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O00590

- ACKR2_HUMAN

UniProt

O00590 - ACKR2_HUMAN

Protein

Atypical chemokine receptor 2

Gene

ACKR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (02 May 2002)
      Previous versions | rss
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    Functioni

    Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.2 Publications

    GO - Molecular functioni

    1. C-C chemokine receptor activity Source: Ensembl
    2. chemokine receptor activity Source: ProtInc
    3. C-X-C chemokine receptor activity Source: InterPro
    4. scavenger receptor activity Source: UniProtKB

    GO - Biological processi

    1. chemokine-mediated signaling pathway Source: GOC
    2. chemotaxis Source: ProtInc
    3. G-protein coupled receptor signaling pathway Source: ProtInc
    4. immune response Source: ProtInc
    5. inflammatory response Source: UniProtKB-KW
    6. multicellular organismal development Source: ProtInc
    7. neutrophil activation Source: InterPro
    8. receptor-mediated endocytosis Source: GOC

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Inflammatory response

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Atypical chemokine receptor 2
    Alternative name(s):
    C-C chemokine receptor D6
    Chemokine receptor CCR-10
    Chemokine receptor CCR-9
    Chemokine-binding protein 2
    Chemokine-binding protein D6
    Gene namesi
    Name:ACKR2
    Synonyms:CCBP2, CCR10, CMKBR9, D6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:1565. ACKR2.

    Subcellular locationi

    Early endosome. Recycling endosome. Cell membrane; Multi-pass membrane protein
    Note: Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.

    GO - Cellular componenti

    1. actin filament Source: UniProtKB
    2. early endosome Source: UniProtKB-SubCell
    3. integral component of plasma membrane Source: ProtInc
    4. plasma membrane Source: UniProtKB
    5. recycling endosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Endosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26139.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 384384Atypical chemokine receptor 2PRO_0000069219Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi117 ↔ 195PROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated on serine residues in the C-terminal cytoplasmic tail.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiO00590.
    PRIDEiO00590.

    PTM databases

    PhosphoSiteiO00590.

    Expressioni

    Tissue specificityi

    Found in endothelial cells lining afferent lymphatics in dermis and lymph nodes. Also found in lymph nodes subcapsular and medullary sinuses, tonsillar lymphatic sinuses and lymphatics in mucosa and submucosa of small and large intestine and appendix. Also found in some malignant vascular tumors. Expressed at high levels in Kaposi sarcoma-related pathologies. Expressed on apoptotic neutrophils (at protein level). Expressed primarily in placenta and fetal liver, and found at very low levels in the lung and lymph node.3 Publications

    Inductioni

    By interleukin-6 and interferon-gamma.1 Publication

    Gene expression databases

    BgeeiO00590.
    CleanExiHS_CCBP2.
    HS_CCR10.
    GenevestigatoriO00590.

    Organism-specific databases

    HPAiHPA013819.

    Interactioni

    Protein-protein interaction databases

    BioGridi107643. 8 interactions.
    MINTiMINT-6631488.
    STRINGi9606.ENSP00000273145.

    Structurei

    3D structure databases

    ProteinModelPortaliO00590.
    SMRiO00590. Positions 36-328.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5050ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini72 – 9221CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini114 – 1185ExtracellularSequence Analysis
    Topological domaini141 – 16222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini184 – 21734ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini239 – 25012CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini272 – 29322ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini315 – 38470CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei51 – 7121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei93 – 11321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei119 – 14022Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei163 – 18321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei218 – 23821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei251 – 27121Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei294 – 31421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni327 – 38458C-terminal cytoplasmic tailAdd
    BLAST

    Domaini

    The C-terminal cytoplasmic tail controls its phosphorylation, stability, intracellular trafficking itinerary, and chemokine scavenging properties.

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG297330.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiO00590.
    KOiK04187.
    OMAiHCCFTPI.
    OrthoDBiEOG7HMS1P.
    PhylomeDBiO00590.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001277. Chemokine_CXCR4.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR00645. CXCCHMKINER4.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O00590-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAATASPQPL ATEDADSENS SFYYYDYLDE VAFMLCRKDA VVSFGKVFLP    50
    VFYSLIFVLG LSGNLLLLMV LLRYVPRRRM VEIYLLNLAI SNLLFLVTLP 100
    FWGISVAWHW VFGSFLCKMV STLYTINFYS GIFFISCMSL DKYLEIVHAQ 150
    PYHRLRTRAK SLLLATIVWA VSLAVSIPDM VFVQTHENPK GVWNCHADFG 200
    GHGTIWKLFL RFQQNLLGFL LPLLAMIFFY SRIGCVLVRL RPAGQGRALK 250
    IAAALVVAFF VLWFPYNLTL FLHTLLDLQV FGNCEVSQHL DYALQVTESI 300
    AFLHCCFSPI LYAFSSHRFR QYLKAFLAAV LGWHLAPGTA QASLSSCSES 350
    SILTAQEEMT GMNDLGERQS ENYPNKEDVG NKSA 384
    Length:384
    Mass (Da):43,443
    Last modified:May 2, 2002 - v2
    Checksum:i464C5703C1DE9A6A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti17 – 171S → A in AAB97728. (PubMed:9364936)Curated
    Sequence conflicti161 – 1611S → N in AAB97728. (PubMed:9364936)Curated
    Sequence conflicti356 – 3561Q → L in AAB97728. (PubMed:9364936)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti41 – 411V → A.
    Corresponds to variant rs2228467 [ dbSNP | Ensembl ].
    VAR_049379
    Natural varianti248 – 2481A → V.
    Corresponds to variant rs2228469 [ dbSNP | Ensembl ].
    VAR_049380
    Natural varianti311 – 3111L → V.
    Corresponds to variant rs6779520 [ dbSNP | Ensembl ].
    VAR_049381
    Natural varianti373 – 3731Y → S.1 Publication
    Corresponds to variant rs2228468 [ dbSNP | Ensembl ].
    VAR_024252

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U94888 mRNA. Translation: AAB97728.1.
    Y12815 mRNA. Translation: CAA73346.1.
    AY262687 Genomic DNA. Translation: AAP20651.1.
    BT006800 mRNA. Translation: AAP35446.1.
    AK313561 mRNA. Translation: BAG36335.1.
    BC008816 mRNA. Translation: AAH08816.1.
    BC011631 mRNA. Translation: AAH11631.1.
    BC020558 mRNA. Translation: AAH20558.1.
    BC101629 mRNA. Translation: AAI01630.1.
    BC112045 mRNA. Translation: AAI12046.1.
    CCDSiCCDS2706.1.
    RefSeqiNP_001287.2. NM_001296.4.
    UniGeneiHs.146346.

    Genome annotation databases

    EnsembliENST00000273145; ENSP00000273145; ENSG00000144648.
    ENST00000422265; ENSP00000416996; ENSG00000144648.
    ENST00000442925; ENSP00000396150; ENSG00000144648.
    GeneIDi1238.
    KEGGihsa:1238.
    UCSCiuc003cme.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U94888 mRNA. Translation: AAB97728.1 .
    Y12815 mRNA. Translation: CAA73346.1 .
    AY262687 Genomic DNA. Translation: AAP20651.1 .
    BT006800 mRNA. Translation: AAP35446.1 .
    AK313561 mRNA. Translation: BAG36335.1 .
    BC008816 mRNA. Translation: AAH08816.1 .
    BC011631 mRNA. Translation: AAH11631.1 .
    BC020558 mRNA. Translation: AAH20558.1 .
    BC101629 mRNA. Translation: AAI01630.1 .
    BC112045 mRNA. Translation: AAI12046.1 .
    CCDSi CCDS2706.1.
    RefSeqi NP_001287.2. NM_001296.4.
    UniGenei Hs.146346.

    3D structure databases

    ProteinModelPortali O00590.
    SMRi O00590. Positions 36-328.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107643. 8 interactions.
    MINTi MINT-6631488.
    STRINGi 9606.ENSP00000273145.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O00590.

    Proteomic databases

    PaxDbi O00590.
    PRIDEi O00590.

    Protocols and materials databases

    DNASUi 1238.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000273145 ; ENSP00000273145 ; ENSG00000144648 .
    ENST00000422265 ; ENSP00000416996 ; ENSG00000144648 .
    ENST00000442925 ; ENSP00000396150 ; ENSG00000144648 .
    GeneIDi 1238.
    KEGGi hsa:1238.
    UCSCi uc003cme.3. human.

    Organism-specific databases

    CTDi 1238.
    GeneCardsi GC03P042846.
    HGNCi HGNC:1565. ACKR2.
    HPAi HPA013819.
    MIMi 602648. gene.
    neXtProti NX_O00590.
    PharmGKBi PA26139.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG297330.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi O00590.
    KOi K04187.
    OMAi HCCFTPI.
    OrthoDBi EOG7HMS1P.
    PhylomeDBi O00590.
    TreeFami TF330966.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.

    Miscellaneous databases

    GeneWikii CCBP2.
    GenomeRNAii 1238.
    NextBioi 5057.
    PROi O00590.
    SOURCEi Search...

    Gene expression databases

    Bgeei O00590.
    CleanExi HS_CCBP2.
    HS_CCR10.
    Genevestigatori O00590.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001277. Chemokine_CXCR4.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR00645. CXCCHMKINER4.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3."
      Bonini J.A., Martin S.K., Dralyuk F., Roe M.W., Philipson L.H., Steiner D.F.
      DNA Cell Biol. 16:1249-1256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. "Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6."
      Nibbs R.J.B., Wylie S.M., Yang J., Landau N.R., Graham G.J.
      J. Biol. Chem. 272:32078-32083(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-373.
      Tissue: Placenta.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver and Placenta.
    7. "The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors."
      Nibbs R.J.B., Kriehuber E., Ponath P.D., Parent D., Qin S., Campbell J.D., Henderson A., Kerjaschki D., Maurer D., Graham G.J., Rot A.
      Am. J. Pathol. 158:867-877(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    8. Cited for: C-TERMINAL CYTOPLASMIC TAIL, SUBCELLULAR LOCATION, PHOSPHORYLATION.
    9. "Chemokine decoy receptors: structure-function and biological properties."
      Bonecchi R., Savino B., Borroni E.M., Mantovani A., Locati M.
      Curr. Top. Microbiol. Immunol. 341:15-36(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    10. "The atypical chemokine receptor D6 controls macrophage efferocytosis and cytokine secretion during the resolution of inflammation."
      Pashover-Schallinger E., Aswad M., Schif-Zuck S., Shapiro H., Singer P., Ariel A.
      FASEB J. 26:3891-3900(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    11. "The biochemistry and biology of the atypical chemokine receptors."
      Graham G.J., Locati M., Mantovani A., Rot A., Thelen M.
      Immunol. Lett. 145:30-38(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    12. Cited for: REVIEW.
    13. Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY.
    14. "Regulation of the immune and inflammatory responses by the 'atypical' chemokine receptor D6."
      Graham G.J., Locati M.
      J. Pathol. 229:168-175(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    15. "Review: Structure-function and biological properties of the atypical chemokine receptor D6."
      Cancellieri C., Caronni N., Vacchini A., Savino B., Borroni E.M., Locati M., Bonecchi R.
      Mol. Immunol. 55:87-93(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    16. "Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6."
      Borroni E.M., Cancellieri C., Vacchini A., Benureau Y., Lagane B., Bachelerie F., Arenzana-Seisdedos F., Mizuno K., Mantovani A., Bonecchi R., Locati M.
      Sci. Signal. 6:RA30-RA30(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiACKR2_HUMAN
    AccessioniPrimary (citable) accession number: O00590
    Secondary accession number(s): B2R8Y8
    , O00537, Q53YA1, Q86UN9, Q96A02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: May 2, 2002
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3