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Protein

Atypical chemokine receptor 2

Gene

ACKR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.2 Publications

GO - Molecular functioni

  • C-C chemokine receptor activity Source: Ensembl
  • chemokine receptor activity Source: ProtInc
  • C-X-C chemokine receptor activity Source: InterPro
  • scavenger receptor activity Source: UniProtKB

GO - Biological processi

  • chemokine-mediated signaling pathway Source: GOC
  • chemotaxis Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • immune response Source: ProtInc
  • inflammatory response Source: UniProtKB-KW
  • multicellular organismal development Source: ProtInc
  • neutrophil activation Source: InterPro
  • receptor-mediated endocytosis Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
Atypical chemokine receptor 2
Alternative name(s):
C-C chemokine receptor D6
Chemokine receptor CCR-10
Chemokine receptor CCR-9
Chemokine-binding protein 2
Chemokine-binding protein D6
Gene namesi
Name:ACKR2
Synonyms:CCBP2, CCR10, CMKBR9, D6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:1565. ACKR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5050ExtracellularSequence AnalysisAdd
BLAST
Transmembranei51 – 7121Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini72 – 9221CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei93 – 11321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini114 – 1185ExtracellularSequence Analysis
Transmembranei119 – 14022Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini141 – 16222CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei163 – 18321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini184 – 21734ExtracellularSequence AnalysisAdd
BLAST
Transmembranei218 – 23821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini239 – 25012CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei251 – 27121Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini272 – 29322ExtracellularSequence AnalysisAdd
BLAST
Transmembranei294 – 31421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini315 – 38470CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • actin filament Source: UniProtKB
  • early endosome Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: UniProtKB
  • recycling endosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26139.

Polymorphism and mutation databases

BioMutaiCCBP2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Atypical chemokine receptor 2PRO_0000069219Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi117 ↔ 195PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated on serine residues in the C-terminal cytoplasmic tail.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO00590.
PRIDEiO00590.

PTM databases

PhosphoSiteiO00590.

Expressioni

Tissue specificityi

Found in endothelial cells lining afferent lymphatics in dermis and lymph nodes. Also found in lymph nodes subcapsular and medullary sinuses, tonsillar lymphatic sinuses and lymphatics in mucosa and submucosa of small and large intestine and appendix. Also found in some malignant vascular tumors. Expressed at high levels in Kaposi sarcoma-related pathologies. Expressed on apoptotic neutrophils (at protein level). Expressed primarily in placenta and fetal liver, and found at very low levels in the lung and lymph node.3 Publications

Inductioni

By interleukin-6 and interferon-gamma.1 Publication

Gene expression databases

BgeeiO00590.
CleanExiHS_CCBP2.
HS_CCR10.
ExpressionAtlasiO00590. baseline and differential.
GenevisibleiO00590. HS.

Organism-specific databases

HPAiHPA013819.

Interactioni

Protein-protein interaction databases

BioGridi107643. 9 interactions.
MINTiMINT-6631488.
STRINGi9606.ENSP00000273145.

Structurei

3D structure databases

ProteinModelPortaliO00590.
SMRiO00590. Positions 36-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni327 – 38458C-terminal cytoplasmic tailAdd
BLAST

Domaini

The C-terminal cytoplasmic tail controls its phosphorylation, stability, intracellular trafficking itinerary, and chemokine scavenging properties.

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG297330.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO00590.
KOiK04187.
OMAiHCCFTPI.
OrthoDBiEOG7HMS1P.
PhylomeDBiO00590.
TreeFamiTF330966.

Family and domain databases

InterProiIPR001277. Chemokine_CXCR4.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR00645. CXCCHMKINER4.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATASPQPL ATEDADSENS SFYYYDYLDE VAFMLCRKDA VVSFGKVFLP
60 70 80 90 100
VFYSLIFVLG LSGNLLLLMV LLRYVPRRRM VEIYLLNLAI SNLLFLVTLP
110 120 130 140 150
FWGISVAWHW VFGSFLCKMV STLYTINFYS GIFFISCMSL DKYLEIVHAQ
160 170 180 190 200
PYHRLRTRAK SLLLATIVWA VSLAVSIPDM VFVQTHENPK GVWNCHADFG
210 220 230 240 250
GHGTIWKLFL RFQQNLLGFL LPLLAMIFFY SRIGCVLVRL RPAGQGRALK
260 270 280 290 300
IAAALVVAFF VLWFPYNLTL FLHTLLDLQV FGNCEVSQHL DYALQVTESI
310 320 330 340 350
AFLHCCFSPI LYAFSSHRFR QYLKAFLAAV LGWHLAPGTA QASLSSCSES
360 370 380
SILTAQEEMT GMNDLGERQS ENYPNKEDVG NKSA
Length:384
Mass (Da):43,443
Last modified:May 2, 2002 - v2
Checksum:i464C5703C1DE9A6A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171S → A in AAB97728 (PubMed:9364936).Curated
Sequence conflicti161 – 1611S → N in AAB97728 (PubMed:9364936).Curated
Sequence conflicti356 – 3561Q → L in AAB97728 (PubMed:9364936).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti41 – 411V → A.
Corresponds to variant rs2228467 [ dbSNP | Ensembl ].
VAR_049379
Natural varianti248 – 2481A → V.
Corresponds to variant rs2228469 [ dbSNP | Ensembl ].
VAR_049380
Natural varianti311 – 3111L → V.
Corresponds to variant rs6779520 [ dbSNP | Ensembl ].
VAR_049381
Natural varianti373 – 3731Y → S.1 Publication
Corresponds to variant rs2228468 [ dbSNP | Ensembl ].
VAR_024252

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94888 mRNA. Translation: AAB97728.1.
Y12815 mRNA. Translation: CAA73346.1.
AY262687 Genomic DNA. Translation: AAP20651.1.
BT006800 mRNA. Translation: AAP35446.1.
AK313561 mRNA. Translation: BAG36335.1.
BC008816 mRNA. Translation: AAH08816.1.
BC011631 mRNA. Translation: AAH11631.1.
BC020558 mRNA. Translation: AAH20558.1.
BC101629 mRNA. Translation: AAI01630.1.
BC112045 mRNA. Translation: AAI12046.1.
CCDSiCCDS2706.1.
RefSeqiNP_001287.2. NM_001296.4.
UniGeneiHs.146346.

Genome annotation databases

EnsembliENST00000273145; ENSP00000273145; ENSG00000144648.
ENST00000422265; ENSP00000416996; ENSG00000144648.
ENST00000442925; ENSP00000396150; ENSG00000144648.
GeneIDi1238.
KEGGihsa:1238.
UCSCiuc003cme.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94888 mRNA. Translation: AAB97728.1.
Y12815 mRNA. Translation: CAA73346.1.
AY262687 Genomic DNA. Translation: AAP20651.1.
BT006800 mRNA. Translation: AAP35446.1.
AK313561 mRNA. Translation: BAG36335.1.
BC008816 mRNA. Translation: AAH08816.1.
BC011631 mRNA. Translation: AAH11631.1.
BC020558 mRNA. Translation: AAH20558.1.
BC101629 mRNA. Translation: AAI01630.1.
BC112045 mRNA. Translation: AAI12046.1.
CCDSiCCDS2706.1.
RefSeqiNP_001287.2. NM_001296.4.
UniGeneiHs.146346.

3D structure databases

ProteinModelPortaliO00590.
SMRiO00590. Positions 36-328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107643. 9 interactions.
MINTiMINT-6631488.
STRINGi9606.ENSP00000273145.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO00590.

Polymorphism and mutation databases

BioMutaiCCBP2.

Proteomic databases

PaxDbiO00590.
PRIDEiO00590.

Protocols and materials databases

DNASUi1238.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273145; ENSP00000273145; ENSG00000144648.
ENST00000422265; ENSP00000416996; ENSG00000144648.
ENST00000442925; ENSP00000396150; ENSG00000144648.
GeneIDi1238.
KEGGihsa:1238.
UCSCiuc003cme.3. human.

Organism-specific databases

CTDi1238.
GeneCardsiGC03P042846.
HGNCiHGNC:1565. ACKR2.
HPAiHPA013819.
MIMi602648. gene.
neXtProtiNX_O00590.
PharmGKBiPA26139.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG297330.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO00590.
KOiK04187.
OMAiHCCFTPI.
OrthoDBiEOG7HMS1P.
PhylomeDBiO00590.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.

Miscellaneous databases

ChiTaRSiACKR2. human.
GeneWikiiCCBP2.
GenomeRNAii1238.
NextBioi5057.
PROiO00590.
SOURCEiSearch...

Gene expression databases

BgeeiO00590.
CleanExiHS_CCBP2.
HS_CCR10.
ExpressionAtlasiO00590. baseline and differential.
GenevisibleiO00590. HS.

Family and domain databases

InterProiIPR001277. Chemokine_CXCR4.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR00645. CXCCHMKINER4.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3."
    Bonini J.A., Martin S.K., Dralyuk F., Roe M.W., Philipson L.H., Steiner D.F.
    DNA Cell Biol. 16:1249-1256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6."
    Nibbs R.J.B., Wylie S.M., Yang J., Landau N.R., Graham G.J.
    J. Biol. Chem. 272:32078-32083(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-373.
    Tissue: Placenta.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver and Placenta.
  7. "The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors."
    Nibbs R.J.B., Kriehuber E., Ponath P.D., Parent D., Qin S., Campbell J.D., Henderson A., Kerjaschki D., Maurer D., Graham G.J., Rot A.
    Am. J. Pathol. 158:867-877(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. Cited for: C-TERMINAL CYTOPLASMIC TAIL, SUBCELLULAR LOCATION, PHOSPHORYLATION.
  9. "Chemokine decoy receptors: structure-function and biological properties."
    Bonecchi R., Savino B., Borroni E.M., Mantovani A., Locati M.
    Curr. Top. Microbiol. Immunol. 341:15-36(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  10. "The atypical chemokine receptor D6 controls macrophage efferocytosis and cytokine secretion during the resolution of inflammation."
    Pashover-Schallinger E., Aswad M., Schif-Zuck S., Shapiro H., Singer P., Ariel A.
    FASEB J. 26:3891-3900(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  11. "The biochemistry and biology of the atypical chemokine receptors."
    Graham G.J., Locati M., Mantovani A., Rot A., Thelen M.
    Immunol. Lett. 145:30-38(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  12. Cited for: REVIEW.
  13. Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY.
  14. "Regulation of the immune and inflammatory responses by the 'atypical' chemokine receptor D6."
    Graham G.J., Locati M.
    J. Pathol. 229:168-175(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  15. "Review: Structure-function and biological properties of the atypical chemokine receptor D6."
    Cancellieri C., Caronni N., Vacchini A., Savino B., Borroni E.M., Locati M., Bonecchi R.
    Mol. Immunol. 55:87-93(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  16. "Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6."
    Borroni E.M., Cancellieri C., Vacchini A., Benureau Y., Lagane B., Bachelerie F., Arenzana-Seisdedos F., Mizuno K., Mantovani A., Bonecchi R., Locati M.
    Sci. Signal. 6:RA30-RA30(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiACKR2_HUMAN
AccessioniPrimary (citable) accession number: O00590
Secondary accession number(s): B2R8Y8
, O00537, Q53YA1, Q86UN9, Q96A02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 2, 2002
Last modified: June 24, 2015
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.