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O00506

- STK25_HUMAN

UniProt

O00506 - STK25_HUMAN

Protein

Serine/threonine-protein kinase 25

Gene

STK25

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 149 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.

    Enzyme regulationi

    Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-174, possibly as a consequence of stabilization of dimer formation. The C-terminal non-catalytic region inhibits the kinase activity.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei49 – 491ATPPROSITE-ProRule annotation
    Active sitei140 – 1401Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi26 – 349ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. protein homodimerization activity Source: UniProtKB
    5. protein kinase activity Source: ProtInc
    6. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. establishment or maintenance of cell polarity Source: Ensembl
    2. Golgi localization Source: UniProtKB
    3. positive regulation of axonogenesis Source: Ensembl
    4. response to oxidative stress Source: ProtInc
    5. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiO00506.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase 25 (EC:2.7.11.1)
    Alternative name(s):
    Ste20-like kinase
    Sterile 20/oxidant stress-response kinase 1
    Short name:
    SOK-1
    Short name:
    Ste20/oxidant stress response kinase 1
    Gene namesi
    Name:STK25
    Synonyms:SOK1, YSK1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:11404. STK25.

    Subcellular locationi

    Cytoplasm 1 Publication. Golgi apparatus 1 Publication
    Note: Localizes to the Golgi apparatus.

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Golgi apparatus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi49 – 491K → R: Loss of kinase activity and autophosphorylation. 1 Publication
    Mutagenesisi158 – 1581D → A: Loss of kinase activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA36211.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 426426Serine/threonine-protein kinase 25PRO_0000086713Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei174 – 1741Phosphothreonine; by autocatalysis1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO00506.
    PaxDbiO00506.
    PRIDEiO00506.

    PTM databases

    PhosphoSiteiO00506.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed. Highest levels are found in testis, large intestine, brain and stomach followed by heart and lung.

    Gene expression databases

    ArrayExpressiO00506.
    BgeeiO00506.
    CleanExiHS_STK25.
    GenevestigatoriO00506.

    Organism-specific databases

    HPAiHPA047147.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with CTTNBP2NL.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CAB39Q9Y3763EBI-618295,EBI-306905
    GOLGA2Q083793EBI-618295,EBI-618309
    Golga2Q628392EBI-618295,EBI-618335From a different organism.
    PDCD10Q9BUL89EBI-618295,EBI-740195
    STRNO438153EBI-618295,EBI-1046642
    YWHAZP631042EBI-618295,EBI-347088

    Protein-protein interaction databases

    BioGridi115757. 33 interactions.
    DIPiDIP-34269N.
    IntActiO00506. 37 interactions.
    MINTiMINT-2997826.
    STRINGi9606.ENSP00000325748.

    Structurei

    Secondary structure

    1
    426
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni5 – 73
    Helixi8 – 103
    Helixi16 – 194
    Beta strandi20 – 289
    Beta strandi30 – 3910
    Turni40 – 423
    Beta strandi45 – 528
    Turni53 – 564
    Helixi60 – 7213
    Beta strandi81 – 877
    Beta strandi90 – 967
    Helixi103 – 1075
    Helixi114 – 13320
    Helixi143 – 1453
    Beta strandi146 – 1483
    Beta strandi154 – 1563
    Beta strandi170 – 1723
    Helixi179 – 1813
    Helixi184 – 1874
    Helixi195 – 21016
    Turni214 – 2174
    Helixi220 – 2267
    Turni227 – 2293
    Helixi241 – 25010
    Helixi255 – 2573
    Helixi261 – 2644
    Helixi268 – 2725
    Helixi277 – 2804
    Helixi281 – 29111
    Helixi357 – 3604
    Helixi362 – 37413
    Turni375 – 3773
    Helixi381 – 39616
    Helixi400 – 41415

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2XIKX-ray1.97A1-293[»]
    3W8HX-ray2.43B355-426[»]
    ProteinModelPortaliO00506.
    SMRiO00506. Positions 3-292, 355-418.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 270251Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000234203.
    HOVERGENiHBG108518.
    InParanoidiO00506.
    KOiK08838.
    OMAiFSHNRNH.
    OrthoDBiEOG77T14Q.
    PhylomeDBiO00506.
    TreeFamiTF354217.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O00506-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAHLRGFANQ HSRVDPEELF TKLDRIGKGS FGEVYKGIDN HTKEVVAIKI    50
    IDLEEAEDEI EDIQQEITVL SQCDSPYITR YFGSYLKSTK LWIIMEYLGG 100
    GSALDLLKPG PLEETYIATI LREILKGLDY LHSERKIHRD IKAANVLLSE 150
    QGDVKLADFG VAGQLTDTQI KRNTFVGTPF WMAPEVIKQS AYDFKADIWS 200
    LGITAIELAK GEPPNSDLHP MRVLFLIPKN SPPTLEGQHS KPFKEFVEAC 250
    LNKDPRFRPT AKELLKHKFI TRYTKKTSFL TELIDRYKRW KSEGHGEESS 300
    SEDSDIDGEA EDGEQGPIWT FPPTIRPSPH SKLHKGTALH SSQKPAEPVK 350
    RQPRSQCLST LVRPVFGELK EKHKQSGGSV GALEELENAF SLAEESCPGI 400
    SDKLMVHLVE RVQRFSHNRN HLTSTR 426
    Length:426
    Mass (Da):48,112
    Last modified:July 1, 1997 - v1
    Checksum:i183CE5700FCEA716
    GO
    Isoform 2 (identifier: O00506-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         11-87: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:349
    Mass (Da):39,266
    Checksum:iF1BC727F54CB32A4
    GO
    Isoform 3 (identifier: O00506-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-94: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:332
    Mass (Da):37,297
    Checksum:iB4D6A56543812A3C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti347 – 3482EP → DA in CAA67700. (PubMed:8887545)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti64 – 641Q → H.
    Corresponds to variant rs34341643 [ dbSNP | Ensembl ].
    VAR_051674

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9494Missing in isoform 3. 1 PublicationVSP_054683Add
    BLAST
    Alternative sequencei11 – 8777Missing in isoform 2. 1 PublicationVSP_054397Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99325 mRNA. Translation: CAA67700.1.
    D63780 mRNA. Translation: BAA20420.1.
    AK291808 mRNA. Translation: BAF84497.1.
    AK291947 mRNA. Translation: BAF84636.1.
    AK315966 mRNA. Translation: BAH14337.1.
    BT019961 mRNA. Translation: AAV38764.1.
    AC110299 Genomic DNA. Translation: AAY14683.1.
    DQ093965 Genomic DNA. Translation: AAY88740.1.
    CH471063 Genomic DNA. Translation: EAW71265.1.
    BC007852 mRNA. Translation: AAH07852.1.
    BC091505 mRNA. Translation: AAH91505.1.
    CCDSiCCDS2549.1. [O00506-1]
    CCDS63199.1. [O00506-3]
    CCDS63200.1. [O00506-2]
    PIRiS71886.
    RefSeqiNP_001258906.1. NM_001271977.1. [O00506-1]
    NP_001258907.1. NM_001271978.1. [O00506-1]
    NP_001258908.1. NM_001271979.1. [O00506-2]
    NP_001258909.1. NM_001271980.1. [O00506-2]
    NP_001269234.1. NM_001282305.1. [O00506-3]
    NP_001269236.1. NM_001282307.1. [O00506-3]
    NP_001269237.1. NM_001282308.1. [O00506-3]
    NP_006365.2. NM_006374.4. [O00506-1]
    UniGeneiHs.516807.

    Genome annotation databases

    EnsembliENST00000316586; ENSP00000325748; ENSG00000115694. [O00506-1]
    ENST00000401869; ENSP00000385687; ENSG00000115694. [O00506-1]
    ENST00000403346; ENSP00000384162; ENSG00000115694. [O00506-1]
    ENST00000405585; ENSP00000385541; ENSG00000115694. [O00506-2]
    ENST00000405883; ENSP00000384444; ENSG00000115694. [O00506-2]
    ENST00000535007; ENSP00000446008; ENSG00000115694. [O00506-3]
    ENST00000543554; ENSP00000444886; ENSG00000115694. [O00506-3]
    GeneIDi10494.
    KEGGihsa:10494.
    UCSCiuc002wbm.4. human. [O00506-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99325 mRNA. Translation: CAA67700.1 .
    D63780 mRNA. Translation: BAA20420.1 .
    AK291808 mRNA. Translation: BAF84497.1 .
    AK291947 mRNA. Translation: BAF84636.1 .
    AK315966 mRNA. Translation: BAH14337.1 .
    BT019961 mRNA. Translation: AAV38764.1 .
    AC110299 Genomic DNA. Translation: AAY14683.1 .
    DQ093965 Genomic DNA. Translation: AAY88740.1 .
    CH471063 Genomic DNA. Translation: EAW71265.1 .
    BC007852 mRNA. Translation: AAH07852.1 .
    BC091505 mRNA. Translation: AAH91505.1 .
    CCDSi CCDS2549.1. [O00506-1 ]
    CCDS63199.1. [O00506-3 ]
    CCDS63200.1. [O00506-2 ]
    PIRi S71886.
    RefSeqi NP_001258906.1. NM_001271977.1. [O00506-1 ]
    NP_001258907.1. NM_001271978.1. [O00506-1 ]
    NP_001258908.1. NM_001271979.1. [O00506-2 ]
    NP_001258909.1. NM_001271980.1. [O00506-2 ]
    NP_001269234.1. NM_001282305.1. [O00506-3 ]
    NP_001269236.1. NM_001282307.1. [O00506-3 ]
    NP_001269237.1. NM_001282308.1. [O00506-3 ]
    NP_006365.2. NM_006374.4. [O00506-1 ]
    UniGenei Hs.516807.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2XIK X-ray 1.97 A 1-293 [» ]
    3W8H X-ray 2.43 B 355-426 [» ]
    ProteinModelPortali O00506.
    SMRi O00506. Positions 3-292, 355-418.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115757. 33 interactions.
    DIPi DIP-34269N.
    IntActi O00506. 37 interactions.
    MINTi MINT-2997826.
    STRINGi 9606.ENSP00000325748.

    Chemistry

    BindingDBi O00506.
    ChEMBLi CHEMBL5552.
    GuidetoPHARMACOLOGYi 2218.

    PTM databases

    PhosphoSitei O00506.

    Proteomic databases

    MaxQBi O00506.
    PaxDbi O00506.
    PRIDEi O00506.

    Protocols and materials databases

    DNASUi 10494.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316586 ; ENSP00000325748 ; ENSG00000115694 . [O00506-1 ]
    ENST00000401869 ; ENSP00000385687 ; ENSG00000115694 . [O00506-1 ]
    ENST00000403346 ; ENSP00000384162 ; ENSG00000115694 . [O00506-1 ]
    ENST00000405585 ; ENSP00000385541 ; ENSG00000115694 . [O00506-2 ]
    ENST00000405883 ; ENSP00000384444 ; ENSG00000115694 . [O00506-2 ]
    ENST00000535007 ; ENSP00000446008 ; ENSG00000115694 . [O00506-3 ]
    ENST00000543554 ; ENSP00000444886 ; ENSG00000115694 . [O00506-3 ]
    GeneIDi 10494.
    KEGGi hsa:10494.
    UCSCi uc002wbm.4. human. [O00506-1 ]

    Organism-specific databases

    CTDi 10494.
    GeneCardsi GC02M242453.
    HGNCi HGNC:11404. STK25.
    HPAi HPA047147.
    MIMi 602255. gene.
    neXtProti NX_O00506.
    PharmGKBi PA36211.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000234203.
    HOVERGENi HBG108518.
    InParanoidi O00506.
    KOi K08838.
    OMAi FSHNRNH.
    OrthoDBi EOG77T14Q.
    PhylomeDBi O00506.
    TreeFami TF354217.

    Enzyme and pathway databases

    SignaLinki O00506.

    Miscellaneous databases

    GeneWikii STK25.
    GenomeRNAii 10494.
    NextBioi 35464389.
    PROi O00506.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O00506.
    Bgeei O00506.
    CleanExi HS_STK25.
    Genevestigatori O00506.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway."
      Pombo C.M., Bonventre J.V., Molnar A., Kyriakis J., Force T.
      EMBO J. 15:4537-4546(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways."
      Osada S., Izawa M., Saito R., Mizuno K., Suzuki A., Hirai S., Ohno S.
      Oncogene 14:2047-2057(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Amygdala.
    5. NIEHS SNPs program
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis and Uterus.
    9. "YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta."
      Preisinger C., Short B., De Corte V., Bruyneel E., Haas A., Kopajtich R., Gettemans J., Barr F.A.
      J. Cell Biol. 164:1009-1020(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ENZYME REGULATION, PHOSPHORYLATION AT THR-174, SUBCELLULAR LOCATION, INTERACTION WITH GOLGA2, MUTAGENESIS OF LYS-49 AND ASP-158.
    10. "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein."
      Goudreault M., D'Ambrosio L.M., Kean M.J., Mullin M.J., Larsen B.G., Sanchez A., Chaudhry S., Chen G.I., Sicheri F., Nesvizhskii A.I., Aebersold R., Raught B., Gingras A.C.
      Mol. Cell. Proteomics 8:157-171(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CTTNBP2NL.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSTK25_HUMAN
    AccessioniPrimary (citable) accession number: O00506
    Secondary accession number(s): A8K6Z3
    , A8K7D2, B7Z9K1, Q15522, Q5BJF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 149 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3