UniProtKB - O00559 (RCAS1_HUMAN)
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Protein
Receptor-binding cancer antigen expressed on SiSo cells
Gene
EBAG9
Organism
Homo sapiens (Human)
Status
Functioni
May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.3 Publications
Miscellaneous
May serve as a prognostic marker for cancers such as adenocarcinomas of the lung and breast cancers. It is present and overexpressed in many patients suffering from breast carcinomas, its level of expression correlates with tumor grade, suggesting that it may be involved in cancer immune escape. According to PubMed:12672804, it is however not directly a tumor-associated antigen, but it rather modulates surface expression of tumor-associated O-linked glycan Tn when it is overexpressed, suggesting that it contributes indirectly to the antigenicity of tumor cells.
Caution
It was initially reported to be a ligand for some putative receptor present on T-, B-, natural killer (NK) cells and various human cell lines. However, PubMed:12672804 showed that it does not bind any receptor.Curated
GO - Molecular functioni
- peptidase activator activity involved in apoptotic process Source: UniProtKB
GO - Biological processi
- regulation of cell growth Source: UniProtKB
Keywordsi
Biological process | Apoptosis |
Names & Taxonomyi
Protein namesi | Recommended name: Receptor-binding cancer antigen expressed on SiSo cellsAlternative name(s): Cancer-associated surface antigen RCAS1 Estrogen receptor-binding fragment-associated gene 9 protein |
Gene namesi | Name:EBAG9 Synonyms:RCAS1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000147654.14 |
HGNCi | HGNC:3123 EBAG9 |
MIMi | 605772 gene |
neXtProti | NX_O00559 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 6 | ExtracellularSequence analysis | 6 | |
Transmembranei | 7 – 27 | Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 28 – 213 | CytoplasmicSequence analysisAdd BLAST | 186 |
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 9166 |
OpenTargetsi | ENSG00000147654 |
PharmGKBi | PA27581 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000097195 | 1 – 213 | Receptor-binding cancer antigen expressed on SiSo cellsAdd BLAST | 213 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 36 | PhosphoserineCombined sources | 1 | |
Modified residuei | 41 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 94 | PhosphotyrosineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O00559 |
MaxQBi | O00559 |
PaxDbi | O00559 |
PeptideAtlasi | O00559 |
PRIDEi | O00559 |
PTM databases
iPTMneti | O00559 |
PhosphoSitePlusi | O00559 |
SwissPalmi | O00559 |
Expressioni
Tissue specificityi
Widely expressed. Expressed in ovary, testis, prostate, thymus, muscle and heart, but not in small intestine, colon, lymph nodes, or peripherical blood lymphocytes. The protein is not detected in any of the above organs.
Inductioni
By estrogen.
Gene expression databases
Bgeei | ENSG00000147654 |
CleanExi | HS_EBAG9 |
ExpressionAtlasi | O00559 baseline and differential |
Genevisiblei | O00559 HS |
Organism-specific databases
HPAi | CAB072810 CAB072811 CAB072812 HPA021153 HPA021154 |
Interactioni
Subunit structurei
Homodimer.
Protein-protein interaction databases
BioGridi | 1146073 interactors. |
IntActi | O00559 3 interactors. |
STRINGi | 9606.ENSP00000337675 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 163 – 211 | Sequence analysisAdd BLAST | 49 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 160 – 163 | Poly-Glu | 4 |
Domaini
The coiled coil domain is necessary for the homodimerization.
Keywords - Domaini
Coiled coil, Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IE57 Eukaryota ENOG41101KS LUCA |
GeneTreei | ENSGT00390000004040 |
HOGENOMi | HOG000073537 |
HOVERGENi | HBG059707 |
InParanoidi | O00559 |
KOi | K22455 |
OMAi | FRLFKIC |
OrthoDBi | EOG091G0L0F |
PhylomeDBi | O00559 |
TreeFami | TF326584 |
Family and domain databases
InterProi | View protein in InterPro IPR017025 Cancer-assoc_antigen_RCAS1 |
PANTHERi | PTHR15208 PTHR15208, 1 hit |
PIRSFi | PIRSF034247 RCAS1, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: O00559-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MAITQFRLFK FCTCLATVFS FLKRLICRSG RGRKLSGDQI TLPTTVDYSS
60 70 80 90 100
VPKQTDVEEW TSWDEDAPTS VKIEGGNGNV ATQQNSLEQL EPDYFKDMTP
110 120 130 140 150
TIRKTQKIVI KKREPLNFGI PDGSTGFSSR LAATQDLPFI HQSSELGDLD
160 170 180 190 200
TWQENTNAWE EEEDAAWQAE EVLRQQKLAD REKRAAEQQR KKMEKEAQRL
210
MKKEQNKIGV KLS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 183 | K → E in AAH05249 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 199 | R → Q in BAF83340 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055503 | 174 | R → RSRTNVCLLCSLLFHHPTPT STPYINQSVKIERVSLGQWS YGKSKE in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF006265 mRNA Translation: AAB61617.1 AB007619 mRNA Translation: BAA22572.1 AY653072 mRNA Translation: AAU85838.1 AK290651 mRNA Translation: BAF83340.1 CR456984 mRNA Translation: CAG33265.1 AC079061 Genomic DNA No translation available. AP000427 Genomic DNA No translation available. BC005249 mRNA Translation: AAH05249.1 BC017729 mRNA Translation: AAH17729.1 BC022506 mRNA Translation: AAH22506.1 |
CCDSi | CCDS6313.1 [O00559-1] |
RefSeqi | NP_001265867.1, NM_001278938.1 [O00559-1] NP_004206.1, NM_004215.4 [O00559-1] NP_936056.1, NM_198120.2 [O00559-1] XP_016869449.1, XM_017013960.1 [O00559-1] |
UniGenei | Hs.409368 Hs.632960 |
Genome annotation databases
Ensembli | ENST00000337573; ENSP00000337675; ENSG00000147654 [O00559-1] ENST00000395785; ENSP00000379131; ENSG00000147654 [O00559-1] ENST00000531677; ENSP00000432082; ENSG00000147654 [O00559-2] ENST00000614147; ENSP00000477734; ENSG00000147654 [O00559-2] ENST00000620557; ENSP00000477645; ENSG00000147654 [O00559-1] |
GeneIDi | 9166 |
KEGGi | hsa:9166 |
UCSCi | uc003ynf.5 human [O00559-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | RCAS1_HUMAN | |
Accessioni | O00559Primary (citable) accession number: O00559 Secondary accession number(s): A8K3N6 Q9BS76 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | July 1, 1997 | |
Last modified: | April 25, 2018 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |