SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O00622

- CYR61_HUMAN

UniProt

O00622 - CYR61_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein CYR61

Gene
CYR61, CCN1, GIG1, IGFBP10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.1 Publication

GO - Molecular functioni

  1. extracellular matrix binding Source: Ensembl
  2. heparin binding Source: UniProtKB-KW

GO - Biological processi

  1. anatomical structure morphogenesis Source: ProtInc
  2. apoptotic process involved in heart morphogenesis Source: Ensembl
  3. atrial septum morphogenesis Source: Ensembl
  4. atrioventricular valve morphogenesis Source: Ensembl
  5. cell proliferation Source: ProtInc
  6. chemotaxis Source: UniProtKB-KW
  7. chondroblast differentiation Source: Ensembl
  8. chorio-allantoic fusion Source: Ensembl
  9. extracellular matrix organization Source: Ensembl
  10. intussusceptive angiogenesis Source: Ensembl
  11. labyrinthine layer blood vessel development Source: Ensembl
  12. negative regulation of apoptotic process Source: Ensembl
  13. osteoblast differentiation Source: Ensembl
  14. positive regulation of apoptotic process Source: Ensembl
  15. positive regulation of BMP signaling pathway Source: BHF-UCL
  16. positive regulation of cartilage development Source: Ensembl
  17. positive regulation of cell migration Source: BHF-UCL
  18. positive regulation of cell-substrate adhesion Source: Ensembl
  19. positive regulation of ceramide biosynthetic process Source: Ensembl
  20. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  21. positive regulation of osteoblast differentiation Source: BHF-UCL
  22. positive regulation of osteoblast proliferation Source: BHF-UCL
  23. positive regulation of phospholipase activity Source: Ensembl
  24. positive regulation of protein kinase activity Source: BHF-UCL
  25. positive regulation of protein phosphorylation Source: BHF-UCL
  26. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  27. reactive oxygen species metabolic process Source: Ensembl
  28. regulation of cell growth Source: InterPro
  29. regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  30. ventricular septum development Source: Ensembl
  31. wound healing, spreading of cells Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Chemotaxis

Keywords - Ligandi

Growth factor binding, Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CYR61
Alternative name(s):
CCN family member 1
Cysteine-rich angiogenic inducer 61
Insulin-like growth factor-binding protein 10
Short name:
IBP-10
Short name:
IGF-binding protein 10
Short name:
IGFBP-10
Protein GIG1
Gene namesi
Name:CYR61
Synonyms:CCN1, GIG1, IGFBP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:2654. CYR61.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27126.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Chaini25 – 381357Protein CYR61PRO_0000014398Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi286 ↔ 323 By similarity
Disulfide bondi303 ↔ 337 By similarity
Disulfide bondi314 ↔ 353 By similarity
Disulfide bondi317 ↔ 355 By similarity
Disulfide bondi322 ↔ 359 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiO00622.
PaxDbiO00622.
PRIDEiO00622.

PTM databases

PhosphoSiteiO00622.

Miscellaneous databases

PMAP-CutDBO00622.

Expressioni

Gene expression databases

ArrayExpressiO00622.
BgeeiO00622.
CleanExiHS_CYR61.
GenevestigatoriO00622.

Organism-specific databases

HPAiHPA029853.

Interactioni

Subunit structurei

Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion. In skin fibroblasts it binds ITGA6/ITGB1, in endothelial cells, binds ITGAV/ITGB3 and in platelets, ITGA2B/ITGB3. Binds, in vitro, ITGAV/ITGB5.

Protein-protein interaction databases

BioGridi109712. 9 interactions.
IntActiO00622. 5 interactions.
MINTiMINT-4993925.
STRINGi9606.ENSP00000398736.

Structurei

3D structure databases

ProteinModelPortaliO00622.
SMRiO00622. Positions 295-360.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 9470IGFBP N-terminalAdd
BLAST
Domaini98 – 16467VWFCAdd
BLAST
Domaini228 – 27346TSP type-1Add
BLAST
Domaini286 – 36075CTCKAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni279 – 31537Heparin-binding By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the CCN family.
Contains 1 TSP type-1 domain.
Contains 1 VWFC domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG82014.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiO00622.
KOiK06829.
OMAiKCIVQTT.
OrthoDBiEOG7N8ZXB.
PhylomeDBiO00622.
TreeFamiTF326070.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00622-1 [UniParc]FASTAAdd to Basket

« Hide

MSSRIARALA LVVTLLHLTR LALSTCPAAC HCPLEAPKCA PGVGLVRDGC    50
GCCKVCAKQL NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC 100
EYNSRIYQNG ESFQPNCKHQ CTCIDGAVGC IPLCPQELSL PNLGCPNPRL 150
VKVTGQCCEE WVCDEDSIKD PMEDQDGLLG KELGFDASEV ELTRNNELIA 200
VGKGSSLKRL PVFGMEPRIL YNPLQGQKCI VQTTSWSQCS KTCGTGISTR 250
VTNDNPECRL VKETRICEVR PCGQPVYSSL KKGKKCSKTK KSPEPVRFTY 300
AGCLSVKKYR PKYCGSCVDG RCCTPQLTRT VKMRFRCEDG ETFSKNVMMI 350
QSCKCNYNCP HANEAAFPFY RLFNDIHKFR D 381
Length:381
Mass (Da):42,027
Last modified:July 1, 1997 - v1
Checksum:iFC0BD39C078CA0B1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti334 – 3341R → W.1 Publication
Corresponds to variant rs9658587 [ dbSNP | Ensembl ].
VAR_018934

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti165 – 1651E → Q in CAA72167. 1 Publication
Sequence conflicti210 – 2101L → I in AAB84227. 1 Publication
Sequence conflicti220 – 2201L → R in AAB84227. 1 Publication
Sequence conflicti369 – 3691F → L in AAG59863. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62015 mRNA. Translation: AAB58319.1.
Y11307 mRNA. Translation: CAA72167.1.
Y12084 mRNA. Translation: CAA72802.1.
AF003594 mRNA. Translation: AAB61240.1.
AF031385 mRNA. Translation: AAB84227.1.
Z98053 mRNA. Translation: CAB10848.1.
AF307860 Genomic DNA. Translation: AAG59863.1.
AY443495 Genomic DNA. Translation: AAR05446.1.
BC001271 mRNA. Translation: AAH01271.1.
BC009199 mRNA. Translation: AAH09199.1.
BC016952 mRNA. Translation: AAH16952.1.
CCDSiCCDS706.1.
RefSeqiNP_001545.2. NM_001554.4.
UniGeneiHs.8867.

Genome annotation databases

EnsembliENST00000451137; ENSP00000398736; ENSG00000142871.
GeneIDi3491.
KEGGihsa:3491.
UCSCiuc001dle.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62015 mRNA. Translation: AAB58319.1 .
Y11307 mRNA. Translation: CAA72167.1 .
Y12084 mRNA. Translation: CAA72802.1 .
AF003594 mRNA. Translation: AAB61240.1 .
AF031385 mRNA. Translation: AAB84227.1 .
Z98053 mRNA. Translation: CAB10848.1 .
AF307860 Genomic DNA. Translation: AAG59863.1 .
AY443495 Genomic DNA. Translation: AAR05446.1 .
BC001271 mRNA. Translation: AAH01271.1 .
BC009199 mRNA. Translation: AAH09199.1 .
BC016952 mRNA. Translation: AAH16952.1 .
CCDSi CCDS706.1.
RefSeqi NP_001545.2. NM_001554.4.
UniGenei Hs.8867.

3D structure databases

ProteinModelPortali O00622.
SMRi O00622. Positions 295-360.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109712. 9 interactions.
IntActi O00622. 5 interactions.
MINTi MINT-4993925.
STRINGi 9606.ENSP00000398736.

PTM databases

PhosphoSitei O00622.

Proteomic databases

MaxQBi O00622.
PaxDbi O00622.
PRIDEi O00622.

Protocols and materials databases

DNASUi 3491.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000451137 ; ENSP00000398736 ; ENSG00000142871 .
GeneIDi 3491.
KEGGi hsa:3491.
UCSCi uc001dle.3. human.

Organism-specific databases

CTDi 3491.
GeneCardsi GC01P086046.
HGNCi HGNC:2654. CYR61.
HPAi HPA029853.
MIMi 602369. gene.
neXtProti NX_O00622.
PharmGKBi PA27126.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG82014.
HOGENOMi HOG000231462.
HOVERGENi HBG000635.
InParanoidi O00622.
KOi K06829.
OMAi KCIVQTT.
OrthoDBi EOG7N8ZXB.
PhylomeDBi O00622.
TreeFami TF326070.

Miscellaneous databases

ChiTaRSi CYR61. human.
GeneWikii CYR61.
GenomeRNAii 3491.
NextBioi 13730.
PMAP-CutDB O00622.
PROi O00622.
SOURCEi Search...

Gene expression databases

ArrayExpressi O00622.
Bgeei O00622.
CleanExi HS_CYR61.
Genevestigatori O00622.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view ]
PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTi SM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p."
    Jay P., Berge-Lefranc J.-L., Marsollier C., Mejean C., Taviaux S., Berta P.
    Oncogene 14:1753-1757(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Chromosomal mapping and expression of the human cyr61 gene in tumour cells from the nervous system."
    Martinerie C., Viegas-Pequignot E., Nguyen V.C., Perbal B.
    Mol. Pathol. 50:310-316(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61."
    Albrecht C., von Der Kammer H., Mayhaus M., Klaudiny J., Schweizer M., Nitsch R.M.
    J. Biol. Chem. 275:28929-28936(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Human growth-factor inducible gene product CYR61, complete sequence."
    Kolesnikova T.V., Lau L.F.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  5. "Cloning of HumCyr61 gene expressing down-regulatedly in rhabdomyosarcoma."
    Bi A.B., Yu L.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "Regulation of hCYR61 by vitamin D, serum and cytokines in fetal human osteoblasts."
    Schuetze N., Lechner A., Groll C., Koehrle J., Jakob F.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  7. "Organization and expression of the Cyr61 gene in normal human fibroblasts."
    Leng E., Malcolm T., Tai G., Estable M., Sadowski I.
    J. Biomed. Sci. 9:59-67(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  8. NIEHS SNPs program
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TRP-334.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung, Placenta and Skin.
  10. "The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts."
    Chen C.-C., Mo F.-E., Lau L.F.
    J. Biol. Chem. 276:47329-47337(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN WOUND HEALING.
  11. "Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3."
    Kireeva M.L., Lam S.C., Lau L.F.
    J. Biol. Chem. 273:3090-3096(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH INTEGRIN ALPHA-V/BETA-3.
  12. "Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3)."
    Jedsadayanmata A., Chen C.-C., Kireeva M.L., Lau L.F., Lam S.C.
    J. Biol. Chem. 274:24321-24327(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH INTEGRIN ALPHA-IIB/BETA-3.
  13. "Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans."
    Chen N., Chen C.-C., Lau L.F.
    J. Biol. Chem. 275:24953-24961(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH INTEGRIN ALPHA-6/BETA-1.
  14. "CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain."
    Grzeszkiewicz T.M., Kirschling D.J., Chen N., Lau L.F.
    J. Biol. Chem. 276:21943-21950(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH INTEGRIN ALPHA-V/BETA-6.

Entry informationi

Entry nameiCYR61_HUMAN
AccessioniPrimary (citable) accession number: O00622
Secondary accession number(s): O14934, O43775, Q9BZL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: July 9, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi