C-X-C chemokine receptor type 6 - Homo sapiens (Human)

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O00574 (CXCR6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 117. History...

Clusters with 100%, 90%, 50% identity |

Documents (7) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
C-X-C chemokine receptor type 6
Short name=CXC-R6
Short name=CXCR-6

Alternative name(s):
CDw186
G-protein coupled receptor STRL33
G-protein coupled receptor bonzo
CD_antigen=CD186

Gene names

Name:	CXCR6
Synonyms:	BONZO, STRL33, TYMSTR

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in lymphoid tissues and activated T cells.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemokine-mediated signaling pathway Inferred from electronic annotation. Source: GOC chemotaxis Inferred from electronic annotation. Source: InterPro elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: InterPro viral genome replication Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.2. Source: ProtInc
Molecular_function	C-X-C chemokine receptor activity Inferred from electronic annotation. Source: Compara G-protein coupled receptor activity Traceable author statement Ref.2. Source: ProtInc coreceptor activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 342

342

C-X-C chemokine receptor type 6

PRO_0000069365

Regions

Topological domain

1 – 32

Extracellular Potential

Transmembrane

33 – 59

Helical; Name=1; Potential

Topological domain

60 – 68

Cytoplasmic Potential

Transmembrane

69 – 89

Helical; Name=2; Potential

Topological domain

90 – 103

Extracellular Potential

Transmembrane

104 – 125

Helical; Name=3; Potential

Topological domain

126 – 143

Cytoplasmic Potential

Transmembrane

144 – 164

Helical; Name=4; Potential

Topological domain

165 – 187

Extracellular Potential

Transmembrane

188 – 215

Helical; Name=5; Potential

Topological domain

216 – 231

Cytoplasmic Potential

Transmembrane

232 – 259

Helical; Name=6; Potential

Topological domain

260 – 275

Extracellular Potential

Transmembrane

276 – 293

Helical; Name=7; Potential

Topological domain

294 – 342

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

102 ↔ 180

By similarity

Natural variations

Natural variant

E → K. Ref.4
Corresponds to variant rs2234355 [ dbSNP | Ensembl ].

VAR_024253

Natural variant

D → A in STRL33.3. Ref.2

VAR_003506

Sequences

Sequence

Length

Mass (Da)

Tools

O00574 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 9FBC025556D1082E
Show »

FASTA

342

39,280

        10         20         30         40         50         60 
MAEHDYHEDY GFSSFNDSSQ EEHQDFLQFS KVFLPCMYLV VFVCGLVGNS LVLVISIFYH 

        70         80         90        100        110        120 
KLQSLTDVFL VNLPLADLVF VCTLPFWAYA GIHEWVFGQV MCKSLLGIYT INFYTSMLIL 

       130        140        150        160        170        180 
TCITVDRFIV VVKATKAYNQ QAKRMTWGKV TSLLIWVISL LVSLPQIIYG NVFNLDKLIC 

       190        200        210        220        230        240 
GYHDEAISTV VLATQMTLGF FLPLLTMIVC YSVIIKTLLH AGGFQKHRSL KIIFLVMAVF 

       250        260        270        280        290        300 
LLTQMPFNLM KFIRSTHWEY YAMTSFHYTI MVTEAIAYLR ACLNPVLYAF VSLKFRKNFW 

       310        320        330        340 
KLVKDIGCLP YLGVSHQWKS SEDNSKTFSA SHNVEATSMF QL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression cloning of new receptors used by simian and human immunodeficiency viruses." Deng H.K., Unutmaz D., Kewalramani V.N., Littman D.R. Nature 388:296-300(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1." Liao F., Alkhatib G., Peden K.W.C., Sharma G., Berger E.A., Farber J.M. J. Exp. Med. 185:2015-2023(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-25.
[3]	"TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function." Loetscher M., Amara A., Oberlin E., Brass N., Legler D.F., Loetscher P., D'Apuzzo M., Meese E.U., Rousset D., Virelizier J.-L., Baggiolini M., Arenzana-Seisdedos F., Moser B. Curr. Biol. 7:652-660(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Blood.
[4]	"The influence of a STRL33 mutant on the course of HIV-1 infection." An P., Winkler C., O'Brien S.J. Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-3.
[5]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
+	Additional computationally mapped references.

Web resources

Wikipedia

CXC chemokine receptors entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF007545 mRNA. Translation: AAB64221.1. U73529 mRNA. Translation: AAB61456.1. U73531 mRNA. Translation: AAB61457.1. Y13248 mRNA. Translation: CAA73698.1. AF029759 Genomic DNA. Translation: AAG21918.1. AY322543 Genomic DNA. Translation: AAP84356.1. BC033584 mRNA. Translation: AAH33584.1.
IPI	IPI00012166.
RefSeq	NP_006555.1. NM_006564.1.
UniGene	Hs.34526.
3D structure databases
ProteinModelPortal	O00574.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000304414.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O00574.
Proteomic databases
PaxDb	O00574.
PRIDE	O00574.
Protocols and materials databases
DNASU	10663.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000304552; ENSP00000304414; ENSG00000172215. ENST00000438735; ENSP00000396218; ENSG00000172215. ENST00000457814; ENSP00000396886; ENSG00000172215. ENST00000458629; ENSP00000395704; ENSG00000172215.
GeneID	10663.
KEGG	hsa:10663.
UCSC	uc003cpc.1. human.
Organism-specific databases
CTD	10663.
GeneCards	GC03P045982.
HGNC	HGNC:16647. CXCR6.
HPA	HPA047591.
MIM	605163. gene.
neXtProt	NX_O00574.
PharmGKB	PA38409.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG146723.
HOGENOM	HOG000234122.
HOVERGEN	HBG106917.
InParanoid	O00574.
KO	K04191.
OMA	ARGFQKH.
OrthoDB	EOG4NKBW1.
PhylomeDB	O00574.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	O00574.
Bgee	O00574.
CleanEx	HS_CXCR6.
Genevestigator	O00574.
GermOnline	ENSG00000172215. Homo sapiens.
Family and domain databases
InterPro	IPR002235. Chemokine_CXCR6. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR01105. CXCCHMKINER6. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL5994.
GenomeRNAi	10663.
NextBio	40547.
SOURCE	Search...

Entry information

Entry name

CXCR6_HUMAN

Accession

Primary (citable) accession number: O00574
Secondary accession number(s): O00575, Q9HCA5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 1, 1997
Last modified:	May 1, 2013
This is version 117 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.