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Protein

C-X-C chemokine receptor type 6

Gene

CXCR6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

GO - Molecular functioni

  • coreceptor activity Source: ProtInc
  • C-X-C chemokine receptor activity Source: Ensembl
  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  • chemotaxis Source: InterPro
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • inflammatory response Source: InterPro
  • viral genome replication Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 6
Short name:
CXC-R6
Short name:
CXCR-6
Alternative name(s):
CDw186
G-protein coupled receptor STRL33
G-protein coupled receptor bonzo
CD_antigen: CD186
Gene namesi
Name:CXCR6
Synonyms:BONZO, STRL33, TYMSTR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:16647. CXCR6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 59Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini60 – 68CytoplasmicSequence analysis9
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini90 – 103ExtracellularSequence analysisAdd BLAST14
Transmembranei104 – 125Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini126 – 143CytoplasmicSequence analysisAdd BLAST18
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 187ExtracellularSequence analysisAdd BLAST23
Transmembranei188 – 215Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini216 – 231CytoplasmicSequence analysisAdd BLAST16
Transmembranei232 – 259Helical; Name=6Sequence analysisAdd BLAST28
Topological domaini260 – 275ExtracellularSequence analysisAdd BLAST16
Transmembranei276 – 293Helical; Name=7Sequence analysisAdd BLAST18
Topological domaini294 – 342CytoplasmicSequence analysisAdd BLAST49

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10663.
OpenTargetsiENSG00000172215.
PharmGKBiPA38409.

Chemistry databases

ChEMBLiCHEMBL5994.
GuidetoPHARMACOLOGYi73.

Polymorphism and mutation databases

BioMutaiCXCR6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693651 – 342C-X-C chemokine receptor type 6Add BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi16N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi102 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO00574.
PRIDEiO00574.

PTM databases

iPTMnetiO00574.
PhosphoSitePlusiO00574.

Expressioni

Tissue specificityi

Expressed in lymphoid tissues and activated T cells.

Gene expression databases

BgeeiENSG00000172215.
CleanExiHS_CXCR6.
ExpressionAtlasiO00574. baseline and differential.
GenevisibleiO00574. HS.

Organism-specific databases

HPAiHPA047591.

Interactioni

Protein-protein interaction databases

MINTiMINT-6630856.
STRINGi9606.ENSP00000304414.

Structurei

3D structure databases

ProteinModelPortaliO00574.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO00574.
KOiK04191.
OMAiTPFNLVK.
OrthoDBiEOG091G0D3V.
PhylomeDBiO00574.
TreeFamiTF330966.

Family and domain databases

InterProiIPR002235. Chemokine_CXCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01105. CXCCHMKINER6.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00574-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEHDYHEDY GFSSFNDSSQ EEHQDFLQFS KVFLPCMYLV VFVCGLVGNS
60 70 80 90 100
LVLVISIFYH KLQSLTDVFL VNLPLADLVF VCTLPFWAYA GIHEWVFGQV
110 120 130 140 150
MCKSLLGIYT INFYTSMLIL TCITVDRFIV VVKATKAYNQ QAKRMTWGKV
160 170 180 190 200
TSLLIWVISL LVSLPQIIYG NVFNLDKLIC GYHDEAISTV VLATQMTLGF
210 220 230 240 250
FLPLLTMIVC YSVIIKTLLH AGGFQKHRSL KIIFLVMAVF LLTQMPFNLM
260 270 280 290 300
KFIRSTHWEY YAMTSFHYTI MVTEAIAYLR ACLNPVLYAF VSLKFRKNFW
310 320 330 340
KLVKDIGCLP YLGVSHQWKS SEDNSKTFSA SHNVEATSMF QL
Length:342
Mass (Da):39,280
Last modified:July 1, 1997 - v1
Checksum:i9FBC025556D1082E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0242533E → K.1 PublicationCorresponds to variant rs2234355dbSNPEnsembl.1
Natural variantiVAR_00350625D → A in STRL33.3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007545 mRNA. Translation: AAB64221.1.
U73529 mRNA. Translation: AAB61456.1.
U73531 mRNA. Translation: AAB61457.1.
Y13248 mRNA. Translation: CAA73698.1.
AF029759 Genomic DNA. Translation: AAG21918.1.
AY322543 Genomic DNA. Translation: AAP84356.1.
BC033584 mRNA. Translation: AAH33584.1.
CCDSiCCDS2735.1.
RefSeqiNP_006555.1. NM_006564.1.
XP_005264866.1. XM_005264809.2.
XP_011531592.1. XM_011533290.2.
XP_011531593.1. XM_011533291.2.
UniGeneiHs.34526.
Hs.737579.

Genome annotation databases

EnsembliENST00000304552; ENSP00000304414; ENSG00000172215.
ENST00000438735; ENSP00000396218; ENSG00000172215.
ENST00000457814; ENSP00000396886; ENSG00000172215.
ENST00000458629; ENSP00000395704; ENSG00000172215.
GeneIDi10663.
KEGGihsa:10663.
UCSCiuc003cpc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CXC chemokine receptors entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007545 mRNA. Translation: AAB64221.1.
U73529 mRNA. Translation: AAB61456.1.
U73531 mRNA. Translation: AAB61457.1.
Y13248 mRNA. Translation: CAA73698.1.
AF029759 Genomic DNA. Translation: AAG21918.1.
AY322543 Genomic DNA. Translation: AAP84356.1.
BC033584 mRNA. Translation: AAH33584.1.
CCDSiCCDS2735.1.
RefSeqiNP_006555.1. NM_006564.1.
XP_005264866.1. XM_005264809.2.
XP_011531592.1. XM_011533290.2.
XP_011531593.1. XM_011533291.2.
UniGeneiHs.34526.
Hs.737579.

3D structure databases

ProteinModelPortaliO00574.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-6630856.
STRINGi9606.ENSP00000304414.

Chemistry databases

ChEMBLiCHEMBL5994.
GuidetoPHARMACOLOGYi73.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO00574.
PhosphoSitePlusiO00574.

Polymorphism and mutation databases

BioMutaiCXCR6.

Proteomic databases

PaxDbiO00574.
PRIDEiO00574.

Protocols and materials databases

DNASUi10663.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304552; ENSP00000304414; ENSG00000172215.
ENST00000438735; ENSP00000396218; ENSG00000172215.
ENST00000457814; ENSP00000396886; ENSG00000172215.
ENST00000458629; ENSP00000395704; ENSG00000172215.
GeneIDi10663.
KEGGihsa:10663.
UCSCiuc003cpc.2. human.

Organism-specific databases

CTDi10663.
DisGeNETi10663.
GeneCardsiCXCR6.
HGNCiHGNC:16647. CXCR6.
HPAiHPA047591.
MIMi605163. gene.
neXtProtiNX_O00574.
OpenTargetsiENSG00000172215.
PharmGKBiPA38409.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO00574.
KOiK04191.
OMAiTPFNLVK.
OrthoDBiEOG091G0D3V.
PhylomeDBiO00574.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiCXCR6.
GenomeRNAii10663.
PROiO00574.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172215.
CleanExiHS_CXCR6.
ExpressionAtlasiO00574. baseline and differential.
GenevisibleiO00574. HS.

Family and domain databases

InterProiIPR002235. Chemokine_CXCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01105. CXCCHMKINER6.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXCR6_HUMAN
AccessioniPrimary (citable) accession number: O00574
Secondary accession number(s): O00575, Q9HCA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: November 2, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.