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Protein

U3 small nucleolar ribonucleoprotein protein MPP10

Gene

MPHOSPH10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • maturation of SSU-rRNA Source: GO_Central
  • negative regulation of phosphatase activity Source: UniProtKB
  • RNA processing Source: UniProtKB
  • RNA splicing Source: UniProtKB
  • RNA splicing, via transesterification reactions Source: UniProtKB
  • rRNA processing Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124383-MONOMER.
ReactomeiR-HSA-6790901. rRNA modification in the nucleus and cytosol.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar ribonucleoprotein protein MPP10
Alternative name(s):
M phase phosphoprotein 10
Gene namesi
Name:MPHOSPH10
Synonyms:MPP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:7213. MPHOSPH10.

Subcellular locationi

GO - Cellular componenti

  • chromosome Source: UniProtKB-SubCell
  • Mpp10 complex Source: GO_Central
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: Reactome
  • small nucleolar ribonucleoprotein complex Source: UniProtKB
  • small-subunit processome Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10199.
OpenTargetsiENSG00000124383.
PharmGKBiPA30919.

Polymorphism and mutation databases

BioMutaiMPHOSPH10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001215351 – 681U3 small nucleolar ribonucleoprotein protein MPP10Add BLAST681

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61PhosphoserineSequence analysis1
Modified residuei120PhosphoserineCombined sources1
Modified residuei139PhosphoserineCombined sources1
Modified residuei163PhosphoserineCombined sources1
Modified residuei167PhosphoserineCombined sources1
Modified residuei171PhosphoserineCombined sources1
Modified residuei242PhosphoserineCombined sources1
Modified residuei275PhosphoserineCombined sources1
Modified residuei289PhosphoserineCombined sources1
Cross-linki382Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei609N6-acetyllysineCombined sources1
Cross-linki632Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Phosphorylated in M (mitotic) phase.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO00566.
MaxQBiO00566.
PaxDbiO00566.
PeptideAtlasiO00566.
PRIDEiO00566.

2D gel databases

SWISS-2DPAGEO00566.

PTM databases

iPTMnetiO00566.
PhosphoSitePlusiO00566.
SwissPalmiO00566.

Miscellaneous databases

PMAP-CutDBO00566.

Expressioni

Gene expression databases

BgeeiENSG00000124383.
CleanExiHS_MPHOSPH10.
ExpressionAtlasiO00566. baseline and differential.
GenevisibleiO00566. HS.

Organism-specific databases

HPAiHPA035059.
HPA035060.
HPA049907.

Interactioni

Subunit structurei

Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with IMP3 and IMP4.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CAP621362EBI-5235884,EBI-357253

Protein-protein interaction databases

BioGridi115494. 47 interactors.
IntActiO00566. 4 interactors.
MINTiMINT-1192399.
STRINGi9606.ENSP00000244230.

Structurei

3D structure databases

ProteinModelPortaliO00566.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili109 – 138Sequence analysisAdd BLAST30
Coiled coili205 – 239Sequence analysisAdd BLAST35
Coiled coili284 – 324Sequence analysisAdd BLAST41
Coiled coili348 – 382Sequence analysisAdd BLAST35
Coiled coili469 – 490Sequence analysisAdd BLAST22
Coiled coili574 – 604Sequence analysisAdd BLAST31
Coiled coili648 – 670Sequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi134 – 137Poly-Glu4
Compositional biasi229 – 232Poly-Glu4
Compositional biasi666 – 670Poly-Lys5

Sequence similaritiesi

Belongs to the MPP10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2600. Eukaryota.
COG5384. LUCA.
GeneTreeiENSGT00390000011359.
HOGENOMiHOG000046317.
HOVERGENiHBG052502.
InParanoidiO00566.
KOiK14559.
OMAiFFDLAAF.
OrthoDBiEOG091G09Q2.
PhylomeDBiO00566.
TreeFamiTF105794.

Family and domain databases

InterProiIPR012173. snoRNP_Mpp10.
[Graphical view]
PANTHERiPTHR17039. PTHR17039. 1 hit.
PfamiPF04006. Mpp10. 1 hit.
[Graphical view]
PIRSFiPIRSF017300. snoRNP_Mpp10. 1 hit.

Sequencei

Sequence statusi: Complete.

O00566-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPQVWRRRT LERCLTEVGK ATGRPECFLT IQEGLASKFT SLTKVLYDFN
60 70 80 90 100
KILENGRIHG SPLQKLVIEN FDDEQIWQQL ELQNEPILQY FQNAVSETIN
110 120 130 140 150
DEDISLLPES EEQEREEDGS EIEADDKEDL EDLEEEEVSD MGNDDPEMGE
160 170 180 190 200
RAENSSKSDL RKSPVFSDED SDLDFDISKL EQQSKVQNKG QGKPREKSIV
210 220 230 240 250
DDKFFKLSEM EAYLENIEKE EERKDDNDEE EEDIDFFEDI DSDEDEGGLF
260 270 280 290 300
GSKKLKSGKS SRNLKYKDFF DPVESDEDIT NVHDDELDSN KEDDEIAEEE
310 320 330 340 350
AEELSISETD EDDDLQENED NKQHKESLKR VTFALPDDAE TEDTGVLNVK
360 370 380 390 400
KNSDEVKSSF EKRQEKMNEK IASLEKELLE KKPWQLQGEV TAQKRPENSL
410 420 430 440 450
LEETLHFDHA VRMAPVITEE TTLQLEDIIK QRIRDQAWDD VVRKEKPKED
460 470 480 490 500
AYEYKKRLTL DHEKSKLSLA EIYEQEYIKL NQQKTAEEEN PEHVEIQKMM
510 520 530 540 550
DSLFLKLDAL SNFHFIPKPP VPEIKVVSNL PAITMEEVAP VSVSDAALLA
560 570 580 590 600
PEEIKEKNKA GDIKTAAEKT ATDKKRERRK KKYQKRMKIK EKEKRRKLLE
610 620 630 640 650
KSSVDQAGKY SKTVASEKLK QLTKTGKASF IKDEGKDKAL KSSQAFFSKL
660 670 680
QDQVKMQIND AKKTEKKKKK RQDISVHKLK L
Length:681
Mass (Da):78,864
Last modified:May 30, 2000 - v2
Checksum:iEDF27859D735D4E2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05351169E → A.Corresponds to variant rs10199088dbSNPEnsembl.1
Natural variantiVAR_053512115R → H.Corresponds to variant rs13010513dbSNPEnsembl.1
Natural variantiVAR_053513140D → N.Corresponds to variant rs10175940dbSNPEnsembl.1
Natural variantiVAR_024539229E → D.Corresponds to variant rs1813160dbSNPEnsembl.1
Natural variantiVAR_022000425L → M.Corresponds to variant rs3732240dbSNPEnsembl.1
Natural variantiVAR_014470634E → K.Corresponds to variant rs6574dbSNPEnsembl.1
Natural variantiVAR_053514639A → T.Corresponds to variant rs4852764dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98494 mRNA. Translation: CAA67120.1.
BC126389 mRNA. Translation: AAI26390.1.
CCDSiCCDS1916.1.
RefSeqiNP_005782.1. NM_005791.2.
UniGeneiHs.656208.

Genome annotation databases

EnsembliENST00000244230; ENSP00000244230; ENSG00000124383.
GeneIDi10199.
KEGGihsa:10199.
UCSCiuc002sht.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98494 mRNA. Translation: CAA67120.1.
BC126389 mRNA. Translation: AAI26390.1.
CCDSiCCDS1916.1.
RefSeqiNP_005782.1. NM_005791.2.
UniGeneiHs.656208.

3D structure databases

ProteinModelPortaliO00566.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115494. 47 interactors.
IntActiO00566. 4 interactors.
MINTiMINT-1192399.
STRINGi9606.ENSP00000244230.

PTM databases

iPTMnetiO00566.
PhosphoSitePlusiO00566.
SwissPalmiO00566.

Polymorphism and mutation databases

BioMutaiMPHOSPH10.

2D gel databases

SWISS-2DPAGEO00566.

Proteomic databases

EPDiO00566.
MaxQBiO00566.
PaxDbiO00566.
PeptideAtlasiO00566.
PRIDEiO00566.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244230; ENSP00000244230; ENSG00000124383.
GeneIDi10199.
KEGGihsa:10199.
UCSCiuc002sht.3. human.

Organism-specific databases

CTDi10199.
DisGeNETi10199.
GeneCardsiMPHOSPH10.
HGNCiHGNC:7213. MPHOSPH10.
HPAiHPA035059.
HPA035060.
HPA049907.
MIMi605503. gene.
neXtProtiNX_O00566.
OpenTargetsiENSG00000124383.
PharmGKBiPA30919.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2600. Eukaryota.
COG5384. LUCA.
GeneTreeiENSGT00390000011359.
HOGENOMiHOG000046317.
HOVERGENiHBG052502.
InParanoidiO00566.
KOiK14559.
OMAiFFDLAAF.
OrthoDBiEOG091G09Q2.
PhylomeDBiO00566.
TreeFamiTF105794.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124383-MONOMER.
ReactomeiR-HSA-6790901. rRNA modification in the nucleus and cytosol.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

ChiTaRSiMPHOSPH10. human.
GeneWikiiMPHOSPH10.
GenomeRNAii10199.
PMAP-CutDBO00566.
PROiO00566.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124383.
CleanExiHS_MPHOSPH10.
ExpressionAtlasiO00566. baseline and differential.
GenevisibleiO00566. HS.

Family and domain databases

InterProiIPR012173. snoRNP_Mpp10.
[Graphical view]
PANTHERiPTHR17039. PTHR17039. 1 hit.
PfamiPF04006. Mpp10. 1 hit.
[Graphical view]
PIRSFiPIRSF017300. snoRNP_Mpp10. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMPP10_HUMAN
AccessioniPrimary (citable) accession number: O00566
Secondary accession number(s): A0AVJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.