Unreviewed, UniProtKB/TrEMBL O00617 (O00617_HUMAN)

Names and origin

Protein names

Submitted name:
    Na+/H+ exchanger isoform NHE-3 EMBL AAB50819.1

Gene names

Name:

Na+/H+ exchanger isoform NHE-3 EMBL AAB50819.1

Organism

Homo sapiens (Human) EMBL AAB50819.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	224 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

Ontologies

Gene Ontology (GO)
Biological process	circadian rhythm Inferred from electronic annotation. Source: Compara receptor-mediated endocytosis Inferred from electronic annotation. Source: Compara regulation of pH Inferred from electronic annotation. Source: InterPro regulation of sodium ion transport Inferred from electronic annotation. Source: Compara response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara
Cellular component	apical plasma membrane Inferred from electronic annotation. Source: Compara brush border membrane Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular function	protein binding Inferred from electronic annotation. Source: Compara sodium:hydrogen antiporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	224	1	EMBL AAB50819.1

Sequences

	Sequence		Length	Mass (Da)
	O00617-1 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 55831F8F113EB2CB	FASTA	224	25,839
	10 20 30 40 50 60 IFMFLGISAV NPFIWTWNTA FVLLTLVFIS VYRAIGVVLQ TWLLNRYRMV QLEPIDQVVL 70 80 90 100 110 120 SYGGLRGAVA FALVVLLDGD KVKEKNLFVS TTIIVVFFTV IFQGLTIKPL VQWLKVKRSE 130 140 150 160 170 180 HREPRLNEKL HGRAFDHILS AIEDISGQIG HNYLRDKWSH FDRKFLSRVL MRRSAQKSRD 190 200 210 220 RILNVFHELN LKDAISYVAE GERRGSLAFI RSPSTDNMVN VDFS

References

[1]	"Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA." Dudeja P.K., Rao D.D., Syed I., Joshi V., Dahdal R.Y., Gardner C., Risk M.C., Schmidt L., Bavishi D., Kim K.E., Harig J.M., Goldstein J.L., Layden T.J., Ramaswamy K. Am. J. Physiol. 271:0-0(0) [PubMed: 8843774] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	S83545 mRNA. Translation: AAB50819.1.
IPI	IPI00011184.
UniGene	Hs.658120
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000066230. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:11073. SLC9A3.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	O00617.
Gene expression databases
ArrayExpress	O00617.
Bgee	O00617.
Family and domain databases
InterPro	IPR006153. Cation/H_exchanger. IPR018422. Cation/H_exchanger_cons-reg. IPR001118. Na/H_exchanger_3. IPR018416. Na/H_exchanger_3/9_cons-reg. IPR019775. WD40_repeat_CS. [Graphical view]
PANTHER	PTHR10110. Cation/H_exchanger_cons-reg. 1 hit. PTHR10110:SF19. Na/H_exchanger_3/9_cons-reg. 1 hit.
Pfam	PF00999. Na_H_Exchanger. 1 hit. [Graphical view]
PRINTS	PR01087. NAHEXCHNGR3.
PROSITE	PS00678. WD_REPEATS_1. 1 hit. Uncertain. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O00617_HUMAN

Accession

Primary (citable) accession number: O00617

Entry history

Integrated into UniProtKB/TrEMBL:	July 1, 1997
Last sequence update:	July 1, 1997
Last modified:	May 5, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)