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O00574 (CXCR6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-X-C chemokine receptor type 6

Short name=CXC-R6
Short name=CXCR-6
Alternative name(s):
CDw186
G-protein coupled receptor STRL33
G-protein coupled receptor bonzo
CD_antigen=CD186
Gene names
Name:CXCR6
Synonyms:BONZO, STRL33, TYMSTR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in lymphoid tissues and activated T cells.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342C-X-C chemokine receptor type 6
PRO_0000069365

Regions

Topological domain1 – 3232Extracellular Potential
Transmembrane33 – 5927Helical; Name=1; Potential
Topological domain60 – 689Cytoplasmic Potential
Transmembrane69 – 8921Helical; Name=2; Potential
Topological domain90 – 10314Extracellular Potential
Transmembrane104 – 12522Helical; Name=3; Potential
Topological domain126 – 14318Cytoplasmic Potential
Transmembrane144 – 16421Helical; Name=4; Potential
Topological domain165 – 18723Extracellular Potential
Transmembrane188 – 21528Helical; Name=5; Potential
Topological domain216 – 23116Cytoplasmic Potential
Transmembrane232 – 25928Helical; Name=6; Potential
Topological domain260 – 27516Extracellular Potential
Transmembrane276 – 29318Helical; Name=7; Potential
Topological domain294 – 34249Cytoplasmic Potential

Amino acid modifications

Glycosylation161N-linked (GlcNAc...) Potential
Disulfide bond102 ↔ 180 By similarity

Natural variations

Natural variant31E → K. Ref.4
Corresponds to variant rs2234355 [ dbSNP | Ensembl ].
VAR_024253
Natural variant251D → A in STRL33.3. Ref.2
VAR_003506

Sequences

Sequence LengthMass (Da)Tools
O00574 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 9FBC025556D1082E

FASTA34239,280
        10         20         30         40         50         60 
MAEHDYHEDY GFSSFNDSSQ EEHQDFLQFS KVFLPCMYLV VFVCGLVGNS LVLVISIFYH 

        70         80         90        100        110        120 
KLQSLTDVFL VNLPLADLVF VCTLPFWAYA GIHEWVFGQV MCKSLLGIYT INFYTSMLIL 

       130        140        150        160        170        180 
TCITVDRFIV VVKATKAYNQ QAKRMTWGKV TSLLIWVISL LVSLPQIIYG NVFNLDKLIC 

       190        200        210        220        230        240 
GYHDEAISTV VLATQMTLGF FLPLLTMIVC YSVIIKTLLH AGGFQKHRSL KIIFLVMAVF 

       250        260        270        280        290        300 
LLTQMPFNLM KFIRSTHWEY YAMTSFHYTI MVTEAIAYLR ACLNPVLYAF VSLKFRKNFW 

       310        320        330        340 
KLVKDIGCLP YLGVSHQWKS SEDNSKTFSA SHNVEATSMF QL 

« Hide

References

« Hide 'large scale' references
[1]"Expression cloning of new receptors used by simian and human immunodeficiency viruses."
Deng H.K., Unutmaz D., Kewalramani V.N., Littman D.R.
Nature 388:296-300(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1."
Liao F., Alkhatib G., Peden K.W.C., Sharma G., Berger E.A., Farber J.M.
J. Exp. Med. 185:2015-2023(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-25.
[3]"TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function."
Loetscher M., Amara A., Oberlin E., Brass N., Legler D.F., Loetscher P., D'Apuzzo M., Meese E.U., Rousset D., Virelizier J.-L., Baggiolini M., Arenzana-Seisdedos F., Moser B.
Curr. Biol. 7:652-660(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Blood.
[4]"The influence of a STRL33 mutant on the course of HIV-1 infection."
An P., Winkler C., O'Brien S.J.
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-3.
[5]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
+Additional computationally mapped references.

Web resources

Wikipedia

CXC chemokine receptors entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF007545 mRNA. Translation: AAB64221.1.
U73529 mRNA. Translation: AAB61456.1.
U73531 mRNA. Translation: AAB61457.1.
Y13248 mRNA. Translation: CAA73698.1.
AF029759 Genomic DNA. Translation: AAG21918.1.
AY322543 Genomic DNA. Translation: AAP84356.1.
BC033584 mRNA. Translation: AAH33584.1.
CCDSCCDS2735.1.
RefSeqNP_006555.1. NM_006564.1.
XP_005264866.1. XM_005264809.1.
UniGeneHs.34526.

3D structure databases

ProteinModelPortalO00574.
SMRO00574. Positions 29-303.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-6630856.
STRING9606.ENSP00000304414.

Chemistry

ChEMBLCHEMBL5994.
GuidetoPHARMACOLOGY73.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO00574.

Proteomic databases

PaxDbO00574.
PRIDEO00574.

Protocols and materials databases

DNASU10663.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304552; ENSP00000304414; ENSG00000172215.
ENST00000438735; ENSP00000396218; ENSG00000172215.
ENST00000457814; ENSP00000396886; ENSG00000172215.
ENST00000458629; ENSP00000395704; ENSG00000172215.
GeneID10663.
KEGGhsa:10663.
UCSCuc003cpc.1. human.

Organism-specific databases

CTD10663.
GeneCardsGC03P045982.
HGNCHGNC:16647. CXCR6.
HPAHPA047591.
MIM605163. gene.
neXtProtNX_O00574.
PharmGKBPA38409.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG146723.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidO00574.
KOK04191.
OMAARGFQKH.
OrthoDBEOG7VX8W4.
PhylomeDBO00574.
TreeFamTF330966.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressO00574.
BgeeO00574.
CleanExHS_CXCR6.
GenevestigatorO00574.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR002235. Chemokine_CXCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR01105. CXCCHMKINER6.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCXCR6.
GenomeRNAi10663.
NextBio40547.
PROO00574.
SOURCESearch...

Entry information

Entry nameCXCR6_HUMAN
AccessionPrimary (citable) accession number: O00574
Secondary accession number(s): O00575, Q9HCA5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: July 9, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries