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Protein

Ladinin-1

Gene

LAD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Anchoring filament protein which is a component of the basement membrane zone.By similarity

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • structural molecule activity Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159166-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ladinin-1
Short name:
Lad-1
Alternative name(s):
Linear IgA disease antigen
Short name:
LADA
Gene namesi
Name:LAD1
Synonyms:LAD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:6472. LAD1.

Subcellular locationi

GO - Cellular componenti

  • basement membrane Source: UniProtKB-SubCell
  • cell-cell adherens junction Source: BHF-UCL
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3898.
OpenTargetsiENSG00000159166.
PharmGKBiPA30263.

Polymorphism and mutation databases

BioMutaiLAD1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000843491 – 517Ladinin-1Add BLAST517

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphoserineCombined sources1
Modified residuei64PhosphoserineCombined sources1
Modified residuei78PhosphoserineBy similarity1
Modified residuei121PhosphoserineCombined sources1
Modified residuei123PhosphoserineCombined sources1
Modified residuei347PhosphoserineBy similarity1
Modified residuei356PhosphoserineCombined sources1
Modified residuei394PhosphoserineCombined sources1
Modified residuei424Omega-N-methylarginineCombined sources1
Modified residuei485PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiO00515.
MaxQBiO00515.
PaxDbiO00515.
PeptideAtlasiO00515.
PRIDEiO00515.

PTM databases

iPTMnetiO00515.
PhosphoSitePlusiO00515.

Expressioni

Gene expression databases

BgeeiENSG00000159166.
CleanExiHS_LAD1.
ExpressionAtlasiO00515. baseline and differential.
GenevisibleiO00515. HS.

Organism-specific databases

HPAiHPA007256.
HPA028732.

Interactioni

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi110095. 3 interactors.
IntActiO00515. 4 interactors.
MINTiMINT-3974996.
STRINGi9606.ENSP00000375829.

Structurei

3D structure databases

ProteinModelPortaliO00515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati203 – 205SEK 13
Repeati209 – 211SEK 23
Repeati215 – 217SEK 33
Repeati221 – 223SEK 43
Repeati227 – 229SEK 53
Repeati239 – 241SEK 63
Repeati257 – 259SEK 73
Repeati269 – 271SEK 83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni203 – 2718 X SEK repeatsAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 35Poly-Arg8

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IIRJ. Eukaryota.
ENOG410YZPA. LUCA.
GeneTreeiENSGT00390000005256.
HOGENOMiHOG000113274.
HOVERGENiHBG006240.
InParanoidiO00515.
PhylomeDBiO00515.
TreeFamiTF335896.

Family and domain databases

InterProiIPR017404. Ladinin_1.
[Graphical view]
PIRSFiPIRSF038144. Ladinin_1. 1 hit.

Sequencei

Sequence statusi: Complete.

O00515-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVSRKDWSA LSSLARQRTL EDEEEQERER RRRHRNLSST TDDEAPRLSQ
60 70 80 90 100
NGDRQASASE RLPSVEEAEV PKPLPPASKD EDEDIQSILR TRQERRQRRQ
110 120 130 140 150
VVEAAQAPIQ ERLEAEEGRN SLSPVQATQK PLVSKKELEI PPRRRLSREQ
160 170 180 190 200
RGPWALEEES LVGREPEERK KGVPEKSPVL EKSSMPKKTA PEKSLVSDKT
210 220 230 240 250
SISEKVLASE KTSLSEKIAV SEKRNSSEKK SVLEKTSVSE KSLAPGMALG
260 270 280 290 300
SGRRLVSEKA SIFEKALASE KSPTADAKPA PKRATASEQP LAQEPPASGG
310 320 330 340 350
SPATTKEQRG RALPGKNLPS LAKQGASDPP TVASRLPPVT LQVKIPSKEE
360 370 380 390 400
EADMSSPTQR TYSSSLKRSS PRTISFRMKP KKENSETTLT RSASMKLPDN
410 420 430 440 450
TVKLGEKLER YHTAIRRSES VKSRGLPCTE LFVAPVGVAS KRHLFEKELA
460 470 480 490 500
GQSRAEPASS RKENLRLSGV VTSRLNLWIS RTQESGDQDP QEAQKASSAT
510
ERTQWGQKSD SSLDAEV
Length:517
Mass (Da):57,131
Last modified:September 23, 2008 - v2
Checksum:i622E81B9412A924B
GO

Sequence cautioni

The sequence AAD10849 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04653956A → S.Corresponds to variant rs3738281dbSNPEnsembl.1
Natural variantiVAR_046540155A → P.2 PublicationsCorresponds to variant rs1128316dbSNPEnsembl.1
Natural variantiVAR_046541243L → P.Corresponds to variant rs12088790dbSNPEnsembl.1
Natural variantiVAR_046542279P → Q.Corresponds to variant rs11805972dbSNPEnsembl.1
Natural variantiVAR_046543323K → E.Corresponds to variant rs4128458dbSNPEnsembl.1
Natural variantiVAR_046544503T → S.Corresponds to variant rs2275866dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42408 mRNA. Translation: AAB58817.1.
U58994 Genomic DNA. Translation: AAD10849.1. Sequence problems.
AK313388 mRNA. Translation: BAG36186.1.
BC009742 mRNA. Translation: AAH09742.1.
CCDSiCCDS1410.1.
RefSeqiNP_005549.2. NM_005558.3.
UniGeneiHs.519035.

Genome annotation databases

EnsembliENST00000391967; ENSP00000375829; ENSG00000159166.
GeneIDi3898.
KEGGihsa:3898.
UCSCiuc001gwm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42408 mRNA. Translation: AAB58817.1.
U58994 Genomic DNA. Translation: AAD10849.1. Sequence problems.
AK313388 mRNA. Translation: BAG36186.1.
BC009742 mRNA. Translation: AAH09742.1.
CCDSiCCDS1410.1.
RefSeqiNP_005549.2. NM_005558.3.
UniGeneiHs.519035.

3D structure databases

ProteinModelPortaliO00515.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110095. 3 interactors.
IntActiO00515. 4 interactors.
MINTiMINT-3974996.
STRINGi9606.ENSP00000375829.

PTM databases

iPTMnetiO00515.
PhosphoSitePlusiO00515.

Polymorphism and mutation databases

BioMutaiLAD1.

Proteomic databases

EPDiO00515.
MaxQBiO00515.
PaxDbiO00515.
PeptideAtlasiO00515.
PRIDEiO00515.

Protocols and materials databases

DNASUi3898.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391967; ENSP00000375829; ENSG00000159166.
GeneIDi3898.
KEGGihsa:3898.
UCSCiuc001gwm.4. human.

Organism-specific databases

CTDi3898.
DisGeNETi3898.
GeneCardsiLAD1.
HGNCiHGNC:6472. LAD1.
HPAiHPA007256.
HPA028732.
MIMi602314. gene.
neXtProtiNX_O00515.
OpenTargetsiENSG00000159166.
PharmGKBiPA30263.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIRJ. Eukaryota.
ENOG410YZPA. LUCA.
GeneTreeiENSGT00390000005256.
HOGENOMiHOG000113274.
HOVERGENiHBG006240.
InParanoidiO00515.
PhylomeDBiO00515.
TreeFamiTF335896.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159166-MONOMER.

Miscellaneous databases

ChiTaRSiLAD1. human.
GeneWikiiLAD1.
GenomeRNAii3898.
PROiO00515.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159166.
CleanExiHS_LAD1.
ExpressionAtlasiO00515. baseline and differential.
GenevisibleiO00515. HS.

Family and domain databases

InterProiIPR017404. Ladinin_1.
[Graphical view]
PIRSFiPIRSF038144. Ladinin_1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLAD1_HUMAN
AccessioniPrimary (citable) accession number: O00515
Secondary accession number(s): O95614, Q96GD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 23, 2008
Last modified: November 30, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.