##gff-version 3 O00560 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|Ref.9,ECO:0007744|PubMed:19413330;Dbxref=PMID:19413330 O00560 UniProtKB Chain 2 298 . . . ID=PRO_0000184001;Note=Syntenin-1 O00560 UniProtKB Domain 114 193 . . . Note=PDZ 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143 O00560 UniProtKB Domain 198 273 . . . Note=PDZ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143 O00560 UniProtKB Region 2 60 . . . Note=Interaction with PDCD6IP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22660413;Dbxref=PMID:22660413 O00560 UniProtKB Motif 3 7 . . . Note=LYPX(n)L motif 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08992 O00560 UniProtKB Motif 45 49 . . . Note=LYPX(n)L motif 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08992 O00560 UniProtKB Motif 49 53 . . . Note=LYPX(n)L motif 3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08992 O00560 UniProtKB Binding site 215 215 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:27386966,ECO:0007744|PDB:4Z33;Dbxref=PMID:27386966 O00560 UniProtKB Binding site 250 251 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:27386966,ECO:0007744|PDB:4Z33;Dbxref=PMID:27386966 O00560 UniProtKB Modified residue 2 2 . . . Note=N-acetylserine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|Ref.9,ECO:0007744|PubMed:19413330;Dbxref=PMID:19413330 O00560 UniProtKB Modified residue 6 6 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O00560 UniProtKB Modified residue 46 46 . . . Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 O00560 UniProtKB Alternative sequence 12 17 . . . ID=VSP_038374;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 O00560 UniProtKB Alternative sequence 81 81 . . . ID=VSP_038375;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 O00560 UniProtKB Natural variant 69 69 . . . ID=VAR_013160;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9391086;Dbxref=dbSNP:rs1127509,PMID:9391086 O00560 UniProtKB Mutagenesis 214 214 . . . Note=Disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4%2C5-bisphosphate. Impaired interaction with FZD7 and disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4%2C5-bisphosphate%3B when associated with A-250. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27386966;Dbxref=PMID:27386966 O00560 UniProtKB Mutagenesis 215 215 . . . Note=Disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4%2C5-bisphosphate. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27386966;Dbxref=PMID:27386966 O00560 UniProtKB Mutagenesis 250 250 . . . Note=Disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4%2C5-bisphosphate. Impaired interaction with FZD7 and disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4%2C5-bisphosphate%3B when associated with A-214. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27386966;Dbxref=PMID:27386966 O00560 UniProtKB Sequence conflict 62 62 . . . Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 O00560 UniProtKB Beta strand 111 117 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8BLU O00560 UniProtKB Beta strand 121 123 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1W9O O00560 UniProtKB Beta strand 127 132 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8BLU O00560 UniProtKB Beta strand 135 142 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8BLU O00560 UniProtKB Helix 146 149 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8BLU O00560 UniProtKB Beta strand 157 161 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8BLU O00560 UniProtKB Helix 171 180 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8BLU O00560 UniProtKB Beta strand 186 191 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8BLU O00560 UniProtKB Beta strand 197 202 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1R6J O00560 UniProtKB Beta strand 205 208 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N99 O00560 UniProtKB Beta strand 211 214 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1R6J O00560 UniProtKB Beta strand 217 221 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1R6J O00560 UniProtKB Helix 226 230 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1R6J O00560 UniProtKB Beta strand 234 241 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1R6J O00560 UniProtKB Helix 251 260 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1R6J O00560 UniProtKB Beta strand 263 271 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1R6J O00560 UniProtKB Helix 272 279 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8BLU O00560 UniProtKB Helix 284 290 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8BLU