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Reviewed, UniProtKB/Swiss-Prot O00746 (NDKM_HUMAN)

Last modified June 16, 2009. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Nucleoside diphosphate kinase, mitochondrial
      Short name=NDP kinase, mitochondrial
      Short name=NDK
    EC=2.7.4.6
Alternative name(s):
    nm23-H4
    Nucleoside diphosphate kinase D
      Short name=NDPKD
Gene names
Name: NME4
Synonyms: NM23D
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length187 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Major role in the synthesis of nucleoside triphosphates other than ATP By similarity.

Catalytic activity

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Homohexamer. Interacts with CAPN8 By similarity.

Subcellular location

Mitochondrion intermembrane space.

Tissue specificity

Widely distributed. Found at very high levels in prostate, heart, liver, small intestine, and skeletal muscle tissues, and in low amounts in the brain and in blood leukocytes.

Sequence similarities

Belongs to the NDK family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3333Mitochondrion Potential
Chain34 – 187154Nucleoside diphosphate kinase, mitochondrial
PRO_0000019432

Sites

Active site1511Pros-phosphohistidine intermediate By similarity
Binding site451ATP By similarity
Binding site931ATP By similarity
Binding site1211ATP By similarity
Binding site1271ATP By similarity
Binding site1381ATP By similarity
Binding site1481ATP By similarity

Secondary structure

............................. 187
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O00746-1 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: A56FEF18A7D712D4

FASTA18720,659
        10         20         30         40         50         60 
MGGLFWRSAL RGLRCGPRAP GPSLLVRHGS GGPSWTRERT LVAVKPDGVQ RRLVGDVIQR 

        70         80         90        100        110        120 
FERRGFTLVG MKMLQAPESV LAEHYQDLRR KPFYPALIRY MSSGPVVAMV WEGYNVVRAS 

       130        140        150        160        170        180 
RAMIGHTDSA EAAPGTIRGD FSVHISRNVI HASDSVEGAQ REIQLWFQSS ELVSWADGGQ 


HSSIHPA 

« Hide

References

« Hide 'large scale' references
[1]"nm23-H4, a new member of the family of human nm23/nucleoside diphosphate kinase genes localised on chromosome 16p13."
Milon L., Rousseau-Merck M.-F., Munier A., Erent M., Lascu I., Capeau J., Lacombe M.-L.
Hum. Genet. 99:550-557(1997) [PubMed: 9099850] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Stomach.
[2]"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
Hum. Mol. Genet. 10:339-352(2001) [PubMed: 11157797] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed: 15616553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin and Uterus.
[5]"The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase."
Milon L., Meyer P., Chiadmi M., Munier A., Johansson M., Karlsson A., Lascu I., Capeau J., Janin J., Lacombe M.-L.
J. Biol. Chem. 275:14264-14272(2000) [PubMed: 10799505] [Abstract]
Cited for: CHARACTERIZATION, X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

Y07604 mRNA. Translation: CAA68877.1.
AE006463 Genomic DNA. Translation: AAK61230.1.
Z97634 Genomic DNA. Translation: CAC37288.1.
BC004880 mRNA. Translation: AAH04880.1.
BC017067 mRNA. Translation: AAH17067.1.
IPIIPI00012972.
RefSeqNP_005000.1.
UniGeneHs.9235

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1EHWX-ray2.40A/B36-175[»]
ModBaseSearch...

Protein-protein interaction databases

IntActO00746. 2 interactions.

Proteomic databases

PRIDEO00746.

Genome annotation databases

EnsemblENSG00000103200. Homo sapiens. [Contig view]
GeneID4833.
KEGGhsa:4833.

Organism-specific databases

GeneCardsGC16P000387.
H-InvDBHIX0012647.
HGNCHGNC:7852. NME4.
MIM601818. gene.
PharmGKBPA31657.
GenAtlasSearch...

Phylogenomic databases

HOVERGENO00746.

Enzyme and pathway databases

BRENDA2.7.4.6. 247.
ReactomeREACT_1698. Nucleotide metabolism.

Gene expression databases

ArrayExpressO00746.
BgeeO00746.
CleanExHS_NME4.
GermOnlineENSG00000103200. Homo sapiens.

Family and domain databases

InterProIPR001564. Nuc_diP_kinase_core.
[Graphical view]
Gene3DG3DSA:3.30.70.141. NDK. 1 hit.
PANTHERPTHR11349. Nuc_diP_kinase_core. 1 hit.
PfamPF00334. NDK. 1 hit.
[Graphical view]
PRINTSPR01243. NUCDPKINASE.
ProDomPD001018. NDK. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00562. NDK. 1 hit.
[Graphical view]
PROSITEPS00469. NDP_KINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio18626.
SOURCESearch...

Entry information

Entry nameNDKM_HUMAN
AccessionPrimary (citable) accession number: O00746
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: June 16, 2009
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents