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O00533

- CHL1_HUMAN

UniProt

O00533 - CHL1_HUMAN

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Protein

Neural cell adhesion molecule L1-like protein

Gene

CHL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei753 – 7542Cleavage; by ADAM8By similarity
Sitei1039 – 10402Cleavage; by ADAM8By similarity

GO - Biological processi

  1. adult locomotory behavior Source: Ensembl
  2. axon guidance Source: Reactome
  3. axon regeneration Source: Ensembl
  4. cell adhesion Source: ProtInc
  5. cognition Source: Ensembl
  6. exploration behavior Source: Ensembl
  7. negative regulation of neuron apoptotic process Source: Ensembl
  8. neuron migration Source: Ensembl
  9. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion, Differentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiREACT_22292. CHL1 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Neural cell adhesion molecule L1-like protein
Alternative name(s):
Close homolog of L1
Cleaved into the following chain:
Gene namesi
Name:CHL1
Synonyms:CALL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:1939. CHL1.

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein By similarity
Note: Soluble forms produced by cleavage/shedding also exist.By similarity

GO - Cellular componenti

  1. apical part of cell Source: Ensembl
  2. dendrite Source: Ensembl
  3. extracellular vesicular exosome Source: UniProtKB
  4. integral component of membrane Source: ProtInc
  5. plasma membrane Source: UniProtKB-KW
  6. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

Orphaneti1620. Distal monosomy 3p.
PharmGKBiPA26470.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 12081184Neural cell adhesion molecule L1-like proteinPRO_0000247896Add
BLAST
Chaini25 – ?Processed neural cell adhesion molecule L1-like proteinSequence AnalysisPRO_0000314777

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 109PROSITE-ProRule annotation
Disulfide bondi153 ↔ 204PROSITE-ProRule annotation
Disulfide bondi262 ↔ 310PROSITE-ProRule annotation
Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi352 ↔ 401PROSITE-ProRule annotation
Disulfide bondi445 ↔ 494PROSITE-ProRule annotation
Glycosylationi476 – 4761N-linked (GlcNAc...)1 Publication
Glycosylationi482 – 4821N-linked (GlcNAc...)1 Publication
Disulfide bondi536 ↔ 591PROSITE-ProRule annotation
Glycosylationi562 – 5621N-linked (GlcNAc...)1 Publication
Glycosylationi580 – 5801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi767 – 7671N-linked (GlcNAc...)1 Publication
Glycosylationi822 – 8221N-linked (GlcNAc...)1 Publication
Glycosylationi945 – 9451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1026 – 10261N-linked (GlcNAc...)1 Publication

Post-translational modificationi

Cleavage by metalloprotease ADAM8 in the extracellular part generates 2 soluble forms (125 kDa and 165 kDa) in vitro and is inhibited by metalloprotease inhibitors.
N-glycosylated. Contains N-linked oligosaccharides with a sulfated carbohydrate structure type HNK-1 (SO4-3-GlcUABeta1,3GalBeta1,4GlcNAc) By similarity.By similarity
O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO00533.
PaxDbiO00533.
PRIDEiO00533.

PTM databases

PhosphoSiteiO00533.

Expressioni

Tissue specificityi

Expressed in the fetal and adult brain as well as in Schwann cell culture. Also detected in adult peripheral tissues.1 Publication

Gene expression databases

BgeeiO00533.
CleanExiHS_CHL1.
ExpressionAtlasiO00533. baseline and differential.
GenevestigatoriO00533.

Organism-specific databases

HPAiCAB026120.
HPA003345.

Interactioni

Subunit structurei

May interact with L1CAM. May interact with ITGB1/ITGA1 heterodimer and ITGB1/ITGA2 heterodimer as well as with ANK3 By similarity.By similarity

Protein-protein interaction databases

IntActiO00533. 2 interactions.
STRINGi9606.ENSP00000256509.

Structurei

3D structure databases

ProteinModelPortaliO00533.
SMRiO00533. Positions 31-1002.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 10821058ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1104 – 1208105CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1083 – 110321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 12490Ig-like C2-type 1Add
BLAST
Domaini128 – 22396Ig-like C2-type 2Add
BLAST
Domaini235 – 32894Ig-like C2-type 3Add
BLAST
Domaini331 – 41787Ig-like C2-type 4Add
BLAST
Domaini423 – 51088Ig-like C2-type 5Add
BLAST
Domaini515 – 60793Ig-like C2-type 6Add
BLAST
Domaini614 – 70996Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini714 – 80794Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini809 – 914106Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini918 – 101598Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi555 – 5584DGEA
Motifi1181 – 11855FIG[AQ]Y

Domaini

The FIG[AQ]Y motif seems to be an ankyrin recruitment region.
The DGEA motif seems to be a recognition site for integrin.

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256023.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000231380.
HOVERGENiHBG000144.
InParanoidiO00533.
KOiK06758.
OMAiYVRYQFR.
OrthoDBiEOG7R56RM.
PhylomeDBiO00533.
TreeFamiTF351098.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR026966. Neurofascin/L1/NrCAM_C.
[Graphical view]
PfamiPF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 4 hits.
PF07679. I-set. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O00533-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPLLLGRGL IVYLMFLLLK FSKAIEIPSS VQQVPTIIKQ SKVQVAFPFD
60 70 80 90 100
EYFQIECEAK GNPEPTFSWT KDGNPFYFTD HRIIPSNNSG TFRIPNEGHI
110 120 130 140 150
SHFQGKYRCF ASNKLGIAMS EEIEFIVPSV PKFPKEKIDP LEVEEGDPIV
160 170 180 190 200
LPCNPPKGLP PLHIYWMNIE LEHIEQDERV YMSQKGDLYF ANVEEKDSRN
210 220 230 240 250
DYCCFAAFPR LRTIVQKMPM KLTVNSSNSI KQRKPKLLLP PTESGSESSI
260 270 280 290 300
TILKGEILLL ECFAEGLPTP QVDWNKIGGD LPKGRETKEN YGKTLKIENV
310 320 330 340 350
SYQDKGNYRC TASNFLGTAT HDFHVIVEEP PRWTKKPQSA VYSTGSNGIL
360 370 380 390 400
LCEAEGEPQP TIKWRVNGSP VDNHPFAGDV VFPREISFTN LQPNHTAVYQ
410 420 430 440 450
CEASNVHGTI LANANIDVVD VRPLIQTKDG ENYATVVGYS AFLHCEFFAS
460 470 480 490 500
PEAVVSWQKV EEVKPLEGRR YHIYENGTLQ INRTTEEDAG SYSCWVENAI
510 520 530 540 550
GKTAVTANLD IRNATKLRVS PKNPRIPKLH MLELHCESKC DSHLKHSLKL
560 570 580 590 600
SWSKDGEAFE INGTEDGRII IDGANLTISN VTLEDQGIYC CSAHTALDSA
610 620 630 640 650
ADITQVTVLD VPDPPENLHL SERQNRSVRL TWEAGADHNS NISEYIVEFE
660 670 680 690 700
GNKEEPGRWE ELTRVQGKKT TVILPLAPFV RYQFRVIAVN EVGRSQPSQP
710 720 730 740 750
SDHHETPPAA PDRNPQNIRV QASQPKEMII KWEPLKSMEQ NGPGLEYRVT
760 770 780 790 800
WKPQGAPVEW EEETVTNHTL RVMTPAVYAP YDVKVQAINQ LGSGPDPQSV
810 820 830 840 850
TLYSGEDYPD TAPVIHGVDV INSTLVKVTW STVPKDRVHG RLKGYQINWW
860 870 880 890 900
KTKSLLDGRT HPKEVNILRF SGQRNSGMVP SLDAFSEFHL TVLAYNSKGA
910 920 930 940 950
GPESEPYIFQ TPEGVPEQPT FLKVIKVDKD TATLSWGLPK KLNGNLTGYL
960 970 980 990 1000
LQYQIINDTY EIGELNDINI TTPSKPSWHL SNLNATTKYK FYLRACTSQG
1010 1020 1030 1040 1050
CGKPITEESS TLGEGSKGIG KISGVNLTQK THPIEVFEPG AEHIVRLMTK
1060 1070 1080 1090 1100
NWGDNDSIFQ DVIETRGREY AGLYDDISTQ GWFIGLMCAI ALLTLLLLTV
1110 1120 1130 1140 1150
CFVKRNRGGK YSVKEKEDLH PDPEIQSVKD ETFGEYSDSD EKPLKGSLRS
1160 1170 1180 1190 1200
LNRDMQPTES ADSLVEYGEG DHGLFSEDGS FIGAYAGSKE KGSVESNGSS

TATFPLRA
Length:1,208
Mass (Da):135,071
Last modified:January 11, 2011 - v4
Checksum:iF706F87B60A1685D
GO
Isoform 2 (identifier: O00533-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-227: S → LKHANDSSSSTEIGSKA

Note: Glycosylated on Asn-231.

Show »
Length:1,224
Mass (Da):136,698
Checksum:i979C6315B6D99AC2
GO

Sequence cautioni

The sequence BAD92566.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171L → F.
Corresponds to variant rs2272522 [ dbSNP | Ensembl ].
VAR_027167
Natural varianti287 – 2871T → A.3 Publications
Corresponds to variant rs13060847 [ dbSNP | Ensembl ].
VAR_027168
Natural varianti411 – 4111L → I in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035505
Natural varianti1034 – 10341I → V.3 Publications
Corresponds to variant rs6442827 [ dbSNP | Ensembl ].
VAR_027169

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei227 – 2271S → LKHANDSSSSTEIGSKA in isoform 2. 1 PublicationVSP_020082

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF002246 mRNA. Translation: AAB60937.1.
AB209329 mRNA. Translation: BAD92566.1. Different initiation.
AC011609 Genomic DNA. No translation available.
AC026187 Genomic DNA. No translation available.
BC104918 mRNA. Translation: AAI04919.1.
BC143496 mRNA. Translation: AAI43497.1.
CCDSiCCDS2556.1. [O00533-2]
CCDS58812.1. [O00533-1]
RefSeqiNP_001240316.1. NM_001253387.1. [O00533-1]
NP_006605.2. NM_006614.3. [O00533-2]
XP_006713001.1. XM_006712938.1. [O00533-2]
XP_006713002.1. XM_006712939.1. [O00533-2]
XP_006713003.1. XM_006712940.1. [O00533-2]
UniGeneiHs.148909.
Hs.731409.

Genome annotation databases

EnsembliENST00000256509; ENSP00000256509; ENSG00000134121. [O00533-2]
ENST00000397491; ENSP00000380628; ENSG00000134121. [O00533-1]
GeneIDi10752.
KEGGihsa:10752.
UCSCiuc003bot.3. human. [O00533-2]
uc003bou.3. human. [O00533-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF002246 mRNA. Translation: AAB60937.1 .
AB209329 mRNA. Translation: BAD92566.1 . Different initiation.
AC011609 Genomic DNA. No translation available.
AC026187 Genomic DNA. No translation available.
BC104918 mRNA. Translation: AAI04919.1 .
BC143496 mRNA. Translation: AAI43497.1 .
CCDSi CCDS2556.1. [O00533-2 ]
CCDS58812.1. [O00533-1 ]
RefSeqi NP_001240316.1. NM_001253387.1. [O00533-1 ]
NP_006605.2. NM_006614.3. [O00533-2 ]
XP_006713001.1. XM_006712938.1. [O00533-2 ]
XP_006713002.1. XM_006712939.1. [O00533-2 ]
XP_006713003.1. XM_006712940.1. [O00533-2 ]
UniGenei Hs.148909.
Hs.731409.

3D structure databases

ProteinModelPortali O00533.
SMRi O00533. Positions 31-1002.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O00533. 2 interactions.
STRINGi 9606.ENSP00000256509.

PTM databases

PhosphoSitei O00533.

Proteomic databases

MaxQBi O00533.
PaxDbi O00533.
PRIDEi O00533.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000256509 ; ENSP00000256509 ; ENSG00000134121 . [O00533-2 ]
ENST00000397491 ; ENSP00000380628 ; ENSG00000134121 . [O00533-1 ]
GeneIDi 10752.
KEGGi hsa:10752.
UCSCi uc003bot.3. human. [O00533-2 ]
uc003bou.3. human. [O00533-1 ]

Organism-specific databases

CTDi 10752.
GeneCardsi GC03P000213.
H-InvDB HIX0030810.
HGNCi HGNC:1939. CHL1.
HPAi CAB026120.
HPA003345.
MIMi 607416. gene.
neXtProti NX_O00533.
Orphaneti 1620. Distal monosomy 3p.
PharmGKBi PA26470.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG256023.
GeneTreei ENSGT00760000118840.
HOGENOMi HOG000231380.
HOVERGENi HBG000144.
InParanoidi O00533.
KOi K06758.
OMAi YVRYQFR.
OrthoDBi EOG7R56RM.
PhylomeDBi O00533.
TreeFami TF351098.

Enzyme and pathway databases

Reactomei REACT_22292. CHL1 interactions.

Miscellaneous databases

ChiTaRSi CHL1. human.
GeneWikii CHL1.
GenomeRNAii 10752.
NextBioi 40833.
PROi O00533.
SOURCEi Search...

Gene expression databases

Bgeei O00533.
CleanExi HS_CHL1.
ExpressionAtlasi O00533. baseline and differential.
Genevestigatori O00533.

Family and domain databases

Gene3Di 2.60.40.10. 10 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR026966. Neurofascin/L1/NrCAM_C.
[Graphical view ]
Pfami PF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 4 hits.
PF07679. I-set. 4 hits.
[Graphical view ]
SMARTi SM00060. FN3. 4 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 3 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "In silico-initiated cloning and molecular characterization of a novel human member of the L1 gene family of neural cell adhesion molecules."
    Wei M.-H., Karavanova I., Ivanov S.V., Popescu N.C., Keck C.L., Pack S., Eisen J.A., Lerman M.I.
    Hum. Genet. 103:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, VARIANTS ALA-287 AND VAL-1034.
  2. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-287 AND VAL-1034.
    Tissue: Brain.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-287 AND VAL-1034.
    Tissue: Brain.
  5. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-476; ASN-482; ASN-562; ASN-767; ASN-822 AND ASN-1026.
    Tissue: Plasma.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-411.

Entry informationi

Entry nameiCHL1_HUMAN
AccessioniPrimary (citable) accession number: O00533
Secondary accession number(s): B7ZL03, Q2M3G2, Q59FY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 119 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3