O00590 (CCBP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chemokine-binding protein 2

Alternative name(s):
C-C chemokine receptor D6
Chemokine receptor CCR-10
Chemokine receptor CCR-9
Chemokine-binding protein D6

Gene names

Name:	CCBP2
Synonyms:	CCR10, CMKBR9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for C-C type chemokines including SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed primarily in placenta and fetal liver, and found at very low levels in the lung and lymph node. Found in endothelial cells lining afferent lymphatics in dermis and lymph nodes. Also found in lymph nodes subcapsular and medullary sinuses, tonsillar lymphatic sinuses and lymphatics in mucosa and submucosa of small and large intestine and appendix. Also found in some malignant vascular tumors. Ref.7
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemotaxis Traceable author statement Ref.1. Source: ProtInc elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: InterPro immune response Traceable author statement Ref.1. Source: ProtInc multicellular organismal development Traceable author statement Ref.1. Source: ProtInc neutrophil activation Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	C-C chemokine receptor activity Inferred from electronic annotation. Source: Compara C-X-C chemokine receptor activity Inferred from electronic annotation. Source: InterPro chemokine receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Chemokine-binding protein 2		PRO_0000069219
Regions
	Topological domain	1 – 50	50	Extracellular Potential
	Transmembrane	51 – 71	21	Helical; Name=1; Potential
	Topological domain	72 – 92	21	Cytoplasmic Potential
	Transmembrane	93 – 113	21	Helical; Name=2; Potential
	Topological domain	114 – 118	5	Extracellular Potential
	Transmembrane	119 – 140	22	Helical; Name=3; Potential
	Topological domain	141 – 162	22	Cytoplasmic Potential
	Transmembrane	163 – 183	21	Helical; Name=4; Potential
	Topological domain	184 – 217	34	Extracellular Potential
	Transmembrane	218 – 238	21	Helical; Name=5; Potential
	Topological domain	239 – 250	12	Cytoplasmic Potential
	Transmembrane	251 – 271	21	Helical; Name=6; Potential
	Topological domain	272 – 293	22	Extracellular Potential
	Transmembrane	294 – 314	21	Helical; Name=7; Potential
	Topological domain	315 – 384	70	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	19	1	N-linked (GlcNAc...) Potential
	Disulfide bond	117 ↔ 195		By similarity
Natural variations
	Natural variant	41	1	V → A. Corresponds to variant rs2228467 [ dbSNP | Ensembl ].		VAR_049379
	Natural variant	248	1	A → V. Corresponds to variant rs2228469 [ dbSNP | Ensembl ].		VAR_049380
	Natural variant	311	1	L → V. Corresponds to variant rs6779520 [ dbSNP | Ensembl ].		VAR_049381
	Natural variant	373	1	Y → S. Ref.5 Corresponds to variant rs2228468 [ dbSNP | Ensembl ].		VAR_024252
Experimental info
	Sequence conflict	17	1	S → A in AAB97728. Ref.1
	Sequence conflict	161	1	S → N in AAB97728. Ref.1
	Sequence conflict	356	1	Q → L in AAB97728. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O00590 [UniParc]. Last modified May 2, 2002. Version 2. Checksum: 464C5703C1DE9A6A	FASTA	384	43,443
	10 20 30 40 50 60 MAATASPQPL ATEDADSENS SFYYYDYLDE VAFMLCRKDA VVSFGKVFLP VFYSLIFVLG 70 80 90 100 110 120 LSGNLLLLMV LLRYVPRRRM VEIYLLNLAI SNLLFLVTLP FWGISVAWHW VFGSFLCKMV 130 140 150 160 170 180 STLYTINFYS GIFFISCMSL DKYLEIVHAQ PYHRLRTRAK SLLLATIVWA VSLAVSIPDM 190 200 210 220 230 240 VFVQTHENPK GVWNCHADFG GHGTIWKLFL RFQQNLLGFL LPLLAMIFFY SRIGCVLVRL 250 260 270 280 290 300 RPAGQGRALK IAAALVVAFF VLWFPYNLTL FLHTLLDLQV FGNCEVSQHL DYALQVTESI 310 320 330 340 350 360 AFLHCCFSPI LYAFSSHRFR QYLKAFLAAV LGWHLAPGTA QASLSSCSES SILTAQEEMT 370 380 GMNDLGERQS ENYPNKEDVG NKSA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3." Bonini J.A., Martin S.K., Dralyuk F., Roe M.W., Philipson L.H., Steiner D.F. DNA Cell Biol. 16:1249-1256(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[2]	"Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6." Nibbs R.J.B., Wylie S.M., Yang J., Landau N.R., Graham G.J. J. Biol. Chem. 272:32078-32083(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-373. Tissue: Placenta.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver and Placenta.
[7]	"The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors." Nibbs R.J.B., Kriehuber E., Ponath P.D., Parent D., Qin S., Campbell J.D., Henderson A., Kerjaschki D., Maurer D., Graham G.J., Rot A. Am. J. Pathol. 158:867-877(2001) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U94888 mRNA. Translation: AAB97728.1. Y12815 mRNA. Translation: CAA73346.1. AY262687 Genomic DNA. Translation: AAP20651.1. BT006800 mRNA. Translation: AAP35446.1. AK313561 mRNA. Translation: BAG36335.1. BC008816 mRNA. Translation: AAH08816.1. BC011631 mRNA. Translation: AAH11631.1. BC020558 mRNA. Translation: AAH20558.1. BC101629 mRNA. Translation: AAI01630.1. BC112045 mRNA. Translation: AAI12046.1.
IPI	IPI00012180.
RefSeq	NP_001287.2. NM_001296.4.
UniGene	Hs.146346.
3D structure databases
ProteinModelPortal	O00590.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000273145.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O00590.
Proteomic databases
PaxDb	O00590.
PRIDE	O00590.
Protocols and materials databases
DNASU	1238.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000273145; ENSP00000273145; ENSG00000144648. ENST00000422265; ENSP00000416996; ENSG00000144648. ENST00000442925; ENSP00000396150; ENSG00000144648.
GeneID	1238.
KEGG	hsa:1238.
UCSC	uc003cme.3. human.
Organism-specific databases
CTD	1238.
GeneCards	GC03P042851.
HGNC	HGNC:1565. CCBP2.
HPA	HPA013819.
MIM	602648. gene.
neXtProt	NX_O00590.
PharmGKB	PA26139.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG297330.
HOGENOM	HOG000234122.
HOVERGEN	HBG106917.
InParanoid	O00590.
KO	K04187.
OMA	HWVFGSF.
OrthoDB	EOG4KWJT9.
PhylomeDB	O00590.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	O00590.
CleanEx	HS_CCBP2. HS_CCR10.
Genevestigator	O00590.
GermOnline	ENSG00000144648. Homo sapiens.
Family and domain databases
InterPro	IPR001277. Chemokine_CXCR4. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR00645. CXCCHMKINER4. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1238.
NextBio	5057.
SOURCE	Search...

Entry information

Entry name

CCBP2_HUMAN

Accession

Primary (citable) accession number: O00590
Secondary accession number(s): B2R8Y8 , O00537, Q53YA1, Q86UN9, Q96A02

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	May 2, 2002
Last modified:	May 1, 2013
This is version 121 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.