O00712 (NFIB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear factor 1 B-type
Short name=NF1-B
Short name=Nuclear factor 1/B

Alternative name(s):
CCAAT-box-binding transcription factor
Short name=CTF
Nuclear factor I/B
Short name=NF-I/B
Short name=NFI-B
TGGCA-binding protein

Gene names

Name:

NFIB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	420 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Subunit structure	Binds DNA as a homodimer.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the CTF/NF-I family. Contains 1 CTF/NF-I DNA-binding domain.

Ontologies

Keywords
Biological process	DNA replication Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Ligand	DNA-binding
Molecular function	Activator
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Clara cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB DNA replication Inferred from electronic annotation. Source: UniProtKB-KW Type I pneumocyte differentiation Inferred from sequence or structural similarity. Source: UniProtKB Type II pneumocyte differentiation Inferred from sequence or structural similarity. Source: UniProtKB anterior commissure morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB chondrocyte differentiation Inferred from sequence or structural similarity. Source: UniProtKB commissural neuron axon guidance Inferred from sequence or structural similarity. Source: UniProtKB glial cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB lung ciliated cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of DNA binding Inferred from direct assay Ref.2. Source: UniProtKB negative regulation of epithelial cell proliferation involved in lung morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of mesenchymal cell proliferation involved in lung development Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 19540848Ref.2. Source: UniProtKB principal sensory nucleus of trigeminal nerve development Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cerebellar mossy fiber Inferred from sequence or structural similarity. Source: UniProtKB nucleolus Inferred from direct assay. Source: HPA nucleus Inferred from direct assay Ref.2. Source: UniProtKB
Molecular_function	DNA binding Inferred from direct assay PubMed 19540848Ref.2. Source: UniProtKB RNA polymerase II transcription corepressor activity Inferred from direct assay Ref.2. Source: UniProtKB sequence-specific DNA binding RNA polymerase II transcription factor activity Inferred from direct assay PubMed 19540848Ref.2. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: O00712-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O00712-3)

The sequence of this isoform is not available.

Isoform 3 (identifier: O00712-2)

Also known as: NFI-B3;

The sequence of this isoform differs from the canonical sequence as follows:
     187-188: QD → AR
     189-420: Missing.

Isoform 4 (identifier: O00712-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MMYSPICLTQ → MERIPVSVDFWVVCCAVLKCNPGIPMERIPVSVDFWVVCCAVLKCNPGIPKRMSTLCFGFS

Note: No experimental confirmation available.

Isoform 5 (identifier: O00712-5)

The sequence of this isoform differs from the canonical sequence as follows:
     416-416: S → PNGSGQVVGK...DPSFLHQQQS

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.12
	Chain	2 – 420	419	Nuclear factor 1 B-type		PRO_0000100195
Regions
	DNA binding	1 – 195	195	CTF/NF-I
Amino acid modifications
	Modified residue	2	1	N-acetylmethionine Ref.12
	Modified residue	63	1	Phosphoserine By similarity
	Modified residue	264	1	Phosphoserine Ref.11
	Modified residue	292	1	Phosphoserine By similarity
	Modified residue	295	1	Phosphoserine By similarity
	Modified residue	312	1	Phosphoserine Ref.12
	Modified residue	328	1	Phosphoserine Ref.11 Ref.12
	Modified residue	333	1	Phosphoserine Ref.12
Natural variations
	Alternative sequence	1 – 10	10	MMYSPICLTQ → MERIPVSVDFWVVCCAVLKC NPGIPMERIPVSVDFWVVCC AVLKCNPGIPKRMSTLCFGF S in isoform 4.		VSP_044462
	Alternative sequence	187 – 188	2	QD → AR in isoform 3.		VSP_003545
	Alternative sequence	189 – 420	232	Missing in isoform 3.		VSP_003546
	Alternative sequence	416	1	S → PNGSGQVVGKVPGHFTPVLA PSPHPSAVRPVTLSMTDTKP ITTSTEAYTASGTSQANRYV GLSPRDPSFLHQQQS in isoform 5.		VSP_045065
Experimental info
	Sequence conflict	17	1	I → M in AAB41899. Ref.1
	Sequence conflict	37	1	R → G in BAD18416. Ref.4
	Sequence conflict	74	1	S → F in BX648845. Ref.5
	Sequence conflict	198	1	N → S in BAD18416. Ref.4
	Sequence conflict	284	1	S → R in BX648845. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 15, 2004. Version 2. Checksum: 0F71635FE9D64FA4	FASTA	420	47,442
	10 20 30 40 50 60 MMYSPICLTQ DEFHPFIEAL LPHVRAIAYT WFNLQARKRK YFKKHEKRMS KDEERAVKDE 70 80 90 100 110 120 LLSEKPEIKQ KWASRLLAKL RKDIRQEYRE DFVLTVTGKK HPCCVLSNPD QKGKIRRIDC 130 140 150 160 170 180 LRQADKVWRL DLVMVILFKG IPLESTDGER LMKSPHCTNP ALCVQPHHIT VSVKELDLFL 190 200 210 220 230 240 AYYVQEQDSG QSGSPSHNDP AKNPPGYLED SFVKSGVFNV SELVRVSRTP ITQGTGVNFP 250 260 270 280 290 300 IGEIPSQPYY HDMNSGVNLQ RSLSSPPSSK RPKTISIDEN MEPSPTGDFY PSPSSPAAGS 310 320 330 340 350 360 RTWHERDQDM SSPTTMKKPE KPLFSSASPQ DSSPRLSTFP QHHHPGIPGV AHSVISTRTP 370 380 390 400 410 420 PPPSPLPFPT QAILPPAPSS YFSHPTIRYP PHLNPQDTLK NYVPSYDPSS PQTSQSWYLG
	Isoform 2 (Sequence not available).		–	–
	Isoform 3 (NFI-B3) [UniParc]. Checksum: C718698597C13336	FASTA	188	22,251
	10 20 30 40 50 60 MMYSPICLTQ DEFHPFIEAL LPHVRAIAYT WFNLQARKRK YFKKHEKRMS KDEERAVKDE 70 80 90 100 110 120 LLSEKPEIKQ KWASRLLAKL RKDIRQEYRE DFVLTVTGKK HPCCVLSNPD QKGKIRRIDC 130 140 150 160 170 180 LRQADKVWRL DLVMVILFKG IPLESTDGER LMKSPHCTNP ALCVQPHHIT VSVKELDLFL AYYVQEAR
	Isoform 4 [UniParc]. Checksum: D2797FFB1527C066	FASTA	471	53,049
	10 20 30 40 50 60 MERIPVSVDF WVVCCAVLKC NPGIPMERIP VSVDFWVVCC AVLKCNPGIP KRMSTLCFGF 70 80 90 100 110 120 SDEFHPFIEA LLPHVRAIAY TWFNLQARKR KYFKKHEKRM SKDEERAVKD ELLSEKPEIK 130 140 150 160 170 180 QKWASRLLAK LRKDIRQEYR EDFVLTVTGK KHPCCVLSNP DQKGKIRRID CLRQADKVWR 190 200 210 220 230 240 LDLVMVILFK GIPLESTDGE RLMKSPHCTN PALCVQPHHI TVSVKELDLF LAYYVQEQDS 250 260 270 280 290 300 GQSGSPSHND PAKNPPGYLE DSFVKSGVFN VSELVRVSRT PITQGTGVNF PIGEIPSQPY 310 320 330 340 350 360 YHDMNSGVNL QRSLSSPPSS KRPKTISIDE NMEPSPTGDF YPSPSSPAAG SRTWHERDQD 370 380 390 400 410 420 MSSPTTMKKP EKPLFSSASP QDSSPRLSTF PQHHHPGIPG VAHSVISTRT PPPPSPLPFP 430 440 450 460 470 TQAILPPAPS SYFSHPTIRY PPHLNPQDTL KNYVPSYDPS SPQTSQSWYL G
	Isoform 5 [UniParc]. Checksum: 55BE3377EEEA2C07	FASTA	494	55,181
	10 20 30 40 50 60 MMYSPICLTQ DEFHPFIEAL LPHVRAIAYT WFNLQARKRK YFKKHEKRMS KDEERAVKDE 70 80 90 100 110 120 LLSEKPEIKQ KWASRLLAKL RKDIRQEYRE DFVLTVTGKK HPCCVLSNPD QKGKIRRIDC 130 140 150 160 170 180 LRQADKVWRL DLVMVILFKG IPLESTDGER LMKSPHCTNP ALCVQPHHIT VSVKELDLFL 190 200 210 220 230 240 AYYVQEQDSG QSGSPSHNDP AKNPPGYLED SFVKSGVFNV SELVRVSRTP ITQGTGVNFP 250 260 270 280 290 300 IGEIPSQPYY HDMNSGVNLQ RSLSSPPSSK RPKTISIDEN MEPSPTGDFY PSPSSPAAGS 310 320 330 340 350 360 RTWHERDQDM SSPTTMKKPE KPLFSSASPQ DSSPRLSTFP QHHHPGIPGV AHSVISTRTP 370 380 390 400 410 420 PPPSPLPFPT QAILPPAPSS YFSHPTIRYP PHLNPQDTLK NYVPSYDPSS PQTSQPNGSG 430 440 450 460 470 480 QVVGKVPGHF TPVLAPSPHP SAVRPVTLSM TDTKPITTST EAYTASGTSQ ANRYVGLSPR 490 DPSFLHQQQS WYLG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of NFIB as recurrent translocation partner gene of HMGIC in pleomorphic adenomas." Geurts J.M.W., Schoenmakers E.F.P.M., Roijer E., Astroem A.-K., Stenman G., van de Ven W.J.M. Oncogene 16:865-872(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing." Liu Y., Bernard H.U., Apt D. J. Biol. Chem. 272:10739-10745(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Foreskin.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Amygdala.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Colon epithelium.
[6]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Cervix.
[9]	"Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH." Qian F., Kruse U., Lichter P., Sippel A.E. Genomics 28:66-73(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-283.
[10]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-264 AND SER-328, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-312; SER-328 AND SER-333, MASS SPECTROMETRY, CLEAVAGE OF INITIATOR METHIONINE. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U85193 mRNA. Translation: AAB41899.1. U70862 mRNA. Translation: AAB51197.1. BT007266 mRNA. Translation: AAP35930.1. AK131233 mRNA. Translation: BAD18416.1. BX648845 mRNA. No translation available. AL441963, AL136366 Genomic DNA. Translation: CAH71971.1. AL136366, AL441963 Genomic DNA. Translation: CAH73585.1. AL137017 Genomic DNA. No translation available. AL449443 Genomic DNA. No translation available. CH471071 Genomic DNA. Translation: EAW58699.1. BC001283 mRNA. Translation: AAH01283.1. U07810 mRNA. Translation: AAA93125.1.
IPI	IPI00473116. IPI00646279. IPI00953386.
RefSeq	NP_001177666.1. NM_001190737.1. NP_001177667.1. NM_001190738.1. NP_005587.2. NM_005596.3.
UniGene	Hs.644095.
3D structure databases
ProteinModelPortal	O00712.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000370346.
PTM databases
PhosphoSite	O00712.
Proteomic databases
PaxDb	O00712.
PRIDE	O00712.
Protocols and materials databases
DNASU	4781.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000380953; ENSP00000370340; ENSG00000147862. ENST00000380959; ENSP00000370346; ENSG00000147862.
GeneID	4781.
KEGG	hsa:4781.
UCSC	uc003zle.3. human.
Organism-specific databases
CTD	4781.
GeneCards	GC09M014077.
HGNC	HGNC:7785. NFIB.
HPA	HPA003956.
MIM	600728. gene.
neXtProt	NX_O00712.
PharmGKB	PA31591.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG252172.
HOVERGEN	HBG006561.
KO	K09169.
Enzyme and pathway databases
Pathway_Interaction_DB	hnf3apathway. FOXA1 transcription factor network.
Gene expression databases
ArrayExpress	O00712.
Bgee	O00712.
CleanEx	HS_NFIB.
Genevestigator	O00712.
GermOnline	ENSG00000147862. Homo sapiens.
Family and domain databases
InterPro	IPR000647. CTF/NFI. IPR020604. CTF/NFI_DNA-bd-dom. IPR019739. CTF/NFI_DNA-bd_CS. IPR019548. CTF/NFI_DNA-bd_N. IPR003619. MAD_homology1_Dwarfin-type. [Graphical view]
PANTHER	PTHR11492. PTHR11492. 1 hit.
Pfam	PF00859. CTF_NFI. 1 hit. PF03165. MH1. 1 hit. PF10524. NfI_DNAbd_pre-N. 1 hit. [Graphical view]
SMART	SM00523. DWA. 1 hit. [Graphical view]
PROSITE	PS00349. CTF_NFI_1. 1 hit. PS51080. CTF_NFI_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NFIB. human.
GenomeRNAi	4781.
NextBio	18436.
SOURCE	Search...

Entry information

Entry name

NFIB_HUMAN

Accession

Primary (citable) accession number: O00712
Secondary accession number(s): H7BYE8 , O00166, Q12858, Q5VW29, Q6ZNF9, Q96J45

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	March 15, 2004
Last modified:	April 3, 2013
This is version 117 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.