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Protein

Transcription factor SOX-1

Gene

SOX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi51 – 119HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-1
Gene namesi
Name:SOX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000182968.4.
HGNCiHGNC:11189. SOX1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6656.
OpenTargetsiENSG00000182968.
PharmGKBiPA36026.

Polymorphism and mutation databases

BioMutaiSOX1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487121 – 391Transcription factor SOX-1Add BLAST391

Proteomic databases

MaxQBiO00570.
PaxDbiO00570.
PeptideAtlasiO00570.
PRIDEiO00570.

PTM databases

iPTMnetiO00570.
PhosphoSitePlusiO00570.

Expressioni

Tissue specificityi

Mainly expressed in the developing central nervous system.

Gene expression databases

BgeeiENSG00000182968.
CleanExiHS_SOX1.
GenevisibleiO00570. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
STAT3P407632EBI-2935583,EBI-518675

Protein-protein interaction databases

BioGridi112539. 2 interactors.
IntActiO00570. 1 interactor.
STRINGi9606.ENSP00000330218.

Structurei

3D structure databases

ProteinModelPortaliO00570.
SMRiO00570.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi27 – 43Poly-GlyAdd BLAST17
Compositional biasi145 – 150Poly-Gly6
Compositional biasi197 – 204Poly-Ala8
Compositional biasi280 – 288Poly-Ala9
Compositional biasi296 – 306Poly-AlaAdd BLAST11
Compositional biasi357 – 364Poly-Ala8

Phylogenomic databases

eggNOGiENOG410IPZ0. Eukaryota.
ENOG41102MY. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231647.
HOVERGENiHBG105663.
InParanoidiO00570.
KOiK09267.
OMAiHSRGPCP.
OrthoDBiEOG091G0F15.
PhylomeDBiO00570.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiView protein in InterPro
IPR009071. HMG_box_dom.
IPR031268. SOX-1.
IPR022097. SOX_fam.
PANTHERiPTHR10270:SF250. PTHR10270:SF250. 1 hit.
PfamiView protein in Pfam
PF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O00570-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSMMMETDL HSPGGAQAPT NLSGPAGAGG GGGGGGGGGG GGGAKANQDR
60 70 80 90 100
VKRPMNAFMV WSRGQRRKMA QENPKMHNSE ISKRLGAEWK VMSEAEKRPF
110 120 130 140 150
IDEAKRLRAL HMKEHPDYKY RPRRKTKTLL KKDKYSLAGG LLAAGAGGGG
160 170 180 190 200
AAVAMGVGVG VGAAAVGQRL ESPGGAAGGG YAHVNGWANG AYPGSVAAAA
210 220 230 240 250
AAAAMMQEAQ LAYGQHPGAG GAHPHAHPAH PHPHHPHAHP HNPQPMHRYD
260 270 280 290 300
MGALQYSPIS NSQGYMSASP SGYGGLPYGA AAAAAAAAGG AHQNSAVAAA
310 320 330 340 350
AAAAAASSGA LGALGSLVKS EPSGSPPAPA HSRAPCPGDL REMISMYLPA
360 370 380 390
GEGGDPAAAA AAAAQSRLHS LPQHYQGAGA GVNGTVPLTH I
Length:391
Mass (Da):39,023
Last modified:September 23, 2008 - v2
Checksum:iDD519BA97CF5E052
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165A → P in CAA73847 (PubMed:9337405).Curated1
Sequence conflicti180G → A in CAA73847 (PubMed:9337405).Curated1
Sequence conflicti226 – 227AH → RT in CAA73847 (PubMed:9337405).Curated2
Sequence conflicti287 – 290Missing in CAA73847 (PubMed:9337405).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13436 Genomic DNA. Translation: CAA73847.1.
AL138691 Genomic DNA. No translation available.
CH471085 Genomic DNA. Translation: EAX09158.1.
CCDSiCCDS9523.1.
RefSeqiNP_005977.2. NM_005986.2.
UniGeneiHs.202526.

Genome annotation databases

EnsembliENST00000330949; ENSP00000330218; ENSG00000182968.
GeneIDi6656.
KEGGihsa:6656.
UCSCiuc001vsb.2. human.

Similar proteinsi

Entry informationi

Entry nameiSOX1_HUMAN
AccessioniPrimary (citable) accession number: O00570
Secondary accession number(s): Q5W0Q1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 23, 2008
Last modified: September 27, 2017
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot