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O00533

- CHL1_HUMAN

UniProt

O00533 - CHL1_HUMAN

Protein

Neural cell adhesion molecule L1-like protein

Gene

CHL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 4 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei753 – 7542Cleavage; by ADAM8By similarity
    Sitei1039 – 10402Cleavage; by ADAM8By similarity

    GO - Biological processi

    1. adult locomotory behavior Source: Ensembl
    2. axon guidance Source: Reactome
    3. cell adhesion Source: ProtInc
    4. cognition Source: Ensembl
    5. exploration behavior Source: Ensembl
    6. negative regulation of neuron apoptotic process Source: Ensembl
    7. neuron migration Source: Ensembl
    8. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Cell adhesion, Differentiation, Neurogenesis

    Enzyme and pathway databases

    ReactomeiREACT_22292. CHL1 interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neural cell adhesion molecule L1-like protein
    Alternative name(s):
    Close homolog of L1
    Cleaved into the following chain:
    Gene namesi
    Name:CHL1
    Synonyms:CALL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:1939. CHL1.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity
    Note: Soluble forms produced by cleavage/shedding also exist.By similarity

    GO - Cellular componenti

    1. apical part of cell Source: Ensembl
    2. dendrite Source: Ensembl
    3. integral component of membrane Source: ProtInc
    4. plasma membrane Source: UniProtKB-SubCell
    5. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Extracellular matrix, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti1620. Distal monosomy 3p.
    PharmGKBiPA26470.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 12081184Neural cell adhesion molecule L1-like proteinPRO_0000247896Add
    BLAST
    Chaini25 – ?Processed neural cell adhesion molecule L1-like proteinSequence AnalysisPRO_0000314777

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi57 ↔ 109PROSITE-ProRule annotation
    Disulfide bondi153 ↔ 204PROSITE-ProRule annotation
    Disulfide bondi262 ↔ 310PROSITE-ProRule annotation
    Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi352 ↔ 401PROSITE-ProRule annotation
    Disulfide bondi445 ↔ 494PROSITE-ProRule annotation
    Glycosylationi476 – 4761N-linked (GlcNAc...)1 Publication
    Glycosylationi482 – 4821N-linked (GlcNAc...)1 Publication
    Disulfide bondi536 ↔ 591PROSITE-ProRule annotation
    Glycosylationi562 – 5621N-linked (GlcNAc...)1 Publication
    Glycosylationi580 – 5801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi767 – 7671N-linked (GlcNAc...)1 Publication
    Glycosylationi822 – 8221N-linked (GlcNAc...)1 Publication
    Glycosylationi945 – 9451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1026 – 10261N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    Cleavage by metalloprotease ADAM8 in the extracellular part generates 2 soluble forms (125 kDa and 165 kDa) in vitro and is inhibited by metalloprotease inhibitors.
    N-glycosylated. Contains N-linked oligosaccharides with a sulfated carbohydrate structure type HNK-1 (SO4-3-GlcUABeta1,3GalBeta1,4GlcNAc) By similarity.By similarity
    O-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiO00533.
    PaxDbiO00533.
    PRIDEiO00533.

    PTM databases

    PhosphoSiteiO00533.

    Expressioni

    Tissue specificityi

    Expressed in the fetal and adult brain as well as in Schwann cell culture. Also detected in adult peripheral tissues.1 Publication

    Gene expression databases

    ArrayExpressiO00533.
    BgeeiO00533.
    CleanExiHS_CHL1.
    GenevestigatoriO00533.

    Organism-specific databases

    HPAiCAB026120.
    HPA003345.

    Interactioni

    Subunit structurei

    May interact with L1CAM. May interact with ITGB1/ITGA1 heterodimer and ITGB1/ITGA2 heterodimer as well as with ANK3 By similarity.By similarity

    Protein-protein interaction databases

    IntActiO00533. 2 interactions.
    STRINGi9606.ENSP00000256509.

    Structurei

    3D structure databases

    ProteinModelPortaliO00533.
    SMRiO00533. Positions 31-1013.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 10821058ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1104 – 1208105CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1083 – 110321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 12490Ig-like C2-type 1Add
    BLAST
    Domaini128 – 22396Ig-like C2-type 2Add
    BLAST
    Domaini235 – 32894Ig-like C2-type 3Add
    BLAST
    Domaini331 – 41787Ig-like C2-type 4Add
    BLAST
    Domaini423 – 51088Ig-like C2-type 5Add
    BLAST
    Domaini515 – 60793Ig-like C2-type 6Add
    BLAST
    Domaini614 – 70996Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini714 – 80794Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini809 – 914106Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini918 – 101598Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi555 – 5584DGEA
    Motifi1181 – 11855FIG[AQ]Y

    Domaini

    The FIG[AQ]Y motif seems to be an ankyrin recruitment region.
    The DGEA motif seems to be a recognition site for integrin.

    Sequence similaritiesi

    Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG256023.
    HOGENOMiHOG000231380.
    HOVERGENiHBG000144.
    KOiK06758.
    OMAiYVRYQFR.
    OrthoDBiEOG7R56RM.
    PhylomeDBiO00533.
    TreeFamiTF351098.

    Family and domain databases

    Gene3Di2.60.40.10. 10 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR026966. Neurofascin/L1/NrCAM_C.
    [Graphical view]
    PfamiPF13882. Bravo_FIGEY. 1 hit.
    PF00041. fn3. 4 hits.
    PF07679. I-set. 4 hits.
    [Graphical view]
    SMARTiSM00060. FN3. 4 hits.
    SM00409. IG. 2 hits.
    SM00408. IGc2. 3 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 4 hits.
    PS50835. IG_LIKE. 6 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O00533-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEPLLLGRGL IVYLMFLLLK FSKAIEIPSS VQQVPTIIKQ SKVQVAFPFD     50
    EYFQIECEAK GNPEPTFSWT KDGNPFYFTD HRIIPSNNSG TFRIPNEGHI 100
    SHFQGKYRCF ASNKLGIAMS EEIEFIVPSV PKFPKEKIDP LEVEEGDPIV 150
    LPCNPPKGLP PLHIYWMNIE LEHIEQDERV YMSQKGDLYF ANVEEKDSRN 200
    DYCCFAAFPR LRTIVQKMPM KLTVNSSNSI KQRKPKLLLP PTESGSESSI 250
    TILKGEILLL ECFAEGLPTP QVDWNKIGGD LPKGRETKEN YGKTLKIENV 300
    SYQDKGNYRC TASNFLGTAT HDFHVIVEEP PRWTKKPQSA VYSTGSNGIL 350
    LCEAEGEPQP TIKWRVNGSP VDNHPFAGDV VFPREISFTN LQPNHTAVYQ 400
    CEASNVHGTI LANANIDVVD VRPLIQTKDG ENYATVVGYS AFLHCEFFAS 450
    PEAVVSWQKV EEVKPLEGRR YHIYENGTLQ INRTTEEDAG SYSCWVENAI 500
    GKTAVTANLD IRNATKLRVS PKNPRIPKLH MLELHCESKC DSHLKHSLKL 550
    SWSKDGEAFE INGTEDGRII IDGANLTISN VTLEDQGIYC CSAHTALDSA 600
    ADITQVTVLD VPDPPENLHL SERQNRSVRL TWEAGADHNS NISEYIVEFE 650
    GNKEEPGRWE ELTRVQGKKT TVILPLAPFV RYQFRVIAVN EVGRSQPSQP 700
    SDHHETPPAA PDRNPQNIRV QASQPKEMII KWEPLKSMEQ NGPGLEYRVT 750
    WKPQGAPVEW EEETVTNHTL RVMTPAVYAP YDVKVQAINQ LGSGPDPQSV 800
    TLYSGEDYPD TAPVIHGVDV INSTLVKVTW STVPKDRVHG RLKGYQINWW 850
    KTKSLLDGRT HPKEVNILRF SGQRNSGMVP SLDAFSEFHL TVLAYNSKGA 900
    GPESEPYIFQ TPEGVPEQPT FLKVIKVDKD TATLSWGLPK KLNGNLTGYL 950
    LQYQIINDTY EIGELNDINI TTPSKPSWHL SNLNATTKYK FYLRACTSQG 1000
    CGKPITEESS TLGEGSKGIG KISGVNLTQK THPIEVFEPG AEHIVRLMTK 1050
    NWGDNDSIFQ DVIETRGREY AGLYDDISTQ GWFIGLMCAI ALLTLLLLTV 1100
    CFVKRNRGGK YSVKEKEDLH PDPEIQSVKD ETFGEYSDSD EKPLKGSLRS 1150
    LNRDMQPTES ADSLVEYGEG DHGLFSEDGS FIGAYAGSKE KGSVESNGSS 1200
    TATFPLRA 1208
    Length:1,208
    Mass (Da):135,071
    Last modified:January 11, 2011 - v4
    Checksum:iF706F87B60A1685D
    GO
    Isoform 2 (identifier: O00533-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         227-227: S → LKHANDSSSSTEIGSKA

    Note: Glycosylated on Asn-231.

    Show »
    Length:1,224
    Mass (Da):136,698
    Checksum:i979C6315B6D99AC2
    GO

    Sequence cautioni

    The sequence BAD92566.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti17 – 171L → F.
    Corresponds to variant rs2272522 [ dbSNP | Ensembl ].
    VAR_027167
    Natural varianti287 – 2871T → A.3 Publications
    Corresponds to variant rs13060847 [ dbSNP | Ensembl ].
    VAR_027168
    Natural varianti411 – 4111L → I in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035505
    Natural varianti1034 – 10341I → V.3 Publications
    Corresponds to variant rs6442827 [ dbSNP | Ensembl ].
    VAR_027169

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei227 – 2271S → LKHANDSSSSTEIGSKA in isoform 2. 1 PublicationVSP_020082

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF002246 mRNA. Translation: AAB60937.1.
    AB209329 mRNA. Translation: BAD92566.1. Different initiation.
    AC011609 Genomic DNA. No translation available.
    AC026187 Genomic DNA. No translation available.
    BC104918 mRNA. Translation: AAI04919.1.
    BC143496 mRNA. Translation: AAI43497.1.
    CCDSiCCDS2556.1. [O00533-2]
    CCDS58812.1. [O00533-1]
    RefSeqiNP_001240316.1. NM_001253387.1. [O00533-1]
    NP_006605.2. NM_006614.3. [O00533-2]
    XP_006713001.1. XM_006712938.1. [O00533-2]
    XP_006713002.1. XM_006712939.1. [O00533-2]
    XP_006713003.1. XM_006712940.1. [O00533-2]
    UniGeneiHs.148909.
    Hs.731409.

    Genome annotation databases

    EnsembliENST00000256509; ENSP00000256509; ENSG00000134121. [O00533-2]
    ENST00000397491; ENSP00000380628; ENSG00000134121. [O00533-1]
    GeneIDi10752.
    KEGGihsa:10752.
    UCSCiuc003bot.3. human. [O00533-2]
    uc003bou.3. human. [O00533-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF002246 mRNA. Translation: AAB60937.1 .
    AB209329 mRNA. Translation: BAD92566.1 . Different initiation.
    AC011609 Genomic DNA. No translation available.
    AC026187 Genomic DNA. No translation available.
    BC104918 mRNA. Translation: AAI04919.1 .
    BC143496 mRNA. Translation: AAI43497.1 .
    CCDSi CCDS2556.1. [O00533-2 ]
    CCDS58812.1. [O00533-1 ]
    RefSeqi NP_001240316.1. NM_001253387.1. [O00533-1 ]
    NP_006605.2. NM_006614.3. [O00533-2 ]
    XP_006713001.1. XM_006712938.1. [O00533-2 ]
    XP_006713002.1. XM_006712939.1. [O00533-2 ]
    XP_006713003.1. XM_006712940.1. [O00533-2 ]
    UniGenei Hs.148909.
    Hs.731409.

    3D structure databases

    ProteinModelPortali O00533.
    SMRi O00533. Positions 31-1013.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O00533. 2 interactions.
    STRINGi 9606.ENSP00000256509.

    PTM databases

    PhosphoSitei O00533.

    Proteomic databases

    MaxQBi O00533.
    PaxDbi O00533.
    PRIDEi O00533.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000256509 ; ENSP00000256509 ; ENSG00000134121 . [O00533-2 ]
    ENST00000397491 ; ENSP00000380628 ; ENSG00000134121 . [O00533-1 ]
    GeneIDi 10752.
    KEGGi hsa:10752.
    UCSCi uc003bot.3. human. [O00533-2 ]
    uc003bou.3. human. [O00533-1 ]

    Organism-specific databases

    CTDi 10752.
    GeneCardsi GC03P000213.
    H-InvDB HIX0030810.
    HGNCi HGNC:1939. CHL1.
    HPAi CAB026120.
    HPA003345.
    MIMi 607416. gene.
    neXtProti NX_O00533.
    Orphaneti 1620. Distal monosomy 3p.
    PharmGKBi PA26470.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG256023.
    HOGENOMi HOG000231380.
    HOVERGENi HBG000144.
    KOi K06758.
    OMAi YVRYQFR.
    OrthoDBi EOG7R56RM.
    PhylomeDBi O00533.
    TreeFami TF351098.

    Enzyme and pathway databases

    Reactomei REACT_22292. CHL1 interactions.

    Miscellaneous databases

    ChiTaRSi CHL1. human.
    GeneWikii CHL1.
    GenomeRNAii 10752.
    NextBioi 40833.
    PROi O00533.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O00533.
    Bgeei O00533.
    CleanExi HS_CHL1.
    Genevestigatori O00533.

    Family and domain databases

    Gene3Di 2.60.40.10. 10 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR026966. Neurofascin/L1/NrCAM_C.
    [Graphical view ]
    Pfami PF13882. Bravo_FIGEY. 1 hit.
    PF00041. fn3. 4 hits.
    PF07679. I-set. 4 hits.
    [Graphical view ]
    SMARTi SM00060. FN3. 4 hits.
    SM00409. IG. 2 hits.
    SM00408. IGc2. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 4 hits.
    PS50835. IG_LIKE. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "In silico-initiated cloning and molecular characterization of a novel human member of the L1 gene family of neural cell adhesion molecules."
      Wei M.-H., Karavanova I., Ivanov S.V., Popescu N.C., Keck C.L., Pack S., Eisen J.A., Lerman M.I.
      Hum. Genet. 103:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, VARIANTS ALA-287 AND VAL-1034.
    2. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-287 AND VAL-1034.
      Tissue: Brain.
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-287 AND VAL-1034.
      Tissue: Brain.
    5. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-476; ASN-482; ASN-562; ASN-767; ASN-822 AND ASN-1026.
      Tissue: Plasma.
    6. Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-411.

    Entry informationi

    Entry nameiCHL1_HUMAN
    AccessioniPrimary (citable) accession number: O00533
    Secondary accession number(s): B7ZL03, Q2M3G2, Q59FY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 118 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3