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Protein

C-C motif chemokine 22

Gene

CCL22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.

GO - Molecular functioni

  1. chemokine activity Source: ProtInc

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. cell chemotaxis Source: GOC
  3. chemotaxis Source: ProtInc
  4. immune response Source: ProtInc
  5. inflammatory response Source: ProtInc
  6. response to virus Source: ProtInc
  7. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 22
Alternative name(s):
CC chemokine STCP-1
MDC(1-69)
Macrophage-derived chemokine
Small-inducible cytokine A22
Stimulated T-cell chemotactic protein 1
Cleaved into the following 3 chains:
Gene namesi
Name:CCL22
Synonyms:MDC, SCYA22
ORF Names:A-152E5.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:10621. CCL22.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35553.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 9369C-C motif chemokine 22PRO_0000005224Add
BLAST
Chaini27 – 9367MDC(3-69)PRO_0000005225Add
BLAST
Chaini29 – 9365MDC(5-69)PRO_0000005226Add
BLAST
Chaini31 – 9363MDC(7-69)PRO_0000005227Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 60By similarity
Disulfide bondi37 ↔ 76By similarity

Post-translational modificationi

The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO00626.
PRIDEiO00626.

Miscellaneous databases

PMAP-CutDBB2R4W2.

Expressioni

Tissue specificityi

Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis.1 Publication

Gene expression databases

BgeeiO00626.
CleanExiHS_CCL22.
GenevestigatoriO00626.

Interactioni

Protein-protein interaction databases

BioGridi112270. 6 interactions.
DIPiDIP-5849N.
IntActiO00626. 4 interactions.
MINTiMINT-8091023.
STRINGi9606.ENSP00000219235.

Structurei

3D structure databases

ProteinModelPortaliO00626.
SMRiO00626. Positions 36-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41373.
GeneTreeiENSGT00530000064374.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiO00626.
KOiK05514.
OMAiDREICAD.
OrthoDBiEOG7M3J34.
PhylomeDBiO00626.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRLQTALLV VLVLLAVALQ ATEAGPYGAN MEDSVCCRDY VRYRLPLRVV
60 70 80 90
KHFYWTSDSC PRPGVVLLTF RDKEICADPR VPWVKMILNK LSQ
Length:93
Mass (Da):10,625
Last modified:November 2, 2010 - v2
Checksum:i641FCE999586A7D2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21D → A.6 Publications
Corresponds to variant rs4359426 [ dbSNP | Ensembl ].
VAR_055117

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83239 mRNA. Translation: AAB53372.1.
U83171 mRNA. Translation: AAB58360.1.
EF064764 Genomic DNA. Translation: ABK41947.1.
AK311970 mRNA. Translation: BAG34909.1.
AC004382 Genomic DNA. Translation: AAC24306.1.
AC009052 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW82918.1.
BC027952 mRNA. Translation: AAH27952.1.
CCDSiCCDS10778.1.
RefSeqiNP_002981.2. NM_002990.4.
UniGeneiHs.534347.

Genome annotation databases

EnsembliENST00000219235; ENSP00000219235; ENSG00000102962.
GeneIDi6367.
KEGGihsa:6367.
UCSCiuc002elh.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CCL22 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83239 mRNA. Translation: AAB53372.1.
U83171 mRNA. Translation: AAB58360.1.
EF064764 Genomic DNA. Translation: ABK41947.1.
AK311970 mRNA. Translation: BAG34909.1.
AC004382 Genomic DNA. Translation: AAC24306.1.
AC009052 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW82918.1.
BC027952 mRNA. Translation: AAH27952.1.
CCDSiCCDS10778.1.
RefSeqiNP_002981.2. NM_002990.4.
UniGeneiHs.534347.

3D structure databases

ProteinModelPortaliO00626.
SMRiO00626. Positions 36-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112270. 6 interactions.
DIPiDIP-5849N.
IntActiO00626. 4 interactions.
MINTiMINT-8091023.
STRINGi9606.ENSP00000219235.

Proteomic databases

PaxDbiO00626.
PRIDEiO00626.

Protocols and materials databases

DNASUi6367.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219235; ENSP00000219235; ENSG00000102962.
GeneIDi6367.
KEGGihsa:6367.
UCSCiuc002elh.3. human.

Organism-specific databases

CTDi6367.
GeneCardsiGC16P057392.
H-InvDBHIX0013071.
HGNCiHGNC:10621. CCL22.
MIMi602957. gene.
neXtProtiNX_O00626.
PharmGKBiPA35553.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41373.
GeneTreeiENSGT00530000064374.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiO00626.
KOiK05514.
OMAiDREICAD.
OrthoDBiEOG7M3J34.
PhylomeDBiO00626.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.

Miscellaneous databases

ChiTaRSiCCL22. human.
GeneWikiiCCL22.
GenomeRNAii6367.
NextBioi24738.
PMAP-CutDBB2R4W2.
PROiO00626.
SOURCEiSearch...

Gene expression databases

BgeeiO00626.
CleanExiHS_CCL22.
GenevestigatoriO00626.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional characterization of a novel CC chemokine, stimulated T cell chemotactic protein (STCP-1) that specifically acts on activated T lymphocytes."
    Chang M.-S., McNinch J., Elias C. III, Manthey C.L., Grosshans D., Meng T., Boone T., Andrew D.P.
    J. Biol. Chem. 272:25229-25237(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-2.
    Tissue: Macrophage.
  2. "Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells."
    Godiska R., Chantry D., Raport C.J., Sozzani S., Allavena P., Leviten D., Mantovani A., Gray P.W.
    J. Exp. Med. 185:1595-1604(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-35, VARIANT ALA-2.
    Tissue: Macrophage.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-2.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Peripheral blood.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-2.
  6. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-2.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-2.
    Tissue: Pancreas and Spleen.
  9. "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4."
    Imai T., Chantry D., Raport C.J., Wood C.L., Nishimura M., Godiska R., Yoshie O., Gray P.W.
    J. Biol. Chem. 273:1764-1768(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: RECEPTOR INTERACTION.
  10. Cited for: TISSUE SPECIFICITY, PROTEOLYTIC PROCESSING OF N-TERMINUS, IDENTIFICATION OF MDC(3-69); MDC(5-69) AND MDC(7-69).
    Tissue: Dendritic cell.

Entry informationi

Entry nameiCCL22_HUMAN
AccessioniPrimary (citable) accession number: O00626
Secondary accession number(s): A0N0Q6, B2R4W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 2, 2010
Last modified: January 7, 2015
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.