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O00750

- P3C2B_HUMAN

UniProt

O00750 - P3C2B_HUMAN

Protein

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

Gene

PIK3C2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 151 (01 Oct 2014)
      Sequence version 2 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.1 Publication

    Catalytic activityi

    ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.

    Cofactori

    Calcium, magnesium, or manganese.1 Publication

    Enzyme regulationi

    Activated by GRB2.1 Publication

    GO - Molecular functioni

    1. 1-phosphatidylinositol-3-kinase activity Source: RefGenome
    2. 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: UniProtKB
    3. ATP binding Source: UniProtKB-KW
    4. lipid kinase activity Source: Ensembl
    5. phosphatidylinositol binding Source: InterPro
    6. protein binding Source: IntAct

    GO - Biological processi

    1. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
    2. phosphatidylinositol biosynthetic process Source: Reactome
    3. phosphatidylinositol-mediated signaling Source: InterPro
    4. phospholipid metabolic process Source: Reactome
    5. protein kinase B signaling Source: Ensembl
    6. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.1.137. 2681.
    ReactomeiREACT_121025. Synthesis of PIPs at the plasma membrane.
    SignaLinkiO00750.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (EC:2.7.1.154)
    Short name:
    PI3K-C2-beta
    Short name:
    PtdIns-3-kinase C2 subunit beta
    Alternative name(s):
    C2-PI3K
    Phosphoinositide 3-kinase-C2-beta
    Gene namesi
    Name:PIK3C2B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:8972. PIK3C2B.

    Subcellular locationi

    Microsome 1 Publication. Cell membrane 1 Publication. Cytoplasmcytosol 1 Publication. Nucleus 1 Publication. Endoplasmic reticulum 1 Publication
    Note: Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis.

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. endocytic vesicle Source: Ensembl
    3. endoplasmic reticulum Source: UniProtKB-SubCell
    4. nucleus Source: UniProtKB-SubCell
    5. phosphatidylinositol 3-kinase complex Source: RefGenome
    6. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Microsome, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33305.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16341634Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit betaPRO_0000088798Add
    BLAST

    Proteomic databases

    MaxQBiO00750.
    PaxDbiO00750.
    PeptideAtlasiO00750.
    PRIDEiO00750.

    PTM databases

    PhosphoSiteiO00750.

    Expressioni

    Tissue specificityi

    Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscle and kidney.2 Publications

    Gene expression databases

    ArrayExpressiO00750.
    BgeeiO00750.
    CleanExiHS_PIK3C2B.
    GenevestigatoriO00750.

    Organism-specific databases

    HPAiHPA030515.

    Interactioni

    Subunit structurei

    Part of a complex with ERBB2 and EGFR. Part of a complex with phosphorylated EGFR and GRB2. Interacts with phosphorylated EGFR and PDGFR, maybe indirectly. Interacts with GRB2 and SHC1.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EGFRP005337EBI-641107,EBI-297353
    ERBB2P046262EBI-641107,EBI-641062
    GRB2P629932EBI-641107,EBI-401755
    NCK1P163333EBI-641107,EBI-389883
    TRIM27P143735EBI-641107,EBI-719493

    Protein-protein interaction databases

    BioGridi111305. 11 interactions.
    IntActiO00750. 9 interactions.
    MINTiMINT-2794980.
    STRINGi9606.ENSP00000356155.

    Structurei

    3D structure databases

    ProteinModelPortaliO00750.
    SMRiO00750. Positions 640-1321, 1365-1475, 1506-1626.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini375 – 46389PI3K-RBDPROSITE-ProRule annotationAdd
    BLAST
    Domaini635 – 786152C2 PI3K-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini805 – 981177PIK helicalPROSITE-ProRule annotationAdd
    BLAST
    Domaini1079 – 1343265PI3K/PI4KPROSITE-ProRule annotationAdd
    BLAST
    Domaini1365 – 1481117PXPROSITE-ProRule annotationAdd
    BLAST
    Domaini1517 – 160892C2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 298297Interaction with GRB2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi156 – 1627Pro-rich
    Compositional biasi169 – 1746Pro-rich

    Sequence similaritiesi

    Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation
    Contains 1 C2 domain.PROSITE-ProRule annotation
    Contains 1 C2 PI3K-type domain.PROSITE-ProRule annotation
    Contains 1 PI3K-RBD domain.PROSITE-ProRule annotation
    Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation
    Contains 1 PIK helical domain.PROSITE-ProRule annotation
    Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5032.
    HOVERGENiHBG082099.
    InParanoidiO00750.
    KOiK00923.
    OMAiIHLQERP.
    OrthoDBiEOG71CFK4.
    PhylomeDBiO00750.
    TreeFamiTF102031.

    Family and domain databases

    Gene3Di1.10.1070.11. 1 hit.
    1.25.40.70. 1 hit.
    2.60.40.150. 2 hits.
    3.30.1520.10. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR001683. Phox.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR002420. PI3K_C2_dom.
    IPR000341. PI3K_Ras-bd_dom.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PANTHERiPTHR10048. PTHR10048. 1 hit.
    PfamiPF00168. C2. 1 hit.
    PF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF00794. PI3K_rbd. 1 hit.
    PF00613. PI3Ka. 1 hit.
    PF00787. PX. 1 hit.
    [Graphical view]
    SMARTiSM00239. C2. 1 hit.
    SM00142. PI3K_C2. 1 hit.
    SM00144. PI3K_rbd. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    SM00312. PX. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF49562. SSF49562. 2 hits.
    SSF54236. SSF54236. 1 hit.
    SSF56112. SSF56112. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEiPS50004. C2. 1 hit.
    PS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51546. PI3K_RBD. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    PS50195. PX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O00750-1 [UniParc]FASTAAdd to Basket

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    MSSTQGNGEH WKSLESVGIS RKELAMAEAL QMEYDALSRL RHDKEENRAK     50
    QNADPSLISW DEPGVDFYSK PAGRRTDLKL LRGLSGSDPT LNYNSLSPQE 100
    GPPNHSTSQG PQPGSDPWPK GSLSGDYLYI FDGSDGGVSS SPGPGDIEGS 150
    CKKLSPPPLP PRASIWDTPP LPPRKGSPSS SKISQPSDIN TFSLVEQLPG 200
    KLLEHRILEE EEVLGGGGQG RLLGSVDYDG INDAITRLNL KSTYDAEMLR 250
    DATRGWKEGR GPLDFSKDTS GKPVARSKTM PPQVPPRTYA SRYGNRKNAT 300
    PGKNRRISAA PVGSRPHTVA NGHELFEVSE ERDEEVAAFC HMLDILRSGS 350
    DIQDYFLTGY VWSAVTPSPE HLGDEVNLKV TVLCDRLQEA LTFTCNCSST 400
    VDLLIYQTLC YTHDDLRNVD VGDFVLKPCG LEEFLQNKHA LGSHEYIQYC 450
    RKFDIDIRLQ LMEQKVVRSD LARTVNDDQS PSTLNYLVHL QERPVKQTIS 500
    RQALSLLFDT YHNEVDAFLL ADGDFPLKAD RVVQSVKAIC NALAAVETPE 550
    ITSALNQLPP CPSRMQPKIQ KDPSVLAVRE NREKVVEALT AAILDLVELY 600
    CNTFNADFQT AVPGSRKHDL VQEACHFARS LAFTVYATHR IPIIWATSYE 650
    DFYLSCSLSH GGKELCSPLQ TRRAHFSKYL FHLIVWDQQI CFPVQVNRLP 700
    RETLLCATLY ALPIPPPGSS SEANKQRRVP EALGWVTTPL FNFRQVLTCG 750
    RKLLGLWPAT QENPSARWSA PNFHQPDSVI LQIDFPTSAF DIKFTSPPGD 800
    KFSPRYEFGS LREEDQRKLK DIMQKESLYW LTDADKKRLW EKRYYCHSEV 850
    SSLPLVLASA PSWEWACLPD IYVLLKQWTH MNHQDALGLL HATFPDQEVR 900
    RMAVQWIGSL SDAELLDYLP QLVQALKYEC YLDSPLVRFL LKRAVSDLRV 950
    THYFFWLLKD GLKDSQFSIR YQYLLAALLC CCGKGLREEF NRQCWLVNAL 1000
    AKLAQQVREA APSARQGILR TGLEEVKQFF ALNGSCRLPL SPSLLVKGIV 1050
    PRDCSYFNSN AVPLKLSFQN VDPLGENIRV IFKCGDDLRQ DMLTLQMIRI 1100
    MSKIWVQEGL DMRMVIFRCF STGRGRGMVE MIPNAETLRK IQVEHGVTGS 1150
    FKDRPLADWL QKHNPGEDEY EKAVENFIYS CAGCCVATYV LGICDRHNDN 1200
    IMLKTTGHMF HIDFGRFLGH AQMFGNIKRD RAPFVFTSDM AYVINGGDKP 1250
    SSRFHDFVDL CCQAYNLIRK HTHLFLNLLG LMLSCGIPEL SDLEDLKYVY 1300
    DALRPQDTEA NATTYFTRLI ESSLGSVATK LNFFIHNLAQ MKFTGSDDRL 1350
    TLSFASRTHT LKSSGRISDV FLCRHEKIFH PNKGYIYVVK VMRENTHEAT 1400
    YIQRTFEEFQ ELHNKLRLLF PSSHLPSFPS RFVIGRSRGE AVAERRREEL 1450
    NGYIWHLIHA PPEVAECDLV YTFFHPLPRD EKAMGTSPAP KSSDGTWARP 1500
    VGKVGGEVKL SISYKNNKLF IMVMHIRGLQ LLQDGNDPDP YVKIYLLPDP 1550
    QKTTKRKTKV ARKTCNPTYN EMLVYDGIPK GDLQQRELQL SVLSEQGFWE 1600
    NVLLGEVNIR LRELDLAQEK TGWFALGSRS HGTL 1634
    Length:1,634
    Mass (Da):184,768
    Last modified:August 30, 2005 - v2
    Checksum:iCA817BA77C12E833
    GO

    Sequence cautioni

    The sequence CAA74194.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61G → D in CAA72168. (PubMed:9144573)Curated
    Sequence conflicti63 – 631P → S in CAA74194. (PubMed:9830063)Curated
    Sequence conflicti75 – 751R → W in CAA74194. (PubMed:9830063)Curated
    Sequence conflicti99 – 991Q → L in CAA74194. (PubMed:9830063)Curated
    Sequence conflicti246 – 2461A → V in CAA72168. (PubMed:9144573)Curated
    Sequence conflicti278 – 2781K → E in CAA74194. (PubMed:9830063)Curated
    Sequence conflicti567 – 5671P → S in CAA74194. (PubMed:9830063)Curated
    Sequence conflicti664 – 6652EL → DM in CAA72168. (PubMed:9144573)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11312 mRNA. Translation: CAA72168.1.
    Y13892 mRNA. Translation: CAA74194.1. Different initiation.
    AL606489 Genomic DNA. Translation: CAI16572.1.
    CCDSiCCDS1446.1.
    PIRiJC5500.
    PC4346.
    RefSeqiNP_002637.3. NM_002646.3.
    XP_005245314.1. XM_005245257.1.
    XP_006711447.1. XM_006711384.1.
    UniGeneiHs.497487.

    Genome annotation databases

    EnsembliENST00000367187; ENSP00000356155; ENSG00000133056.
    GeneIDi5287.
    KEGGihsa:5287.
    UCSCiuc001haw.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11312 mRNA. Translation: CAA72168.1 .
    Y13892 mRNA. Translation: CAA74194.1 . Different initiation.
    AL606489 Genomic DNA. Translation: CAI16572.1 .
    CCDSi CCDS1446.1.
    PIRi JC5500.
    PC4346.
    RefSeqi NP_002637.3. NM_002646.3.
    XP_005245314.1. XM_005245257.1.
    XP_006711447.1. XM_006711384.1.
    UniGenei Hs.497487.

    3D structure databases

    ProteinModelPortali O00750.
    SMRi O00750. Positions 640-1321, 1365-1475, 1506-1626.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111305. 11 interactions.
    IntActi O00750. 9 interactions.
    MINTi MINT-2794980.
    STRINGi 9606.ENSP00000356155.

    Chemistry

    BindingDBi O00750.
    ChEMBLi CHEMBL5554.
    GuidetoPHARMACOLOGYi 2151.

    PTM databases

    PhosphoSitei O00750.

    Proteomic databases

    MaxQBi O00750.
    PaxDbi O00750.
    PeptideAtlasi O00750.
    PRIDEi O00750.

    Protocols and materials databases

    DNASUi 5287.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367187 ; ENSP00000356155 ; ENSG00000133056 .
    GeneIDi 5287.
    KEGGi hsa:5287.
    UCSCi uc001haw.3. human.

    Organism-specific databases

    CTDi 5287.
    GeneCardsi GC01M204391.
    HGNCi HGNC:8972. PIK3C2B.
    HPAi HPA030515.
    MIMi 602838. gene.
    neXtProti NX_O00750.
    PharmGKBi PA33305.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5032.
    HOVERGENi HBG082099.
    InParanoidi O00750.
    KOi K00923.
    OMAi IHLQERP.
    OrthoDBi EOG71CFK4.
    PhylomeDBi O00750.
    TreeFami TF102031.

    Enzyme and pathway databases

    BRENDAi 2.7.1.137. 2681.
    Reactomei REACT_121025. Synthesis of PIPs at the plasma membrane.
    SignaLinki O00750.

    Miscellaneous databases

    ChiTaRSi PIK3C2B. human.
    GeneWikii PIK3C2B.
    GenomeRNAii 5287.
    NextBioi 20430.
    PROi O00750.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O00750.
    Bgeei O00750.
    CleanExi HS_PIK3C2B.
    Genevestigatori O00750.

    Family and domain databases

    Gene3Di 1.10.1070.11. 1 hit.
    1.25.40.70. 1 hit.
    2.60.40.150. 2 hits.
    3.30.1520.10. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR001683. Phox.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR002420. PI3K_C2_dom.
    IPR000341. PI3K_Ras-bd_dom.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    PANTHERi PTHR10048. PTHR10048. 1 hit.
    Pfami PF00168. C2. 1 hit.
    PF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF00794. PI3K_rbd. 1 hit.
    PF00613. PI3Ka. 1 hit.
    PF00787. PX. 1 hit.
    [Graphical view ]
    SMARTi SM00239. C2. 1 hit.
    SM00142. PI3K_C2. 1 hit.
    SM00144. PI3K_rbd. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    SM00312. PX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF49562. SSF49562. 2 hits.
    SSF54236. SSF54236. 1 hit.
    SSF56112. SSF56112. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEi PS50004. C2. 1 hit.
    PS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51546. PI3K_RBD. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    PS50195. PX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K."
      Brown R.A., Ho L.K.F., Weber-Hall S.J., Shipley J.M., Fry M.J.
      Biochem. Biophys. Res. Commun. 233:537-544(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Mammary gland.
    2. "Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity."
      Arcaro A., Volinia S., Zvelebil M.J., Stein R.C., Watton S.J., Layton M.J., Gout I., Ahmadi K., Downward J., Waterfield M.D.
      J. Biol. Chem. 273:33082-33090(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
      Tissue: Monocyte.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors."
      Arcaro A., Zvelebil M.J., Wallasch C., Ullrich A., Waterfield M.D., Domin J.
      Mol. Cell. Biol. 20:3817-3830(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH ERBB2 AND EGFR, INTERACTION WITH EGFR AND PDGFR, COFACTOR, FUNCTION.
    5. "Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2."
      Wheeler M., Domin J.
      Mol. Cell. Biol. 21:6660-6667(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH GRB2 AND EGFR, INTERACTION WITH SHC1 AND GRB2, ENZYME REGULATION.
    6. "Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation."
      El Sheikh S.S., Domin J., Tomtitchong P., Abel P., Stamp G., Lalani E.-N.
      BMC Clin. Pathol. 3:4-4(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiP3C2B_HUMAN
    AccessioniPrimary (citable) accession number: O00750
    Secondary accession number(s): O95666, Q5SW99
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 151 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-26 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3