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O00744

- WN10B_HUMAN

UniProt

O00744 - WN10B_HUMAN

Protein

Protein Wnt-10b

Gene

WNT10B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (10 May 2002)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.By similarity

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome
    2. receptor agonist activity Source: BHF-UCL

    GO - Biological processi

    1. bone trabecula formation Source: Ensembl
    2. canonical Wnt signaling pathway Source: BHF-UCL
    3. cell cycle arrest Source: Ensembl
    4. cell fate commitment Source: RefGenome
    5. cellular response to cAMP Source: Ensembl
    6. cellular response to hydrostatic pressure Source: Ensembl
    7. cellular response to parathyroid hormone stimulus Source: Ensembl
    8. cellular response to retinoic acid Source: UniProtKB
    9. chondrocyte differentiation Source: UniProtKB
    10. fungiform papilla development Source: Ensembl
    11. G2/M transition of mitotic cell cycle Source: Ensembl
    12. hematopoietic stem cell proliferation Source: BHF-UCL
    13. lipid metabolic process Source: Ensembl
    14. myoblast differentiation involved in skeletal muscle regeneration Source: Ensembl
    15. negative regulation of epithelial cell proliferation Source: Ensembl
    16. negative regulation of fat cell differentiation Source: BHF-UCL
    17. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    18. neuron differentiation Source: UniProtKB
    19. positive regulation of anagen Source: Ensembl
    20. positive regulation of apoptotic process Source: BHF-UCL
    21. positive regulation of bone mineralization Source: Ensembl
    22. positive regulation of canonical Wnt signaling pathway Source: Ensembl
    23. positive regulation of cell proliferation Source: Ensembl
    24. positive regulation of epithelial cell differentiation Source: Ensembl
    25. positive regulation of G2/M transition of mitotic cell cycle Source: Ensembl
    26. positive regulation of osteoblast differentiation Source: Ensembl
    27. positive regulation of RNA polymerase II transcriptional preinitiation complex assembly Source: Ensembl
    28. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    29. protein stabilization Source: BHF-UCL
    30. regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
    31. regulation of skeletal muscle tissue development Source: Ensembl
    32. sensory perception of taste Source: Ensembl
    33. skeletal muscle fiber development Source: Ensembl
    34. smoothened signaling pathway Source: Ensembl
    35. Wnt signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
    REACT_18372. Class B/2 (Secretin family receptors).
    REACT_27161. Transcriptional regulation of white adipocyte differentiation.
    SignaLinkiO00744.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-10b
    Alternative name(s):
    Protein Wnt-12
    Gene namesi
    Name:WNT10B
    Synonyms:WNT12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:12775. WNT10B.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB
    3. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Split-hand/foot malformation 6 (SHFM6) [MIM:225300]: A limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti332 – 3321R → W in SHFM6. 1 Publication
    VAR_062516

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi225300. phenotype.
    Orphaneti2440. Split hand-split foot malformation.
    PharmGKBiPA37377.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 389361Protein Wnt-10bPRO_0000041463Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei46 – 461Phosphothreonine1 Publication
    Disulfide bondi83 ↔ 94By similarity
    Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi136 ↔ 144By similarity
    Disulfide bondi146 ↔ 199By similarity
    Disulfide bondi247 ↔ 261By similarity
    Disulfide bondi249 ↔ 256By similarity
    Disulfide bondi334 ↔ 349By similarity
    Glycosylationi335 – 3351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi364 ↔ 379By similarity
    Disulfide bondi366 ↔ 376By similarity
    Disulfide bondi371 ↔ 372By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiO00744.
    PRIDEiO00744.

    PTM databases

    PhosphoSiteiO00744.

    Expressioni

    Tissue specificityi

    Detected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain.

    Developmental stagei

    Infant brain has higher levels of WNT10B than adult brain.

    Gene expression databases

    ArrayExpressiO00744.
    BgeeiO00744.
    CleanExiHS_WNT10B.
    GenevestigatoriO00744.

    Organism-specific databases

    HPAiHPA055048.

    Interactioni

    Protein-protein interaction databases

    BioGridi113317. 1 interaction.
    STRINGi9606.ENSP00000301061.

    Structurei

    3D structure databases

    ProteinModelPortaliO00744.
    SMRiO00744. Positions 69-380.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG240772.
    HOGENOMiHOG000039528.
    HOVERGENiHBG001595.
    InParanoidiO00744.
    KOiK01357.
    OMAiSERCNCR.
    OrthoDBiEOG7C8GJ8.
    PhylomeDBiO00744.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR013302. Wnt10.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01893. WNT10PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O00744-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLEEPRPRPP PSGLAGLLFL ALCSRALSNE ILGLKLPGEP PLTANTVCLT    50
    LSGLSKRQLG LCLRNPDVTA SALQGLHIAV HECQHQLRDQ RWNCSALEGG 100
    GRLPHHSAIL KRGFRESAFS FSMLAAGVMH AVATACSLGK LVSCGCGWKG 150
    SGEQDRLRAK LLQLQALSRG KSFPHSLPSP GPGSSPSPGP QDTWEWGGCN 200
    HDMDFGEKFS RDFLDSREAP RDIQARMRIH NNRVGRQVVT ENLKRKCKCH 250
    GTSGSCQFKT CWRAAPEFRA VGAALRERLG RAIFIDTHNR NSGAFQPRLR 300
    PRRLSGELVY FEKSPDFCER DPTMGSPGTR GRACNKTSRL LDGCGSLCCG 350
    RGHNVLRQTR VERCHCRFHW CCYVLCDECK VTEWVNVCK 389
    Length:389
    Mass (Da):43,000
    Last modified:May 10, 2002 - v2
    Checksum:iF973F2CA0DB115EF
    GO
    Isoform 2 (identifier: O00744-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         172-191: SFPHSLPSPGPGSSPSPGPQ → LPGTSRHECESTTTGWGARW
         192-389: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:191
    Mass (Da):20,483
    Checksum:i07A9A02483680C55
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti60 – 601G → D in AAB51685. (PubMed:9284937)Curated
    Sequence conflicti149 – 1491K → R in CAA65769. (PubMed:9121776)Curated
    Sequence conflicti295 – 2951F → S in CAA65769. (PubMed:9121776)Curated
    Sequence conflicti311 – 3111F → L in CAA65769. (PubMed:9121776)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti77 – 771H → Y.1 Publication
    Corresponds to variant rs151284263 [ dbSNP | Ensembl ].
    VAR_062512
    Natural varianti256 – 2561C → Y Associated with obesity; abrogates the ability of WNT10B to activate canonical Wnt signalling and blocks adipogenesis. 1 Publication
    VAR_062513
    Natural varianti285 – 2851I → T.1 Publication
    VAR_062514
    Natural varianti301 – 3011P → S.1 Publication
    Corresponds to variant rs35034312 [ dbSNP | Ensembl ].
    VAR_062515
    Natural varianti332 – 3321R → W in SHFM6. 1 Publication
    VAR_062516

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei172 – 19120SFPHS…SPGPQ → LPGTSRHECESTTTGWGARW in isoform 2. 1 PublicationVSP_056289Add
    BLAST
    Alternative sequencei192 – 389198Missing in isoform 2. 1 PublicationVSP_056290Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U81787 mRNA. Translation: AAB51685.1.
    AB070724 mRNA. Translation: BAB72181.1.
    AK312906 mRNA. Translation: BAG35752.1.
    AC073610 Genomic DNA. No translation available.
    CH471111 Genomic DNA. Translation: EAW58028.1.
    BC096353 mRNA. Translation: AAH96353.1.
    BC096354 mRNA. Translation: AAH96354.1.
    BC096355 mRNA. Translation: AAH96355.1.
    BC096356 mRNA. Translation: AAH96356.1.
    X97057 mRNA. Translation: CAA65769.1.
    AF028700 Genomic DNA. Translation: AAC39549.1.
    CCDSiCCDS8775.1.
    RefSeqiNP_003385.2. NM_003394.3.
    UniGeneiHs.91985.

    Genome annotation databases

    EnsembliENST00000301061; ENSP00000301061; ENSG00000169884.
    ENST00000407467; ENSP00000384691; ENSG00000169884.
    GeneIDi7480.
    KEGGihsa:7480.
    UCSCiuc001rss.3. human.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U81787 mRNA. Translation: AAB51685.1 .
    AB070724 mRNA. Translation: BAB72181.1 .
    AK312906 mRNA. Translation: BAG35752.1 .
    AC073610 Genomic DNA. No translation available.
    CH471111 Genomic DNA. Translation: EAW58028.1 .
    BC096353 mRNA. Translation: AAH96353.1 .
    BC096354 mRNA. Translation: AAH96354.1 .
    BC096355 mRNA. Translation: AAH96355.1 .
    BC096356 mRNA. Translation: AAH96356.1 .
    X97057 mRNA. Translation: CAA65769.1 .
    AF028700 Genomic DNA. Translation: AAC39549.1 .
    CCDSi CCDS8775.1.
    RefSeqi NP_003385.2. NM_003394.3.
    UniGenei Hs.91985.

    3D structure databases

    ProteinModelPortali O00744.
    SMRi O00744. Positions 69-380.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113317. 1 interaction.
    STRINGi 9606.ENSP00000301061.

    PTM databases

    PhosphoSitei O00744.

    Proteomic databases

    PaxDbi O00744.
    PRIDEi O00744.

    Protocols and materials databases

    DNASUi 7480.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000301061 ; ENSP00000301061 ; ENSG00000169884 .
    ENST00000407467 ; ENSP00000384691 ; ENSG00000169884 .
    GeneIDi 7480.
    KEGGi hsa:7480.
    UCSCi uc001rss.3. human.

    Organism-specific databases

    CTDi 7480.
    GeneCardsi GC12M049359.
    HGNCi HGNC:12775. WNT10B.
    HPAi HPA055048.
    MIMi 225300. phenotype.
    601906. gene.
    neXtProti NX_O00744.
    Orphaneti 2440. Split hand-split foot malformation.
    PharmGKBi PA37377.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG240772.
    HOGENOMi HOG000039528.
    HOVERGENi HBG001595.
    InParanoidi O00744.
    KOi K01357.
    OMAi SERCNCR.
    OrthoDBi EOG7C8GJ8.
    PhylomeDBi O00744.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_163710. WNT ligand biogenesis and trafficking.
    REACT_18372. Class B/2 (Secretin family receptors).
    REACT_27161. Transcriptional regulation of white adipocyte differentiation.
    SignaLinki O00744.

    Miscellaneous databases

    GeneWikii WNT10B.
    GenomeRNAii 7480.
    NextBioi 29300.
    PROi O00744.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O00744.
    Bgeei O00744.
    CleanExi HS_WNT10B.
    Genevestigatori O00744.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR013302. Wnt10.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01893. WNT10PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, characterization and chromosomal localization of human WNT10B."
      Hardiman G., Kastelein R.A., Bazan J.F.
      Cytogenet. Cell Genet. 77:278-282(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Proto-oncogene WNT10B is up-regulated by tumor necrosis factor alpha in human gastric cancer cell line MKN45."
      Saitoh T., Kirikoshi H., Mine T., Katoh M.
      Int. J. Oncol. 19:1187-1192(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Subthalamic nucleus.
    4. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    7. "A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas."
      Bui T.D., Rankin J., Smith K., Huguet E.L., Ruben S., Strachan T., Harris A.L., Lindsay S.
      Oncogene 14:1249-1253(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-347 (ISOFORM 1).
      Tissue: Fetal brain.
    8. "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21."
      Bergstein I., Eisenberg L.M., Bhalerao J., Jenkins N.A., Copeland N.G., Osborne M.P., Bowcock A.M., Brown A.M.C.
      Genomics 46:450-458(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 253-368.
      Tissue: Placenta.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-46, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: VARIANTS TYR-77; TYR-256; THR-285 AND SER-301, ASSOCIATION OF VARIANT TYR-256 WITH OBESITY.
    11. "Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation."
      Ugur S.A., Tolun A.
      Hum. Mol. Genet. 17:2644-2653(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT SHFM6 TRP-332.

    Entry informationi

    Entry nameiWN10B_HUMAN
    AccessioniPrimary (citable) accession number: O00744
    Secondary accession number(s): B2R7A5
    , O00747, Q4VAJ4, Q4VAJ5, Q8WZ97
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 10, 2002
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

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