Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-C motif chemokine 21

Gene

CCL21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

GO - Molecular functioni

  • CCR7 chemokine receptor binding Source: BHF-UCL
  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: UniProtKB
  • chemokine receptor binding Source: UniProtKB

GO - Biological processi

  • activation of GTPase activity Source: BHF-UCL
  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • cell-cell signaling Source: ProtInc
  • cell chemotaxis Source: UniProtKB
  • cell maturation Source: BHF-UCL
  • cellular response to interferon-gamma Source: GO_Central
  • cellular response to interleukin-1 Source: GO_Central
  • cellular response to tumor necrosis factor Source: GO_Central
  • chemokine-mediated signaling pathway Source: GO_Central
  • dendritic cell chemotaxis Source: BHF-UCL
  • dendritic cell dendrite assembly Source: BHF-UCL
  • establishment of T cell polarity Source: BHF-UCL
  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • immune response Source: ProtInc
  • immunological synapse formation Source: BHF-UCL
  • inflammatory response Source: GO_Central
  • killing of cells of other organism Source: UniProtKB
  • lymphocyte chemotaxis Source: GO_Central
  • mesangial cell-matrix adhesion Source: BHF-UCL
  • monocyte chemotaxis Source: GO_Central
  • negative regulation of dendritic cell apoptotic process Source: BHF-UCL
  • negative regulation of dendritic cell dendrite assembly Source: BHF-UCL
  • negative regulation of leukocyte tethering or rolling Source: UniProtKB
  • positive regulation of actin filament polymerization Source: BHF-UCL
  • positive regulation of cell adhesion mediated by integrin Source: BHF-UCL
  • positive regulation of cell-matrix adhesion Source: UniProtKB
  • positive regulation of cell motility Source: BHF-UCL
  • positive regulation of chemotaxis Source: BHF-UCL
  • positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
  • positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  • positive regulation of filopodium assembly Source: BHF-UCL
  • positive regulation of glycoprotein biosynthetic process Source: BHF-UCL
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
  • positive regulation of JNK cascade Source: BHF-UCL
  • positive regulation of myeloid dendritic cell chemotaxis Source: BHF-UCL
  • positive regulation of neutrophil chemotaxis Source: BHF-UCL
  • positive regulation of phosphatidylinositol 3-kinase activity Source: BHF-UCL
  • positive regulation of protein kinase activity Source: BHF-UCL
  • positive regulation of protein kinase B signaling Source: BHF-UCL
  • positive regulation of pseudopodium assembly Source: BHF-UCL
  • positive regulation of receptor-mediated endocytosis Source: BHF-UCL
  • positive regulation of T cell migration Source: MGI
  • release of sequestered calcium ion into cytosol Source: BHF-UCL
  • response to prostaglandin E Source: BHF-UCL
  • ruffle organization Source: BHF-UCL
  • T cell costimulation Source: BHF-UCL

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
SIGNORiO00585

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 21
Alternative name(s):
6Ckine
Beta-chemokine exodus-2
Secondary lymphoid-tissue chemokine
Short name:
SLC
Small-inducible cytokine A21
Gene namesi
Name:CCL21
Synonyms:SCYA21
ORF Names:UNQ784/PRO1600
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000137077.7
HGNCiHGNC:10620 CCL21
MIMi602737 gene
neXtProtiNX_O00585

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6366
OpenTargetsiENSG00000137077
PharmGKBiPA35552

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000000522024 – 134C-C motif chemokine 21Add BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 571 Publication
Disulfide bondi32 ↔ 751 Publication
Disulfide bondi103 ↔ 122Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO00585
PeptideAtlasiO00585
PRIDEiO00585
ProteomicsDBi47987

PTM databases

iPTMnetiO00585
PhosphoSitePlusiO00585

Miscellaneous databases

PMAP-CutDBiO00585

Expressioni

Tissue specificityi

Highly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate levels found in small intestine, thyroid gland and trachea. Low level expression in thymus, bone marrow, liver, and pancreas. Also found in tonsil, fetal heart and fetal spleen.

Gene expression databases

BgeeiENSG00000137077
CleanExiHS_CCL21
ExpressionAtlasiO00585 baseline and differential
GenevisibleiO00585 HS

Organism-specific databases

HPAiCAB005067
HPA051210

Interactioni

Subunit structurei

Monomer. Binds to CCR7. Interacts with PDPN; relocalizes PDPN to the basolateral membrane (PubMed:14978162).2 Publications

GO - Molecular functioni

  • CCR7 chemokine receptor binding Source: BHF-UCL
  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: UniProtKB
  • chemokine receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112269, 9 interactors
DIPiDIP-5854N
IntActiO00585, 11 interactors
MINTiO00585
STRINGi9606.ENSP00000259607

Structurei

Secondary structure

1134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi42 – 44Combined sources3
Beta strandi45 – 51Combined sources7
Turni53 – 56Combined sources4
Beta strandi61 – 68Combined sources8
Beta strandi74 – 76Combined sources3
Helixi81 – 90Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L4NNMR-A24-134[»]
5EKIX-ray1.90A/B/C/D/E/F24-102[»]
DisProtiDP00765
ProteinModelPortaliO00585
SMRiO00585
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 134C-terminal basic extensionAdd BLAST37

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3QM Eukaryota
ENOG410Z7F2 LUCA
GeneTreeiENSGT00730000111297
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiO00585
KOiK16062
OMAiCKRTEQP
OrthoDBiEOG091G14NY
PhylomeDBiO00585
TreeFamiTF338224

Family and domain databases

CDDicd01119 Chemokine_CC_DCCL, 1 hit
InterProiView protein in InterPro
IPR030593 CCL21
IPR034133 Chemokine_CC_DCCL
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015:SF72 PTHR12015:SF72, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00585-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQSLALSLL ILVLAFGIPR TQGSDGGAQD CCLKYSQRKI PAKVVRSYRK
60 70 80 90 100
QEPSLGCSIP AILFLPRKRS QAELCADPKE LWVQQLMQHL DKTPSPQKPA
110 120 130
QGCRKDRGAS KTGKKGKGSK GCKRTERSQT PKGP
Length:134
Mass (Da):14,646
Last modified:July 1, 1997 - v1
Checksum:iFB48C2F71CB4A9D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002409 mRNA Translation: BAA21817.1
AF001979 mRNA Translation: AAB86594.1
U88320 mRNA Translation: AAB91454.1
AF030572 Genomic DNA Translation: AAQ13417.1
AJ005654 Genomic DNA Translation: CAA06653.1
EF064765 Genomic DNA Translation: ABK41948.1
AY358887 mRNA Translation: AAQ89246.1
AK311901 mRNA Translation: BAG34842.1
CR450326 mRNA Translation: CAG29322.1
CH471071 Genomic DNA Translation: EAW58415.1
BC027918 mRNA Translation: AAH27918.1
CCDSiCCDS6571.1
RefSeqiNP_002980.1, NM_002989.3
UniGeneiHs.57907

Genome annotation databases

EnsembliENST00000259607; ENSP00000259607; ENSG00000137077
GeneIDi6366
KEGGihsa:6366
UCSCiuc003zvo.5 human

Similar proteinsi

Entry informationi

Entry nameiCCL21_HUMAN
AccessioniPrimary (citable) accession number: O00585
Secondary accession number(s): Q6ICR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: June 20, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health