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O00507

- USP9Y_HUMAN

UniProt

O00507 - USP9Y_HUMAN

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Protein

Probable ubiquitin carboxyl-terminal hydrolase FAF-Y

Gene

USP9Y

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiqitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1568 – 15681NucleophilePROSITE-ProRule annotation
Active sitei1881 – 18811Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. co-SMAD binding Source: BHF-UCL
  2. cysteine-type peptidase activity Source: ProtInc
  3. ubiquitin-specific protease activity Source: ProtInc

GO - Biological processi

  1. BMP signaling pathway Source: UniProtKB
  2. protein deubiquitination Source: UniProtKB
  3. spermatogenesis Source: ProtInc
  4. transforming growth factor beta receptor signaling pathway Source: UniProtKB
  5. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.028.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase FAF-Y (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme FAF-Y
Fat facets protein-related, Y-linked
Ubiquitin thioesterase FAF-Y
Ubiquitin-specific protease 9, Y chromosome
Ubiquitin-specific-processing protease FAF-Y
Gene namesi
Name:USP9Y
Synonyms:DFFRY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome Y

Organism-specific databases

HGNCiHGNC:12633. USP9Y.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

USP9Y is located in the 'azoospermia factor a' (AZFa) region on chromosome Y which is deleted in Sertoli cell-only syndrome. This is an infertility disorder in which no germ cells are visible in seminiferous tubules leading to azoospermia. However, AZFa deletions resulting in complete loss of USP9Y have also been found in normospermic men (PubMed:19246359).1 Publication
Spermatogenic failure Y-linked 2 (SPGFY2) [MIM:415000]: A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility.
Note: The disease may be caused by mutations affecting the gene represented in this entry. The role of USP9Y in spermatogenesis failure is uncertain. A 4-bp deletion in a splice-donor site, causing exon skipping and protein truncation has been observed in non-obstructive azoospermia (PubMed:10581029). However, complete USP9Y deletion has been detected in individuals with no spermatogenic defects (PubMed:19246359).2 Publications

Organism-specific databases

MIMi415000. phenotype.
Orphaneti1646. Partial chromosome Y deletion.
PharmGKBiPA37258.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 25552555Probable ubiquitin carboxyl-terminal hydrolase FAF-YPRO_0000080690Add
BLAST

Proteomic databases

MaxQBiO00507.
PaxDbiO00507.
PRIDEiO00507.

PTM databases

PhosphoSiteiO00507.

Expressioni

Tissue specificityi

Widely expressed in embryonic and adult tissues.

Gene expression databases

BgeeiO00507.
CleanExiHS_USP10.
HS_USP9Y.
GenevestigatoriO00507.

Interactioni

Subunit structurei

Interacts with SMAD4.By similarity

Protein-protein interaction databases

BioGridi113892. 8 interactions.
IntActiO00507. 5 interactions.
MINTiMINT-7230431.
STRINGi9606.ENSP00000342812.

Structurei

3D structure databases

ProteinModelPortaliO00507.
SMRiO00507. Positions 1557-1995.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1559 – 1958400USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5077.
GeneTreeiENSGT00760000119158.
HOGENOMiHOG000231283.
HOVERGENiHBG073749.
InParanoidiO00507.
KOiK11840.
OMAiRNIATIN.
OrthoDBiEOG722J7K.
PhylomeDBiO00507.
TreeFamiTF323966.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform Long (identifier: O00507-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTAITHGSPV GGNDSQGQVL DGQSQHLFQQ NQTSSPDSSN ENSVATPPPE
60 70 80 90 100
EQGQGDAPPQ HEDEEPAFPH TELANLDDMI NRPRWVVPVL PKGELEVLLE
110 120 130 140 150
AAIDLSVKGL DVKSEACQRF FRDGLTISFT KILMDEAVSG WKFEIHRCII
160 170 180 190 200
NNTHRLVELC VAKLSQDWFP LLELLAMALN PHCKFHIYNG TRPCELISSN
210 220 230 240 250
AQLPEDELFA RSSDPRSPKG WLVDLINKFG TLNGFQILHD RFFNGSALNI
260 270 280 290 300
QIIAALIKPF GQCYEFLSQH TLKKYFIPVI EIVPHLLENL TDEELKKEAK
310 320 330 340 350
NEAKNDALSM IIKSLKNLAS RISGQDETIK NLEIFRLKMI LRLLQISSFN
360 370 380 390 400
GKMNALNEIN KVISSVSYYT HRHSNPEEEE WLTAERMAEW IQQNNILSIV
410 420 430 440 450
LQDSLHQPQY VEKLEKILRF VIKEKALTLQ DLDNIWAAQA GKHEAIVKNV
460 470 480 490 500
HDLLAKLAWD FSPGQLDHLF DCFKASWTNA SKKQREKLLE LIRRLAEDDK
510 520 530 540 550
DGVMAHKVLN LLWNLAQSDD VPVDIMDLAL SAHIKILDYS CSQDRDAQKI
560 570 580 590 600
QWIDHFIEEL RTNDKWVIPA LKQIREICSL FGEASQNLSQ TQRSPHIFYR
610 620 630 640 650
HDLINQLQQN HALVTLVAEN LATYMNSIRL YAGDHEDYDP QTVRLGSRYS
660 670 680 690 700
HVQEVQERLN FLRFLLKDGQ LWLCAPQAKQ IWKCLAENAV YLCDREACFK
710 720 730 740 750
WYSKLMGDEP DLDPDINKDF FESNVLQLDP SLLTENGMKC FERFFKAVNC
760 770 780 790 800
RERKLIAKRR SYMMDDLELI GLDYLWRVVI QSSDEIANRA IDLLKEIYTN
810 820 830 840 850
LGPRLKANQV VIHEDFIQSC FDRLKASYDT LCVFDGDKNS INCARQEAIR
860 870 880 890 900
MVRVLTVIKE YINECDSDYH KERMILPMSR AFRGKHLSLI VRFPNQGRQV
910 920 930 940 950
DELDIWSHTN DTIGSVRRCI VNRIKANVAH KKIELFVGGE LIDSEDDRKL
960 970 980 990 1000
IGQLNLKDKS LITAKLTQIN FNMPSSPDSS SDSSTASPGN HRNHYNDGPN
1010 1020 1030 1040 1050
LEVESCLPGV IMSVHPRYIS FLWQVADLGS NLNMPPLRDG ARVLMKLMPP
1060 1070 1080 1090 1100
DRTAVEKLRA VCLDHAKLGE GKLSPPLDSL FFGPSASQVL YLTEVVYALL
1110 1120 1130 1140 1150
MPAGVPLTDG SSDFQVHFLK SGGLPLVLSM LIRNNFLPNT DMETRRGAYL
1160 1170 1180 1190 1200
NALKIAKLLL TAIGYGHVRA VAEACQPVVD GTDPITQINQ VTHDQAVVLQ
1210 1220 1230 1240 1250
SALQSIPNPS SECVLRNESI LLAQEISNEA SRYMPDICVI RAIQKIIWAS
1260 1270 1280 1290 1300
ACGALGLVFS PNEEITKIYQ MTTNGSNKLE VEDEQVCCEA LEVMTLCFAL
1310 1320 1330 1340 1350
LPTALDALSK EKAWQTFIID LLLHCPSKTV RQLAQEQFFL MCTRCCMGHR
1360 1370 1380 1390 1400
PLLFFITLLF TILGSTAREK GKYSGDYFTL LRHLLNYAYN GNINIPNAEV
1410 1420 1430 1440 1450
LLVSEIDWLK RIRDNVKNTG ETGVEEPILE GHLGVTKELL AFQTSEKKYH
1460 1470 1480 1490 1500
FGCEKGGANL IKELIDDFIF PASKVYLQYL RSGELPAEQA IPVCSSPVTI
1510 1520 1530 1540 1550
NAGFELLVAL AIGCVRNLKQ IVDCLTEMYY MGTAITTCEA LTEWEYLPPV
1560 1570 1580 1590 1600
GPRPPKGFVG LKNAGATCYM NSVIQQLYMI PSIRNSILAI EGTGSDLHDD
1610 1620 1630 1640 1650
MFGDEKQDSE SNVDPRDDVF GYPHQFEDKP ALSKTEDRKE YNIGVLRHLQ
1660 1670 1680 1690 1700
VIFGHLAASQ LQYYVPRGFW KQFRLWGEPV NLREQHDALE FFNSLVDSLD
1710 1720 1730 1740 1750
EALKALGHPA ILSKVLGGSF ADQKICQGCP HRYECEESFT TLNVDIRNHQ
1760 1770 1780 1790 1800
NLLDSLEQYI KGDLLEGANA YHCEKCDKKV DTVKRLLIKK LPRVLAIQLK
1810 1820 1830 1840 1850
RFDYDWEREC AIKFNDYFEF PRELDMGPYT VAGVANLERD NVNSENELIE
1860 1870 1880 1890 1900
QKEQSDNETA GGTKYRLVGV LVHSGQASGG HYYSYIIQRN GKDDQTDHWY
1910 1920 1930 1940 1950
KFDDGDVTEC KMDDDEEMKN QCFGGEYMGE VFDHMMKRMS YRRQKRWWNA
1960 1970 1980 1990 2000
YILFYEQMDM IDEDDEMIRY ISELTIARPH QIIMSPAIER SVRKQNVKFM
2010 2020 2030 2040 2050
HNRLQYSLEY FQFVKKLLTC NGVYLNPAPG QDYLLPEAEE ITMISIQLAA
2060 2070 2080 2090 2100
RFLFTTGFHT KKIVRGPASD WYDALCVLLR HSKNVRFWFT HNVLFNVSNR
2110 2120 2130 2140 2150
FSEYLLECPS AEVRGAFAKL IVFIAHFSLQ DGSCPSPFAS PGPSSQACDN
2160 2170 2180 2190 2200
LSLSDHLLRA TLNLLRREVS EHGHHLQQYF NLFVMYANLG VAEKTQLLKL
2210 2220 2230 2240 2250
NVPATFMLVS LDEGPGPPIK YQYAELGKLY SVVSQLIRCC NVSSTMQSSI
2260 2270 2280 2290 2300
NGNPPLPNPF GDLNLSQPIM PIQQNVLDIL FVRTSYVKKI IEDCSNSEDT
2310 2320 2330 2340 2350
IKLLRFCSWE NPQFSSTVLS ELLWQVAYSY TYELRPYLDL LFQILLIEDS
2360 2370 2380 2390 2400
WQTHRIHNAL KGIPDDRDGL FDTIQRSKNH YQKRAYQCIK CMVALFSSCP
2410 2420 2430 2440 2450
VAYQILQGNG DLKRKWTWAV EWLGDELERR PYTGNPQYSY NNWSPPVQSN
2460 2470 2480 2490 2500
ETANGYFLER SHSARMTLAK ACELCPEEEP DDQDAPDEHE PSPSEDAPLY
2510 2520 2530 2540 2550
PHSPASQYQQ NNHVHGQPYT GPAAHHLNNP QKTGQRTQEN YEGNEEVSSP

QMKDQ
Length:2,555
Mass (Da):291,077
Last modified:May 5, 2009 - v2
Checksum:i421D47D5899F4415
GO
Isoform Short (identifier: O00507-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2071-2555: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:2,070
Mass (Da):235,723
Checksum:i70219CB0CCD269C5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti206 – 2061D → E in CAA73940. (PubMed:9384609)Curated
Sequence conflicti206 – 2061D → E in CAA73941. (PubMed:9384609)Curated
Sequence conflicti282 – 2821I → M in AAC51833. (PubMed:9381176)Curated
Sequence conflicti524 – 5241D → Y in AAC51833. (PubMed:9381176)Curated
Sequence conflicti542 – 5421S → A in AAC51833. (PubMed:9381176)Curated
Sequence conflicti666 – 6661L → V in AAC51833. (PubMed:9381176)Curated
Sequence conflicti883 – 8831R → C in CAA73940. (PubMed:9384609)Curated
Sequence conflicti883 – 8831R → C in CAA73941. (PubMed:9384609)Curated
Sequence conflicti907 – 9071S → F in CAA73940. (PubMed:9384609)Curated
Sequence conflicti907 – 9071S → F in CAA73941. (PubMed:9384609)Curated
Sequence conflicti946 – 9461D → N in CAA73940. (PubMed:9384609)Curated
Sequence conflicti946 – 9461D → N in CAA73941. (PubMed:9384609)Curated
Sequence conflicti1002 – 10021E → K in CAA73940. (PubMed:9384609)Curated
Sequence conflicti1002 – 10021E → K in CAA73941. (PubMed:9384609)Curated
Sequence conflicti1017 – 10171R → K in CAA73940. (PubMed:9384609)Curated
Sequence conflicti1017 – 10171R → K in CAA73941. (PubMed:9384609)Curated
Sequence conflicti1025 – 10273VAD → FAN in CAA73940. (PubMed:9384609)Curated
Sequence conflicti1025 – 10273VAD → FAN in CAA73941. (PubMed:9384609)Curated
Sequence conflicti1038 – 10392RD → KN in CAA73940. (PubMed:9384609)Curated
Sequence conflicti1038 – 10392RD → KN in CAA73941. (PubMed:9384609)Curated
Sequence conflicti1067 – 10671K → N in CAA73940. (PubMed:9384609)Curated
Sequence conflicti1067 – 10671K → N in CAA73941. (PubMed:9384609)Curated
Sequence conflicti1258 – 12581V → F in CAA73940. (PubMed:9384609)Curated
Sequence conflicti1258 – 12581V → F in CAA73941. (PubMed:9384609)Curated
Sequence conflicti1733 – 17331Y → F in CAA73940. (PubMed:9384609)Curated
Sequence conflicti1733 – 17331Y → F in CAA73941. (PubMed:9384609)Curated
Sequence conflicti1953 – 19531L → P in CAA73940. (PubMed:9384609)Curated
Sequence conflicti1953 – 19531L → P in CAA73941. (PubMed:9384609)Curated
Sequence conflicti2086 – 20861R → G in AAC51833. (PubMed:9381176)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651E → D.
Corresponds to variant rs7067496 [ dbSNP | Ensembl ].
VAR_055350
Natural varianti211 – 2111R → C.
Corresponds to variant rs2032596 [ dbSNP | Ensembl ].
VAR_055351
Natural varianti1035 – 10351P → S.
Corresponds to variant rs20319 [ dbSNP | Ensembl ].
VAR_029328
Natural varianti1060 – 10601A → T.1 Publication
Corresponds to variant rs20320 [ dbSNP | Ensembl ].
VAR_016194
Natural varianti1705 – 17051A → S.
Corresponds to variant rs2032606 [ dbSNP | Ensembl ].
VAR_055352

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2071 – 2555485Missing in isoform Short. CuratedVSP_005272Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF000986 mRNA. Translation: AAC51833.1.
Y13618 mRNA. Translation: CAA73940.1.
Y13619 mRNA. Translation: CAA73941.1.
AC002531 Genomic DNA. No translation available.
CCDSiCCDS14781.1. [O00507-1]
RefSeqiNP_004645.2. NM_004654.3. [O00507-1]
UniGeneiHs.598540.

Genome annotation databases

EnsembliENST00000338981; ENSP00000342812; ENSG00000114374. [O00507-1]
GeneIDi8287.
KEGGihsa:8287.
UCSCiuc004fst.1. human. [O00507-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF000986 mRNA. Translation: AAC51833.1 .
Y13618 mRNA. Translation: CAA73940.1 .
Y13619 mRNA. Translation: CAA73941.1 .
AC002531 Genomic DNA. No translation available.
CCDSi CCDS14781.1. [O00507-1 ]
RefSeqi NP_004645.2. NM_004654.3. [O00507-1 ]
UniGenei Hs.598540.

3D structure databases

ProteinModelPortali O00507.
SMRi O00507. Positions 1557-1995.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113892. 8 interactions.
IntActi O00507. 5 interactions.
MINTi MINT-7230431.
STRINGi 9606.ENSP00000342812.

Protein family/group databases

MEROPSi C19.028.

PTM databases

PhosphoSitei O00507.

Proteomic databases

MaxQBi O00507.
PaxDbi O00507.
PRIDEi O00507.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000338981 ; ENSP00000342812 ; ENSG00000114374 . [O00507-1 ]
GeneIDi 8287.
KEGGi hsa:8287.
UCSCi uc004fst.1. human. [O00507-1 ]

Organism-specific databases

CTDi 8287.
GeneCardsi GC0YP014813.
GeneReviewsi USP9Y.
HGNCi HGNC:12633. USP9Y.
MIMi 400005. gene.
415000. phenotype.
neXtProti NX_O00507.
Orphaneti 1646. Partial chromosome Y deletion.
PharmGKBi PA37258.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5077.
GeneTreei ENSGT00760000119158.
HOGENOMi HOG000231283.
HOVERGENi HBG073749.
InParanoidi O00507.
KOi K11840.
OMAi RNIATIN.
OrthoDBi EOG722J7K.
PhylomeDBi O00507.
TreeFami TF323966.

Miscellaneous databases

GeneWikii USP9Y.
GenomeRNAii 8287.
NextBioi 31053.
PROi O00507.
SOURCEi Search...

Gene expression databases

Bgeei O00507.
CleanExi HS_USP10.
HS_USP9Y.
Genevestigatori O00507.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 3 hits.
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2."
    Jones M.H., Furlong R.A., Burkin H., Chalmers I.J., Brown G.M., Khwaja O., Affara N.A.
    Hum. Mol. Genet. 5:1695-1701(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Functional coherence of the human Y chromosome."
    Lahn B.T., Page D.C.
    Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene."
    Brown G.M., Furlong R.A., Sargent C.A., Erickson R.P., Longepied G., Mitchell M., Jones M.H., Hargreave T.B., Cooke H.J., Affara N.A.
    Hum. Mol. Genet. 7:97-107(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE MAPPING, VARIANT THR-1060.
    Tissue: Fetal brain, Retina and Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "An azoospermic man with a de novo point mutation in the Y-chromosomal gene USP9Y."
    Sun C., Skaletsky H., Birren B., Devon K., Tang Z., Silber S., Oates R., Page D.C.
    Nat. Genet. 23:429-432(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INVOLVEMENT IN SPERMATOGENIC FAILURE.
  6. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
  7. Cited for: LACK OF INVOLVEMENT IN SPERMATOGENIC FAILURE.

Entry informationi

Entry nameiUSP9Y_HUMAN
AccessioniPrimary (citable) accession number: O00507
Secondary accession number(s): O14601
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3