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O00574

- CXCR6_HUMAN

UniProt

O00574 - CXCR6_HUMAN

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Protein

C-X-C chemokine receptor type 6

Gene

CXCR6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

GO - Molecular functioni

  1. coreceptor activity Source: ProtInc
  2. C-X-C chemokine receptor activity Source: Ensembl
  3. G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  1. chemotaxis Source: InterPro
  2. G-protein coupled receptor signaling pathway Source: ProtInc
  3. inflammatory response Source: InterPro
  4. viral genome replication Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 6
Short name:
CXC-R6
Short name:
CXCR-6
Alternative name(s):
CDw186
G-protein coupled receptor STRL33
G-protein coupled receptor bonzo
CD_antigen: CD186
Gene namesi
Name:CXCR6
Synonyms:BONZO, STRL33, TYMSTR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:16647. CXCR6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
BLAST
Transmembranei33 – 5927Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini60 – 689CytoplasmicSequence Analysis
Transmembranei69 – 8921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini90 – 10314ExtracellularSequence AnalysisAdd
BLAST
Transmembranei104 – 12522Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini126 – 14318CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei144 – 16421Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini165 – 18723ExtracellularSequence AnalysisAdd
BLAST
Transmembranei188 – 21528Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini216 – 23116CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei232 – 25928Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27516ExtracellularSequence AnalysisAdd
BLAST
Transmembranei276 – 29318Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini294 – 34249CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38409.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342C-X-C chemokine receptor type 6PRO_0000069365Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi102 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO00574.
PRIDEiO00574.

PTM databases

PhosphoSiteiO00574.

Expressioni

Tissue specificityi

Expressed in lymphoid tissues and activated T cells.

Gene expression databases

BgeeiO00574.
CleanExiHS_CXCR6.
ExpressionAtlasiO00574. baseline and differential.
GenevestigatoriO00574.

Organism-specific databases

HPAiHPA047591.

Interactioni

Protein-protein interaction databases

MINTiMINT-6630856.
STRINGi9606.ENSP00000304414.

Structurei

3D structure databases

ProteinModelPortaliO00574.
SMRiO00574. Positions 29-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146723.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO00574.
KOiK04191.
OMAiARGFQKH.
OrthoDBiEOG7VX8W4.
PhylomeDBiO00574.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR002235. Chemokine_CXCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01105. CXCCHMKINER6.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00574-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEHDYHEDY GFSSFNDSSQ EEHQDFLQFS KVFLPCMYLV VFVCGLVGNS
60 70 80 90 100
LVLVISIFYH KLQSLTDVFL VNLPLADLVF VCTLPFWAYA GIHEWVFGQV
110 120 130 140 150
MCKSLLGIYT INFYTSMLIL TCITVDRFIV VVKATKAYNQ QAKRMTWGKV
160 170 180 190 200
TSLLIWVISL LVSLPQIIYG NVFNLDKLIC GYHDEAISTV VLATQMTLGF
210 220 230 240 250
FLPLLTMIVC YSVIIKTLLH AGGFQKHRSL KIIFLVMAVF LLTQMPFNLM
260 270 280 290 300
KFIRSTHWEY YAMTSFHYTI MVTEAIAYLR ACLNPVLYAF VSLKFRKNFW
310 320 330 340
KLVKDIGCLP YLGVSHQWKS SEDNSKTFSA SHNVEATSMF QL
Length:342
Mass (Da):39,280
Last modified:July 1, 1997 - v1
Checksum:i9FBC025556D1082E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31E → K.1 Publication
Corresponds to variant rs2234355 [ dbSNP | Ensembl ].
VAR_024253
Natural varianti25 – 251D → A in STRL33.3. 1 Publication
VAR_003506

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007545 mRNA. Translation: AAB64221.1.
U73529 mRNA. Translation: AAB61456.1.
U73531 mRNA. Translation: AAB61457.1.
Y13248 mRNA. Translation: CAA73698.1.
AF029759 Genomic DNA. Translation: AAG21918.1.
AY322543 Genomic DNA. Translation: AAP84356.1.
BC033584 mRNA. Translation: AAH33584.1.
CCDSiCCDS2735.1.
RefSeqiNP_006555.1. NM_006564.1.
XP_005264866.1. XM_005264809.1.
UniGeneiHs.34526.

Genome annotation databases

EnsembliENST00000304552; ENSP00000304414; ENSG00000172215.
ENST00000438735; ENSP00000396218; ENSG00000172215.
ENST00000457814; ENSP00000396886; ENSG00000172215.
ENST00000458629; ENSP00000395704; ENSG00000172215.
GeneIDi10663.
KEGGihsa:10663.
UCSCiuc003cpc.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CXC chemokine receptors entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007545 mRNA. Translation: AAB64221.1 .
U73529 mRNA. Translation: AAB61456.1 .
U73531 mRNA. Translation: AAB61457.1 .
Y13248 mRNA. Translation: CAA73698.1 .
AF029759 Genomic DNA. Translation: AAG21918.1 .
AY322543 Genomic DNA. Translation: AAP84356.1 .
BC033584 mRNA. Translation: AAH33584.1 .
CCDSi CCDS2735.1.
RefSeqi NP_006555.1. NM_006564.1.
XP_005264866.1. XM_005264809.1.
UniGenei Hs.34526.

3D structure databases

ProteinModelPortali O00574.
SMRi O00574. Positions 29-303.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-6630856.
STRINGi 9606.ENSP00000304414.

Chemistry

ChEMBLi CHEMBL5994.
GuidetoPHARMACOLOGYi 73.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O00574.

Proteomic databases

PaxDbi O00574.
PRIDEi O00574.

Protocols and materials databases

DNASUi 10663.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304552 ; ENSP00000304414 ; ENSG00000172215 .
ENST00000438735 ; ENSP00000396218 ; ENSG00000172215 .
ENST00000457814 ; ENSP00000396886 ; ENSG00000172215 .
ENST00000458629 ; ENSP00000395704 ; ENSG00000172215 .
GeneIDi 10663.
KEGGi hsa:10663.
UCSCi uc003cpc.1. human.

Organism-specific databases

CTDi 10663.
GeneCardsi GC03P045982.
HGNCi HGNC:16647. CXCR6.
HPAi HPA047591.
MIMi 605163. gene.
neXtProti NX_O00574.
PharmGKBi PA38409.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146723.
GeneTreei ENSGT00760000118785.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi O00574.
KOi K04191.
OMAi ARGFQKH.
OrthoDBi EOG7VX8W4.
PhylomeDBi O00574.
TreeFami TF330966.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii CXCR6.
GenomeRNAii 10663.
NextBioi 40547.
PROi O00574.
SOURCEi Search...

Gene expression databases

Bgeei O00574.
CleanExi HS_CXCR6.
ExpressionAtlasi O00574. baseline and differential.
Genevestigatori O00574.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR002235. Chemokine_CXCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00657. CCCHEMOKINER.
PR01105. CXCCHMKINER6.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression cloning of new receptors used by simian and human immunodeficiency viruses."
    Deng H.K., Unutmaz D., Kewalramani V.N., Littman D.R.
    Nature 388:296-300(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1."
    Liao F., Alkhatib G., Peden K.W.C., Sharma G., Berger E.A., Farber J.M.
    J. Exp. Med. 185:2015-2023(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-25.
  3. "TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function."
    Loetscher M., Amara A., Oberlin E., Brass N., Legler D.F., Loetscher P., D'Apuzzo M., Meese E.U., Rousset D., Virelizier J.-L., Baggiolini M., Arenzana-Seisdedos F., Moser B.
    Curr. Biol. 7:652-660(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Blood.
  4. "The influence of a STRL33 mutant on the course of HIV-1 infection."
    An P., Winkler C., O'Brien S.J.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-3.
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.

Entry informationi

Entry nameiCXCR6_HUMAN
AccessioniPrimary (citable) accession number: O00574
Secondary accession number(s): O00575, Q9HCA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: October 29, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3