Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O00507

- USP9Y_HUMAN

UniProt

O00507 - USP9Y_HUMAN

Protein

Probable ubiquitin carboxyl-terminal hydrolase FAF-Y

Gene

USP9Y

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiqitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1568 – 15681NucleophilePROSITE-ProRule annotation
    Active sitei1881 – 18811Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. co-SMAD binding Source: BHF-UCL
    2. cysteine-type peptidase activity Source: ProtInc
    3. ubiquitin-specific protease activity Source: ProtInc

    GO - Biological processi

    1. BMP signaling pathway Source: UniProtKB
    2. protein deubiquitination Source: UniProtKB
    3. spermatogenesis Source: ProtInc
    4. transforming growth factor beta receptor signaling pathway Source: UniProtKB
    5. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.028.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin carboxyl-terminal hydrolase FAF-Y (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme FAF-Y
    Fat facets protein-related, Y-linked
    Ubiquitin thioesterase FAF-Y
    Ubiquitin-specific protease 9, Y chromosome
    Ubiquitin-specific-processing protease FAF-Y
    Gene namesi
    Name:USP9Y
    Synonyms:DFFRY
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome Y

    Organism-specific databases

    HGNCiHGNC:12633. USP9Y.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Involvement in diseasei

    USP9Y is located in the 'azoospermia factor a' (AZFa) region on chromosome Y which is deleted in Sertoli cell-only syndrome. This is an infertility disorder in which no germ cells are visible in seminiferous tubules leading to azoospermia. However, AZFa deletions resulting in complete loss of USP9Y have also been found in normospermic men (PubMed:19246359).1 Publication
    Spermatogenic failure Y-linked 2 (SPGFY2) [MIM:415000]: A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility.
    Note: The disease may be caused by mutations affecting the gene represented in this entry. The role of USP9Y in spermatogenesis failure is uncertain. A 4-bp deletion in a splice-donor site, causing exon skipping and protein truncation has been observed in non-obstructive azoospermia (PubMed:10581029). However, complete USP9Y deletion has been detected in individuals with no spermatogenic defects (PubMed:19246359).2 Publications

    Organism-specific databases

    MIMi415000. phenotype.
    Orphaneti1646. Partial chromosome Y deletion.
    PharmGKBiPA37258.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 25552555Probable ubiquitin carboxyl-terminal hydrolase FAF-YPRO_0000080690Add
    BLAST

    Proteomic databases

    MaxQBiO00507.
    PaxDbiO00507.
    PRIDEiO00507.

    PTM databases

    PhosphoSiteiO00507.

    Expressioni

    Tissue specificityi

    Widely expressed in embryonic and adult tissues.

    Gene expression databases

    BgeeiO00507.
    CleanExiHS_USP10.
    HS_USP9Y.
    GenevestigatoriO00507.

    Interactioni

    Subunit structurei

    Interacts with SMAD4.By similarity

    Protein-protein interaction databases

    BioGridi113892. 7 interactions.
    IntActiO00507. 5 interactions.
    MINTiMINT-7230431.
    STRINGi9606.ENSP00000342812.

    Structurei

    3D structure databases

    ProteinModelPortaliO00507.
    SMRiO00507. Positions 1557-1995.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1559 – 1958400USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5077.
    HOGENOMiHOG000231283.
    HOVERGENiHBG073749.
    InParanoidiO00507.
    KOiK11840.
    OMAiRNIATIN.
    OrthoDBiEOG722J7K.
    PhylomeDBiO00507.
    TreeFamiTF323966.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 3 hits.
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform Long (identifier: O00507-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTAITHGSPV GGNDSQGQVL DGQSQHLFQQ NQTSSPDSSN ENSVATPPPE     50
    EQGQGDAPPQ HEDEEPAFPH TELANLDDMI NRPRWVVPVL PKGELEVLLE 100
    AAIDLSVKGL DVKSEACQRF FRDGLTISFT KILMDEAVSG WKFEIHRCII 150
    NNTHRLVELC VAKLSQDWFP LLELLAMALN PHCKFHIYNG TRPCELISSN 200
    AQLPEDELFA RSSDPRSPKG WLVDLINKFG TLNGFQILHD RFFNGSALNI 250
    QIIAALIKPF GQCYEFLSQH TLKKYFIPVI EIVPHLLENL TDEELKKEAK 300
    NEAKNDALSM IIKSLKNLAS RISGQDETIK NLEIFRLKMI LRLLQISSFN 350
    GKMNALNEIN KVISSVSYYT HRHSNPEEEE WLTAERMAEW IQQNNILSIV 400
    LQDSLHQPQY VEKLEKILRF VIKEKALTLQ DLDNIWAAQA GKHEAIVKNV 450
    HDLLAKLAWD FSPGQLDHLF DCFKASWTNA SKKQREKLLE LIRRLAEDDK 500
    DGVMAHKVLN LLWNLAQSDD VPVDIMDLAL SAHIKILDYS CSQDRDAQKI 550
    QWIDHFIEEL RTNDKWVIPA LKQIREICSL FGEASQNLSQ TQRSPHIFYR 600
    HDLINQLQQN HALVTLVAEN LATYMNSIRL YAGDHEDYDP QTVRLGSRYS 650
    HVQEVQERLN FLRFLLKDGQ LWLCAPQAKQ IWKCLAENAV YLCDREACFK 700
    WYSKLMGDEP DLDPDINKDF FESNVLQLDP SLLTENGMKC FERFFKAVNC 750
    RERKLIAKRR SYMMDDLELI GLDYLWRVVI QSSDEIANRA IDLLKEIYTN 800
    LGPRLKANQV VIHEDFIQSC FDRLKASYDT LCVFDGDKNS INCARQEAIR 850
    MVRVLTVIKE YINECDSDYH KERMILPMSR AFRGKHLSLI VRFPNQGRQV 900
    DELDIWSHTN DTIGSVRRCI VNRIKANVAH KKIELFVGGE LIDSEDDRKL 950
    IGQLNLKDKS LITAKLTQIN FNMPSSPDSS SDSSTASPGN HRNHYNDGPN 1000
    LEVESCLPGV IMSVHPRYIS FLWQVADLGS NLNMPPLRDG ARVLMKLMPP 1050
    DRTAVEKLRA VCLDHAKLGE GKLSPPLDSL FFGPSASQVL YLTEVVYALL 1100
    MPAGVPLTDG SSDFQVHFLK SGGLPLVLSM LIRNNFLPNT DMETRRGAYL 1150
    NALKIAKLLL TAIGYGHVRA VAEACQPVVD GTDPITQINQ VTHDQAVVLQ 1200
    SALQSIPNPS SECVLRNESI LLAQEISNEA SRYMPDICVI RAIQKIIWAS 1250
    ACGALGLVFS PNEEITKIYQ MTTNGSNKLE VEDEQVCCEA LEVMTLCFAL 1300
    LPTALDALSK EKAWQTFIID LLLHCPSKTV RQLAQEQFFL MCTRCCMGHR 1350
    PLLFFITLLF TILGSTAREK GKYSGDYFTL LRHLLNYAYN GNINIPNAEV 1400
    LLVSEIDWLK RIRDNVKNTG ETGVEEPILE GHLGVTKELL AFQTSEKKYH 1450
    FGCEKGGANL IKELIDDFIF PASKVYLQYL RSGELPAEQA IPVCSSPVTI 1500
    NAGFELLVAL AIGCVRNLKQ IVDCLTEMYY MGTAITTCEA LTEWEYLPPV 1550
    GPRPPKGFVG LKNAGATCYM NSVIQQLYMI PSIRNSILAI EGTGSDLHDD 1600
    MFGDEKQDSE SNVDPRDDVF GYPHQFEDKP ALSKTEDRKE YNIGVLRHLQ 1650
    VIFGHLAASQ LQYYVPRGFW KQFRLWGEPV NLREQHDALE FFNSLVDSLD 1700
    EALKALGHPA ILSKVLGGSF ADQKICQGCP HRYECEESFT TLNVDIRNHQ 1750
    NLLDSLEQYI KGDLLEGANA YHCEKCDKKV DTVKRLLIKK LPRVLAIQLK 1800
    RFDYDWEREC AIKFNDYFEF PRELDMGPYT VAGVANLERD NVNSENELIE 1850
    QKEQSDNETA GGTKYRLVGV LVHSGQASGG HYYSYIIQRN GKDDQTDHWY 1900
    KFDDGDVTEC KMDDDEEMKN QCFGGEYMGE VFDHMMKRMS YRRQKRWWNA 1950
    YILFYEQMDM IDEDDEMIRY ISELTIARPH QIIMSPAIER SVRKQNVKFM 2000
    HNRLQYSLEY FQFVKKLLTC NGVYLNPAPG QDYLLPEAEE ITMISIQLAA 2050
    RFLFTTGFHT KKIVRGPASD WYDALCVLLR HSKNVRFWFT HNVLFNVSNR 2100
    FSEYLLECPS AEVRGAFAKL IVFIAHFSLQ DGSCPSPFAS PGPSSQACDN 2150
    LSLSDHLLRA TLNLLRREVS EHGHHLQQYF NLFVMYANLG VAEKTQLLKL 2200
    NVPATFMLVS LDEGPGPPIK YQYAELGKLY SVVSQLIRCC NVSSTMQSSI 2250
    NGNPPLPNPF GDLNLSQPIM PIQQNVLDIL FVRTSYVKKI IEDCSNSEDT 2300
    IKLLRFCSWE NPQFSSTVLS ELLWQVAYSY TYELRPYLDL LFQILLIEDS 2350
    WQTHRIHNAL KGIPDDRDGL FDTIQRSKNH YQKRAYQCIK CMVALFSSCP 2400
    VAYQILQGNG DLKRKWTWAV EWLGDELERR PYTGNPQYSY NNWSPPVQSN 2450
    ETANGYFLER SHSARMTLAK ACELCPEEEP DDQDAPDEHE PSPSEDAPLY 2500
    PHSPASQYQQ NNHVHGQPYT GPAAHHLNNP QKTGQRTQEN YEGNEEVSSP 2550
    QMKDQ 2555
    Length:2,555
    Mass (Da):291,077
    Last modified:May 5, 2009 - v2
    Checksum:i421D47D5899F4415
    GO
    Isoform Short (identifier: O00507-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2071-2555: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:2,070
    Mass (Da):235,723
    Checksum:i70219CB0CCD269C5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti206 – 2061D → E in CAA73940. (PubMed:9384609)Curated
    Sequence conflicti206 – 2061D → E in CAA73941. (PubMed:9384609)Curated
    Sequence conflicti282 – 2821I → M in AAC51833. (PubMed:9381176)Curated
    Sequence conflicti524 – 5241D → Y in AAC51833. (PubMed:9381176)Curated
    Sequence conflicti542 – 5421S → A in AAC51833. (PubMed:9381176)Curated
    Sequence conflicti666 – 6661L → V in AAC51833. (PubMed:9381176)Curated
    Sequence conflicti883 – 8831R → C in CAA73940. (PubMed:9384609)Curated
    Sequence conflicti883 – 8831R → C in CAA73941. (PubMed:9384609)Curated
    Sequence conflicti907 – 9071S → F in CAA73940. (PubMed:9384609)Curated
    Sequence conflicti907 – 9071S → F in CAA73941. (PubMed:9384609)Curated
    Sequence conflicti946 – 9461D → N in CAA73940. (PubMed:9384609)Curated
    Sequence conflicti946 – 9461D → N in CAA73941. (PubMed:9384609)Curated
    Sequence conflicti1002 – 10021E → K in CAA73940. (PubMed:9384609)Curated
    Sequence conflicti1002 – 10021E → K in CAA73941. (PubMed:9384609)Curated
    Sequence conflicti1017 – 10171R → K in CAA73940. (PubMed:9384609)Curated
    Sequence conflicti1017 – 10171R → K in CAA73941. (PubMed:9384609)Curated
    Sequence conflicti1025 – 10273VAD → FAN in CAA73940. (PubMed:9384609)Curated
    Sequence conflicti1025 – 10273VAD → FAN in CAA73941. (PubMed:9384609)Curated
    Sequence conflicti1038 – 10392RD → KN in CAA73940. (PubMed:9384609)Curated
    Sequence conflicti1038 – 10392RD → KN in CAA73941. (PubMed:9384609)Curated
    Sequence conflicti1067 – 10671K → N in CAA73940. (PubMed:9384609)Curated
    Sequence conflicti1067 – 10671K → N in CAA73941. (PubMed:9384609)Curated
    Sequence conflicti1258 – 12581V → F in CAA73940. (PubMed:9384609)Curated
    Sequence conflicti1258 – 12581V → F in CAA73941. (PubMed:9384609)Curated
    Sequence conflicti1733 – 17331Y → F in CAA73940. (PubMed:9384609)Curated
    Sequence conflicti1733 – 17331Y → F in CAA73941. (PubMed:9384609)Curated
    Sequence conflicti1953 – 19531L → P in CAA73940. (PubMed:9384609)Curated
    Sequence conflicti1953 – 19531L → P in CAA73941. (PubMed:9384609)Curated
    Sequence conflicti2086 – 20861R → G in AAC51833. (PubMed:9381176)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti65 – 651E → D.
    Corresponds to variant rs7067496 [ dbSNP | Ensembl ].
    VAR_055350
    Natural varianti211 – 2111R → C.
    Corresponds to variant rs2032596 [ dbSNP | Ensembl ].
    VAR_055351
    Natural varianti1035 – 10351P → S.
    Corresponds to variant rs20319 [ dbSNP | Ensembl ].
    VAR_029328
    Natural varianti1060 – 10601A → T.1 Publication
    Corresponds to variant rs20320 [ dbSNP | Ensembl ].
    VAR_016194
    Natural varianti1705 – 17051A → S.
    Corresponds to variant rs2032606 [ dbSNP | Ensembl ].
    VAR_055352

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2071 – 2555485Missing in isoform Short. CuratedVSP_005272Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000986 mRNA. Translation: AAC51833.1.
    Y13618 mRNA. Translation: CAA73940.1.
    Y13619 mRNA. Translation: CAA73941.1.
    AC002531 Genomic DNA. No translation available.
    CCDSiCCDS14781.1. [O00507-1]
    RefSeqiNP_004645.2. NM_004654.3. [O00507-1]
    UniGeneiHs.598540.

    Genome annotation databases

    EnsembliENST00000338981; ENSP00000342812; ENSG00000114374. [O00507-1]
    GeneIDi8287.
    KEGGihsa:8287.
    UCSCiuc004fst.1. human. [O00507-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000986 mRNA. Translation: AAC51833.1 .
    Y13618 mRNA. Translation: CAA73940.1 .
    Y13619 mRNA. Translation: CAA73941.1 .
    AC002531 Genomic DNA. No translation available.
    CCDSi CCDS14781.1. [O00507-1 ]
    RefSeqi NP_004645.2. NM_004654.3. [O00507-1 ]
    UniGenei Hs.598540.

    3D structure databases

    ProteinModelPortali O00507.
    SMRi O00507. Positions 1557-1995.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113892. 7 interactions.
    IntActi O00507. 5 interactions.
    MINTi MINT-7230431.
    STRINGi 9606.ENSP00000342812.

    Protein family/group databases

    MEROPSi C19.028.

    PTM databases

    PhosphoSitei O00507.

    Proteomic databases

    MaxQBi O00507.
    PaxDbi O00507.
    PRIDEi O00507.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338981 ; ENSP00000342812 ; ENSG00000114374 . [O00507-1 ]
    GeneIDi 8287.
    KEGGi hsa:8287.
    UCSCi uc004fst.1. human. [O00507-1 ]

    Organism-specific databases

    CTDi 8287.
    GeneCardsi GC0YP014813.
    GeneReviewsi USP9Y.
    HGNCi HGNC:12633. USP9Y.
    MIMi 400005. gene.
    415000. phenotype.
    neXtProti NX_O00507.
    Orphaneti 1646. Partial chromosome Y deletion.
    PharmGKBi PA37258.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5077.
    HOGENOMi HOG000231283.
    HOVERGENi HBG073749.
    InParanoidi O00507.
    KOi K11840.
    OMAi RNIATIN.
    OrthoDBi EOG722J7K.
    PhylomeDBi O00507.
    TreeFami TF323966.

    Miscellaneous databases

    GeneWikii USP9Y.
    GenomeRNAii 8287.
    NextBioi 31053.
    PROi O00507.
    SOURCEi Search...

    Gene expression databases

    Bgeei O00507.
    CleanExi HS_USP10.
    HS_USP9Y.
    Genevestigatori O00507.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 3 hits.
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2."
      Jones M.H., Furlong R.A., Burkin H., Chalmers I.J., Brown G.M., Khwaja O., Affara N.A.
      Hum. Mol. Genet. 5:1695-1701(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "Functional coherence of the human Y chromosome."
      Lahn B.T., Page D.C.
      Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene."
      Brown G.M., Furlong R.A., Sargent C.A., Erickson R.P., Longepied G., Mitchell M., Jones M.H., Hargreave T.B., Cooke H.J., Affara N.A.
      Hum. Mol. Genet. 7:97-107(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE MAPPING, VARIANT THR-1060.
      Tissue: Fetal brain, Retina and Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "An azoospermic man with a de novo point mutation in the Y-chromosomal gene USP9Y."
      Sun C., Skaletsky H., Birren B., Devon K., Tang Z., Silber S., Oates R., Page D.C.
      Nat. Genet. 23:429-432(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE INVOLVEMENT IN SPERMATOGENIC FAILURE.
    6. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
    7. Cited for: LACK OF INVOLVEMENT IN SPERMATOGENIC FAILURE.

    Entry informationi

    Entry nameiUSP9Y_HUMAN
    AccessioniPrimary (citable) accession number: O00507
    Secondary accession number(s): O14601
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 139 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome Y
      Human chromosome Y: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3