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Protein

Netrin-3

Gene

NTN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Netrins control guidance of CNS commissural axons and peripheral motor axons.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-375170. CDO in myogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin-3
Alternative name(s):
Netrin-2-like protein
Gene namesi
Name:NTN3
Synonyms:NTN2L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:8030. NTN3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164724231.

Polymorphism and mutation databases

BioMutaiNTN3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 580553Netrin-3PRO_0000017085Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi92 ↔ 125By similarity
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence analysis
Disulfide bondi255 ↔ 264By similarity
Disulfide bondi257 ↔ 274By similarity
Disulfide bondi276 ↔ 285By similarity
Disulfide bondi288 ↔ 308By similarity
Disulfide bondi311 ↔ 320By similarity
Disulfide bondi313 ↔ 338By similarity
Disulfide bondi341 ↔ 350By similarity
Disulfide bondi353 ↔ 371By similarity
Disulfide bondi374 ↔ 386By similarity
Disulfide bondi376 ↔ 393By similarity
Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence analysis
Disulfide bondi395 ↔ 404By similarity
Disulfide bondi407 ↔ 421By similarity
Disulfide bondi441 ↔ 514By similarity
Disulfide bondi460 ↔ 577By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO00634.
PRIDEiO00634.

Expressioni

Tissue specificityi

Spinal cord.1 Publication

Gene expression databases

BgeeiO00634.
CleanExiHS_NTN3.
GenevisibleiO00634. HS.

Organism-specific databases

HPAiHPA050817.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DRAXINQ8NBI32EBI-10831998,EBI-10827752

Protein-protein interaction databases

IntActiO00634. 1 interaction.
STRINGi9606.ENSP00000293973.

Structurei

3D structure databases

ProteinModelPortaliO00634.
SMRiO00634. Positions 28-448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 254219Laminin N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini255 – 30854Laminin EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini311 – 37161Laminin EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini374 – 42148Laminin EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini441 – 577137NTRPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi500 – 5023Cell attachment site; atypicalSequence analysis

Sequence similaritiesi

Contains 3 laminin EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin N-terminal domain.PROSITE-ProRule annotation
Contains 1 NTR domain.PROSITE-ProRule annotation

Keywords - Domaini

Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3512. Eukaryota.
ENOG410XS7U. LUCA.
GeneTreeiENSGT00840000129717.
HOGENOMiHOG000286017.
HOVERGENiHBG006464.
InParanoidiO00634.
KOiK06844.
OMAiGFFSSHC.
OrthoDBiEOG7SR4KJ.
PhylomeDBiO00634.
TreeFamiTF352481.

Family and domain databases

InterProiIPR002049. Laminin_EGF.
IPR008211. Laminin_N.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PfamiPF00053. Laminin_EGF. 3 hits.
PF00055. Laminin_N. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00180. EGF_Lam. 3 hits.
SM00136. LamNT. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01248. EGF_LAM_1. 3 hits.
PS50027. EGF_LAM_2. 3 hits.
PS51117. LAMININ_NTER. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGWPWGLLL TAGTLFAALS PGPPAPADPC HDEGGAPRGC VPGLVNAALG
60 70 80 90 100
REVLASSTCG RPATRACDAS DPRRAHSPAL LTSPGGTASP LCWRSESLPR
110 120 130 140 150
APLNVTLTVP LGKAFELVFV SLRFCSAPPA SVALLKSQDH GRSWAPLGFF
160 170 180 190 200
SSHCDLDYGR LPAPANGPAG PGPEALCFPA PLAQPDGSGL LAFSMQDSSP
210 220 230 240 250
PGLDLDSSPV LQDWVTATDV RVVLTRPSTA GDPRDMEAVV PYSYAATDLQ
260 270 280 290 300
VGGRCKCNGH ASRCLLDTQG HLICDCRHGT EGPDCGRCKP FYCDRPWQRA
310 320 330 340 350
TARESHACLA CSCNGHARRC RFNMELYRLS GRRSGGVCLN CRHNTAGRHC
360 370 380 390 400
HYCREGFYRD PGRALSDRRA CRACDCHPVG AAGKTCNQTT GQCPCKDGVT
410 420 430 440 450
GLTCNRCAPG FQQSRSPVAP CVKTPIPGPT EDSSPVQPQD CDSHCKPARG
460 470 480 490 500
SYRISLKKFC KKDYAVQVAV GARGEARGAW TRFPVAVLAV FRSGEERARR
510 520 530 540 550
GSSALWVPAG DAACGCPRLL PGRRYLLLGG GPGAAAGGAG GRGPGLIAAR
560 570 580
GSLVLPWRDA WTRRLRRLQR RERRGRCSAA
Length:580
Mass (Da):61,466
Last modified:July 1, 1997 - v1
Checksum:i15F99643E74C644C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti425 – 4251P → S.
Corresponds to variant rs34818219 [ dbSNP | Ensembl ].
VAR_050086

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86759 mRNA. Translation: AAC51247.1.
U86758 Genomic DNA. Translation: AAC51246.1.
CCDSiCCDS10469.1.
RefSeqiNP_006172.1. NM_006181.2.
UniGeneiHs.158336.

Genome annotation databases

EnsembliENST00000293973; ENSP00000293973; ENSG00000162068.
GeneIDi4917.
KEGGihsa:4917.
UCSCiuc002cqj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86759 mRNA. Translation: AAC51247.1.
U86758 Genomic DNA. Translation: AAC51246.1.
CCDSiCCDS10469.1.
RefSeqiNP_006172.1. NM_006181.2.
UniGeneiHs.158336.

3D structure databases

ProteinModelPortaliO00634.
SMRiO00634. Positions 28-448.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO00634. 1 interaction.
STRINGi9606.ENSP00000293973.

Polymorphism and mutation databases

BioMutaiNTN3.

Proteomic databases

PaxDbiO00634.
PRIDEiO00634.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293973; ENSP00000293973; ENSG00000162068.
GeneIDi4917.
KEGGihsa:4917.
UCSCiuc002cqj.3. human.

Organism-specific databases

CTDi4917.
GeneCardsiNTN3.
HGNCiHGNC:8030. NTN3.
HPAiHPA050817.
MIMi602349. gene.
neXtProtiNX_O00634.
PharmGKBiPA164724231.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3512. Eukaryota.
ENOG410XS7U. LUCA.
GeneTreeiENSGT00840000129717.
HOGENOMiHOG000286017.
HOVERGENiHBG006464.
InParanoidiO00634.
KOiK06844.
OMAiGFFSSHC.
OrthoDBiEOG7SR4KJ.
PhylomeDBiO00634.
TreeFamiTF352481.

Enzyme and pathway databases

ReactomeiR-HSA-375170. CDO in myogenesis.

Miscellaneous databases

GenomeRNAii4917.
NextBioi18935.
PROiO00634.
SOURCEiSearch...

Gene expression databases

BgeeiO00634.
CleanExiHS_NTN3.
GenevisibleiO00634. HS.

Family and domain databases

InterProiIPR002049. Laminin_EGF.
IPR008211. Laminin_N.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PfamiPF00053. Laminin_EGF. 3 hits.
PF00055. Laminin_N. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00180. EGF_Lam. 3 hits.
SM00136. LamNT. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01248. EGF_LAM_1. 3 hits.
PS50027. EGF_LAM_2. 3 hits.
PS51117. LAMININ_NTER. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3."
    Burn T.C., Connors T.D., Van Raay T.J., Dackowski W.R., Millholland J.M., Klinger K.W., Landes G.M.
    Genome Res. 6:525-537(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The NTN2L gene encoding a novel human netrin maps to the autosomal dominant polycystic kidney disease region on chromosome 16p13.3."
    Van Raay T.J., Foskett S.M., Connors T.D., Klinger K.W., Landes G.M., Burn T.C.
    Genomics 41:279-282(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.

Entry informationi

Entry nameiNET3_HUMAN
AccessioniPrimary (citable) accession number: O00634
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 1, 1997
Last modified: May 11, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.