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Protein

Transcription factor SOX-1

Gene

SOX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi51 – 11969HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • core promoter sequence-specific DNA binding Source: UniProtKB
  • DNA binding Source: UniProtKB
  • sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-1
Gene namesi
Name:SOX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:11189. SOX1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36026.

Polymorphism and mutation databases

BioMutaiSOX1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Transcription factor SOX-1PRO_0000048712Add
BLAST

Proteomic databases

PaxDbiO00570.
PRIDEiO00570.

PTM databases

PhosphoSiteiO00570.

Expressioni

Tissue specificityi

Mainly expressed in the developing central nervous system.

Gene expression databases

BgeeiO00570.
CleanExiHS_SOX1.
GenevisibleiO00570. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
STAT3P407632EBI-2935583,EBI-518675

Protein-protein interaction databases

BioGridi112539. 1 interaction.
IntActiO00570. 1 interaction.
STRINGi9606.ENSP00000330218.

Structurei

3D structure databases

ProteinModelPortaliO00570.
SMRiO00570. Positions 49-127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 4317Poly-GlyAdd
BLAST
Compositional biasi145 – 1506Poly-Gly
Compositional biasi197 – 2048Poly-Ala
Compositional biasi280 – 2889Poly-Ala
Compositional biasi296 – 30611Poly-AlaAdd
BLAST
Compositional biasi357 – 3648Poly-Ala

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG321816.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231647.
HOVERGENiHBG105663.
InParanoidiO00570.
KOiK09267.
OMAiLHSPGPQ.
OrthoDBiEOG7TMZVP.
PhylomeDBiO00570.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR022097. TF_SOX.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00570-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSMMMETDL HSPGGAQAPT NLSGPAGAGG GGGGGGGGGG GGGAKANQDR
60 70 80 90 100
VKRPMNAFMV WSRGQRRKMA QENPKMHNSE ISKRLGAEWK VMSEAEKRPF
110 120 130 140 150
IDEAKRLRAL HMKEHPDYKY RPRRKTKTLL KKDKYSLAGG LLAAGAGGGG
160 170 180 190 200
AAVAMGVGVG VGAAAVGQRL ESPGGAAGGG YAHVNGWANG AYPGSVAAAA
210 220 230 240 250
AAAAMMQEAQ LAYGQHPGAG GAHPHAHPAH PHPHHPHAHP HNPQPMHRYD
260 270 280 290 300
MGALQYSPIS NSQGYMSASP SGYGGLPYGA AAAAAAAAGG AHQNSAVAAA
310 320 330 340 350
AAAAAASSGA LGALGSLVKS EPSGSPPAPA HSRAPCPGDL REMISMYLPA
360 370 380 390
GEGGDPAAAA AAAAQSRLHS LPQHYQGAGA GVNGTVPLTH I
Length:391
Mass (Da):39,023
Last modified:September 23, 2008 - v2
Checksum:iDD519BA97CF5E052
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti165 – 1651A → P in CAA73847 (PubMed:9337405).Curated
Sequence conflicti180 – 1801G → A in CAA73847 (PubMed:9337405).Curated
Sequence conflicti226 – 2272AH → RT in CAA73847 (PubMed:9337405).Curated
Sequence conflicti287 – 2904Missing in CAA73847 (PubMed:9337405).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13436 Genomic DNA. Translation: CAA73847.1.
AL138691 Genomic DNA. Translation: CAH72340.1.
CH471085 Genomic DNA. Translation: EAX09158.1.
CCDSiCCDS9523.1.
RefSeqiNP_005977.2. NM_005986.2.
UniGeneiHs.202526.

Genome annotation databases

EnsembliENST00000330949; ENSP00000330218; ENSG00000182968.
GeneIDi6656.
KEGGihsa:6656.
UCSCiuc001vsb.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13436 Genomic DNA. Translation: CAA73847.1.
AL138691 Genomic DNA. Translation: CAH72340.1.
CH471085 Genomic DNA. Translation: EAX09158.1.
CCDSiCCDS9523.1.
RefSeqiNP_005977.2. NM_005986.2.
UniGeneiHs.202526.

3D structure databases

ProteinModelPortaliO00570.
SMRiO00570. Positions 49-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112539. 1 interaction.
IntActiO00570. 1 interaction.
STRINGi9606.ENSP00000330218.

PTM databases

PhosphoSiteiO00570.

Polymorphism and mutation databases

BioMutaiSOX1.

Proteomic databases

PaxDbiO00570.
PRIDEiO00570.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330949; ENSP00000330218; ENSG00000182968.
GeneIDi6656.
KEGGihsa:6656.
UCSCiuc001vsb.1. human.

Organism-specific databases

CTDi6656.
GeneCardsiGC13P112721.
HGNCiHGNC:11189. SOX1.
MIMi602148. gene.
neXtProtiNX_O00570.
PharmGKBiPA36026.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG321816.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231647.
HOVERGENiHBG105663.
InParanoidiO00570.
KOiK09267.
OMAiLHSPGPQ.
OrthoDBiEOG7TMZVP.
PhylomeDBiO00570.
TreeFamiTF351735.

Miscellaneous databases

GenomeRNAii6656.
NextBioi25947.
PROiO00570.
SOURCEiSearch...

Gene expression databases

BgeeiO00570.
CleanExiHS_SOX1.
GenevisibleiO00570. HS.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR022097. TF_SOX.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and mapping of the human SOX1: a highly conserved gene expressed in the developing brain."
    Malas S., Duthie S.M., Mohri F., Lovell-Badge R., Episkopou V.
    Mamm. Genome 8:866-868(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSOX1_HUMAN
AccessioniPrimary (citable) accession number: O00570
Secondary accession number(s): Q5W0Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 23, 2008
Last modified: June 24, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.