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O00584

- RNT2_HUMAN

UniProt

O00584 - RNT2_HUMAN

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Protein

Ribonuclease T2

Gene

RNASET2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism.By similarity3 Publications

Enzyme regulationi

Inhibited by Zn2+ and Cu2+.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651By similarity
Active sitei114 – 1141By similarity
Active sitei118 – 1181By similarity

GO - Molecular functioni

  1. ribonuclease activity Source: UniProtKB
  2. ribonuclease T2 activity Source: InterPro
  3. RNA binding Source: InterPro

GO - Biological processi

  1. RNA catabolic process Source: UniProtKB
  2. RNA phosphodiester bond hydrolysis Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease T2 (EC:3.1.27.-)
Alternative name(s):
Ribonuclease 6
Gene namesi
Name:RNASET2
Synonyms:RNASE6PL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21686. RNASET2.

Subcellular locationi

Secreted. Lysosome lumen. Endoplasmic reticulum lumen
Note: Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction.

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB
  2. extracellular region Source: ProtInc
  3. extracellular space Source: UniProtKB
  4. extracellular vesicular exosome Source: UniProtKB
  5. lysosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Lysosome, Secreted

Pathology & Biotechi

Involvement in diseasei

Leukoencephalopathy, cystic, without megalencephaly (LCWM) [MIM:612951]: An infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti184 – 1841C → R in LCWM; the loss of a disulfide bond may affect protein folding and stability; the protein is retained in the endoplasmic reticulum. 1 Publication
VAR_063596

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi612951. phenotype.
Orphaneti85136. Cystic leukoencephalopathy without megalencephaly.
PharmGKBiPA128394541.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 256232Ribonuclease T2PRO_0000030987Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi48 ↔ 551 Publication
Disulfide bondi75 ↔ 1211 Publication
Glycosylationi76 – 761N-linked (GlcNAc...)1 Publication
Glycosylationi106 – 1061N-linked (GlcNAc...)1 Publication
Disulfide bondi184 ↔ 2411 Publication
Disulfide bondi202 ↔ 2131 Publication
Glycosylationi212 – 2121N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO00584.
PaxDbiO00584.
PeptideAtlasiO00584.
PRIDEiO00584.

PTM databases

PhosphoSiteiO00584.

Expressioni

Tissue specificityi

Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain.1 Publication

Gene expression databases

BgeeiO00584.
CleanExiHS_RNASET2.
ExpressionAtlasiO00584. baseline and differential.
GenevestigatoriO00584.

Organism-specific databases

HPAiHPA029013.

Interactioni

Protein-protein interaction databases

BioGridi114188. 11 interactions.
IntActiO00584. 5 interactions.
STRINGi9606.ENSP00000028008.

Structurei

Secondary structure

1
256
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi36 – 427Combined sources
Helixi44 – 474Combined sources
Beta strandi50 – 523Combined sources
Helixi53 – 553Combined sources
Beta strandi63 – 719Combined sources
Helixi83 – 897Combined sources
Helixi90 – 967Combined sources
Helixi108 – 11710Combined sources
Helixi119 – 1224Combined sources
Helixi126 – 1283Combined sources
Helixi131 – 14515Combined sources
Helixi147 – 1537Combined sources
Helixi165 – 17612Combined sources
Beta strandi181 – 1855Combined sources
Beta strandi195 – 20410Combined sources
Turni205 – 2073Combined sources
Beta strandi243 – 2475Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3T0OX-ray1.59A25-256[»]
ProteinModelPortaliO00584.
SMRiO00584. Positions 34-252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase T2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG285082.
GeneTreeiENSGT00640000091563.
HOVERGENiHBG050037.
InParanoidiO00584.
KOiK01166.
OMAiILTHHWP.
PhylomeDBiO00584.
TreeFamiTF315063.

Family and domain databases

Gene3Di3.90.730.10. 1 hit.
InterProiIPR001568. RNase_T2-like.
IPR018188. RNase_T2_AS.
[Graphical view]
PANTHERiPTHR11240. PTHR11240. 1 hit.
PfamiPF00445. Ribonuclease_T2. 1 hit.
[Graphical view]
SUPFAMiSSF55895. SSF55895. 1 hit.
PROSITEiPS00530. RNASE_T2_1. 1 hit.
PS00531. RNASE_T2_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O00584-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPAALRGAL LGCLCLALLC LGGADKRLRD NHEWKKLIMV QHWPETVCEK
60 70 80 90 100
IQNDCRDPPD YWTIHGLWPD KSEGCNRSWP FNLEEIKDLL PEMRAYWPDV
110 120 130 140 150
IHSFPNRSRF WKHEWEKHGT CAAQVDALNS QKKYFGRSLE LYRELDLNSV
160 170 180 190 200
LLKLGIKPSI NYYQVADFKD ALARVYGVIP KIQCLPPSQD EEVQTIGQIE
210 220 230 240 250
LCLTKQDQQL QNCTEPGEQP SPKQEVWLAN GAAESRGLRV CEDGPVFYPP

PKKTKH
Length:256
Mass (Da):29,481
Last modified:November 1, 1999 - v2
Checksum:i7C8BB08B8ED853EB
GO
Isoform 2 (identifier: O00584-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-121: DLLPEMRAYWPDVIHSFPNRSRFWKHEWEKHGTC → KNWMEITDSSLPSPSTLPIINIFYSVLHLLQLMN
     122-256: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:121
Mass (Da):14,000
Checksum:i984FAD634B7286E8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti184 – 1841C → R in LCWM; the loss of a disulfide bond may affect protein folding and stability; the protein is retained in the endoplasmic reticulum. 1 Publication
VAR_063596
Natural varianti236 – 2361R → W.
Corresponds to variant rs11159 [ dbSNP | Ensembl ].
VAR_013004

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei88 – 12134DLLPE…KHGTC → KNWMEITDSSLPSPSTLPII NIFYSVLHLLQLMN in isoform 2. 1 PublicationVSP_008405Add
BLAST
Alternative sequencei122 – 256135Missing in isoform 2. 1 PublicationVSP_008406Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U85625 mRNA. Translation: AAC51363.2.
AJ419865 mRNA. Translation: CAD12030.1.
AJ419866 mRNA. Translation: CAD12031.1.
AK315467 mRNA. Translation: BAG37854.1.
AL133458, AL159163 Genomic DNA. Translation: CAI21600.1.
AL159163, AL133458 Genomic DNA. Translation: CAI15001.1.
CH471051 Genomic DNA. Translation: EAW47512.1.
CH471051 Genomic DNA. Translation: EAW47513.1.
CH471051 Genomic DNA. Translation: EAW47514.1.
BC001660 mRNA. Translation: AAH01660.1.
BC001819 mRNA. Translation: AAH01819.1.
BC039713 mRNA. Translation: AAH39713.1.
BC051912 mRNA. Translation: AAH51912.1.
CCDSiCCDS5295.1. [O00584-1]
PIRiS78046.
RefSeqiNP_003721.2. NM_003730.4. [O00584-1]
UniGeneiHs.529989.

Genome annotation databases

EnsembliENST00000421787; ENSP00000390833; ENSG00000026297. [O00584-2]
ENST00000476238; ENSP00000422846; ENSG00000026297. [O00584-1]
ENST00000508775; ENSP00000426455; ENSG00000026297. [O00584-1]
GeneIDi8635.
KEGGihsa:8635.
UCSCiuc003qve.3. human. [O00584-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U85625 mRNA. Translation: AAC51363.2 .
AJ419865 mRNA. Translation: CAD12030.1 .
AJ419866 mRNA. Translation: CAD12031.1 .
AK315467 mRNA. Translation: BAG37854.1 .
AL133458 , AL159163 Genomic DNA. Translation: CAI21600.1 .
AL159163 , AL133458 Genomic DNA. Translation: CAI15001.1 .
CH471051 Genomic DNA. Translation: EAW47512.1 .
CH471051 Genomic DNA. Translation: EAW47513.1 .
CH471051 Genomic DNA. Translation: EAW47514.1 .
BC001660 mRNA. Translation: AAH01660.1 .
BC001819 mRNA. Translation: AAH01819.1 .
BC039713 mRNA. Translation: AAH39713.1 .
BC051912 mRNA. Translation: AAH51912.1 .
CCDSi CCDS5295.1. [O00584-1 ]
PIRi S78046.
RefSeqi NP_003721.2. NM_003730.4. [O00584-1 ]
UniGenei Hs.529989.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3T0O X-ray 1.59 A 25-256 [» ]
ProteinModelPortali O00584.
SMRi O00584. Positions 34-252.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114188. 11 interactions.
IntActi O00584. 5 interactions.
STRINGi 9606.ENSP00000028008.

PTM databases

PhosphoSitei O00584.

Proteomic databases

MaxQBi O00584.
PaxDbi O00584.
PeptideAtlasi O00584.
PRIDEi O00584.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000421787 ; ENSP00000390833 ; ENSG00000026297 . [O00584-2 ]
ENST00000476238 ; ENSP00000422846 ; ENSG00000026297 . [O00584-1 ]
ENST00000508775 ; ENSP00000426455 ; ENSG00000026297 . [O00584-1 ]
GeneIDi 8635.
KEGGi hsa:8635.
UCSCi uc003qve.3. human. [O00584-1 ]

Organism-specific databases

CTDi 8635.
GeneCardsi GC06M167342.
HGNCi HGNC:21686. RNASET2.
HPAi HPA029013.
MIMi 612944. gene.
612951. phenotype.
neXtProti NX_O00584.
Orphaneti 85136. Cystic leukoencephalopathy without megalencephaly.
PharmGKBi PA128394541.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG285082.
GeneTreei ENSGT00640000091563.
HOVERGENi HBG050037.
InParanoidi O00584.
KOi K01166.
OMAi ILTHHWP.
PhylomeDBi O00584.
TreeFami TF315063.

Miscellaneous databases

ChiTaRSi RNASET2. human.
GeneWikii RNASET2.
GenomeRNAii 8635.
NextBioi 32371.
PROi O00584.
SOURCEi Search...

Gene expression databases

Bgeei O00584.
CleanExi HS_RNASET2.
ExpressionAtlasi O00584. baseline and differential.
Genevestigatori O00584.

Family and domain databases

Gene3Di 3.90.730.10. 1 hit.
InterProi IPR001568. RNase_T2-like.
IPR018188. RNase_T2_AS.
[Graphical view ]
PANTHERi PTHR11240. PTHR11240. 1 hit.
Pfami PF00445. Ribonuclease_T2. 1 hit.
[Graphical view ]
SUPFAMi SSF55895. SSF55895. 1 hit.
PROSITEi PS00530. RNASE_T2_1. 1 hit.
PS00531. RNASE_T2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning of a human member located in a region of chromosome 6 (6q27) frequently deleted in human malignancies."
    Trubia M., Sessa L., Taramelli R.
    Genomics 42:342-344(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Physical and transcript map of the region between D6S264 and D6S149 on chromosome 6q27, the minimal region of allele loss in sporadic epithelial ovarian cancer."
    Liu Y., Emilion G., Mungall A.J., Dunham I., Beck S., LeMeuth-Metzinger V., Shelling A.N., Charnock F.M., Ganesan T.S.
    Oncogene 21:387-399(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon, Pancreas and Spleen.
  7. Cited for: SUBCELLULAR LOCATION.
  8. "Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins."
    Campomenosi P., Salis S., Lindqvist C., Mariani D., Nordstrom T., Acquati F., Taramelli R.
    Arch. Biochem. Biophys. 449:17-26(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  9. Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT LCWM ARG-184, CHARACTERIZATION OF VARIANT LCWM ARG-184.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA."
    Haud N., Kara F., Diekmann S., Henneke M., Willer J.R., Hillwig M.S., Gregg R.G., Macintosh G.C., Gartner J., Alia A., Hurlstone A.F.
    Proc. Natl. Acad. Sci. U.S.A. 108:1099-1103(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, CHARACTERIZATION OF VARIANT LCWM ARG-184.
  12. Cited for: X-RAY CRYSTALLOGRAPHY (1.59 ANGSTROMS) OF 25-256, GLYCOSYLATION AT ASN-76; ASN-106 AND ASN-212, FUNCTION, ENZYME REGULATION, DISULFIDE BONDS, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiRNT2_HUMAN
AccessioniPrimary (citable) accession number: O00584
Secondary accession number(s): B2RDA7
, E1P5C3, Q5T8Q0, Q8TCU2, Q9BZ46, Q9BZ47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3