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O00574

- CXCR6_HUMAN

UniProt

O00574 - CXCR6_HUMAN

Protein

C-X-C chemokine receptor type 6

Gene

CXCR6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

    GO - Molecular functioni

    1. coreceptor activity Source: ProtInc
    2. C-X-C chemokine receptor activity Source: Ensembl
    3. G-protein coupled receptor activity Source: ProtInc

    GO - Biological processi

    1. chemotaxis Source: InterPro
    2. G-protein coupled receptor signaling pathway Source: ProtInc
    3. inflammatory response Source: InterPro
    4. viral genome replication Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C chemokine receptor type 6
    Short name:
    CXC-R6
    Short name:
    CXCR-6
    Alternative name(s):
    CDw186
    G-protein coupled receptor STRL33
    G-protein coupled receptor bonzo
    CD_antigen: CD186
    Gene namesi
    Name:CXCR6
    Synonyms:BONZO, STRL33, TYMSTR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:16647. CXCR6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38409.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342C-X-C chemokine receptor type 6PRO_0000069365Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi102 ↔ 180PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO00574.
    PRIDEiO00574.

    PTM databases

    PhosphoSiteiO00574.

    Expressioni

    Tissue specificityi

    Expressed in lymphoid tissues and activated T cells.

    Gene expression databases

    ArrayExpressiO00574.
    BgeeiO00574.
    CleanExiHS_CXCR6.
    GenevestigatoriO00574.

    Organism-specific databases

    HPAiHPA047591.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-6630856.
    STRINGi9606.ENSP00000304414.

    Structurei

    3D structure databases

    ProteinModelPortaliO00574.
    SMRiO00574. Positions 29-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini60 – 689CytoplasmicSequence Analysis
    Topological domaini90 – 10314ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini126 – 14318CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini165 – 18723ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini216 – 23116CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27516ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini294 – 34249CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5927Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei69 – 8921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei104 – 12522Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei144 – 16421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei188 – 21528Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei232 – 25928Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei276 – 29318Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146723.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiO00574.
    KOiK04191.
    OMAiARGFQKH.
    OrthoDBiEOG7VX8W4.
    PhylomeDBiO00574.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR002235. Chemokine_CXCR6.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR01105. CXCCHMKINER6.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O00574-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEHDYHEDY GFSSFNDSSQ EEHQDFLQFS KVFLPCMYLV VFVCGLVGNS    50
    LVLVISIFYH KLQSLTDVFL VNLPLADLVF VCTLPFWAYA GIHEWVFGQV 100
    MCKSLLGIYT INFYTSMLIL TCITVDRFIV VVKATKAYNQ QAKRMTWGKV 150
    TSLLIWVISL LVSLPQIIYG NVFNLDKLIC GYHDEAISTV VLATQMTLGF 200
    FLPLLTMIVC YSVIIKTLLH AGGFQKHRSL KIIFLVMAVF LLTQMPFNLM 250
    KFIRSTHWEY YAMTSFHYTI MVTEAIAYLR ACLNPVLYAF VSLKFRKNFW 300
    KLVKDIGCLP YLGVSHQWKS SEDNSKTFSA SHNVEATSMF QL 342
    Length:342
    Mass (Da):39,280
    Last modified:July 1, 1997 - v1
    Checksum:i9FBC025556D1082E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti3 – 31E → K.1 Publication
    Corresponds to variant rs2234355 [ dbSNP | Ensembl ].
    VAR_024253
    Natural varianti25 – 251D → A in STRL33.3. 1 Publication
    VAR_003506

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007545 mRNA. Translation: AAB64221.1.
    U73529 mRNA. Translation: AAB61456.1.
    U73531 mRNA. Translation: AAB61457.1.
    Y13248 mRNA. Translation: CAA73698.1.
    AF029759 Genomic DNA. Translation: AAG21918.1.
    AY322543 Genomic DNA. Translation: AAP84356.1.
    BC033584 mRNA. Translation: AAH33584.1.
    CCDSiCCDS2735.1.
    RefSeqiNP_006555.1. NM_006564.1.
    XP_005264866.1. XM_005264809.1.
    UniGeneiHs.34526.

    Genome annotation databases

    EnsembliENST00000304552; ENSP00000304414; ENSG00000172215.
    ENST00000438735; ENSP00000396218; ENSG00000172215.
    ENST00000457814; ENSP00000396886; ENSG00000172215.
    ENST00000458629; ENSP00000395704; ENSG00000172215.
    GeneIDi10663.
    KEGGihsa:10663.
    UCSCiuc003cpc.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CXC chemokine receptors entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007545 mRNA. Translation: AAB64221.1 .
    U73529 mRNA. Translation: AAB61456.1 .
    U73531 mRNA. Translation: AAB61457.1 .
    Y13248 mRNA. Translation: CAA73698.1 .
    AF029759 Genomic DNA. Translation: AAG21918.1 .
    AY322543 Genomic DNA. Translation: AAP84356.1 .
    BC033584 mRNA. Translation: AAH33584.1 .
    CCDSi CCDS2735.1.
    RefSeqi NP_006555.1. NM_006564.1.
    XP_005264866.1. XM_005264809.1.
    UniGenei Hs.34526.

    3D structure databases

    ProteinModelPortali O00574.
    SMRi O00574. Positions 29-303.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-6630856.
    STRINGi 9606.ENSP00000304414.

    Chemistry

    ChEMBLi CHEMBL5994.
    GuidetoPHARMACOLOGYi 73.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O00574.

    Proteomic databases

    PaxDbi O00574.
    PRIDEi O00574.

    Protocols and materials databases

    DNASUi 10663.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304552 ; ENSP00000304414 ; ENSG00000172215 .
    ENST00000438735 ; ENSP00000396218 ; ENSG00000172215 .
    ENST00000457814 ; ENSP00000396886 ; ENSG00000172215 .
    ENST00000458629 ; ENSP00000395704 ; ENSG00000172215 .
    GeneIDi 10663.
    KEGGi hsa:10663.
    UCSCi uc003cpc.1. human.

    Organism-specific databases

    CTDi 10663.
    GeneCardsi GC03P045982.
    HGNCi HGNC:16647. CXCR6.
    HPAi HPA047591.
    MIMi 605163. gene.
    neXtProti NX_O00574.
    PharmGKBi PA38409.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146723.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi O00574.
    KOi K04191.
    OMAi ARGFQKH.
    OrthoDBi EOG7VX8W4.
    PhylomeDBi O00574.
    TreeFami TF330966.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii CXCR6.
    GenomeRNAii 10663.
    NextBioi 40547.
    PROi O00574.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O00574.
    Bgeei O00574.
    CleanExi HS_CXCR6.
    Genevestigatori O00574.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR002235. Chemokine_CXCR6.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR01105. CXCCHMKINER6.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression cloning of new receptors used by simian and human immunodeficiency viruses."
      Deng H.K., Unutmaz D., Kewalramani V.N., Littman D.R.
      Nature 388:296-300(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1."
      Liao F., Alkhatib G., Peden K.W.C., Sharma G., Berger E.A., Farber J.M.
      J. Exp. Med. 185:2015-2023(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-25.
    3. "TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function."
      Loetscher M., Amara A., Oberlin E., Brass N., Legler D.F., Loetscher P., D'Apuzzo M., Meese E.U., Rousset D., Virelizier J.-L., Baggiolini M., Arenzana-Seisdedos F., Moser B.
      Curr. Biol. 7:652-660(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Blood.
    4. "The influence of a STRL33 mutant on the course of HIV-1 infection."
      An P., Winkler C., O'Brien S.J.
      Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-3.
    5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.

    Entry informationi

    Entry nameiCXCR6_HUMAN
    AccessioniPrimary (citable) accession number: O00574
    Secondary accession number(s): O00575, Q9HCA5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    3. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3