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Protein

Sarcolipin

Gene

SLN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Required for muscle-based, non-shivering thermogenesis (By similarity). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle.By similarity2 Publications

GO - Molecular functioni

  1. ATPase binding Source: BHF-UCL
  2. enzyme inhibitor activity Source: BHF-UCL

GO - Biological processi

  1. calcium ion transport Source: UniProtKB
  2. negative regulation of calcium ion binding Source: BHF-UCL
  3. negative regulation of calcium ion import Source: BHF-UCL
  4. negative regulation of calcium ion transmembrane transporter activity Source: BHF-UCL
  5. negative regulation of catalytic activity Source: BHF-UCL
  6. negative regulation of protein complex disassembly Source: BHF-UCL
  7. positive regulation of protein depolymerization Source: BHF-UCL
  8. regulation of calcium ion transport Source: UniProtKB
  9. regulation of calcium-transporting ATPase activity Source: UniProtKB
  10. regulation of relaxation of muscle Source: UniProtKB
  11. sarcoplasmic reticulum calcium ion transport Source: UniProtKB
Complete GO annotation...

Protein family/group databases

TCDBi1.A.50.2.1. the phospholamban (ca(2+)-channel and ca(2+)-atpase regulator) (plb) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sarcolipin
Gene namesi
Name:SLN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:11089. SLN.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77Cytoplasmic1 Publication
Transmembranei8 – 2619HelicalAdd
BLAST
Topological domaini27 – 315Lumenal1 Publication

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. sarcoplasmic reticulum Source: UniProtKB
  3. sarcoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Sarcoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35942.

Polymorphism and mutation databases

BioMutaiSLN.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3131SarcolipinPRO_0000045898Add
BLAST

PTM databases

PhosphoSiteiO00631.

Expressioni

Gene expression databases

BgeeiO00631.
CleanExiHS_SLN.
GenevestigatoriO00631.

Organism-specific databases

HPAiCAB011628.

Interactioni

Subunit structurei

Interacts with calcium ATPase ATP2A1/SERCA1.

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC155Q8N6L03EBI-10180786,EBI-749265
SYNE4Q8N2053EBI-10180786,EBI-7131783
TMEM79Q9BSE23EBI-10180786,EBI-8649725

Protein-protein interaction databases

BioGridi112474. 6 interactions.
IntActiO00631. 3 interactions.
STRINGi9606.ENSP00000304707.

Structurei

Secondary structure

1
31
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 84Combined sources
Helixi9 – 2517Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JDMNMR-A1-31[»]
ProteinModelPortaliO00631.
SMRiO00631. Positions 1-31.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00631.

Family & Domainsi

Sequence similaritiesi

Belongs to the sarcolipin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG140204.
GeneTreeiENSGT00530000065188.
HOGENOMiHOG000142457.
InParanoidiO00631.
OrthoDBiEOG7XH6TJ.
PhylomeDBiO00631.

Family and domain databases

InterProiIPR008028. Sarcolipin.
[Graphical view]
PfamiPF05366. Sarcolipin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00631-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
MGINTRELFL NFTIVLITVI LMWLLVRSYQ Y
Length:31
Mass (Da):3,762
Last modified:July 1, 1997 - v1
Checksum:i9B245D9ACD26C58F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96094 mRNA. Translation: AAB86981.1.
U96093 Genomic DNA. Translation: AAB86980.1.
AK312097 mRNA. Translation: BAG35033.1.
CR450290 mRNA. Translation: CAG29286.1.
BC094685 mRNA. Translation: AAH94685.1.
BC104150 mRNA. Translation: AAI04151.1.
BC104185 mRNA. Translation: AAI04186.1.
BC113930 mRNA. Translation: AAI13931.1.
BC113987 mRNA. Translation: AAI13988.1.
CCDSiCCDS31667.1.
RefSeqiNP_003054.1. NM_003063.2.
UniGeneiHs.334629.

Genome annotation databases

EnsembliENST00000305991; ENSP00000304707; ENSG00000170290.
ENST00000525934; ENSP00000434189; ENSG00000170290.
ENST00000531293; ENSP00000435380; ENSG00000170290.
GeneIDi6588.
KEGGihsa:6588.
UCSCiuc001pjp.3. human.

Polymorphism and mutation databases

BioMutaiSLN.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96094 mRNA. Translation: AAB86981.1.
U96093 Genomic DNA. Translation: AAB86980.1.
AK312097 mRNA. Translation: BAG35033.1.
CR450290 mRNA. Translation: CAG29286.1.
BC094685 mRNA. Translation: AAH94685.1.
BC104150 mRNA. Translation: AAI04151.1.
BC104185 mRNA. Translation: AAI04186.1.
BC113930 mRNA. Translation: AAI13931.1.
BC113987 mRNA. Translation: AAI13988.1.
CCDSiCCDS31667.1.
RefSeqiNP_003054.1. NM_003063.2.
UniGeneiHs.334629.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JDMNMR-A1-31[»]
ProteinModelPortaliO00631.
SMRiO00631. Positions 1-31.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112474. 6 interactions.
IntActiO00631. 3 interactions.
STRINGi9606.ENSP00000304707.

Protein family/group databases

TCDBi1.A.50.2.1. the phospholamban (ca(2+)-channel and ca(2+)-atpase regulator) (plb) family.

PTM databases

PhosphoSiteiO00631.

Polymorphism and mutation databases

BioMutaiSLN.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305991; ENSP00000304707; ENSG00000170290.
ENST00000525934; ENSP00000434189; ENSG00000170290.
ENST00000531293; ENSP00000435380; ENSG00000170290.
GeneIDi6588.
KEGGihsa:6588.
UCSCiuc001pjp.3. human.

Organism-specific databases

CTDi6588.
GeneCardsiGC11M107612.
H-InvDBHIX0010086.
HGNCiHGNC:11089. SLN.
HPAiCAB011628.
MIMi602203. gene.
neXtProtiNX_O00631.
PharmGKBiPA35942.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG140204.
GeneTreeiENSGT00530000065188.
HOGENOMiHOG000142457.
InParanoidiO00631.
OrthoDBiEOG7XH6TJ.
PhylomeDBiO00631.

Miscellaneous databases

EvolutionaryTraceiO00631.
GeneWikiiSarcolipin.
GenomeRNAii6588.
NextBioi25633.
PROiO00631.
SOURCEiSearch...

Gene expression databases

BgeeiO00631.
CleanExiHS_SLN.
GenevestigatoriO00631.

Family and domain databases

InterProiIPR008028. Sarcolipin.
[Graphical view]
PfamiPF05366. Sarcolipin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the gene encoding human sarcolipin (SLN), a proteolipid associated with SERCA1: absence of structural mutations in five patients with Brody disease."
    Odermatt A., Taschner P.E.M., Scherer S.W., Beatty B., Khanna V.K., Cornblath D.R., Chaudhry V., Yee W.-C., Schrank B., Karpati G., Breuning M.H., Knoers N., Maclennan D.H.
    Genomics 45:541-553(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PNS.
  5. "Sarcolipin regulates the activity of SERCA1, the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+-ATPase."
    Odermatt A., Becker S., Khanna V.K., Kurzydlowski K., Leisner E., Pette D., MacLennan D.H.
    J. Biol. Chem. 273:12360-12369(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY.
  6. "Structure and orientation of sarcolipin in lipid environments."
    Mascioni A., Karim C., Barany G., Thomas D.D., Veglia G.
    Biochemistry 41:475-482(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR, FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSARCO_HUMAN
AccessioniPrimary (citable) accession number: O00631
Secondary accession number(s): Q6ICV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: April 29, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.