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Protein

C-C motif chemokine 22

Gene

CCL22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: ProtInc

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • cellular response to interferon-gamma Source: GO_Central
  • cellular response to interleukin-1 Source: GO_Central
  • cellular response to tumor necrosis factor Source: GO_Central
  • chemokine-mediated signaling pathway Source: GO_Central
  • chemotaxis Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • immune response Source: ProtInc
  • inflammatory response Source: ProtInc
  • lymphocyte chemotaxis Source: GO_Central
  • monocyte chemotaxis Source: GO_Central
  • neutrophil chemotaxis Source: GO_Central
  • positive regulation of ERK1 and ERK2 cascade Source: GO_Central
  • positive regulation of GTPase activity Source: GO_Central
  • response to virus Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102962-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 22
Alternative name(s):
CC chemokine STCP-1
MDC(1-69)
Macrophage-derived chemokine
Small-inducible cytokine A22
Stimulated T-cell chemotactic protein 1
Cleaved into the following 3 chains:
Gene namesi
Name:CCL22
Synonyms:MDC, SCYA22
ORF Names:A-152E5.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:10621. CCL22.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: Reactome
  • extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6367.
OpenTargetsiENSG00000102962.
PharmGKBiPA35553.

Polymorphism and mutation databases

BioMutaiCCL22.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000000522425 – 93C-C motif chemokine 22Add BLAST69
ChainiPRO_000000522527 – 93MDC(3-69)Add BLAST67
ChainiPRO_000000522629 – 93MDC(5-69)Add BLAST65
ChainiPRO_000000522731 – 93MDC(7-69)Add BLAST63

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 60By similarity
Disulfide bondi37 ↔ 76By similarity

Post-translational modificationi

The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO00626.
PeptideAtlasiO00626.
PRIDEiO00626.

PTM databases

iPTMnetiO00626.
PhosphoSitePlusiO00626.

Miscellaneous databases

PMAP-CutDBB2R4W2.

Expressioni

Tissue specificityi

Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis.1 Publication

Gene expression databases

BgeeiENSG00000102962.
CleanExiHS_CCL22.
GenevisibleiO00626. HS.

Interactioni

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: ProtInc

Protein-protein interaction databases

BioGridi112270. 33 interactors.
DIPiDIP-5849N.
IntActiO00626. 4 interactors.
MINTiMINT-8091023.
STRINGi9606.ENSP00000219235.

Structurei

3D structure databases

ProteinModelPortaliO00626.
SMRiO00626.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J20K. Eukaryota.
ENOG41113E8. LUCA.
GeneTreeiENSGT00530000064374.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiO00626.
KOiK05514.
OMAiDREICAD.
OrthoDBiEOG091G13Z3.
PhylomeDBiO00626.
TreeFamiTF334888.

Family and domain databases

InterProiIPR030598. CCL22.
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR12015:SF102. PTHR12015:SF102. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRLQTALLV VLVLLAVALQ ATEAGPYGAN MEDSVCCRDY VRYRLPLRVV
60 70 80 90
KHFYWTSDSC PRPGVVLLTF RDKEICADPR VPWVKMILNK LSQ
Length:93
Mass (Da):10,625
Last modified:November 2, 2010 - v2
Checksum:i641FCE999586A7D2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0551172D → A.6 PublicationsCorresponds to variant rs4359426dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83239 mRNA. Translation: AAB53372.1.
U83171 mRNA. Translation: AAB58360.1.
EF064764 Genomic DNA. Translation: ABK41947.1.
AK311970 mRNA. Translation: BAG34909.1.
AC004382 Genomic DNA. Translation: AAC24306.1.
AC009052 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW82918.1.
BC027952 mRNA. Translation: AAH27952.1.
CCDSiCCDS10778.1.
RefSeqiNP_002981.2. NM_002990.4.
XP_016879020.1. XM_017023531.1.
UniGeneiHs.534347.

Genome annotation databases

EnsembliENST00000219235; ENSP00000219235; ENSG00000102962.
GeneIDi6367.
KEGGihsa:6367.
UCSCiuc002elh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CCL22 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83239 mRNA. Translation: AAB53372.1.
U83171 mRNA. Translation: AAB58360.1.
EF064764 Genomic DNA. Translation: ABK41947.1.
AK311970 mRNA. Translation: BAG34909.1.
AC004382 Genomic DNA. Translation: AAC24306.1.
AC009052 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW82918.1.
BC027952 mRNA. Translation: AAH27952.1.
CCDSiCCDS10778.1.
RefSeqiNP_002981.2. NM_002990.4.
XP_016879020.1. XM_017023531.1.
UniGeneiHs.534347.

3D structure databases

ProteinModelPortaliO00626.
SMRiO00626.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112270. 33 interactors.
DIPiDIP-5849N.
IntActiO00626. 4 interactors.
MINTiMINT-8091023.
STRINGi9606.ENSP00000219235.

PTM databases

iPTMnetiO00626.
PhosphoSitePlusiO00626.

Polymorphism and mutation databases

BioMutaiCCL22.

Proteomic databases

PaxDbiO00626.
PeptideAtlasiO00626.
PRIDEiO00626.

Protocols and materials databases

DNASUi6367.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219235; ENSP00000219235; ENSG00000102962.
GeneIDi6367.
KEGGihsa:6367.
UCSCiuc002elh.4. human.

Organism-specific databases

CTDi6367.
DisGeNETi6367.
GeneCardsiCCL22.
H-InvDBHIX0013071.
HGNCiHGNC:10621. CCL22.
MIMi602957. gene.
neXtProtiNX_O00626.
OpenTargetsiENSG00000102962.
PharmGKBiPA35553.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J20K. Eukaryota.
ENOG41113E8. LUCA.
GeneTreeiENSGT00530000064374.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiO00626.
KOiK05514.
OMAiDREICAD.
OrthoDBiEOG091G13Z3.
PhylomeDBiO00626.
TreeFamiTF334888.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102962-MONOMER.

Miscellaneous databases

ChiTaRSiCCL22. human.
GeneWikiiCCL22.
GenomeRNAii6367.
PMAP-CutDBB2R4W2.
PROiO00626.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102962.
CleanExiHS_CCL22.
GenevisibleiO00626. HS.

Family and domain databases

InterProiIPR030598. CCL22.
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR12015:SF102. PTHR12015:SF102. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL22_HUMAN
AccessioniPrimary (citable) accession number: O00626
Secondary accession number(s): A0N0Q6, B2R4W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 2, 2010
Last modified: November 30, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.