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O00567

- NOP56_HUMAN

UniProt

O00567 - NOP56_HUMAN

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Protein

Nucleolar protein 56

Gene

NOP56

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs.2 Publications

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. RNA binding Source: ProtInc
  3. snoRNA binding Source: BHF-UCL

GO - Biological processi

  1. cell death Source: UniProtKB-KW
  2. rRNA processing Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis

Enzyme and pathway databases

ReactomeiREACT_16907. Association of TriC/CCT with target proteins during biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 56
Alternative name(s):
Nucleolar protein 5A
Gene namesi
Name:NOP56
Synonyms:NOL5A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15911. NOP56.

Subcellular locationi

Nucleusnucleolus. Cytoplasm By similarity. Nucleusnucleoplasm Curated

GO - Cellular componenti

  1. box C/D snoRNP complex Source: BHF-UCL
  2. cytoplasm Source: UniProtKB-KW
  3. membrane Source: UniProtKB
  4. nucleolus Source: HPA
  5. pre-snoRNP complex Source: BHF-UCL
  6. small nucleolar ribonucleoprotein complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Spinocerebellar ataxia 36 (SCA36) [MIM:614153]: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA36 is characterized by complicated clinical features, with ataxia as the first symptom, followed by characteristic late-onset involvement of the motor neuron system. Ataxic symptoms, such as gait and truncal instability, ataxic dysarthria, and uncoordinated limbs, start in late forties to fifties. Characteristically, affected individuals exhibit tongue atrophy with fasciculation. Progression of motor neuron involvement is typically limited to the tongue and main proximal skeletal muscles in both upper and lower extremities.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry. Caused by large hexanucleotide CGCCTG repeat expansions within intron 1. These expansions induce RNA foci and sequester the RNA-binding protein SRSF2. In addition, the transcription of MIR1292, a microRNA gene located just 19 bp 3' of the GGCCTG repeat, is significantly decreased.

Keywords - Diseasei

Neurodegeneration, Spinocerebellar ataxia

Organism-specific databases

MIMi614153. phenotype.
Orphaneti276198. Spinocerebellar ataxia type 36.
PharmGKBiPA164724063.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594Nucleolar protein 56PRO_0000219025Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei314 – 3141Phosphoserine1 Publication
Modified residuei467 – 4671PhosphoserineBy similarity
Modified residuei468 – 4681PhosphothreonineBy similarity
Modified residuei511 – 5111Phosphoserine1 Publication
Modified residuei519 – 5191Phosphoserine2 Publications
Modified residuei520 – 5201Phosphoserine3 Publications
Modified residuei561 – 5611N6-acetyllysineBy similarity
Modified residuei563 – 5631PhosphoserineBy similarity
Modified residuei569 – 5691Phosphoserine1 Publication
Modified residuei570 – 5701Phosphoserine3 Publications
Modified residuei579 – 5791Phosphoserine1 Publication
Modified residuei581 – 5811Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO00567.
PaxDbiO00567.
PRIDEiO00567.

2D gel databases

SWISS-2DPAGEO00567.

PTM databases

PhosphoSiteiO00567.

Expressioni

Gene expression databases

BgeeiO00567.
ExpressionAtlasiO00567. baseline and differential.
GenevestigatoriO00567.

Organism-specific databases

HPAiHPA049918.

Interactioni

Subunit structurei

Part of a large pre-ribosomal ribonucleoprotein (RNP) complex, that consists of at least 62 ribosomal proteins, 45 nonribosomal proteins and both pre-rRNA and mature rRNA species. Within this complex directly interacts with TCOF1 in an RNA-independent manner. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles; the core proteins NHP2L1, NOP56, NOP58 and FBL assemble stepwise onto the snoRNA. Interacts NOP1 and NOP58. Interacts with NUFIP1, RUVBL1 and RUVBL2; RUVBL1:RUVBL2 seem to bridge the association of NOP56 with NUFIP1.3 Publications

Protein-protein interaction databases

BioGridi115783. 126 interactions.
IntActiO00567. 18 interactions.
MINTiMINT-2997885.
STRINGi9606.ENSP00000370589.

Structurei

3D structure databases

ProteinModelPortaliO00567.
SMRiO00567. Positions 148-405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini292 – 410119NopPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi438 – 589152Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the NOP5/NOP56 family.Curated
Contains 1 Nop domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1498.
GeneTreeiENSGT00550000075068.
HOGENOMiHOG000196309.
InParanoidiO00567.
KOiK14564.
OMAiRIDCFMD.
OrthoDBiEOG7T7GT0.
PhylomeDBiO00567.
TreeFamiTF105713.

Family and domain databases

InterProiIPR012974. NOP5_N.
IPR002687. Nop_dom.
IPR012976. NOSIC.
[Graphical view]
PfamiPF01798. Nop. 1 hit.
PF08156. NOP5NT. 1 hit.
PF08060. NOSIC. 1 hit.
[Graphical view]
SMARTiSM00931. NOSIC. 1 hit.
[Graphical view]
PROSITEiPS51358. NOP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00567-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLLHVLFEH AVGYALLALK EVEEISLLQP QVEESVLNLG KFHSIVRLVA
60 70 80 90 100
FCPFASSQVA LENANAVSEG VVHEDLRLLL ETHLPSKKKK VLLGVGDPKI
110 120 130 140 150
GAAIQEELGY NCQTGGVIAE ILRGVRLHFH NLVKGLTDLS ACKAQLGLGH
160 170 180 190 200
SYSRAKVKFN VNRVDNMIIQ SISLLDQLDK DINTFSMRVR EWYGYHFPEL
210 220 230 240 250
VKIINDNATY CRLAQFIGNR RELNEDKLEK LEELTMDGAK AKAILDASRS
260 270 280 290 300
SMGMDISAID LINIESFSSR VVSLSEYRQS LHTYLRSKMS QVAPSLSALI
310 320 330 340 350
GEAVGARLIA HAGSLTNLAK YPASTVQILG AEKALFRALK TRGNTPKYGL
360 370 380 390 400
IFHSTFIGRA AAKNKGRISR YLANKCSIAS RIDCFSEVPT SVFGEKLREQ
410 420 430 440 450
VEERLSFYET GEIPRKNLDV MKEAMVQAEE AAAEITRKLE KQEKKRLKKE
460 470 480 490 500
KKRLAALALA SSENSSSTPE ECEEMSEKPK KKKKQKPQEV PQENGMEDPS
510 520 530 540 550
ISFSKPKKKK SFSKEELMSS DLEETAGSTS IPKRKKSTPK EETVNDPEEA
560 570 580 590
GHRSGSKKKR KFSKEEPVSS GPEEAVGKSS SKKKKKFHKA SQED
Length:594
Mass (Da):66,050
Last modified:October 31, 2006 - v4
Checksum:i17D81E25DEBD052F
GO

Sequence cautioni

The sequence CAA72789.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171L → V in CAA72789. (PubMed:9372940)Curated
Sequence conflicti427 – 4271Q → QAE in CAA72789. (PubMed:9372940)Curated
Sequence conflicti555 – 5551G → R in CAA72789. (PubMed:9372940)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti121 – 1211I → V.
Corresponds to variant rs2273137 [ dbSNP | Ensembl ].
VAR_028793
Natural varianti475 – 4751M → T.1 Publication
Corresponds to variant rs6753 [ dbSNP | Ensembl ].
VAR_028794
Natural varianti576 – 5761V → A.
Corresponds to variant rs5856 [ dbSNP | Ensembl ].
VAR_014471

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y12065 mRNA. Translation: CAA72789.1. Different initiation.
AL049712 Genomic DNA. Translation: CAC01444.2.
BC104791 mRNA. Translation: AAI04792.1.
BC104793 mRNA. Translation: AAI04794.1.
CCDSiCCDS13030.1.
RefSeqiNP_006383.2. NM_006392.3.
UniGeneiHs.376064.

Genome annotation databases

EnsembliENST00000329276; ENSP00000370589; ENSG00000101361.
GeneIDi10528.
KEGGihsa:10528.
UCSCiuc002wgh.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y12065 mRNA. Translation: CAA72789.1 . Different initiation.
AL049712 Genomic DNA. Translation: CAC01444.2 .
BC104791 mRNA. Translation: AAI04792.1 .
BC104793 mRNA. Translation: AAI04794.1 .
CCDSi CCDS13030.1.
RefSeqi NP_006383.2. NM_006392.3.
UniGenei Hs.376064.

3D structure databases

ProteinModelPortali O00567.
SMRi O00567. Positions 148-405.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115783. 126 interactions.
IntActi O00567. 18 interactions.
MINTi MINT-2997885.
STRINGi 9606.ENSP00000370589.

PTM databases

PhosphoSitei O00567.

2D gel databases

SWISS-2DPAGE O00567.

Proteomic databases

MaxQBi O00567.
PaxDbi O00567.
PRIDEi O00567.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329276 ; ENSP00000370589 ; ENSG00000101361 .
GeneIDi 10528.
KEGGi hsa:10528.
UCSCi uc002wgh.3. human.

Organism-specific databases

CTDi 10528.
GeneCardsi GC20P002736.
HGNCi HGNC:15911. NOP56.
HPAi HPA049918.
MIMi 614153. phenotype.
614154. gene.
neXtProti NX_O00567.
Orphaneti 276198. Spinocerebellar ataxia type 36.
PharmGKBi PA164724063.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1498.
GeneTreei ENSGT00550000075068.
HOGENOMi HOG000196309.
InParanoidi O00567.
KOi K14564.
OMAi RIDCFMD.
OrthoDBi EOG7T7GT0.
PhylomeDBi O00567.
TreeFami TF105713.

Enzyme and pathway databases

Reactomei REACT_16907. Association of TriC/CCT with target proteins during biosynthesis.

Miscellaneous databases

ChiTaRSi NOP56. human.
GeneWikii NOL5A.
GenomeRNAii 10528.
NextBioi 39942.
PROi O00567.
SOURCEi Search...

Gene expression databases

Bgeei O00567.
ExpressionAtlasi O00567. baseline and differential.
Genevestigatori O00567.

Family and domain databases

InterProi IPR012974. NOP5_N.
IPR002687. Nop_dom.
IPR012976. NOSIC.
[Graphical view ]
Pfami PF01798. Nop. 1 hit.
PF08156. NOP5NT. 1 hit.
PF08060. NOSIC. 1 hit.
[Graphical view ]
SMARTi SM00931. NOSIC. 1 hit.
[Graphical view ]
PROSITEi PS51358. NOP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis."
    Gautier T., Berges T., Tollervey D., Hurt E.
    Mol. Cell. Biol. 17:7088-7098(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-475.
    Tissue: Cervix carcinoma.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Bienvenut W.V.
    Submitted (AUG-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 21-41; 78-87; 91-99; 127-134; 191-202; 213-220; 231-240; 271-278; 289-333; 348-359; 405-415; 423-437 AND 541-553, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Cervix carcinoma.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP."
    Watkins N.J., Dickmanns A., Luhrmann R.
    Mol. Cell. Biol. 22:8342-8352(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: ASSOCIATION WITH U14 BOX C/D SNORNA.
  7. "Proteomic analysis of human Nop56p-associated pre-ribosomal ribonucleoprotein complexes. Possible link between Nop56p and the nucleolar protein treacle responsible for Treacher Collins syndrome."
    Hayano T., Yanagida M., Yamauchi Y., Shinkawa T., Isobe T., Takahashi N.
    J. Biol. Chem. 278:34309-34319(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN A PRE-RIBOSOMAL RNP COMPLEX, INTERACTION WITH TCOF1, IDENTIFICATION BY MASS SPECTROMETRY.
  8. "Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex."
    Watkins N.J., Lemm I., Ingelfinger D., Schneider C., Hossbach M., Urlaub H., Luehrmann R.
    Mol. Cell 16:789-798(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN BOX C/D SNORNA BIOGENESIS, ASSOCIATION WITH U3 BOX C/D SNORNA.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line."
    Giorgianni F., Zhao Y., Desiderio D.M., Beranova-Giorgianni S.
    Electrophoresis 28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Prostate cancer.
  11. "A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly."
    McKeegan K.S., Debieux C.M., Boulon S., Bertrand E., Watkins N.J.
    Mol. Cell. Biol. 27:6782-6793(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: ASSOCIATION WITH U8 BOX C/D SNORNA, INTERACTION WITH NUFIP1.
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-511; SER-519; SER-520; SER-570; SER-579 AND SER-581, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Evidence that the AAA+ proteins TIP48 and TIP49 bridge interactions between 15.5K and the related NOP56 and NOP58 proteins during box C/D snoRNP biogenesis."
    McKeegan K.S., Debieux C.M., Watkins N.J.
    Mol. Cell. Biol. 29:4971-4981(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RUVBL1 AND RUVBL2.
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-519; SER-520; SER-569 AND SER-570, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-520, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. "Expansion of intronic GGCCTG hexanucleotide repeat in NOP56 causes SCA36, a type of spinocerebellar ataxia accompanied by motor neuron involvement."
    Kobayashi H., Abe K., Matsuura T., Ikeda Y., Hitomi T., Akechi Y., Habu T., Liu W., Okuda H., Koizumi A.
    Am. J. Hum. Genet. 89:121-130(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SCA36.
  19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-314 AND SER-570, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNOP56_HUMAN
AccessioniPrimary (citable) accession number: O00567
Secondary accession number(s): Q2M3T6, Q9NQ05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 31, 2006
Last modified: October 29, 2014
This is version 143 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3