Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O00548

- DLL1_HUMAN

UniProt

O00548 - DLL1_HUMAN

Protein

Delta-like protein 1

Gene

DLL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 2 (31 Oct 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.1 Publication

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. Notch binding Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell-cell signaling Source: Ensembl
    2. cell differentiation Source: UniProtKB
    3. cell fate determination Source: UniProtKB
    4. compartment pattern specification Source: Ensembl
    5. determination of left/right symmetry Source: BHF-UCL
    6. heart looping Source: BHF-UCL
    7. hemopoiesis Source: UniProtKB
    8. inner ear development Source: Ensembl
    9. left/right axis specification Source: Ensembl
    10. loop of Henle development Source: Ensembl
    11. negative regulation of auditory receptor cell differentiation Source: Ensembl
    12. negative regulation of interleukin-10 production Source: UniProt
    13. negative regulation of myeloid cell differentiation Source: Ensembl
    14. neuronal stem cell maintenance Source: UniProtKB
    15. Notch receptor processing Source: Reactome
    16. Notch signaling pathway Source: UniProtKB
    17. positive regulation of Notch signaling pathway Source: Ensembl
    18. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    19. proximal tubule development Source: Ensembl
    20. regulation of cell adhesion Source: UniProtKB
    21. somite specification Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Notch signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
    REACT_118636. Signaling by NOTCH4.
    REACT_118862. Signaling by NOTCH3.
    REACT_160089. Constitutive Signaling by NOTCH1 HD Domain Mutants.
    REACT_160106. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
    REACT_160205. NOTCH2 Activation and Transmission of Signal to the Nucleus.
    REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    SignaLinkiO00548.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Delta-like protein 1
    Alternative name(s):
    Drosophila Delta homolog 1
    Short name:
    Delta1
    Short name:
    H-Delta-1
    Gene namesi
    Name:DLL1
    ORF Names:UNQ146/PRO172
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:2908. DLL1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic vesicle Source: Ensembl
    2. extracellular region Source: UniProtKB
    3. integral component of plasma membrane Source: UniProtKB
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti93925. Alobar holoprosencephaly.
    93924. Lobar holoprosencephaly.
    280200. Microform holoprosencephaly.
    93926. Midline interhemispheric variant of holoprosencephaly.
    220386. Semilobar holoprosencephaly.
    280195. Septopreoptic holoprosencephaly.
    PharmGKBiPA27364.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 723706Delta-like protein 1PRO_0000007506Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi179 ↔ 188By similarity
    Disulfide bondi192 ↔ 204By similarity
    Disulfide bondi212 ↔ 221By similarity
    Disulfide bondi226 ↔ 237By similarity
    Disulfide bondi230 ↔ 243By similarity
    Disulfide bondi245 ↔ 254By similarity
    Disulfide bondi257 ↔ 268By similarity
    Disulfide bondi263 ↔ 274By similarity
    Disulfide bondi276 ↔ 285By similarity
    Disulfide bondi292 ↔ 304By similarity
    Disulfide bondi298 ↔ 314By similarity
    Disulfide bondi316 ↔ 325By similarity
    Disulfide bondi332 ↔ 343By similarity
    Disulfide bondi337 ↔ 352By similarity
    Disulfide bondi354 ↔ 363By similarity
    Disulfide bondi370 ↔ 381By similarity
    Disulfide bondi375 ↔ 391By similarity
    Disulfide bondi393 ↔ 402By similarity
    Disulfide bondi409 ↔ 420By similarity
    Disulfide bondi414 ↔ 429By similarity
    Disulfide bondi431 ↔ 440By similarity
    Disulfide bondi447 ↔ 458By similarity
    Disulfide bondi452 ↔ 467By similarity
    Disulfide bondi469 ↔ 478By similarity
    Glycosylationi477 – 4771N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi485 ↔ 496By similarity
    Disulfide bondi490 ↔ 505By similarity
    Disulfide bondi507 ↔ 516By similarity

    Post-translational modificationi

    Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiO00548.
    PRIDEiO00548.

    PTM databases

    PhosphoSiteiO00548.

    Expressioni

    Tissue specificityi

    Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.

    Gene expression databases

    BgeeiO00548.
    CleanExiHS_DLL1.
    GenevestigatoriO00548.

    Interactioni

    Subunit structurei

    Interacts with Notch receptors.

    Protein-protein interaction databases

    BioGridi118391. 6 interactions.
    STRINGi9606.ENSP00000355718.

    Structurei

    3D structure databases

    ProteinModelPortaliO00548.
    SMRiO00548. Positions 22-551.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 545528ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini569 – 723155CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei546 – 56823HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini177 – 22145DSLPROSITE-ProRule annotationAdd
    BLAST
    Domaini226 – 25429EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini257 – 28529EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini292 – 32534EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini332 – 36332EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini370 – 40233EGF-like 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini409 – 44032EGF-like 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini447 – 47832EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini485 – 51632EGF-like 8PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DSL domain.PROSITE-ProRule annotation
    Contains 8 EGF-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249767.
    HOGENOMiHOG000267024.
    HOVERGENiHBG007139.
    InParanoidiO00548.
    KOiK06051.
    OMAiRCTDNPD.
    OrthoDBiEOG7GQXZ5.
    PhylomeDBiO00548.
    TreeFamiTF351835.

    Family and domain databases

    InterProiIPR001774. DSL.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR011651. Notch_ligand_N.
    [Graphical view]
    PfamiPF01414. DSL. 1 hit.
    PF00008. EGF. 6 hits.
    PF07657. MNNL. 1 hit.
    [Graphical view]
    SMARTiSM00051. DSL. 1 hit.
    SM00181. EGF. 4 hits.
    SM00179. EGF_CA. 4 hits.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 2 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
    PS51051. DSL. 1 hit.
    PS00022. EGF_1. 8 hits.
    PS01186. EGF_2. 8 hits.
    PS50026. EGF_3. 7 hits.
    PS01187. EGF_CA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O00548-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSRCALALA VLSALLCQVW SSGVFELKLQ EFVNKKGLLG NRNCCRGGAG    50
    PPPCACRTFF RVCLKHYQAS VSPEPPCTYG SAVTPVLGVD SFSLPDGGGA 100
    DSAFSNPIRF PFGFTWPGTF SLIIEALHTD SPDDLATENP ERLISRLATQ 150
    RHLTVGEEWS QDLHSSGRTD LKYSYRFVCD EHYYGEGCSV FCRPRDDAFG 200
    HFTCGERGEK VCNPGWKGPY CTEPICLPGC DEQHGFCDKP GECKCRVGWQ 250
    GRYCDECIRY PGCLHGTCQQ PWQCNCQEGW GGLFCNQDLN YCTHHKPCKN 300
    GATCTNTGQG SYTCSCRPGY TGATCELGID ECDPSPCKNG GSCTDLENSY 350
    SCTCPPGFYG KICELSAMTC ADGPCFNGGR CSDSPDGGYS CRCPVGYSGF 400
    NCEKKIDYCS SSPCSNGAKC VDLGDAYLCR CQAGFSGRHC DDNVDDCASS 450
    PCANGGTCRD GVNDFSCTCP PGYTGRNCSA PVSRCEHAPC HNGATCHERG 500
    HRYVCECARG YGGPNCQFLL PELPPGPAVV DLTEKLEGQG GPFPWVAVCA 550
    GVILVLMLLL GCAAVVVCVR LRLQKHRPPA DPCRGETETM NNLANCQREK 600
    DISVSIIGAT QIKNTNKKAD FHGDHSADKN GFKARYPAVD YNLVQDLKGD 650
    DTAVRDAHSK RDTKCQPQGS SGEEKGTPTT LRGGEASERK RPDSGCSTSK 700
    DTKYQSVYVI SEEKDECVIA TEV 723
    Length:723
    Mass (Da):78,056
    Last modified:October 31, 2006 - v2
    Checksum:i094B8F235DFD899D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti498 – 4981E → Q in AAF05834. (PubMed:10688816)Curated
    Sequence conflicti502 – 5021R → G in AAB61286. (PubMed:10079256)Curated
    Sequence conflicti502 – 5021R → G in AAF05834. (PubMed:10688816)Curated
    Sequence conflicti502 – 5021R → G in AAG09716. 1 PublicationCurated
    Sequence conflicti510 – 5101G → S in AAF05834. (PubMed:10688816)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti444 – 4441V → M.
    Corresponds to variant rs16901311 [ dbSNP | Ensembl ].
    VAR_048976

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF003522 mRNA. Translation: AAB61286.1.
    AF196571 mRNA. Translation: AAF05834.1.
    AF222310 Genomic DNA. Translation: AAG09716.1.
    AY358892 mRNA. Translation: AAQ89251.1.
    AK314234 mRNA. Translation: BAG36904.1.
    AL078605 Genomic DNA. Translation: CAB89569.1.
    CH471051 Genomic DNA. Translation: EAW47425.1.
    CCDSiCCDS5313.1.
    RefSeqiNP_005609.3. NM_005618.3.
    UniGeneiHs.379912.

    Genome annotation databases

    EnsembliENST00000366756; ENSP00000355718; ENSG00000198719.
    GeneIDi28514.
    KEGGihsa:28514.
    UCSCiuc003qxm.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF003522 mRNA. Translation: AAB61286.1 .
    AF196571 mRNA. Translation: AAF05834.1 .
    AF222310 Genomic DNA. Translation: AAG09716.1 .
    AY358892 mRNA. Translation: AAQ89251.1 .
    AK314234 mRNA. Translation: BAG36904.1 .
    AL078605 Genomic DNA. Translation: CAB89569.1 .
    CH471051 Genomic DNA. Translation: EAW47425.1 .
    CCDSi CCDS5313.1.
    RefSeqi NP_005609.3. NM_005618.3.
    UniGenei Hs.379912.

    3D structure databases

    ProteinModelPortali O00548.
    SMRi O00548. Positions 22-551.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118391. 6 interactions.
    STRINGi 9606.ENSP00000355718.

    PTM databases

    PhosphoSitei O00548.

    Proteomic databases

    PaxDbi O00548.
    PRIDEi O00548.

    Protocols and materials databases

    DNASUi 28514.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000366756 ; ENSP00000355718 ; ENSG00000198719 .
    GeneIDi 28514.
    KEGGi hsa:28514.
    UCSCi uc003qxm.3. human.

    Organism-specific databases

    CTDi 28514.
    GeneCardsi GC06M170591.
    HGNCi HGNC:2908. DLL1.
    MIMi 606582. gene.
    neXtProti NX_O00548.
    Orphaneti 93925. Alobar holoprosencephaly.
    93924. Lobar holoprosencephaly.
    280200. Microform holoprosencephaly.
    93926. Midline interhemispheric variant of holoprosencephaly.
    220386. Semilobar holoprosencephaly.
    280195. Septopreoptic holoprosencephaly.
    PharmGKBi PA27364.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG249767.
    HOGENOMi HOG000267024.
    HOVERGENi HBG007139.
    InParanoidi O00548.
    KOi K06051.
    OMAi RCTDNPD.
    OrthoDBi EOG7GQXZ5.
    PhylomeDBi O00548.
    TreeFami TF351835.

    Enzyme and pathway databases

    Reactomei REACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
    REACT_118636. Signaling by NOTCH4.
    REACT_118862. Signaling by NOTCH3.
    REACT_160089. Constitutive Signaling by NOTCH1 HD Domain Mutants.
    REACT_160106. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
    REACT_160205. NOTCH2 Activation and Transmission of Signal to the Nucleus.
    REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    SignaLinki O00548.

    Miscellaneous databases

    ChiTaRSi DLL1. human.
    GeneWikii Delta-like_1.
    GenomeRNAii 28514.
    NextBioi 50984.
    PROi O00548.
    SOURCEi Search...

    Gene expression databases

    Bgeei O00548.
    CleanExi HS_DLL1.
    Genevestigatori O00548.

    Family and domain databases

    InterProi IPR001774. DSL.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR011651. Notch_ligand_N.
    [Graphical view ]
    Pfami PF01414. DSL. 1 hit.
    PF00008. EGF. 6 hits.
    PF07657. MNNL. 1 hit.
    [Graphical view ]
    SMARTi SM00051. DSL. 1 hit.
    SM00181. EGF. 4 hits.
    SM00179. EGF_CA. 4 hits.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 2 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
    PS51051. DSL. 1 hit.
    PS00022. EGF_1. 8 hits.
    PS01186. EGF_2. 8 hits.
    PS50026. EGF_3. 7 hits.
    PS01187. EGF_CA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells."
      Han W., Ye Q., Moore M.A.S.
      Blood 95:1616-1625(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Human Delta 1 gene sequence."
      Oda T., Chandrasekharappa S.C.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation."
      Jaleco A.C., Neves H., Hooijberg E., Gameiro P., Clode N., Haury M., Henrique D., Parreira L.
      J. Exp. Med. 194:991-1001(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiDLL1_HUMAN
    AccessioniPrimary (citable) accession number: O00548
    Secondary accession number(s): B2RAK7, Q9NU41, Q9UJV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 144 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3