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Protein

Uroplakin-2

Gene

UPK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity).By similarity

GO - Biological processi

  • epithelial cell differentiation Source: UniProtKB
  • membrane organization Source: InterPro
  • multicellular organism development Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uroplakin-2
Short name:
UP2
Alternative name(s):
Uroplakin II
Short name:
UPII
Gene namesi
Name:UPK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:12579. UPK2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini85 – 15571LumenalSequence analysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence analysisAdd
BLAST
Topological domaini177 – 1848CytoplasmicSequence analysis

GO - Cellular componenti

  • apical plasma membrane Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • integral component of endoplasmic reticulum membrane Source: InterPro
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37211.

Polymorphism and mutation databases

BioMutaiUPK2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Propeptidei26 – 8459By similarityPRO_0000022630Add
BLAST
Chaini85 – 184100Uroplakin-2PRO_0000022631Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence analysis
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

MaxQBiO00526.
PaxDbiO00526.
PRIDEiO00526.
TopDownProteomicsiO00526.

PTM databases

iPTMnetiO00526.
PhosphoSiteiO00526.

Expressioni

Tissue specificityi

Expressed in ureter.1 Publication

Gene expression databases

BgeeiO00526.
CleanExiHS_UPK2.
GenevisibleiO00526. HS.

Organism-specific databases

HPAiHPA043312.
HPA061106.

Interactioni

Subunit structurei

Interacts with uroplakin-1a (UPK1A).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC155Q8N6L03EBI-10179682,EBI-749265

Protein-protein interaction databases

BioGridi113225. 3 interactions.
IntActiO00526. 1 interaction.
STRINGi9606.ENSP00000264031.

Structurei

3D structure databases

ProteinModelPortaliO00526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uroplakin-2 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8ZD. Eukaryota.
ENOG4111EC7. LUCA.
GeneTreeiENSGT00390000006115.
HOGENOMiHOG000132917.
HOVERGENiHBG016837.
InParanoidiO00526.
OMAiPRRNMES.
OrthoDBiEOG79GT7V.
PhylomeDBiO00526.
TreeFamiTF337797.

Family and domain databases

InterProiIPR009952. Uroplakin_II.
[Graphical view]
PANTHERiPTHR17573. PTHR17573. 1 hit.
PfamiPF07353. Uroplakin_II. 1 hit.
[Graphical view]
PIRSFiPIRSF016439. Uroplakin_II. 1 hit.
ProDomiPD022112. Uroplakin_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00526-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLLPIRTL PLILILLALL SPGAADFNIS SLSGLLSPAL TESLLVALPP
60 70 80 90 100
CHLTGGNATL MVRRANDSKV VTSSFVVPPC RGRRELVSVV DSGAGFTVTR
110 120 130 140 150
LSAYQVTNLV PGTKFYISYL VKKGTATESS REIPMSTLPR RNMESIGLGM
160 170 180
ARTGGMVVIT VLLSVAMFLL VLGFIIALAL GSRK
Length:184
Mass (Da):19,438
Last modified:May 30, 2000 - v2
Checksum:i83D963F06050A585
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti149 – 1491G → A in AAB58416 (Ref. 7) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471A → S.
Corresponds to variant rs3886020 [ dbSNP | Ensembl ].
VAR_051473
Natural varianti160 – 1601T → M.
Corresponds to variant rs45530531 [ dbSNP | Ensembl ].
VAR_062246

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13645 mRNA. Translation: CAA73996.1.
AB078607 Genomic DNA. Translation: BAB84089.1.
AY455312 mRNA. Translation: AAR19396.1.
EF445028 Genomic DNA. Translation: ACA06070.1.
BC113900 mRNA. Translation: AAI13901.1.
AF000562 mRNA. Translation: AAB58416.1.
CCDSiCCDS8404.1.
PIRiT09609.
RefSeqiNP_006751.1. NM_006760.3.
UniGeneiHs.379613.

Genome annotation databases

EnsembliENST00000264031; ENSP00000264031; ENSG00000110375.
GeneIDi7379.
KEGGihsa:7379.
UCSCiuc001puh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13645 mRNA. Translation: CAA73996.1.
AB078607 Genomic DNA. Translation: BAB84089.1.
AY455312 mRNA. Translation: AAR19396.1.
EF445028 Genomic DNA. Translation: ACA06070.1.
BC113900 mRNA. Translation: AAI13901.1.
AF000562 mRNA. Translation: AAB58416.1.
CCDSiCCDS8404.1.
PIRiT09609.
RefSeqiNP_006751.1. NM_006760.3.
UniGeneiHs.379613.

3D structure databases

ProteinModelPortaliO00526.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113225. 3 interactions.
IntActiO00526. 1 interaction.
STRINGi9606.ENSP00000264031.

PTM databases

iPTMnetiO00526.
PhosphoSiteiO00526.

Polymorphism and mutation databases

BioMutaiUPK2.

Proteomic databases

MaxQBiO00526.
PaxDbiO00526.
PRIDEiO00526.
TopDownProteomicsiO00526.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264031; ENSP00000264031; ENSG00000110375.
GeneIDi7379.
KEGGihsa:7379.
UCSCiuc001puh.4. human.

Organism-specific databases

CTDi7379.
GeneCardsiUPK2.
HGNCiHGNC:12579. UPK2.
HPAiHPA043312.
HPA061106.
MIMi611558. gene.
neXtProtiNX_O00526.
PharmGKBiPA37211.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J8ZD. Eukaryota.
ENOG4111EC7. LUCA.
GeneTreeiENSGT00390000006115.
HOGENOMiHOG000132917.
HOVERGENiHBG016837.
InParanoidiO00526.
OMAiPRRNMES.
OrthoDBiEOG79GT7V.
PhylomeDBiO00526.
TreeFamiTF337797.

Miscellaneous databases

GeneWikiiUPK2.
GenomeRNAii7379.
NextBioi28896.
PROiO00526.
SOURCEiSearch...

Gene expression databases

BgeeiO00526.
CleanExiHS_UPK2.
GenevisibleiO00526. HS.

Family and domain databases

InterProiIPR009952. Uroplakin_II.
[Graphical view]
PANTHERiPTHR17573. PTHR17573. 1 hit.
PfamiPF07353. Uroplakin_II. 1 hit.
[Graphical view]
PIRSFiPIRSF016439. Uroplakin_II. 1 hit.
ProDomiPD022112. Uroplakin_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Ureter.
  2. Smith B.A.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 163.
  3. "Genetic detection for hematogenous micrometastasis in patients with various types of malignant tumors using Uroplakin II derived primers in polymerase chain reaction."
    Hirata H., Hisatomi H., Kawakita M., Nagao K., Yamamoto S., Hikiji K., Nakamoto T., Harasawa H., Kaneko N., Matsuda T., Yamamoto M., Kanamaru T.
    Oncol. Rep. 10:963-966(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  4. "Cloning of human uroplakin II gene from Chinese transitional cell carcinoma of bladder patients."
    Tong Q.S., Zheng L.D., Chen F.M., Zeng F.Q., Zhao J., Wang L., Lu G.C.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Urinary bladder.
  5. NHLBI resequencing and genotyping service (RS&G)
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. Su S.L.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 146-184.
    Tissue: Urinary bladder carcinoma.

Entry informationi

Entry nameiUPK2_HUMAN
AccessioniPrimary (citable) accession number: O00526
Secondary accession number(s): B0YJ92, O00457, Q53YV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: May 11, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.