO-950; ARG-956 AND SER-1000. |
| + | Additional computationally mapped references. |
Web resources
| GeneReviews |
| Mendelian genes mannosidase, alpha, class 2B, member 1 (MAN2B1) Leiden Open Variation Database (LOVD) |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U05572 mRNA. Translation: AAB03816.1. Different initiation. U60266 mRNA. Translation: AAC34130.1. U60899 U60898 Genomic DNA. Translation: AAC51362.1.BC000736 mRNA. Translation: AAH00736.1. U68567 mRNA. Translation: AAC50812.1. Different initiation. |
| IPI | IPI00012989. |
| RefSeq | NP_000519.2. NM_000528.3. NP_001166969.1. NM_001173498.1. |
| UniGene | Hs.356769. Hs.657204. |
3D structure databases | |
| ProteinModelPortal | O00754. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O00754. 1 interaction. |
| MINT | MINT-253662. |
| STRING | 9606.ENSP00000395473. |
Protein family/group databases | |
| CAZy | GH38. Glycoside Hydrolase Family 38. |
PTM databases | |
| PhosphoSite | O00754. |
Proteomic databases | |
| PaxDb | O00754. |
| PRIDE | O00754. |
Protocols and materials databases | |
| DNASU | 4125. |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000456935; ENSP00000395473; ENSG00000104774. |
| GeneID | 4125. |
| KEGG | hsa:4125. |
| UCSC | uc002mub.2. human. |
Organism-specific databases | |
| CTD | 4125. |
| GeneCards | GC19M012757. |
| HGNC | HGNC:6826. MAN2B1. |
| HPA | HPA041530. |
| MIM | 248500. phenotype. 609458. gene. |
| neXtProt | NX_O00754. |
| Orphanet | 61. Alpha-mannosidosis. |
| PharmGKB | PA30575. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | NOG306356. |
| HOGENOM | HOG000007676. |
| HOVERGEN | HBG052391. |
| InParanoid | O00754. |
| KO | K12311. |
| OMA | NMQLTVL. |
| OrthoDB | EOG4DV5KJ. |
| PhylomeDB | O00754. |
Enzyme and pathway databases | |
| BRENDA | 3.2.1.24. 2681. |
Gene expression databases | |
| ArrayExpress | O00754. |
| Bgee | O00754. |
| CleanEx | HS_MAN2B1. |
| Genevestigator | O00754. |
| GermOnline | ENSG00000104774. Homo sapiens. |
Family and domain databases | |
| Gene3D | 2.60.40.1180. 1 hit. 3.20.110.10. 1 hit. |
| InterPro | IPR011013. Gal_mutarotase_SF_dom. IPR011330. Glyco_hydro/deAcase_b/a-brl. IPR013780. Glyco_hydro_13_b. IPR027291. Glyco_hydro_38/57_N. IPR011682. Glyco_hydro_38_C. IPR015341. Glyco_hydro_38_cen_dom. IPR000602. Glyco_hydro_38_N. [Graphical view] |
| Pfam | PF09261. Alpha-mann_mid. 1 hit. PF01074. Glyco_hydro_38. 1 hit. PF07748. Glyco_hydro_38C. 1 hit. [Graphical view] |
| SMART | SM00872. Alpha-mann_mid. 1 hit. [Graphical view] |
| SUPFAM | SSF74650. Gal_mut_like. 1 hit. SSF88713. Glyco_hydro/deAcase_b/a-brl. 1 hit. |
| ProtoNet | Search... |
Other | |
| BindingDB | O00754. |
| ChEMBL | CHEMBL4059. |
| ChiTaRS | MAN2B1. human. |
| GenomeRNAi | 4125. |
| NextBio | 16196. |
| SOURCE | Search... |
Entry information
| Entry name | MA2B1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O00754 Secondary accession number(s): O15330 Q9BW13 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Glycosyl hydrolases Classification of glycosyl hydrolase families and list of entries |
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
