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Protein

Syntenin-1

Gene

SDCBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).1 Publication6 Publications

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • cytoskeletal adaptor activity Source: UniProtKB
  • frizzled binding Source: BHF-UCL
  • glycoprotein binding Source: Ensembl
  • identical protein binding Source: IntAct
  • interleukin-5 receptor binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB
  • protein N-terminus binding Source: UniProtKB
  • syndecan binding Source: UniProtKB

GO - Biological processi

  • actin cytoskeleton organization Source: UniProtKB
  • chemical synaptic transmission Source: UniProtKB
  • ephrin receptor signaling pathway Source: Reactome
  • intracellular signal transduction Source: UniProtKB
  • negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
  • negative regulation of receptor internalization Source: UniProtKB
  • positive regulation of cell growth Source: UniProtKB
  • positive regulation of cell migration Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of epithelial to mesenchymal transition Source: UniProtKB
  • positive regulation of exosomal secretion Source: UniProtKB
  • positive regulation of extracellular exosome assembly Source: UniProtKB
  • positive regulation of JNK cascade Source: BHF-UCL
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  • positive regulation of phosphorylation Source: BHF-UCL
  • positive regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
  • protein targeting to membrane Source: UniProtKB
  • Ras protein signal transduction Source: Ensembl
  • regulation of mitotic cell cycle Source: UniProtKB
  • substrate-dependent cell migration, cell extension Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137575-MONOMER.
ReactomeiR-HSA-3928664. Ephrin signaling.
R-HSA-447043. Neurofascin interactions.
R-HSA-6798695. Neutrophil degranulation.
SignaLinkiO00560.
SIGNORiO00560.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntenin-1
Alternative name(s):
Melanoma differentiation-associated protein 9
Short name:
MDA-9
Pro-TGF-alpha cytoplasmic domain-interacting protein 18
Short name:
TACIP18
Scaffold protein Pbp1
Syndecan-binding protein 1
Gene namesi
Name:SDCBP
Synonyms:MDA9, SYCL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:10662. SDCBP.

Subcellular locationi

GO - Cellular componenti

  • adherens junction Source: UniProtKB
  • blood microparticle Source: UniProtKB
  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: BHF-UCL
  • cytoskeleton Source: UniProtKB
  • cytosol Source: Reactome
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • extracellular vesicle Source: UniProtKB
  • focal adhesion Source: UniProtKB-SubCell
  • interleukin-5 receptor complex Source: UniProtKB
  • melanosome Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
  • membrane raft Source: UniProtKB
  • nucleus Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane, Nucleus, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6386.
OpenTargetsiENSG00000137575.
PharmGKBiPA35592.

Polymorphism and mutation databases

BioMutaiSDCBP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001840012 – 298Syntenin-1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei6PhosphoserineCombined sources1
Modified residuei46PhosphotyrosineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine residues.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO00560.
MaxQBiO00560.
PaxDbiO00560.
PeptideAtlasiO00560.
PRIDEiO00560.
TopDownProteomicsiO00560-1. [O00560-1]

PTM databases

iPTMnetiO00560.
PhosphoSitePlusiO00560.
SwissPalmiO00560.

Expressioni

Tissue specificityi

Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.1 Publication

Inductioni

By IFNG/IFN-gamma in melanoma cells.

Gene expression databases

BgeeiENSG00000137575.
CleanExiHS_SDCBP.
ExpressionAtlasiO00560. baseline and differential.
GenevisibleiO00560. HS.

Organism-specific databases

HPAiCAB012245.
HPA023840.

Interactioni

Subunit structurei

Monomer and homodimer (By similarity). Interacts with SDC1, SDC2, SDC3, SDC4, NRXN2, EPHA7, EPHB1, NF2 isoform 1, TGFA and IL5RA. Interacts with neurofascin, SDCBP2 and PTPRJ (By similarity). Interacts with PDCD6IP (PubMed:22660413). Forms a complex with PDCD6IP and SDC2 (PubMed:22660413). Interacts (via C-terminus) with TGFBR1 (PubMed:25893292).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself6EBI-727004,EBI-727004
ABI2Q9NYB93EBI-727004,EBI-743598
AESQ081173EBI-727004,EBI-717810
ANKRD40Q6AI123EBI-727004,EBI-2838246
ANP32BQ926885EBI-727004,EBI-762428
APIPQ96GX95EBI-727004,EBI-359248
BCL2L15Q5TBC73EBI-727004,EBI-10247136
C11orf57Q6ZUT19EBI-727004,EBI-3920396
C11orf57Q6ZUT1-23EBI-727004,EBI-10180231
C11orf68Q9H3H33EBI-727004,EBI-721765
C1orf109Q9NX043EBI-727004,EBI-8643161
CADPSA2RRN73EBI-727004,EBI-10179719
CADPSQ9ULU8-43EBI-727004,EBI-10180690
CALCOCO2Q131373EBI-727004,EBI-739580
CCDC102BA1A4H13EBI-727004,EBI-10171570
CCDC36Q8IYA83EBI-727004,EBI-8638439
CCDC53Q9Y3C05EBI-727004,EBI-712969
CDAP323205EBI-727004,EBI-9250559
CDC34P494275EBI-727004,EBI-975634
CDCP1Q9H5V85EBI-727004,EBI-1019736
CDIPTO147353EBI-727004,EBI-358858
CEP55D3DR373EBI-727004,EBI-10173536
CGGBP1Q9UFW83EBI-727004,EBI-723153
CLK2P497603EBI-727004,EBI-750020
CLK3P497615EBI-727004,EBI-745579
CMTM5Q96DZ93EBI-727004,EBI-2548702
COX4I1P130733EBI-727004,EBI-1056574
COX4I1Q86WV23EBI-727004,EBI-10260134
CRYAAP024895EBI-727004,EBI-6875961
CT45A3Q8NHU05EBI-727004,EBI-8643558
CT45A5Q6NSH33EBI-727004,EBI-8635816
CUTCQ9NTM95EBI-727004,EBI-714918
DCTDP323215EBI-727004,EBI-739870
DCTPP1Q9H7733EBI-727004,EBI-723569
DDX39BQ138384EBI-727004,EBI-348622
DMC1Q145653EBI-727004,EBI-930865
DRAP1Q149194EBI-727004,EBI-712941
DTNBP1Q96EV83EBI-727004,EBI-465804
EAF1Q96JC93EBI-727004,EBI-769261
EDARADDQ8WWZ33EBI-727004,EBI-2949647
EIF1ADQ8N9N85EBI-727004,EBI-750700
EIF5A2Q9GZV45EBI-727004,EBI-748028
ELAVL1Q157173EBI-727004,EBI-374260
ENOX1Q8TC923EBI-727004,EBI-713221
ERICH2A1L1623EBI-727004,EBI-2682520
FAM118AQ9NWS63EBI-727004,EBI-8638992
FAM118BQ9BPY33EBI-727004,EBI-726822
FAM9BQ8IZU05EBI-727004,EBI-10175124
FLAD1Q8NFF53EBI-727004,EBI-742815
FOXP2O154093EBI-727004,EBI-983612
FTH1Q6NZ443EBI-727004,EBI-10180219
FTLP027925EBI-727004,EBI-713279
FZD7O750844EBI-727004,EBI-746917
GPATCH11Q8N9543EBI-727004,EBI-2555378
hCG_1744368A0A024RA769EBI-727004,EBI-10180729
HEL-S-182mPV9HW603EBI-727004,EBI-10180762
HEL-S-25V9HW403EBI-727004,EBI-10330099
HMGB3O153475EBI-727004,EBI-2214136
HNRNPCP079105EBI-727004,EBI-357966
HOMEZQ8IX15-33EBI-727004,EBI-10172004
HOXA1P496393EBI-727004,EBI-740785
HPRT1P004925EBI-727004,EBI-748210
HSBP1O755069EBI-727004,EBI-748664
IKZF1Q134223EBI-727004,EBI-745305
INO80EQ8NBZ05EBI-727004,EBI-769401
KCNH1O952593EBI-727004,EBI-2909270
KCTD1Q719H95EBI-727004,EBI-9027502
KCTD6Q8NC695EBI-727004,EBI-2511344
KCTD9Q7L2735EBI-727004,EBI-4397613
KHDRBS2Q5VWX15EBI-727004,EBI-742808
KLHL12Q53G597EBI-727004,EBI-740929
KLHL2O951983EBI-727004,EBI-746999
KRTAP10-7P604093EBI-727004,EBI-10172290
KRTAP5-9P263715EBI-727004,EBI-3958099
LDOC1O957515EBI-727004,EBI-740738
LGALS2P051627EBI-727004,EBI-7181544
LSM6P623125EBI-727004,EBI-373310
LZTFL1Q9NQ485EBI-727004,EBI-2824799
MAD2L1Q132573EBI-727004,EBI-78203
MAPRE3Q9UPY87EBI-727004,EBI-726739
MBD3O959833EBI-727004,EBI-1783068
MED4Q9NPJ63EBI-727004,EBI-394607
MID2Q9UJV3-23EBI-727004,EBI-10172526
MRFAP1L1Q96HT87EBI-727004,EBI-748896
MTUS2Q5JR593EBI-727004,EBI-742948
NADKO955445EBI-727004,EBI-743949
NAGKQ9UJ705EBI-727004,EBI-372578
NECAB2H3BTW25EBI-727004,EBI-10172876
NECTIN1Q152238EBI-727004,EBI-1771314
NOTCH2NLQ7Z3S93EBI-727004,EBI-945833
NT5C2P499023EBI-727004,EBI-742084
OSTF1Q928823EBI-727004,EBI-1051152
PDE4DIPQ5VU433EBI-727004,EBI-1105124
PHC2Q8IXK03EBI-727004,EBI-713786
PNMA1Q8ND907EBI-727004,EBI-302345
PNMA2Q9UL425EBI-727004,EBI-302355
PRPF38AQ8NAV13EBI-727004,EBI-715374
PRPF40AO75400-23EBI-727004,EBI-5280197
PRR13Q9NZ813EBI-727004,EBI-740924
PSMC6P623337EBI-727004,EBI-357669
PSTPIP1O435863EBI-727004,EBI-1050964
PTSQ033933EBI-727004,EBI-712344
PUF60Q9UHX13EBI-727004,EBI-1053259
PYCRLQ53H963EBI-727004,EBI-2959680
RBM39Q144983EBI-727004,EBI-395290
REEP6Q96HR95EBI-727004,EBI-750345
RELQ048643EBI-727004,EBI-307352
RIC8AQ9NPQ8-43EBI-727004,EBI-9091816
RNH1P134895EBI-727004,EBI-1237106
ROPN1Q9HAT05EBI-727004,EBI-1378139
RPL22P352684EBI-727004,EBI-354533
RTN1Q16799-33EBI-727004,EBI-10180131
RUNDC3AQ59EK93EBI-727004,EBI-747225
SDCCAG3Q96C92-23EBI-727004,EBI-10178036
SEPT3Q9UH035EBI-727004,EBI-727037
SETQ011053EBI-727004,EBI-1053182
SIAH1Q8IUQ43EBI-727004,EBI-747107
SMARCA2P51531-23EBI-727004,EBI-10212306
SREK1IP1Q8N9Q25EBI-727004,EBI-10268630
SRSF11Q055193EBI-727004,EBI-1051785
SRSF7Q166295EBI-727004,EBI-398885
SSNA1O438055EBI-727004,EBI-2515299
SULT1B1O437043EBI-727004,EBI-10179062
TDO2P487757EBI-727004,EBI-743494
TEKT1Q969V43EBI-727004,EBI-10180409
TFCP2Q128003EBI-727004,EBI-717422
THG1LQ9NWX63EBI-727004,EBI-746510
TIFAQ96CG37EBI-727004,EBI-740711
TKFCQ3LXA33EBI-727004,EBI-4291069
TMEM239Q8WW343EBI-727004,EBI-9675724
TNFAIP8O953795EBI-727004,EBI-1049336
TNFAIP8L3Q5GJ754EBI-727004,EBI-11976033
TRAF5O004637EBI-727004,EBI-523498
TRIM27P143733EBI-727004,EBI-719493
TRIM32Q130495EBI-727004,EBI-742790
TRIM38O006353EBI-727004,EBI-2130415
TRIM54Q9BYV25EBI-727004,EBI-2130429
UBE2AP494595EBI-727004,EBI-2339348
WASLO004015EBI-727004,EBI-957615
ZBTB14O438293EBI-727004,EBI-10176632
ZBTB8AQ96BR95EBI-727004,EBI-742740
ZCCHC10Q8TBK63EBI-727004,EBI-597063
ZCCHC17Q9NP647EBI-727004,EBI-746345

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • cytoskeletal adaptor activity Source: UniProtKB
  • frizzled binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • interleukin-5 receptor binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB
  • protein N-terminus binding Source: UniProtKB
  • syndecan binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112287. 205 interactors.
DIPiDIP-42705N.
IntActiO00560. 259 interactors.
MINTiMINT-5002159.
STRINGi9606.ENSP00000260130.

Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi113 – 118Combined sources6
Beta strandi121 – 123Combined sources3
Beta strandi126 – 132Combined sources7
Beta strandi135 – 141Combined sources7
Helixi146 – 149Combined sources4
Beta strandi157 – 161Combined sources5
Helixi171 – 180Combined sources10
Beta strandi183 – 191Combined sources9
Beta strandi197 – 202Combined sources6
Beta strandi205 – 208Combined sources4
Beta strandi211 – 214Combined sources4
Beta strandi217 – 221Combined sources5
Helixi226 – 230Combined sources5
Beta strandi234 – 241Combined sources8
Helixi251 – 260Combined sources10
Beta strandi263 – 271Combined sources9
Helixi272 – 274Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N99X-ray1.94A/B113-273[»]
1NTEX-ray1.24A197-273[»]
1OBXX-ray1.35A197-270[»]
1OBYX-ray1.85A/B197-270[»]
1OBZX-ray1.69A/B113-273[»]
1R6JX-ray0.73A197-273[»]
1V1TX-ray1.80A/B113-273[»]
1W9EX-ray1.56A/B113-273[»]
1W9OX-ray2.25A/B113-273[»]
1W9QX-ray1.70A/B113-273[»]
1YBOX-ray2.30A/B113-273[»]
4Z33X-ray2.45A/B111-275[»]
ProteinModelPortaliO00560.
SMRiO00560.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00560.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 193PDZ 1PROSITE-ProRule annotationAdd BLAST80
Domaini198 – 273PDZ 2PROSITE-ProRule annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 60Interaction with PDCD6IP1 PublicationAdd BLAST59

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi3 – 7LYPX(n)L motif 1By similarity5
Motifi45 – 49LYPX(n)L motif 2By similarity5
Motifi49 – 53LYPX(n)L motif 3By similarity5

Sequence similaritiesi

Contains 2 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEB7. Eukaryota.
ENOG410YNPQ. LUCA.
GeneTreeiENSGT00390000014465.
HOGENOMiHOG000231604.
HOVERGENiHBG053211.
InParanoidiO00560.
KOiK17254.
PhylomeDBiO00560.
TreeFamiTF327131.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR001478. PDZ.
IPR030528. SDCBP.
[Graphical view]
PANTHERiPTHR12345:SF10. PTHR12345:SF10. 1 hit.
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O00560-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLYPSLEDL KVDKVIQAQT AFSANPANPA ILSEASAPIP HDGNLYPRLY
60 70 80 90 100
PELSQYMGLS LNEEEIRANV AVVSGAPLQG QLVARPSSIN YMVAPVTGND
110 120 130 140 150
VGIRRAEIKQ GIREVILCKD QDGKIGLRLK SIDNGIFVQL VQANSPASLV
160 170 180 190 200
GLRFGDQVLQ INGENCAGWS SDKAHKVLKQ AFGEKITMTI RDRPFERTIT
210 220 230 240 250
MHKDSTGHVG FIFKNGKITS IVKDSSAARN GLLTEHNICE INGQNVIGLK
260 270 280 290
DSQIADILST SGTVVTITIM PAFIFEHIIK RMAPSIMKSL MDHTIPEV
Length:298
Mass (Da):32,444
Last modified:July 1, 1997 - v1
Checksum:i574E1349F86F949F
GO
Isoform 2 (identifier: O00560-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-81: Missing.

Show »
Length:297
Mass (Da):32,316
Checksum:i67FED210EFB6EEF6
GO
Isoform 3 (identifier: O00560-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-17: Missing.

Show »
Length:292
Mass (Da):31,762
Checksum:i004BFE46AC4D9FBA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62N → S in AAB51246 (PubMed:9391086).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05369926P → T.Corresponds to variant rs11550282dbSNPEnsembl.1
Natural variantiVAR_01316069N → S.1 PublicationCorresponds to variant rs1127509dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03837412 – 17Missing in isoform 3. 1 Publication6
Alternative sequenceiVSP_03837581Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006636 mRNA. Translation: AAC52050.1.
AF000652 mRNA. Translation: AAB97144.1.
U83463 mRNA. Translation: AAB51246.1.
AK300647 mRNA. Translation: BAG62335.1.
AK312274 mRNA. Translation: BAG35204.1.
AC068522 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW86814.1.
BC113674 mRNA. Translation: AAI13675.1.
BC113676 mRNA. Translation: AAI13677.1.
BC143915 mRNA. Translation: AAI43916.1.
BC143916 mRNA. Translation: AAI43917.1.
CCDSiCCDS47862.1. [O00560-2]
CCDS47863.1. [O00560-3]
CCDS6172.1. [O00560-1]
PIRiJC6537.
RefSeqiNP_001007068.1. NM_001007067.1. [O00560-1]
NP_001007069.1. NM_001007068.1. [O00560-3]
NP_001007070.1. NM_001007069.1. [O00560-2]
NP_001007071.1. NM_001007070.1. [O00560-2]
NP_005616.2. NM_005625.3. [O00560-1]
UniGeneiHs.200804.

Genome annotation databases

EnsembliENST00000260130; ENSP00000260130; ENSG00000137575. [O00560-1]
ENST00000413219; ENSP00000411771; ENSG00000137575. [O00560-1]
ENST00000424270; ENSP00000395351; ENSG00000137575. [O00560-3]
ENST00000447182; ENSP00000409288; ENSG00000137575. [O00560-2]
GeneIDi6386.
KEGGihsa:6386.
UCSCiuc003xtn.3. human. [O00560-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006636 mRNA. Translation: AAC52050.1.
AF000652 mRNA. Translation: AAB97144.1.
U83463 mRNA. Translation: AAB51246.1.
AK300647 mRNA. Translation: BAG62335.1.
AK312274 mRNA. Translation: BAG35204.1.
AC068522 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW86814.1.
BC113674 mRNA. Translation: AAI13675.1.
BC113676 mRNA. Translation: AAI13677.1.
BC143915 mRNA. Translation: AAI43916.1.
BC143916 mRNA. Translation: AAI43917.1.
CCDSiCCDS47862.1. [O00560-2]
CCDS47863.1. [O00560-3]
CCDS6172.1. [O00560-1]
PIRiJC6537.
RefSeqiNP_001007068.1. NM_001007067.1. [O00560-1]
NP_001007069.1. NM_001007068.1. [O00560-3]
NP_001007070.1. NM_001007069.1. [O00560-2]
NP_001007071.1. NM_001007070.1. [O00560-2]
NP_005616.2. NM_005625.3. [O00560-1]
UniGeneiHs.200804.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N99X-ray1.94A/B113-273[»]
1NTEX-ray1.24A197-273[»]
1OBXX-ray1.35A197-270[»]
1OBYX-ray1.85A/B197-270[»]
1OBZX-ray1.69A/B113-273[»]
1R6JX-ray0.73A197-273[»]
1V1TX-ray1.80A/B113-273[»]
1W9EX-ray1.56A/B113-273[»]
1W9OX-ray2.25A/B113-273[»]
1W9QX-ray1.70A/B113-273[»]
1YBOX-ray2.30A/B113-273[»]
4Z33X-ray2.45A/B111-275[»]
ProteinModelPortaliO00560.
SMRiO00560.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112287. 205 interactors.
DIPiDIP-42705N.
IntActiO00560. 259 interactors.
MINTiMINT-5002159.
STRINGi9606.ENSP00000260130.

PTM databases

iPTMnetiO00560.
PhosphoSitePlusiO00560.
SwissPalmiO00560.

Polymorphism and mutation databases

BioMutaiSDCBP.

Proteomic databases

EPDiO00560.
MaxQBiO00560.
PaxDbiO00560.
PeptideAtlasiO00560.
PRIDEiO00560.
TopDownProteomicsiO00560-1. [O00560-1]

Protocols and materials databases

DNASUi6386.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260130; ENSP00000260130; ENSG00000137575. [O00560-1]
ENST00000413219; ENSP00000411771; ENSG00000137575. [O00560-1]
ENST00000424270; ENSP00000395351; ENSG00000137575. [O00560-3]
ENST00000447182; ENSP00000409288; ENSG00000137575. [O00560-2]
GeneIDi6386.
KEGGihsa:6386.
UCSCiuc003xtn.3. human. [O00560-1]

Organism-specific databases

CTDi6386.
DisGeNETi6386.
GeneCardsiSDCBP.
HGNCiHGNC:10662. SDCBP.
HPAiCAB012245.
HPA023840.
MIMi602217. gene.
neXtProtiNX_O00560.
OpenTargetsiENSG00000137575.
PharmGKBiPA35592.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEB7. Eukaryota.
ENOG410YNPQ. LUCA.
GeneTreeiENSGT00390000014465.
HOGENOMiHOG000231604.
HOVERGENiHBG053211.
InParanoidiO00560.
KOiK17254.
PhylomeDBiO00560.
TreeFamiTF327131.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137575-MONOMER.
ReactomeiR-HSA-3928664. Ephrin signaling.
R-HSA-447043. Neurofascin interactions.
R-HSA-6798695. Neutrophil degranulation.
SignaLinkiO00560.
SIGNORiO00560.

Miscellaneous databases

ChiTaRSiSDCBP. human.
EvolutionaryTraceiO00560.
GeneWikiiSDCBP.
GenomeRNAii6386.
PROiO00560.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137575.
CleanExiHS_SDCBP.
ExpressionAtlasiO00560. baseline and differential.
GenevisibleiO00560. HS.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR001478. PDZ.
IPR030528. SDCBP.
[Graphical view]
PANTHERiPTHR12345:SF10. PTHR12345:SF10. 1 hit.
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSDCB1_HUMAN
AccessioniPrimary (citable) accession number: O00560
Secondary accession number(s): B2R5Q7
, B4DUH3, B7ZLN2, O00173, O43391, Q14CP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: July 1, 1997
Last modified: November 30, 2016
This is version 175 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.