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O00506

- STK25_HUMAN

UniProt

O00506 - STK25_HUMAN

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Protein
Serine/threonine-protein kinase 25
Gene
STK25, SOK1, YSK1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium.

Enzyme regulationi

Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-174, possibly as a consequence of stabilization of dimer formation. The C-terminal non-catalytic region inhibits the kinase activity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491ATP By similarity
Active sitei140 – 1401Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 349ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein binding Source: IntAct
  4. protein homodimerization activity Source: UniProtKB
  5. protein kinase activity Source: ProtInc
  6. receptor signaling protein serine/threonine kinase activity Source: RefGenome

GO - Biological processi

  1. Golgi localization Source: UniProtKB
  2. apoptotic process Source: RefGenome
  3. establishment or maintenance of cell polarity Source: Ensembl
  4. positive regulation of axonogenesis Source: Ensembl
  5. regulation of cell differentiation Source: RefGenome
  6. response to oxidative stress Source: ProtInc
  7. signal transduction Source: ProtInc
  8. signal transduction by phosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiO00506.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 25 (EC:2.7.11.1)
Alternative name(s):
Ste20-like kinase
Sterile 20/oxidant stress-response kinase 1
Short name:
SOK-1
Short name:
Ste20/oxidant stress response kinase 1
Gene namesi
Name:STK25
Synonyms:SOK1, YSK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:11404. STK25.

Subcellular locationi

Cytoplasm. Golgi apparatus
Note: Localizes to the Golgi apparatus.1 Publication

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. cytoplasm Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi49 – 491K → R: Loss of kinase activity and autophosphorylation. 1 Publication
Mutagenesisi158 – 1581D → A: Loss of kinase activity. 1 Publication

Organism-specific databases

PharmGKBiPA36211.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Serine/threonine-protein kinase 25
PRO_0000086713Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei174 – 1741Phosphothreonine; by autocatalysis1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO00506.
PaxDbiO00506.
PRIDEiO00506.

PTM databases

PhosphoSiteiO00506.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highest levels are found in testis, large intestine, brain and stomach followed by heart and lung.

Gene expression databases

ArrayExpressiO00506.
BgeeiO00506.
CleanExiHS_STK25.
GenevestigatoriO00506.

Organism-specific databases

HPAiHPA047147.

Interactioni

Subunit structurei

Homodimer. Interacts with CTTNBP2NL.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CAB39Q9Y3763EBI-618295,EBI-306905
GOLGA2Q083793EBI-618295,EBI-618309
Golga2Q628392EBI-618295,EBI-618335From a different organism.
PDCD10Q9BUL89EBI-618295,EBI-740195
STRNO438153EBI-618295,EBI-1046642
YWHAZP631042EBI-618295,EBI-347088

Protein-protein interaction databases

BioGridi115757. 33 interactions.
DIPiDIP-34269N.
IntActiO00506. 36 interactions.
MINTiMINT-2997826.
STRINGi9606.ENSP00000325748.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni5 – 73
Helixi8 – 103
Helixi16 – 194
Beta strandi20 – 289
Beta strandi30 – 3910
Turni40 – 423
Beta strandi45 – 528
Turni53 – 564
Helixi60 – 7213
Beta strandi81 – 877
Beta strandi90 – 967
Helixi103 – 1075
Helixi114 – 13320
Helixi143 – 1453
Beta strandi146 – 1483
Beta strandi154 – 1563
Beta strandi170 – 1723
Helixi179 – 1813
Helixi184 – 1874
Helixi195 – 21016
Turni214 – 2174
Helixi220 – 2267
Turni227 – 2293
Helixi241 – 25010
Helixi255 – 2573
Helixi261 – 2644
Helixi268 – 2725
Helixi277 – 2804
Helixi281 – 29111
Helixi357 – 3604
Helixi362 – 37413
Turni375 – 3773
Helixi381 – 39616
Helixi400 – 41415

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XIKX-ray1.97A1-293[»]
3W8HX-ray2.43B355-426[»]
ProteinModelPortaliO00506.
SMRiO00506. Positions 3-292, 355-418.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 270251Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000234203.
HOVERGENiHBG108518.
InParanoidiO00506.
KOiK08838.
OMAiFSHNRNH.
OrthoDBiEOG77T14Q.
PhylomeDBiO00506.
TreeFamiTF354217.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O00506-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAHLRGFANQ HSRVDPEELF TKLDRIGKGS FGEVYKGIDN HTKEVVAIKI    50
IDLEEAEDEI EDIQQEITVL SQCDSPYITR YFGSYLKSTK LWIIMEYLGG 100
GSALDLLKPG PLEETYIATI LREILKGLDY LHSERKIHRD IKAANVLLSE 150
QGDVKLADFG VAGQLTDTQI KRNTFVGTPF WMAPEVIKQS AYDFKADIWS 200
LGITAIELAK GEPPNSDLHP MRVLFLIPKN SPPTLEGQHS KPFKEFVEAC 250
LNKDPRFRPT AKELLKHKFI TRYTKKTSFL TELIDRYKRW KSEGHGEESS 300
SEDSDIDGEA EDGEQGPIWT FPPTIRPSPH SKLHKGTALH SSQKPAEPVK 350
RQPRSQCLST LVRPVFGELK EKHKQSGGSV GALEELENAF SLAEESCPGI 400
SDKLMVHLVE RVQRFSHNRN HLTSTR 426
Length:426
Mass (Da):48,112
Last modified:July 1, 1997 - v1
Checksum:i183CE5700FCEA716
GO
Isoform 2 (identifier: O00506-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-87: Missing.

Note: No experimental confirmation available.

Show »
Length:349
Mass (Da):39,266
Checksum:iF1BC727F54CB32A4
GO
Isoform 3 (identifier: O00506-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.

Note: No experimental confirmation available.

Show »
Length:332
Mass (Da):37,297
Checksum:iB4D6A56543812A3C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti64 – 641Q → H.
Corresponds to variant rs34341643 [ dbSNP | Ensembl ].
VAR_051674

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9494Missing in isoform 3.
VSP_054683Add
BLAST
Alternative sequencei11 – 8777Missing in isoform 2.
VSP_054397Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti347 – 3482EP → DA in CAA67700. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99325 mRNA. Translation: CAA67700.1.
D63780 mRNA. Translation: BAA20420.1.
AK291808 mRNA. Translation: BAF84497.1.
AK291947 mRNA. Translation: BAF84636.1.
AK315966 mRNA. Translation: BAH14337.1.
BT019961 mRNA. Translation: AAV38764.1.
AC110299 Genomic DNA. Translation: AAY14683.1.
DQ093965 Genomic DNA. Translation: AAY88740.1.
CH471063 Genomic DNA. Translation: EAW71265.1.
BC007852 mRNA. Translation: AAH07852.1.
BC091505 mRNA. Translation: AAH91505.1.
CCDSiCCDS2549.1. [O00506-1]
CCDS63199.1. [O00506-3]
CCDS63200.1. [O00506-2]
PIRiS71886.
RefSeqiNP_001258906.1. NM_001271977.1. [O00506-1]
NP_001258907.1. NM_001271978.1. [O00506-1]
NP_001258908.1. NM_001271979.1. [O00506-2]
NP_001258909.1. NM_001271980.1. [O00506-2]
NP_001269234.1. NM_001282305.1. [O00506-3]
NP_001269236.1. NM_001282307.1. [O00506-3]
NP_001269237.1. NM_001282308.1. [O00506-3]
NP_006365.2. NM_006374.4. [O00506-1]
UniGeneiHs.516807.

Genome annotation databases

EnsembliENST00000316586; ENSP00000325748; ENSG00000115694.
ENST00000401869; ENSP00000385687; ENSG00000115694.
ENST00000403346; ENSP00000384162; ENSG00000115694.
ENST00000405585; ENSP00000385541; ENSG00000115694.
ENST00000535007; ENSP00000446008; ENSG00000115694.
GeneIDi10494.
KEGGihsa:10494.
UCSCiuc002wbm.4. human. [O00506-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99325 mRNA. Translation: CAA67700.1 .
D63780 mRNA. Translation: BAA20420.1 .
AK291808 mRNA. Translation: BAF84497.1 .
AK291947 mRNA. Translation: BAF84636.1 .
AK315966 mRNA. Translation: BAH14337.1 .
BT019961 mRNA. Translation: AAV38764.1 .
AC110299 Genomic DNA. Translation: AAY14683.1 .
DQ093965 Genomic DNA. Translation: AAY88740.1 .
CH471063 Genomic DNA. Translation: EAW71265.1 .
BC007852 mRNA. Translation: AAH07852.1 .
BC091505 mRNA. Translation: AAH91505.1 .
CCDSi CCDS2549.1. [O00506-1 ]
CCDS63199.1. [O00506-3 ]
CCDS63200.1. [O00506-2 ]
PIRi S71886.
RefSeqi NP_001258906.1. NM_001271977.1. [O00506-1 ]
NP_001258907.1. NM_001271978.1. [O00506-1 ]
NP_001258908.1. NM_001271979.1. [O00506-2 ]
NP_001258909.1. NM_001271980.1. [O00506-2 ]
NP_001269234.1. NM_001282305.1. [O00506-3 ]
NP_001269236.1. NM_001282307.1. [O00506-3 ]
NP_001269237.1. NM_001282308.1. [O00506-3 ]
NP_006365.2. NM_006374.4. [O00506-1 ]
UniGenei Hs.516807.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2XIK X-ray 1.97 A 1-293 [» ]
3W8H X-ray 2.43 B 355-426 [» ]
ProteinModelPortali O00506.
SMRi O00506. Positions 3-292, 355-418.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115757. 33 interactions.
DIPi DIP-34269N.
IntActi O00506. 36 interactions.
MINTi MINT-2997826.
STRINGi 9606.ENSP00000325748.

Chemistry

BindingDBi O00506.
ChEMBLi CHEMBL5552.
GuidetoPHARMACOLOGYi 2218.

PTM databases

PhosphoSitei O00506.

Proteomic databases

MaxQBi O00506.
PaxDbi O00506.
PRIDEi O00506.

Protocols and materials databases

DNASUi 10494.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316586 ; ENSP00000325748 ; ENSG00000115694 .
ENST00000401869 ; ENSP00000385687 ; ENSG00000115694 .
ENST00000403346 ; ENSP00000384162 ; ENSG00000115694 .
ENST00000405585 ; ENSP00000385541 ; ENSG00000115694 .
ENST00000535007 ; ENSP00000446008 ; ENSG00000115694 .
GeneIDi 10494.
KEGGi hsa:10494.
UCSCi uc002wbm.4. human. [O00506-1 ]

Organism-specific databases

CTDi 10494.
GeneCardsi GC02M242453.
HGNCi HGNC:11404. STK25.
HPAi HPA047147.
MIMi 602255. gene.
neXtProti NX_O00506.
PharmGKBi PA36211.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000234203.
HOVERGENi HBG108518.
InParanoidi O00506.
KOi K08838.
OMAi FSHNRNH.
OrthoDBi EOG77T14Q.
PhylomeDBi O00506.
TreeFami TF354217.

Enzyme and pathway databases

SignaLinki O00506.

Miscellaneous databases

GeneWikii STK25.
GenomeRNAii 10494.
NextBioi 35464389.
PROi O00506.
SOURCEi Search...

Gene expression databases

ArrayExpressi O00506.
Bgeei O00506.
CleanExi HS_STK25.
Genevestigatori O00506.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway."
    Pombo C.M., Bonventre J.V., Molnar A., Kyriakis J., Force T.
    EMBO J. 15:4537-4546(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways."
    Osada S., Izawa M., Saito R., Mizuno K., Suzuki A., Hirai S., Ohno S.
    Oncogene 14:2047-2057(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Amygdala.
  5. NIEHS SNPs program
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis and Uterus.
  9. "YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta."
    Preisinger C., Short B., De Corte V., Bruyneel E., Haas A., Kopajtich R., Gettemans J., Barr F.A.
    J. Cell Biol. 164:1009-1020(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ENZYME REGULATION, PHOSPHORYLATION AT THR-174, SUBCELLULAR LOCATION, INTERACTION WITH GOLGA2, MUTAGENESIS OF LYS-49 AND ASP-158.
  10. "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein."
    Goudreault M., D'Ambrosio L.M., Kean M.J., Mullin M.J., Larsen B.G., Sanchez A., Chaudhry S., Chen G.I., Sicheri F., Nesvizhskii A.I., Aebersold R., Raught B., Gingras A.C.
    Mol. Cell. Proteomics 8:157-171(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CTTNBP2NL.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSTK25_HUMAN
AccessioniPrimary (citable) accession number: O00506
Secondary accession number(s): A8K6Z3
, A8K7D2, B7Z9K1, Q15522, Q5BJF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 1, 1997
Last modified: September 3, 2014
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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