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O00584

- RNT2_HUMAN

UniProt

O00584 - RNT2_HUMAN

Protein

Ribonuclease T2

Gene

RNASET2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA By similarity. Probably plays a role in cellular RNA catabolism.By similarity3 Publications

    Enzyme regulationi

    Inhibited by Zn2+ and Cu2+.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651By similarity
    Active sitei114 – 1141By similarity
    Active sitei118 – 1181By similarity

    GO - Molecular functioni

    1. ribonuclease activity Source: UniProtKB
    2. ribonuclease T2 activity Source: InterPro
    3. RNA binding Source: InterPro

    GO - Biological processi

    1. RNA catabolic process Source: UniProtKB
    2. RNA phosphodiester bond hydrolysis Source: GOC

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease T2 (EC:3.1.27.-)
    Alternative name(s):
    Ribonuclease 6
    Gene namesi
    Name:RNASET2
    Synonyms:RNASE6PL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21686. RNASET2.

    Subcellular locationi

    Secreted. Lysosome lumen. Endoplasmic reticulum lumen
    Note: Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction.

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB
    2. extracellular region Source: ProtInc
    3. extracellular space Source: UniProtKB
    4. extracellular vesicular exosome Source: UniProt
    5. lysosomal lumen Source: UniProtKB-SubCell
    6. lysosome Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Lysosome, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Leukoencephalopathy, cystic, without megalencephaly (LCWM) [MIM:612951]: An infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti184 – 1841C → R in LCWM; the loss of a disulfide bond may affect protein folding and stability; the protein is retained in the endoplasmic reticulum. 1 Publication
    VAR_063596

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi612951. phenotype.
    Orphaneti85136. Cystic leukoencephalopathy without megalencephaly.
    PharmGKBiPA128394541.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 256232Ribonuclease T2PRO_0000030987Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi48 ↔ 551 Publication
    Disulfide bondi75 ↔ 1211 Publication
    Glycosylationi76 – 761N-linked (GlcNAc...)1 Publication
    Glycosylationi106 – 1061N-linked (GlcNAc...)1 Publication
    Disulfide bondi184 ↔ 2411 Publication
    Disulfide bondi202 ↔ 2131 Publication
    Glycosylationi212 – 2121N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiO00584.
    PaxDbiO00584.
    PeptideAtlasiO00584.
    PRIDEiO00584.

    PTM databases

    PhosphoSiteiO00584.

    Expressioni

    Tissue specificityi

    Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain.1 Publication

    Gene expression databases

    ArrayExpressiO00584.
    BgeeiO00584.
    CleanExiHS_RNASET2.
    GenevestigatoriO00584.

    Organism-specific databases

    HPAiHPA029013.

    Interactioni

    Protein-protein interaction databases

    BioGridi114188. 8 interactions.
    IntActiO00584. 5 interactions.
    STRINGi9606.ENSP00000028008.

    Structurei

    Secondary structure

    1
    256
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi36 – 427
    Helixi44 – 474
    Beta strandi50 – 523
    Helixi53 – 553
    Beta strandi63 – 719
    Helixi83 – 897
    Helixi90 – 967
    Helixi108 – 11710
    Helixi119 – 1224
    Helixi126 – 1283
    Helixi131 – 14515
    Helixi147 – 1537
    Helixi165 – 17612
    Beta strandi181 – 1855
    Beta strandi195 – 20410
    Turni205 – 2073
    Beta strandi243 – 2475

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3T0OX-ray1.59A25-256[»]
    ProteinModelPortaliO00584.
    SMRiO00584. Positions 34-252.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RNase T2 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG285082.
    HOVERGENiHBG050037.
    InParanoidiO00584.
    KOiK01166.
    OMAiILTHHWP.
    PhylomeDBiO00584.
    TreeFamiTF315063.

    Family and domain databases

    Gene3Di3.90.730.10. 1 hit.
    InterProiIPR001568. RNase_T2-like.
    IPR018188. RNase_T2_AS.
    [Graphical view]
    PANTHERiPTHR11240. PTHR11240. 1 hit.
    PfamiPF00445. Ribonuclease_T2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55895. SSF55895. 1 hit.
    PROSITEiPS00530. RNASE_T2_1. 1 hit.
    PS00531. RNASE_T2_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O00584-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRPAALRGAL LGCLCLALLC LGGADKRLRD NHEWKKLIMV QHWPETVCEK    50
    IQNDCRDPPD YWTIHGLWPD KSEGCNRSWP FNLEEIKDLL PEMRAYWPDV 100
    IHSFPNRSRF WKHEWEKHGT CAAQVDALNS QKKYFGRSLE LYRELDLNSV 150
    LLKLGIKPSI NYYQVADFKD ALARVYGVIP KIQCLPPSQD EEVQTIGQIE 200
    LCLTKQDQQL QNCTEPGEQP SPKQEVWLAN GAAESRGLRV CEDGPVFYPP 250
    PKKTKH 256
    Length:256
    Mass (Da):29,481
    Last modified:November 1, 1999 - v2
    Checksum:i7C8BB08B8ED853EB
    GO
    Isoform 2 (identifier: O00584-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         88-121: DLLPEMRAYWPDVIHSFPNRSRFWKHEWEKHGTC → KNWMEITDSSLPSPSTLPIINIFYSVLHLLQLMN
         122-256: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:121
    Mass (Da):14,000
    Checksum:i984FAD634B7286E8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti184 – 1841C → R in LCWM; the loss of a disulfide bond may affect protein folding and stability; the protein is retained in the endoplasmic reticulum. 1 Publication
    VAR_063596
    Natural varianti236 – 2361R → W.
    Corresponds to variant rs11159 [ dbSNP | Ensembl ].
    VAR_013004

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei88 – 12134DLLPE…KHGTC → KNWMEITDSSLPSPSTLPII NIFYSVLHLLQLMN in isoform 2. 1 PublicationVSP_008405Add
    BLAST
    Alternative sequencei122 – 256135Missing in isoform 2. 1 PublicationVSP_008406Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U85625 mRNA. Translation: AAC51363.2.
    AJ419865 mRNA. Translation: CAD12030.1.
    AJ419866 mRNA. Translation: CAD12031.1.
    AK315467 mRNA. Translation: BAG37854.1.
    AL133458, AL159163 Genomic DNA. Translation: CAI21600.1.
    AL159163, AL133458 Genomic DNA. Translation: CAI15001.1.
    CH471051 Genomic DNA. Translation: EAW47512.1.
    CH471051 Genomic DNA. Translation: EAW47513.1.
    CH471051 Genomic DNA. Translation: EAW47514.1.
    BC001660 mRNA. Translation: AAH01660.1.
    BC001819 mRNA. Translation: AAH01819.1.
    BC039713 mRNA. Translation: AAH39713.1.
    BC051912 mRNA. Translation: AAH51912.1.
    CCDSiCCDS5295.1. [O00584-1]
    PIRiS78046.
    RefSeqiNP_003721.2. NM_003730.4. [O00584-1]
    UniGeneiHs.529989.

    Genome annotation databases

    EnsembliENST00000421787; ENSP00000390833; ENSG00000026297. [O00584-2]
    ENST00000476238; ENSP00000422846; ENSG00000026297. [O00584-1]
    ENST00000508775; ENSP00000426455; ENSG00000026297. [O00584-1]
    GeneIDi8635.
    KEGGihsa:8635.
    UCSCiuc003qve.3. human. [O00584-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U85625 mRNA. Translation: AAC51363.2 .
    AJ419865 mRNA. Translation: CAD12030.1 .
    AJ419866 mRNA. Translation: CAD12031.1 .
    AK315467 mRNA. Translation: BAG37854.1 .
    AL133458 , AL159163 Genomic DNA. Translation: CAI21600.1 .
    AL159163 , AL133458 Genomic DNA. Translation: CAI15001.1 .
    CH471051 Genomic DNA. Translation: EAW47512.1 .
    CH471051 Genomic DNA. Translation: EAW47513.1 .
    CH471051 Genomic DNA. Translation: EAW47514.1 .
    BC001660 mRNA. Translation: AAH01660.1 .
    BC001819 mRNA. Translation: AAH01819.1 .
    BC039713 mRNA. Translation: AAH39713.1 .
    BC051912 mRNA. Translation: AAH51912.1 .
    CCDSi CCDS5295.1. [O00584-1 ]
    PIRi S78046.
    RefSeqi NP_003721.2. NM_003730.4. [O00584-1 ]
    UniGenei Hs.529989.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3T0O X-ray 1.59 A 25-256 [» ]
    ProteinModelPortali O00584.
    SMRi O00584. Positions 34-252.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114188. 8 interactions.
    IntActi O00584. 5 interactions.
    STRINGi 9606.ENSP00000028008.

    PTM databases

    PhosphoSitei O00584.

    Proteomic databases

    MaxQBi O00584.
    PaxDbi O00584.
    PeptideAtlasi O00584.
    PRIDEi O00584.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000421787 ; ENSP00000390833 ; ENSG00000026297 . [O00584-2 ]
    ENST00000476238 ; ENSP00000422846 ; ENSG00000026297 . [O00584-1 ]
    ENST00000508775 ; ENSP00000426455 ; ENSG00000026297 . [O00584-1 ]
    GeneIDi 8635.
    KEGGi hsa:8635.
    UCSCi uc003qve.3. human. [O00584-1 ]

    Organism-specific databases

    CTDi 8635.
    GeneCardsi GC06M167342.
    HGNCi HGNC:21686. RNASET2.
    HPAi HPA029013.
    MIMi 612944. gene.
    612951. phenotype.
    neXtProti NX_O00584.
    Orphaneti 85136. Cystic leukoencephalopathy without megalencephaly.
    PharmGKBi PA128394541.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG285082.
    HOVERGENi HBG050037.
    InParanoidi O00584.
    KOi K01166.
    OMAi ILTHHWP.
    PhylomeDBi O00584.
    TreeFami TF315063.

    Miscellaneous databases

    ChiTaRSi RNASET2. human.
    GeneWikii RNASET2.
    GenomeRNAii 8635.
    NextBioi 32371.
    PROi O00584.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O00584.
    Bgeei O00584.
    CleanExi HS_RNASET2.
    Genevestigatori O00584.

    Family and domain databases

    Gene3Di 3.90.730.10. 1 hit.
    InterProi IPR001568. RNase_T2-like.
    IPR018188. RNase_T2_AS.
    [Graphical view ]
    PANTHERi PTHR11240. PTHR11240. 1 hit.
    Pfami PF00445. Ribonuclease_T2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55895. SSF55895. 1 hit.
    PROSITEi PS00530. RNASE_T2_1. 1 hit.
    PS00531. RNASE_T2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning of a human member located in a region of chromosome 6 (6q27) frequently deleted in human malignancies."
      Trubia M., Sessa L., Taramelli R.
      Genomics 42:342-344(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Physical and transcript map of the region between D6S264 and D6S149 on chromosome 6q27, the minimal region of allele loss in sporadic epithelial ovarian cancer."
      Liu Y., Emilion G., Mungall A.J., Dunham I., Beck S., LeMeuth-Metzinger V., Shelling A.N., Charnock F.M., Ganesan T.S.
      Oncogene 21:387-399(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon, Pancreas and Spleen.
    7. Cited for: SUBCELLULAR LOCATION.
    8. "Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins."
      Campomenosi P., Salis S., Lindqvist C., Mariani D., Nordstrom T., Acquati F., Taramelli R.
      Arch. Biochem. Biophys. 449:17-26(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    9. Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT LCWM ARG-184, CHARACTERIZATION OF VARIANT LCWM ARG-184.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA."
      Haud N., Kara F., Diekmann S., Henneke M., Willer J.R., Hillwig M.S., Gregg R.G., Macintosh G.C., Gartner J., Alia A., Hurlstone A.F.
      Proc. Natl. Acad. Sci. U.S.A. 108:1099-1103(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, CHARACTERIZATION OF VARIANT LCWM ARG-184.
    12. Cited for: X-RAY CRYSTALLOGRAPHY (1.59 ANGSTROMS) OF 25-256, GLYCOSYLATION AT ASN-76; ASN-106 AND ASN-212, FUNCTION, ENZYME REGULATION, DISULFIDE BONDS, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiRNT2_HUMAN
    AccessioniPrimary (citable) accession number: O00584
    Secondary accession number(s): B2RDA7
    , E1P5C3, Q5T8Q0, Q8TCU2, Q9BZ46, Q9BZ47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3