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O00750

- P3C2B_HUMAN

UniProt

O00750 - P3C2B_HUMAN

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Protein

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

Gene
PIK3C2B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.1 Publication

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.

Cofactori

Calcium, magnesium, or manganese.1 Publication

Enzyme regulationi

Activated by GRB2.1 Publication

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: RefGenome
  2. 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: UniProtKB
  3. ATP binding Source: UniProtKB-KW
  4. lipid kinase activity Source: Ensembl
  5. phosphatidylinositol binding Source: InterPro
  6. protein binding Source: IntAct

GO - Biological processi

  1. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
  2. phosphatidylinositol biosynthetic process Source: Reactome
  3. phosphatidylinositol-mediated signaling Source: InterPro
  4. phospholipid metabolic process Source: Reactome
  5. protein kinase B signaling Source: Ensembl
  6. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.137. 2681.
ReactomeiREACT_121025. Synthesis of PIPs at the plasma membrane.
SignaLinkiO00750.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (EC:2.7.1.154)
Short name:
PI3K-C2-beta
Short name:
PtdIns-3-kinase C2 subunit beta
Alternative name(s):
C2-PI3K
Phosphoinositide 3-kinase-C2-beta
Gene namesi
Name:PIK3C2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:8972. PIK3C2B.

Subcellular locationi

Microsome. Cell membrane. Cytoplasmcytosol. Nucleus. Endoplasmic reticulum
Note: Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis.1 Publication

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. endocytic vesicle Source: Ensembl
  3. endoplasmic reticulum Source: UniProtKB-SubCell
  4. nucleus Source: UniProtKB-SubCell
  5. phosphatidylinositol 3-kinase complex Source: RefGenome
  6. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Microsome, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33305.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16341634Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit betaPRO_0000088798Add
BLAST

Proteomic databases

MaxQBiO00750.
PaxDbiO00750.
PeptideAtlasiO00750.
PRIDEiO00750.

PTM databases

PhosphoSiteiO00750.

Expressioni

Tissue specificityi

Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscle and kidney.2 Publications

Gene expression databases

ArrayExpressiO00750.
BgeeiO00750.
CleanExiHS_PIK3C2B.
GenevestigatoriO00750.

Organism-specific databases

HPAiHPA030515.

Interactioni

Subunit structurei

Part of a complex with ERBB2 and EGFR. Part of a complex with phosphorylated EGFR and GRB2. Interacts with phosphorylated EGFR and PDGFR, maybe indirectly. Interacts with GRB2 and SHC1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005337EBI-641107,EBI-297353
ERBB2P046262EBI-641107,EBI-641062
GRB2P629932EBI-641107,EBI-401755
NCK1P163333EBI-641107,EBI-389883
TRIM27P143735EBI-641107,EBI-719493

Protein-protein interaction databases

BioGridi111305. 11 interactions.
IntActiO00750. 9 interactions.
MINTiMINT-2794980.
STRINGi9606.ENSP00000356155.

Structurei

3D structure databases

ProteinModelPortaliO00750.
SMRiO00750. Positions 640-1321, 1365-1475, 1506-1626.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini375 – 46389PI3K-RBDAdd
BLAST
Domaini635 – 786152C2 PI3K-typeAdd
BLAST
Domaini805 – 981177PIK helicalAdd
BLAST
Domaini1079 – 1343265PI3K/PI4KAdd
BLAST
Domaini1365 – 1481117PXAdd
BLAST
Domaini1517 – 160892C2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 298297Interaction with GRB2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi156 – 1627Pro-rich
Compositional biasi169 – 1746Pro-rich

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.
Contains 1 C2 domain.
Contains 1 PI3K-RBD domain.
Contains 1 PI3K/PI4K domain.
Contains 1 PIK helical domain.

Phylogenomic databases

eggNOGiCOG5032.
HOVERGENiHBG082099.
InParanoidiO00750.
KOiK00923.
OMAiIHLQERP.
OrthoDBiEOG71CFK4.
PhylomeDBiO00750.
TreeFamiTF102031.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 2 hits.
3.30.1520.10. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR001683. Phox.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00168. C2. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00142. PI3K_C2. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
PS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00750-1 [UniParc]FASTAAdd to Basket

« Hide

MSSTQGNGEH WKSLESVGIS RKELAMAEAL QMEYDALSRL RHDKEENRAK     50
QNADPSLISW DEPGVDFYSK PAGRRTDLKL LRGLSGSDPT LNYNSLSPQE 100
GPPNHSTSQG PQPGSDPWPK GSLSGDYLYI FDGSDGGVSS SPGPGDIEGS 150
CKKLSPPPLP PRASIWDTPP LPPRKGSPSS SKISQPSDIN TFSLVEQLPG 200
KLLEHRILEE EEVLGGGGQG RLLGSVDYDG INDAITRLNL KSTYDAEMLR 250
DATRGWKEGR GPLDFSKDTS GKPVARSKTM PPQVPPRTYA SRYGNRKNAT 300
PGKNRRISAA PVGSRPHTVA NGHELFEVSE ERDEEVAAFC HMLDILRSGS 350
DIQDYFLTGY VWSAVTPSPE HLGDEVNLKV TVLCDRLQEA LTFTCNCSST 400
VDLLIYQTLC YTHDDLRNVD VGDFVLKPCG LEEFLQNKHA LGSHEYIQYC 450
RKFDIDIRLQ LMEQKVVRSD LARTVNDDQS PSTLNYLVHL QERPVKQTIS 500
RQALSLLFDT YHNEVDAFLL ADGDFPLKAD RVVQSVKAIC NALAAVETPE 550
ITSALNQLPP CPSRMQPKIQ KDPSVLAVRE NREKVVEALT AAILDLVELY 600
CNTFNADFQT AVPGSRKHDL VQEACHFARS LAFTVYATHR IPIIWATSYE 650
DFYLSCSLSH GGKELCSPLQ TRRAHFSKYL FHLIVWDQQI CFPVQVNRLP 700
RETLLCATLY ALPIPPPGSS SEANKQRRVP EALGWVTTPL FNFRQVLTCG 750
RKLLGLWPAT QENPSARWSA PNFHQPDSVI LQIDFPTSAF DIKFTSPPGD 800
KFSPRYEFGS LREEDQRKLK DIMQKESLYW LTDADKKRLW EKRYYCHSEV 850
SSLPLVLASA PSWEWACLPD IYVLLKQWTH MNHQDALGLL HATFPDQEVR 900
RMAVQWIGSL SDAELLDYLP QLVQALKYEC YLDSPLVRFL LKRAVSDLRV 950
THYFFWLLKD GLKDSQFSIR YQYLLAALLC CCGKGLREEF NRQCWLVNAL 1000
AKLAQQVREA APSARQGILR TGLEEVKQFF ALNGSCRLPL SPSLLVKGIV 1050
PRDCSYFNSN AVPLKLSFQN VDPLGENIRV IFKCGDDLRQ DMLTLQMIRI 1100
MSKIWVQEGL DMRMVIFRCF STGRGRGMVE MIPNAETLRK IQVEHGVTGS 1150
FKDRPLADWL QKHNPGEDEY EKAVENFIYS CAGCCVATYV LGICDRHNDN 1200
IMLKTTGHMF HIDFGRFLGH AQMFGNIKRD RAPFVFTSDM AYVINGGDKP 1250
SSRFHDFVDL CCQAYNLIRK HTHLFLNLLG LMLSCGIPEL SDLEDLKYVY 1300
DALRPQDTEA NATTYFTRLI ESSLGSVATK LNFFIHNLAQ MKFTGSDDRL 1350
TLSFASRTHT LKSSGRISDV FLCRHEKIFH PNKGYIYVVK VMRENTHEAT 1400
YIQRTFEEFQ ELHNKLRLLF PSSHLPSFPS RFVIGRSRGE AVAERRREEL 1450
NGYIWHLIHA PPEVAECDLV YTFFHPLPRD EKAMGTSPAP KSSDGTWARP 1500
VGKVGGEVKL SISYKNNKLF IMVMHIRGLQ LLQDGNDPDP YVKIYLLPDP 1550
QKTTKRKTKV ARKTCNPTYN EMLVYDGIPK GDLQQRELQL SVLSEQGFWE 1600
NVLLGEVNIR LRELDLAQEK TGWFALGSRS HGTL 1634
Length:1,634
Mass (Da):184,768
Last modified:August 30, 2005 - v2
Checksum:iCA817BA77C12E833
GO

Sequence cautioni

The sequence CAA74194.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61G → D in CAA72168. 1 Publication
Sequence conflicti63 – 631P → S in CAA74194. 1 Publication
Sequence conflicti75 – 751R → W in CAA74194. 1 Publication
Sequence conflicti99 – 991Q → L in CAA74194. 1 Publication
Sequence conflicti246 – 2461A → V in CAA72168. 1 Publication
Sequence conflicti278 – 2781K → E in CAA74194. 1 Publication
Sequence conflicti567 – 5671P → S in CAA74194. 1 Publication
Sequence conflicti664 – 6652EL → DM in CAA72168. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y11312 mRNA. Translation: CAA72168.1.
Y13892 mRNA. Translation: CAA74194.1. Different initiation.
AL606489 Genomic DNA. Translation: CAI16572.1.
CCDSiCCDS1446.1.
PIRiJC5500.
PC4346.
RefSeqiNP_002637.3. NM_002646.3.
XP_005245314.1. XM_005245257.1.
XP_006711447.1. XM_006711384.1.
UniGeneiHs.497487.

Genome annotation databases

EnsembliENST00000367187; ENSP00000356155; ENSG00000133056.
GeneIDi5287.
KEGGihsa:5287.
UCSCiuc001haw.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y11312 mRNA. Translation: CAA72168.1 .
Y13892 mRNA. Translation: CAA74194.1 . Different initiation.
AL606489 Genomic DNA. Translation: CAI16572.1 .
CCDSi CCDS1446.1.
PIRi JC5500.
PC4346.
RefSeqi NP_002637.3. NM_002646.3.
XP_005245314.1. XM_005245257.1.
XP_006711447.1. XM_006711384.1.
UniGenei Hs.497487.

3D structure databases

ProteinModelPortali O00750.
SMRi O00750. Positions 640-1321, 1365-1475, 1506-1626.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111305. 11 interactions.
IntActi O00750. 9 interactions.
MINTi MINT-2794980.
STRINGi 9606.ENSP00000356155.

Chemistry

BindingDBi O00750.
ChEMBLi CHEMBL5554.
GuidetoPHARMACOLOGYi 2151.

PTM databases

PhosphoSitei O00750.

Proteomic databases

MaxQBi O00750.
PaxDbi O00750.
PeptideAtlasi O00750.
PRIDEi O00750.

Protocols and materials databases

DNASUi 5287.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367187 ; ENSP00000356155 ; ENSG00000133056 .
GeneIDi 5287.
KEGGi hsa:5287.
UCSCi uc001haw.3. human.

Organism-specific databases

CTDi 5287.
GeneCardsi GC01M204391.
HGNCi HGNC:8972. PIK3C2B.
HPAi HPA030515.
MIMi 602838. gene.
neXtProti NX_O00750.
PharmGKBi PA33305.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5032.
HOVERGENi HBG082099.
InParanoidi O00750.
KOi K00923.
OMAi IHLQERP.
OrthoDBi EOG71CFK4.
PhylomeDBi O00750.
TreeFami TF102031.

Enzyme and pathway databases

BRENDAi 2.7.1.137. 2681.
Reactomei REACT_121025. Synthesis of PIPs at the plasma membrane.
SignaLinki O00750.

Miscellaneous databases

ChiTaRSi PIK3C2B. human.
GeneWikii PIK3C2B.
GenomeRNAii 5287.
NextBioi 20430.
PROi O00750.
SOURCEi Search...

Gene expression databases

ArrayExpressi O00750.
Bgeei O00750.
CleanExi HS_PIK3C2B.
Genevestigatori O00750.

Family and domain databases

Gene3Di 1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 2 hits.
3.30.1520.10. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR001683. Phox.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
PANTHERi PTHR10048. PTHR10048. 1 hit.
Pfami PF00168. C2. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
PF00787. PX. 1 hit.
[Graphical view ]
SMARTi SM00239. C2. 1 hit.
SM00142. PI3K_C2. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
SM00312. PX. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEi PS50004. C2. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
PS50195. PX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K."
    Brown R.A., Ho L.K.F., Weber-Hall S.J., Shipley J.M., Fry M.J.
    Biochem. Biophys. Res. Commun. 233:537-544(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Mammary gland.
  2. "Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity."
    Arcaro A., Volinia S., Zvelebil M.J., Stein R.C., Watton S.J., Layton M.J., Gout I., Ahmadi K., Downward J., Waterfield M.D.
    J. Biol. Chem. 273:33082-33090(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Tissue: Monocyte.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors."
    Arcaro A., Zvelebil M.J., Wallasch C., Ullrich A., Waterfield M.D., Domin J.
    Mol. Cell. Biol. 20:3817-3830(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH ERBB2 AND EGFR, INTERACTION WITH EGFR AND PDGFR, COFACTOR, FUNCTION.
  5. "Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2."
    Wheeler M., Domin J.
    Mol. Cell. Biol. 21:6660-6667(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH GRB2 AND EGFR, INTERACTION WITH SHC1 AND GRB2, ENZYME REGULATION.
  6. "Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation."
    El Sheikh S.S., Domin J., Tomtitchong P., Abel P., Stamp G., Lalani E.-N.
    BMC Clin. Pathol. 3:4-4(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiP3C2B_HUMAN
AccessioniPrimary (citable) accession number: O00750
Secondary accession number(s): O95666, Q5SW99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 30, 2005
Last modified: September 3, 2014
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-26 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi