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O00626

- CCL22_HUMAN

UniProt

O00626 - CCL22_HUMAN

Protein

C-C motif chemokine 22

Gene

CCL22

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.

    GO - Molecular functioni

    1. chemokine activity Source: ProtInc

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. cell chemotaxis Source: GOC
    3. chemotaxis Source: ProtInc
    4. immune response Source: ProtInc
    5. inflammatory response Source: ProtInc
    6. response to virus Source: ProtInc
    7. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 22
    Alternative name(s):
    CC chemokine STCP-1
    MDC(1-69)
    Macrophage-derived chemokine
    Small-inducible cytokine A22
    Stimulated T-cell chemotactic protein 1
    Cleaved into the following 3 chains:
    Gene namesi
    Name:CCL22
    Synonyms:MDC, SCYA22
    ORF Names:A-152E5.1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:10621. CCL22.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: ProtInc

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35553.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 24241 PublicationAdd
    BLAST
    Chaini25 – 9369C-C motif chemokine 22PRO_0000005224Add
    BLAST
    Chaini27 – 9367MDC(3-69)PRO_0000005225Add
    BLAST
    Chaini29 – 9365MDC(5-69)PRO_0000005226Add
    BLAST
    Chaini31 – 9363MDC(7-69)PRO_0000005227Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi36 ↔ 60By similarity
    Disulfide bondi37 ↔ 76By similarity

    Post-translational modificationi

    The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.1 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiO00626.
    PRIDEiO00626.

    Miscellaneous databases

    PMAP-CutDBB2R4W2.

    Expressioni

    Tissue specificityi

    Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis.1 Publication

    Gene expression databases

    BgeeiO00626.
    CleanExiHS_CCL22.
    GenevestigatoriO00626.

    Interactioni

    Protein-protein interaction databases

    BioGridi112270. 6 interactions.
    DIPiDIP-5849N.
    IntActiO00626. 4 interactions.
    MINTiMINT-8091023.
    STRINGi9606.ENSP00000219235.

    Structurei

    3D structure databases

    ProteinModelPortaliO00626.
    SMRiO00626. Positions 36-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41373.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiO00626.
    KOiK05514.
    OMAiCAKEVKT.
    OrthoDBiEOG7M3J34.
    PhylomeDBiO00626.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O00626-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRLQTALLV VLVLLAVALQ ATEAGPYGAN MEDSVCCRDY VRYRLPLRVV   50
    KHFYWTSDSC PRPGVVLLTF RDKEICADPR VPWVKMILNK LSQ 93
    Length:93
    Mass (Da):10,625
    Last modified:November 2, 2010 - v2
    Checksum:i641FCE999586A7D2
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti2 – 21D → A.6 Publications
    Corresponds to variant rs4359426 [ dbSNP | Ensembl ].
    VAR_055117

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U83239 mRNA. Translation: AAB53372.1.
    U83171 mRNA. Translation: AAB58360.1.
    EF064764 Genomic DNA. Translation: ABK41947.1.
    AK311970 mRNA. Translation: BAG34909.1.
    AC004382 Genomic DNA. Translation: AAC24306.1.
    AC009052 Genomic DNA. No translation available.
    CH471092 Genomic DNA. Translation: EAW82918.1.
    BC027952 mRNA. Translation: AAH27952.1.
    CCDSiCCDS10778.1.
    RefSeqiNP_002981.2. NM_002990.4.
    UniGeneiHs.534347.

    Genome annotation databases

    EnsembliENST00000219235; ENSP00000219235; ENSG00000102962.
    GeneIDi6367.
    KEGGihsa:6367.
    UCSCiuc002elh.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CCL22 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U83239 mRNA. Translation: AAB53372.1 .
    U83171 mRNA. Translation: AAB58360.1 .
    EF064764 Genomic DNA. Translation: ABK41947.1 .
    AK311970 mRNA. Translation: BAG34909.1 .
    AC004382 Genomic DNA. Translation: AAC24306.1 .
    AC009052 Genomic DNA. No translation available.
    CH471092 Genomic DNA. Translation: EAW82918.1 .
    BC027952 mRNA. Translation: AAH27952.1 .
    CCDSi CCDS10778.1.
    RefSeqi NP_002981.2. NM_002990.4.
    UniGenei Hs.534347.

    3D structure databases

    ProteinModelPortali O00626.
    SMRi O00626. Positions 36-91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112270. 6 interactions.
    DIPi DIP-5849N.
    IntActi O00626. 4 interactions.
    MINTi MINT-8091023.
    STRINGi 9606.ENSP00000219235.

    Proteomic databases

    PaxDbi O00626.
    PRIDEi O00626.

    Protocols and materials databases

    DNASUi 6367.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000219235 ; ENSP00000219235 ; ENSG00000102962 .
    GeneIDi 6367.
    KEGGi hsa:6367.
    UCSCi uc002elh.3. human.

    Organism-specific databases

    CTDi 6367.
    GeneCardsi GC16P057392.
    H-InvDB HIX0013071.
    HGNCi HGNC:10621. CCL22.
    MIMi 602957. gene.
    neXtProti NX_O00626.
    PharmGKBi PA35553.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41373.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi O00626.
    KOi K05514.
    OMAi CAKEVKT.
    OrthoDBi EOG7M3J34.
    PhylomeDBi O00626.
    TreeFami TF334888.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.

    Miscellaneous databases

    ChiTaRSi CCL22. human.
    GeneWikii CCL22.
    GenomeRNAii 6367.
    NextBioi 24738.
    PMAP-CutDB B2R4W2.
    PROi O00626.
    SOURCEi Search...

    Gene expression databases

    Bgeei O00626.
    CleanExi HS_CCL22.
    Genevestigatori O00626.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional characterization of a novel CC chemokine, stimulated T cell chemotactic protein (STCP-1) that specifically acts on activated T lymphocytes."
      Chang M.-S., McNinch J., Elias C. III, Manthey C.L., Grosshans D., Meng T., Boone T., Andrew D.P.
      J. Biol. Chem. 272:25229-25237(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-2.
      Tissue: Macrophage.
    2. "Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells."
      Godiska R., Chantry D., Raport C.J., Sozzani S., Allavena P., Leviten D., Mantovani A., Gray P.W.
      J. Exp. Med. 185:1595-1604(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-35, VARIANT ALA-2.
      Tissue: Macrophage.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-2.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Peripheral blood.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-2.
    6. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-2.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-2.
      Tissue: Pancreas and Spleen.
    9. "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4."
      Imai T., Chantry D., Raport C.J., Wood C.L., Nishimura M., Godiska R., Yoshie O., Gray P.W.
      J. Biol. Chem. 273:1764-1768(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: RECEPTOR INTERACTION.
    10. Cited for: TISSUE SPECIFICITY, PROTEOLYTIC PROCESSING OF N-TERMINUS, IDENTIFICATION OF MDC(3-69); MDC(5-69) AND MDC(7-69).
      Tissue: Dendritic cell.

    Entry informationi

    Entry nameiCCL22_HUMAN
    AccessioniPrimary (citable) accession number: O00626
    Secondary accession number(s): A0N0Q6, B2R4W2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3