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Protein

E3 ubiquitin-protein ligase TRIM38

Gene

TRIM38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling.1 Publication

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 63RING-typePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri88 – 129B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

  • signal transducer activity Source: UniProtKB
  • transferase activity Source: UniProtKB-KW
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processImmunity, Innate immunity, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-877300. Interferon gamma signaling.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM38 (EC:2.3.2.27)
Alternative name(s):
RING finger protein 15
RING-type E3 ubiquitin transferase TRIM38Curated
Tripartite motif-containing protein 38
Zinc finger protein RoRet
Gene namesi
Name:TRIM38
Synonyms:RNF15, RORET
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:10059. TRIM38.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

DisGeNETi10475.
OpenTargetsiENSG00000112343.
PharmGKBiPA35532.

Polymorphism and mutation databases

BioMutaiTRIM38.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562561 – 465E3 ubiquitin-protein ligase TRIM38Add BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO00635.
MaxQBiO00635.
PaxDbiO00635.
PeptideAtlasiO00635.
PRIDEiO00635.

PTM databases

iPTMnetiO00635.
PhosphoSitePlusiO00635.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000112343.
CleanExiHS_TRIM38.
ExpressionAtlasiO00635. baseline and differential.
GenevisibleiO00635. HS.

Organism-specific databases

HPAiHPA031685.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115738. 29 interactors.
IntActiO00635. 22 interactors.
MINTiMINT-232573.
STRINGi9606.ENSP00000230099.

Structurei

3D structure databases

ProteinModelPortaliO00635.
SMRiO00635.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini274 – 465B30.2/SPRYPROSITE-ProRule annotationAdd BLAST192

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 63RING-typePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri88 – 129B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITEY. Eukaryota.
ENOG410Y1I6. LUCA.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiO00635.
KOiK12014.
OMAiLEDRCTE.
OrthoDBiEOG091G05W2.
PhylomeDBiO00635.
TreeFamiTF342569.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiView protein in InterPro
IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PfamiView protein in Pfam
PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiView protein in SMART
SM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O00635-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTTSTKKM MEEATCSICL SLMTNPVSIN CGHSYCHLCI TDFFKNPSQK
60 70 80 90 100
QLRQETFCCP QCRAPFHMDS LRPNKQLGSL IEALKETDQE MSCEEHGEQF
110 120 130 140 150
HLFCEDEGQL ICWRCERAPQ HKGHTTALVE DVCQGYKEKL QKAVTKLKQL
160 170 180 190 200
EDRCTEQKLS TAMRITKWKE KVQIQRQKIR SDFKNLQCFL HEEEKSYLWR
210 220 230 240 250
LEKEEQQTLS RLRDYEAGLG LKSNELKSHI LELEEKCQGS AQKLLQNVND
260 270 280 290 300
TLSRSWAVKL ETSEAVSLEL HTMCNVSKLY FDVKKMLRSH QVSVTLDPDT
310 320 330 340 350
AHHELILSED RRQVTRGYTQ ENQDTSSRRF TAFPCVLGCE GFTSGRRYFE
360 370 380 390 400
VDVGEGTGWD LGVCMENVQR GTGMKQEPQS GFWTLRLCKK KGYVALTSPP
410 420 430 440 450
TSLHLHEQPL LVGIFLDYEA GVVSFYNGNT GCHIFTFPKA SFSDTLRPYF
460
QVYQYSPLFL PPPGD
Length:465
Mass (Da):53,416
Last modified:July 1, 1997 - v1
Checksum:i30A884051A2DA058
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23M → I in AAH26930 (PubMed:15489334).Curated1
Sequence conflicti411L → P in BAG36059 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013513421G → R. Corresponds to variant dbSNP:rs10317Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91328 Genomic DNA. Translation: AAB82084.1.
U90547 mRNA. Translation: AAB53425.1.
AK313248 mRNA. Translation: BAG36059.1.
BC026930 mRNA. Translation: AAH26930.1.
CCDSiCCDS4568.1.
RefSeqiNP_006346.1. NM_006355.4.
XP_005248856.1. XM_005248799.4.
XP_005248857.1. XM_005248800.4.
UniGeneiHs.584851.
Hs.742026.

Genome annotation databases

EnsembliENST00000357085; ENSP00000349596; ENSG00000112343.
GeneIDi10475.
KEGGihsa:10475.
UCSCiuc003nfm.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91328 Genomic DNA. Translation: AAB82084.1.
U90547 mRNA. Translation: AAB53425.1.
AK313248 mRNA. Translation: BAG36059.1.
BC026930 mRNA. Translation: AAH26930.1.
CCDSiCCDS4568.1.
RefSeqiNP_006346.1. NM_006355.4.
XP_005248856.1. XM_005248799.4.
XP_005248857.1. XM_005248800.4.
UniGeneiHs.584851.
Hs.742026.

3D structure databases

ProteinModelPortaliO00635.
SMRiO00635.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115738. 29 interactors.
IntActiO00635. 22 interactors.
MINTiMINT-232573.
STRINGi9606.ENSP00000230099.

PTM databases

iPTMnetiO00635.
PhosphoSitePlusiO00635.

Polymorphism and mutation databases

BioMutaiTRIM38.

Proteomic databases

EPDiO00635.
MaxQBiO00635.
PaxDbiO00635.
PeptideAtlasiO00635.
PRIDEiO00635.

Protocols and materials databases

DNASUi10475.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357085; ENSP00000349596; ENSG00000112343.
GeneIDi10475.
KEGGihsa:10475.
UCSCiuc003nfm.5. human.

Organism-specific databases

CTDi10475.
DisGeNETi10475.
GeneCardsiTRIM38.
HGNCiHGNC:10059. TRIM38.
HPAiHPA031685.
neXtProtiNX_O00635.
OpenTargetsiENSG00000112343.
PharmGKBiPA35532.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITEY. Eukaryota.
ENOG410Y1I6. LUCA.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiO00635.
KOiK12014.
OMAiLEDRCTE.
OrthoDBiEOG091G05W2.
PhylomeDBiO00635.
TreeFamiTF342569.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-HSA-877300. Interferon gamma signaling.

Miscellaneous databases

ChiTaRSiTRIM38. human.
GenomeRNAii10475.
PROiO00635.

Gene expression databases

BgeeiENSG00000112343.
CleanExiHS_TRIM38.
ExpressionAtlasiO00635. baseline and differential.
GenevisibleiO00635. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiView protein in InterPro
IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PfamiView protein in Pfam
PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiView protein in SMART
SM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRI38_HUMAN
AccessioniPrimary (citable) accession number: O00635
Secondary accession number(s): B2R862
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: July 1, 1997
Last modified: March 15, 2017
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.