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Protein

Protein CYR61

Gene

CYR61

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Chemotaxis

Keywords - Ligandi

Growth factor binding, Heparin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000142871-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CYR61
Alternative name(s):
CCN family member 1
Cysteine-rich angiogenic inducer 61
Insulin-like growth factor-binding protein 10
Short name:
IBP-10
Short name:
IGF-binding protein 10
Short name:
IGFBP-10
Protein GIG1
Gene namesi
Name:CYR61
Synonyms:CCN1, GIG1, IGFBP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:2654. CYR61.

Subcellular locationi

GO - Cellular componenti

  • extracellular matrix Source: UniProtKB
  • proteinaceous extracellular matrix Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3491.
OpenTargetsiENSG00000142871.
PharmGKBiPA27126.

Polymorphism and mutation databases

BioMutaiCYR61.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001439825 – 381Protein CYR61Add BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei188Phosphoserine; by FAM20C1 Publication1
Disulfide bondi286 ↔ 323By similarity
Disulfide bondi303 ↔ 337By similarity
Disulfide bondi314 ↔ 353By similarity
Disulfide bondi317 ↔ 355By similarity
Disulfide bondi322 ↔ 359By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiO00622.
PaxDbiO00622.
PeptideAtlasiO00622.
PRIDEiO00622.

PTM databases

iPTMnetiO00622.
PhosphoSitePlusiO00622.

Miscellaneous databases

PMAP-CutDBO00622.

Expressioni

Gene expression databases

BgeeiENSG00000142871.
CleanExiHS_CYR61.
ExpressionAtlasiO00622. baseline and differential.
GenevisibleiO00622. HS.

Organism-specific databases

HPAiHPA029853.

Interactioni

Subunit structurei

Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion. In skin fibroblasts it binds ITGA6/ITGB1, in endothelial cells, binds ITGAV/ITGB3 and in platelets, ITGA2B/ITGB3. Binds, in vitro, ITGAV/ITGB5.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109712. 10 interactors.
IntActiO00622. 6 interactors.
MINTiMINT-4993925.
STRINGi9606.ENSP00000398736.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D0ZX-ray2.20X/Y24-29[»]
4D11X-ray2.85L/O/P/X/Z24-29[»]
ProteinModelPortaliO00622.
SMRiO00622.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 94IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST70
Domaini98 – 164VWFCPROSITE-ProRule annotationAdd BLAST67
Domaini228 – 273TSP type-1PROSITE-ProRule annotationAdd BLAST46
Domaini286 – 360CTCKPROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni279 – 315Heparin-bindingBy similarityAdd BLAST37

Sequence similaritiesi

Belongs to the CCN family.Curated
Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIY0. Eukaryota.
ENOG41119KZ. LUCA.
GeneTreeiENSGT00760000119225.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiO00622.
KOiK06829.
OMAiKCIVQTT.
OrthoDBiEOG091G0SQP.
PhylomeDBiO00622.
TreeFamiTF326070.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. TSP1_rpt.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00622-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRIARALA LVVTLLHLTR LALSTCPAAC HCPLEAPKCA PGVGLVRDGC
60 70 80 90 100
GCCKVCAKQL NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC
110 120 130 140 150
EYNSRIYQNG ESFQPNCKHQ CTCIDGAVGC IPLCPQELSL PNLGCPNPRL
160 170 180 190 200
VKVTGQCCEE WVCDEDSIKD PMEDQDGLLG KELGFDASEV ELTRNNELIA
210 220 230 240 250
VGKGSSLKRL PVFGMEPRIL YNPLQGQKCI VQTTSWSQCS KTCGTGISTR
260 270 280 290 300
VTNDNPECRL VKETRICEVR PCGQPVYSSL KKGKKCSKTK KSPEPVRFTY
310 320 330 340 350
AGCLSVKKYR PKYCGSCVDG RCCTPQLTRT VKMRFRCEDG ETFSKNVMMI
360 370 380
QSCKCNYNCP HANEAAFPFY RLFNDIHKFR D
Length:381
Mass (Da):42,027
Last modified:July 1, 1997 - v1
Checksum:iFC0BD39C078CA0B1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165E → Q in CAA72167 (PubMed:9536281).Curated1
Sequence conflicti210L → I in AAB84227 (Ref. 5) Curated1
Sequence conflicti220L → R in AAB84227 (Ref. 5) Curated1
Sequence conflicti369F → L in AAG59863 (PubMed:11810026).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018934334R → W.1 PublicationCorresponds to variant rs9658587dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62015 mRNA. Translation: AAB58319.1.
Y11307 mRNA. Translation: CAA72167.1.
Y12084 mRNA. Translation: CAA72802.1.
AF003594 mRNA. Translation: AAB61240.1.
AF031385 mRNA. Translation: AAB84227.1.
Z98053 mRNA. Translation: CAB10848.1.
AF307860 Genomic DNA. Translation: AAG59863.1.
AY443495 Genomic DNA. Translation: AAR05446.1.
BC001271 mRNA. Translation: AAH01271.1.
BC009199 mRNA. Translation: AAH09199.1.
BC016952 mRNA. Translation: AAH16952.1.
CCDSiCCDS706.1.
RefSeqiNP_001545.2. NM_001554.4.
UniGeneiHs.8867.

Genome annotation databases

EnsembliENST00000451137; ENSP00000398736; ENSG00000142871.
GeneIDi3491.
KEGGihsa:3491.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62015 mRNA. Translation: AAB58319.1.
Y11307 mRNA. Translation: CAA72167.1.
Y12084 mRNA. Translation: CAA72802.1.
AF003594 mRNA. Translation: AAB61240.1.
AF031385 mRNA. Translation: AAB84227.1.
Z98053 mRNA. Translation: CAB10848.1.
AF307860 Genomic DNA. Translation: AAG59863.1.
AY443495 Genomic DNA. Translation: AAR05446.1.
BC001271 mRNA. Translation: AAH01271.1.
BC009199 mRNA. Translation: AAH09199.1.
BC016952 mRNA. Translation: AAH16952.1.
CCDSiCCDS706.1.
RefSeqiNP_001545.2. NM_001554.4.
UniGeneiHs.8867.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D0ZX-ray2.20X/Y24-29[»]
4D11X-ray2.85L/O/P/X/Z24-29[»]
ProteinModelPortaliO00622.
SMRiO00622.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109712. 10 interactors.
IntActiO00622. 6 interactors.
MINTiMINT-4993925.
STRINGi9606.ENSP00000398736.

PTM databases

iPTMnetiO00622.
PhosphoSitePlusiO00622.

Polymorphism and mutation databases

BioMutaiCYR61.

Proteomic databases

EPDiO00622.
PaxDbiO00622.
PeptideAtlasiO00622.
PRIDEiO00622.

Protocols and materials databases

DNASUi3491.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000451137; ENSP00000398736; ENSG00000142871.
GeneIDi3491.
KEGGihsa:3491.

Organism-specific databases

CTDi3491.
DisGeNETi3491.
GeneCardsiCYR61.
HGNCiHGNC:2654. CYR61.
HPAiHPA029853.
MIMi602369. gene.
neXtProtiNX_O00622.
OpenTargetsiENSG00000142871.
PharmGKBiPA27126.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIY0. Eukaryota.
ENOG41119KZ. LUCA.
GeneTreeiENSGT00760000119225.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiO00622.
KOiK06829.
OMAiKCIVQTT.
OrthoDBiEOG091G0SQP.
PhylomeDBiO00622.
TreeFamiTF326070.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000142871-MONOMER.

Miscellaneous databases

ChiTaRSiCYR61. human.
GeneWikiiCYR61.
GenomeRNAii3491.
PMAP-CutDBO00622.
PROiO00622.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142871.
CleanExiHS_CYR61.
ExpressionAtlasiO00622. baseline and differential.
GenevisibleiO00622. HS.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. TSP1_rpt.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYR61_HUMAN
AccessioniPrimary (citable) accession number: O00622
Secondary accession number(s): O14934, O43775, Q9BZL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: November 2, 2016
This is version 154 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.