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O00548

- DLL1_HUMAN

UniProt

O00548 - DLL1_HUMAN

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Protein

Delta-like protein 1

Gene

DLL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.1 Publication

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. Notch binding Source: UniProtKB

GO - Biological processi

  1. cell-cell signaling Source: Ensembl
  2. cell differentiation Source: UniProtKB
  3. cell fate determination Source: UniProtKB
  4. compartment pattern specification Source: Ensembl
  5. determination of left/right symmetry Source: BHF-UCL
  6. heart looping Source: BHF-UCL
  7. hemopoiesis Source: UniProtKB
  8. inner ear development Source: Ensembl
  9. left/right axis specification Source: Ensembl
  10. loop of Henle development Source: Ensembl
  11. negative regulation of auditory receptor cell differentiation Source: Ensembl
  12. negative regulation of interleukin-10 production Source: UniProt
  13. negative regulation of myeloid cell differentiation Source: Ensembl
  14. neuronal stem cell maintenance Source: UniProtKB
  15. Notch receptor processing Source: Reactome
  16. Notch signaling pathway Source: UniProtKB
  17. positive regulation of Notch signaling pathway Source: Ensembl
  18. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  19. proximal tubule development Source: Ensembl
  20. regulation of cell adhesion Source: UniProtKB
  21. somite specification Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Notch signaling pathway

Enzyme and pathway databases

ReactomeiREACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_118636. Signaling by NOTCH4.
REACT_118862. Signaling by NOTCH3.
REACT_160089. Constitutive Signaling by NOTCH1 HD Domain Mutants.
REACT_160106. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
REACT_160205. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
SignaLinkiO00548.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-like protein 1
Alternative name(s):
Drosophila Delta homolog 1
Short name:
Delta1
Short name:
H-Delta-1
Gene namesi
Name:DLL1
ORF Names:UNQ146/PRO172
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:2908. DLL1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 545528ExtracellularSequence AnalysisAdd
BLAST
Transmembranei546 – 56823HelicalSequence AnalysisAdd
BLAST
Topological domaini569 – 723155CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasmic vesicle Source: Ensembl
  2. extracellular region Source: UniProtKB
  3. integral component of plasma membrane Source: UniProtKB
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti93925. Alobar holoprosencephaly.
93924. Lobar holoprosencephaly.
280200. Microform holoprosencephaly.
93926. Midline interhemispheric variant of holoprosencephaly.
220386. Semilobar holoprosencephaly.
280195. Septopreoptic holoprosencephaly.
PharmGKBiPA27364.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 723706Delta-like protein 1PRO_0000007506Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi179 ↔ 188By similarity
Disulfide bondi192 ↔ 204By similarity
Disulfide bondi212 ↔ 221By similarity
Disulfide bondi226 ↔ 237By similarity
Disulfide bondi230 ↔ 243By similarity
Disulfide bondi245 ↔ 254By similarity
Disulfide bondi257 ↔ 268By similarity
Disulfide bondi263 ↔ 274By similarity
Disulfide bondi276 ↔ 285By similarity
Disulfide bondi292 ↔ 304By similarity
Disulfide bondi298 ↔ 314By similarity
Disulfide bondi316 ↔ 325By similarity
Disulfide bondi332 ↔ 343By similarity
Disulfide bondi337 ↔ 352By similarity
Disulfide bondi354 ↔ 363By similarity
Disulfide bondi370 ↔ 381By similarity
Disulfide bondi375 ↔ 391By similarity
Disulfide bondi393 ↔ 402By similarity
Disulfide bondi409 ↔ 420By similarity
Disulfide bondi414 ↔ 429By similarity
Disulfide bondi431 ↔ 440By similarity
Disulfide bondi447 ↔ 458By similarity
Disulfide bondi452 ↔ 467By similarity
Disulfide bondi469 ↔ 478By similarity
Glycosylationi477 – 4771N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi485 ↔ 496By similarity
Disulfide bondi490 ↔ 505By similarity
Disulfide bondi507 ↔ 516By similarity

Post-translational modificationi

Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiO00548.
PRIDEiO00548.

PTM databases

PhosphoSiteiO00548.

Expressioni

Tissue specificityi

Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.

Gene expression databases

BgeeiO00548.
CleanExiHS_DLL1.
GenevestigatoriO00548.

Interactioni

Subunit structurei

Interacts with Notch receptors.

Protein-protein interaction databases

BioGridi118391. 6 interactions.
STRINGi9606.ENSP00000355718.

Structurei

3D structure databases

ProteinModelPortaliO00548.
SMRiO00548. Positions 22-551.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini177 – 22145DSLPROSITE-ProRule annotationAdd
BLAST
Domaini226 – 25429EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini257 – 28529EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini292 – 32534EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini332 – 36332EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini370 – 40233EGF-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini409 – 44032EGF-like 6PROSITE-ProRule annotationAdd
BLAST
Domaini447 – 47832EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini485 – 51632EGF-like 8PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DSL domain.PROSITE-ProRule annotation
Contains 8 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249767.
GeneTreeiENSGT00760000118786.
HOGENOMiHOG000267024.
HOVERGENiHBG007139.
InParanoidiO00548.
KOiK06051.
OMAiRCTDNPD.
OrthoDBiEOG7GQXZ5.
PhylomeDBiO00548.
TreeFamiTF351835.

Family and domain databases

InterProiIPR001774. DSL.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011651. Notch_ligand_N.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 6 hits.
PF07657. MNNL. 1 hit.
[Graphical view]
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 4 hits.
SM00179. EGF_CA. 4 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 8 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O00548-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSRCALALA VLSALLCQVW SSGVFELKLQ EFVNKKGLLG NRNCCRGGAG
60 70 80 90 100
PPPCACRTFF RVCLKHYQAS VSPEPPCTYG SAVTPVLGVD SFSLPDGGGA
110 120 130 140 150
DSAFSNPIRF PFGFTWPGTF SLIIEALHTD SPDDLATENP ERLISRLATQ
160 170 180 190 200
RHLTVGEEWS QDLHSSGRTD LKYSYRFVCD EHYYGEGCSV FCRPRDDAFG
210 220 230 240 250
HFTCGERGEK VCNPGWKGPY CTEPICLPGC DEQHGFCDKP GECKCRVGWQ
260 270 280 290 300
GRYCDECIRY PGCLHGTCQQ PWQCNCQEGW GGLFCNQDLN YCTHHKPCKN
310 320 330 340 350
GATCTNTGQG SYTCSCRPGY TGATCELGID ECDPSPCKNG GSCTDLENSY
360 370 380 390 400
SCTCPPGFYG KICELSAMTC ADGPCFNGGR CSDSPDGGYS CRCPVGYSGF
410 420 430 440 450
NCEKKIDYCS SSPCSNGAKC VDLGDAYLCR CQAGFSGRHC DDNVDDCASS
460 470 480 490 500
PCANGGTCRD GVNDFSCTCP PGYTGRNCSA PVSRCEHAPC HNGATCHERG
510 520 530 540 550
HRYVCECARG YGGPNCQFLL PELPPGPAVV DLTEKLEGQG GPFPWVAVCA
560 570 580 590 600
GVILVLMLLL GCAAVVVCVR LRLQKHRPPA DPCRGETETM NNLANCQREK
610 620 630 640 650
DISVSIIGAT QIKNTNKKAD FHGDHSADKN GFKARYPAVD YNLVQDLKGD
660 670 680 690 700
DTAVRDAHSK RDTKCQPQGS SGEEKGTPTT LRGGEASERK RPDSGCSTSK
710 720
DTKYQSVYVI SEEKDECVIA TEV
Length:723
Mass (Da):78,056
Last modified:October 31, 2006 - v2
Checksum:i094B8F235DFD899D
GO
Isoform 2 (identifier: O00548-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     224-247: PICLPGCDEQHGFCDKPGECKCRV → RESLGRHRWLTRPRTRTTRRDGAS
     248-723: Missing.

Show »
Length:247
Mass (Da):27,355
Checksum:iD93EB99469AE4871
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti498 – 4981E → Q in AAF05834. (PubMed:10688816)Curated
Sequence conflicti502 – 5021R → G in AAB61286. (PubMed:10079256)Curated
Sequence conflicti502 – 5021R → G in AAF05834. (PubMed:10688816)Curated
Sequence conflicti502 – 5021R → G in AAG09716. (PubMed:19906316)Curated
Sequence conflicti510 – 5101G → S in AAF05834. (PubMed:10688816)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti444 – 4441V → M.
Corresponds to variant rs16901311 [ dbSNP | Ensembl ].
VAR_048976

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei224 – 24724PICLP…CKCRV → RESLGRHRWLTRPRTRTTRR DGAS in isoform 2. 1 PublicationVSP_057186Add
BLAST
Alternative sequencei248 – 723476Missing in isoform 2. 1 PublicationVSP_057187Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003522 mRNA. Translation: AAB61286.1.
AF196571 mRNA. Translation: AAF05834.1.
EU927387 mRNA. Translation: ACH57449.1.
AF222310 Genomic DNA. Translation: AAG09716.1.
AY358892 mRNA. Translation: AAQ89251.1.
AK314234 mRNA. Translation: BAG36904.1.
AL078605 Genomic DNA. Translation: CAB89569.1.
CH471051 Genomic DNA. Translation: EAW47425.1.
CCDSiCCDS5313.1.
RefSeqiNP_005609.3. NM_005618.3.
UniGeneiHs.379912.

Genome annotation databases

EnsembliENST00000366756; ENSP00000355718; ENSG00000198719.
ENST00000616526; ENSP00000480905; ENSG00000275555.
GeneIDi28514.
KEGGihsa:28514.
UCSCiuc003qxm.3. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003522 mRNA. Translation: AAB61286.1 .
AF196571 mRNA. Translation: AAF05834.1 .
EU927387 mRNA. Translation: ACH57449.1 .
AF222310 Genomic DNA. Translation: AAG09716.1 .
AY358892 mRNA. Translation: AAQ89251.1 .
AK314234 mRNA. Translation: BAG36904.1 .
AL078605 Genomic DNA. Translation: CAB89569.1 .
CH471051 Genomic DNA. Translation: EAW47425.1 .
CCDSi CCDS5313.1.
RefSeqi NP_005609.3. NM_005618.3.
UniGenei Hs.379912.

3D structure databases

ProteinModelPortali O00548.
SMRi O00548. Positions 22-551.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118391. 6 interactions.
STRINGi 9606.ENSP00000355718.

PTM databases

PhosphoSitei O00548.

Proteomic databases

PaxDbi O00548.
PRIDEi O00548.

Protocols and materials databases

DNASUi 28514.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000366756 ; ENSP00000355718 ; ENSG00000198719 .
ENST00000616526 ; ENSP00000480905 ; ENSG00000275555 .
GeneIDi 28514.
KEGGi hsa:28514.
UCSCi uc003qxm.3. human.

Organism-specific databases

CTDi 28514.
GeneCardsi GC06M170591.
HGNCi HGNC:2908. DLL1.
MIMi 606582. gene.
neXtProti NX_O00548.
Orphaneti 93925. Alobar holoprosencephaly.
93924. Lobar holoprosencephaly.
280200. Microform holoprosencephaly.
93926. Midline interhemispheric variant of holoprosencephaly.
220386. Semilobar holoprosencephaly.
280195. Septopreoptic holoprosencephaly.
PharmGKBi PA27364.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG249767.
GeneTreei ENSGT00760000118786.
HOGENOMi HOG000267024.
HOVERGENi HBG007139.
InParanoidi O00548.
KOi K06051.
OMAi RCTDNPD.
OrthoDBi EOG7GQXZ5.
PhylomeDBi O00548.
TreeFami TF351835.

Enzyme and pathway databases

Reactomei REACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_118636. Signaling by NOTCH4.
REACT_118862. Signaling by NOTCH3.
REACT_160089. Constitutive Signaling by NOTCH1 HD Domain Mutants.
REACT_160106. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
REACT_160205. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
SignaLinki O00548.

Miscellaneous databases

ChiTaRSi DLL1. human.
GeneWikii Delta-like_1.
GenomeRNAii 28514.
NextBioi 50984.
PROi O00548.
SOURCEi Search...

Gene expression databases

Bgeei O00548.
CleanExi HS_DLL1.
Genevestigatori O00548.

Family and domain databases

InterProi IPR001774. DSL.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011651. Notch_ligand_N.
[Graphical view ]
Pfami PF01414. DSL. 1 hit.
PF00008. EGF. 6 hits.
PF07657. MNNL. 1 hit.
[Graphical view ]
SMARTi SM00051. DSL. 1 hit.
SM00181. EGF. 4 hits.
SM00179. EGF_CA. 4 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 2 hits.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 8 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells."
    Han W., Ye Q., Moore M.A.S.
    Blood 95:1616-1625(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site."
    Wang P., Yu P., Gao P., Shi T., Ma D.
    BMC Genomics 10:518-518(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  4. "Human Delta 1 gene sequence."
    Oda T., Chandrasekharappa S.C.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation."
    Jaleco A.C., Neves H., Hooijberg E., Gameiro P., Clode N., Haury M., Henrique D., Parreira L.
    J. Exp. Med. 194:991-1001(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiDLL1_HUMAN
AccessioniPrimary (citable) accession number: O00548
Secondary accession number(s): B2RAK7
, B5M0B3, Q9NU41, Q9UJV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 31, 2006
Last modified: November 26, 2014
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

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