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O00506

- STK25_HUMAN

UniProt

O00506 - STK25_HUMAN

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Protein

Serine/threonine-protein kinase 25

Gene

STK25

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium.

Enzyme regulationi

Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-174, possibly as a consequence of stabilization of dimer formation. The C-terminal non-catalytic region inhibits the kinase activity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491ATPPROSITE-ProRule annotation
Active sitei140 – 1401Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 349ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein homodimerization activity Source: UniProtKB
  4. protein kinase activity Source: ProtInc
  5. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. establishment or maintenance of cell polarity Source: Ensembl
  2. Golgi localization Source: UniProtKB
  3. positive regulation of axonogenesis Source: Ensembl
  4. response to oxidative stress Source: ProtInc
  5. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiO00506.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 25 (EC:2.7.11.1)
Alternative name(s):
Ste20-like kinase
Sterile 20/oxidant stress-response kinase 1
Short name:
SOK-1
Short name:
Ste20/oxidant stress response kinase 1
Gene namesi
Name:STK25
Synonyms:SOK1, YSK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:11404. STK25.

Subcellular locationi

Cytoplasm 1 Publication. Golgi apparatus 1 Publication
Note: Localizes to the Golgi apparatus.

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. Golgi apparatus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi49 – 491K → R: Loss of kinase activity and autophosphorylation. 1 Publication
Mutagenesisi158 – 1581D → A: Loss of kinase activity. 1 Publication

Organism-specific databases

PharmGKBiPA36211.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Serine/threonine-protein kinase 25PRO_0000086713Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei174 – 1741Phosphothreonine; by autocatalysis1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO00506.
PaxDbiO00506.
PRIDEiO00506.

PTM databases

PhosphoSiteiO00506.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highest levels are found in testis, large intestine, brain and stomach followed by heart and lung.

Gene expression databases

BgeeiO00506.
CleanExiHS_STK25.
ExpressionAtlasiO00506. baseline and differential.
GenevestigatoriO00506.

Organism-specific databases

HPAiHPA047147.

Interactioni

Subunit structurei

Homodimer. Interacts with CTTNBP2NL.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CAB39Q9Y3763EBI-618295,EBI-306905
GOLGA2Q083793EBI-618295,EBI-618309
Golga2Q628392EBI-618295,EBI-618335From a different organism.
PDCD10Q9BUL89EBI-618295,EBI-740195
STRNO438153EBI-618295,EBI-1046642
YWHAZP631042EBI-618295,EBI-347088

Protein-protein interaction databases

BioGridi115757. 46 interactions.
DIPiDIP-34269N.
IntActiO00506. 37 interactions.
MINTiMINT-2997826.
STRINGi9606.ENSP00000325748.

Structurei

Secondary structure

1
426
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni5 – 73Combined sources
Helixi8 – 103Combined sources
Helixi16 – 194Combined sources
Beta strandi20 – 289Combined sources
Beta strandi30 – 3910Combined sources
Turni40 – 423Combined sources
Beta strandi45 – 528Combined sources
Turni53 – 564Combined sources
Helixi60 – 7213Combined sources
Beta strandi81 – 877Combined sources
Beta strandi90 – 967Combined sources
Helixi103 – 1075Combined sources
Helixi114 – 13320Combined sources
Helixi143 – 1453Combined sources
Beta strandi146 – 1483Combined sources
Beta strandi154 – 1563Combined sources
Beta strandi170 – 1723Combined sources
Helixi179 – 1813Combined sources
Helixi184 – 1874Combined sources
Helixi195 – 21016Combined sources
Turni214 – 2174Combined sources
Helixi220 – 2267Combined sources
Turni227 – 2293Combined sources
Helixi241 – 25010Combined sources
Helixi255 – 2573Combined sources
Helixi261 – 2644Combined sources
Helixi268 – 2725Combined sources
Helixi277 – 2804Combined sources
Helixi281 – 29111Combined sources
Helixi357 – 3604Combined sources
Helixi362 – 37413Combined sources
Turni375 – 3773Combined sources
Helixi381 – 39616Combined sources
Helixi400 – 41415Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XIKX-ray1.97A1-293[»]
3W8HX-ray2.43B355-426[»]
ProteinModelPortaliO00506.
SMRiO00506. Positions 3-292, 355-418.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 270251Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00640000091192.
HOGENOMiHOG000234203.
HOVERGENiHBG108518.
InParanoidiO00506.
KOiK08838.
OMAiFSHNRNH.
OrthoDBiEOG77T14Q.
PhylomeDBiO00506.
TreeFamiTF354217.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O00506-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHLRGFANQ HSRVDPEELF TKLDRIGKGS FGEVYKGIDN HTKEVVAIKI
60 70 80 90 100
IDLEEAEDEI EDIQQEITVL SQCDSPYITR YFGSYLKSTK LWIIMEYLGG
110 120 130 140 150
GSALDLLKPG PLEETYIATI LREILKGLDY LHSERKIHRD IKAANVLLSE
160 170 180 190 200
QGDVKLADFG VAGQLTDTQI KRNTFVGTPF WMAPEVIKQS AYDFKADIWS
210 220 230 240 250
LGITAIELAK GEPPNSDLHP MRVLFLIPKN SPPTLEGQHS KPFKEFVEAC
260 270 280 290 300
LNKDPRFRPT AKELLKHKFI TRYTKKTSFL TELIDRYKRW KSEGHGEESS
310 320 330 340 350
SEDSDIDGEA EDGEQGPIWT FPPTIRPSPH SKLHKGTALH SSQKPAEPVK
360 370 380 390 400
RQPRSQCLST LVRPVFGELK EKHKQSGGSV GALEELENAF SLAEESCPGI
410 420
SDKLMVHLVE RVQRFSHNRN HLTSTR
Length:426
Mass (Da):48,112
Last modified:July 1, 1997 - v1
Checksum:i183CE5700FCEA716
GO
Isoform 2 (identifier: O00506-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-87: Missing.

Note: No experimental confirmation available.

Show »
Length:349
Mass (Da):39,266
Checksum:iF1BC727F54CB32A4
GO
Isoform 3 (identifier: O00506-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.

Note: No experimental confirmation available.

Show »
Length:332
Mass (Da):37,297
Checksum:iB4D6A56543812A3C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti347 – 3482EP → DA in CAA67700. (PubMed:8887545)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti64 – 641Q → H.
Corresponds to variant rs34341643 [ dbSNP | Ensembl ].
VAR_051674

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9494Missing in isoform 3. 1 PublicationVSP_054683Add
BLAST
Alternative sequencei11 – 8777Missing in isoform 2. 1 PublicationVSP_054397Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99325 mRNA. Translation: CAA67700.1.
D63780 mRNA. Translation: BAA20420.1.
AK291808 mRNA. Translation: BAF84497.1.
AK291947 mRNA. Translation: BAF84636.1.
AK315966 mRNA. Translation: BAH14337.1.
BT019961 mRNA. Translation: AAV38764.1.
AC110299 Genomic DNA. Translation: AAY14683.1.
DQ093965 Genomic DNA. Translation: AAY88740.1.
CH471063 Genomic DNA. Translation: EAW71265.1.
BC007852 mRNA. Translation: AAH07852.1.
BC091505 mRNA. Translation: AAH91505.1.
CCDSiCCDS2549.1. [O00506-1]
CCDS63199.1. [O00506-3]
CCDS63200.1. [O00506-2]
PIRiS71886.
RefSeqiNP_001258906.1. NM_001271977.1. [O00506-1]
NP_001258907.1. NM_001271978.1. [O00506-1]
NP_001258908.1. NM_001271979.1. [O00506-2]
NP_001258909.1. NM_001271980.1. [O00506-2]
NP_001269234.1. NM_001282305.1. [O00506-3]
NP_001269236.1. NM_001282307.1. [O00506-3]
NP_001269237.1. NM_001282308.1. [O00506-3]
NP_006365.2. NM_006374.4. [O00506-1]
UniGeneiHs.516807.

Genome annotation databases

EnsembliENST00000316586; ENSP00000325748; ENSG00000115694. [O00506-1]
ENST00000401869; ENSP00000385687; ENSG00000115694. [O00506-1]
ENST00000403346; ENSP00000384162; ENSG00000115694. [O00506-1]
ENST00000405585; ENSP00000385541; ENSG00000115694. [O00506-2]
ENST00000405883; ENSP00000384444; ENSG00000115694. [O00506-2]
ENST00000535007; ENSP00000446008; ENSG00000115694. [O00506-3]
ENST00000543554; ENSP00000444886; ENSG00000115694. [O00506-3]
GeneIDi10494.
KEGGihsa:10494.
UCSCiuc002wbm.4. human. [O00506-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99325 mRNA. Translation: CAA67700.1 .
D63780 mRNA. Translation: BAA20420.1 .
AK291808 mRNA. Translation: BAF84497.1 .
AK291947 mRNA. Translation: BAF84636.1 .
AK315966 mRNA. Translation: BAH14337.1 .
BT019961 mRNA. Translation: AAV38764.1 .
AC110299 Genomic DNA. Translation: AAY14683.1 .
DQ093965 Genomic DNA. Translation: AAY88740.1 .
CH471063 Genomic DNA. Translation: EAW71265.1 .
BC007852 mRNA. Translation: AAH07852.1 .
BC091505 mRNA. Translation: AAH91505.1 .
CCDSi CCDS2549.1. [O00506-1 ]
CCDS63199.1. [O00506-3 ]
CCDS63200.1. [O00506-2 ]
PIRi S71886.
RefSeqi NP_001258906.1. NM_001271977.1. [O00506-1 ]
NP_001258907.1. NM_001271978.1. [O00506-1 ]
NP_001258908.1. NM_001271979.1. [O00506-2 ]
NP_001258909.1. NM_001271980.1. [O00506-2 ]
NP_001269234.1. NM_001282305.1. [O00506-3 ]
NP_001269236.1. NM_001282307.1. [O00506-3 ]
NP_001269237.1. NM_001282308.1. [O00506-3 ]
NP_006365.2. NM_006374.4. [O00506-1 ]
UniGenei Hs.516807.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2XIK X-ray 1.97 A 1-293 [» ]
3W8H X-ray 2.43 B 355-426 [» ]
ProteinModelPortali O00506.
SMRi O00506. Positions 3-292, 355-418.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115757. 46 interactions.
DIPi DIP-34269N.
IntActi O00506. 37 interactions.
MINTi MINT-2997826.
STRINGi 9606.ENSP00000325748.

Chemistry

BindingDBi O00506.
ChEMBLi CHEMBL5552.
GuidetoPHARMACOLOGYi 2218.

PTM databases

PhosphoSitei O00506.

Proteomic databases

MaxQBi O00506.
PaxDbi O00506.
PRIDEi O00506.

Protocols and materials databases

DNASUi 10494.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316586 ; ENSP00000325748 ; ENSG00000115694 . [O00506-1 ]
ENST00000401869 ; ENSP00000385687 ; ENSG00000115694 . [O00506-1 ]
ENST00000403346 ; ENSP00000384162 ; ENSG00000115694 . [O00506-1 ]
ENST00000405585 ; ENSP00000385541 ; ENSG00000115694 . [O00506-2 ]
ENST00000405883 ; ENSP00000384444 ; ENSG00000115694 . [O00506-2 ]
ENST00000535007 ; ENSP00000446008 ; ENSG00000115694 . [O00506-3 ]
ENST00000543554 ; ENSP00000444886 ; ENSG00000115694 . [O00506-3 ]
GeneIDi 10494.
KEGGi hsa:10494.
UCSCi uc002wbm.4. human. [O00506-1 ]

Organism-specific databases

CTDi 10494.
GeneCardsi GC02M242434.
HGNCi HGNC:11404. STK25.
HPAi HPA047147.
MIMi 602255. gene.
neXtProti NX_O00506.
PharmGKBi PA36211.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00640000091192.
HOGENOMi HOG000234203.
HOVERGENi HBG108518.
InParanoidi O00506.
KOi K08838.
OMAi FSHNRNH.
OrthoDBi EOG77T14Q.
PhylomeDBi O00506.
TreeFami TF354217.

Enzyme and pathway databases

SignaLinki O00506.

Miscellaneous databases

GeneWikii STK25.
GenomeRNAii 10494.
NextBioi 35464389.
PROi O00506.
SOURCEi Search...

Gene expression databases

Bgeei O00506.
CleanExi HS_STK25.
ExpressionAtlasi O00506. baseline and differential.
Genevestigatori O00506.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway."
    Pombo C.M., Bonventre J.V., Molnar A., Kyriakis J., Force T.
    EMBO J. 15:4537-4546(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways."
    Osada S., Izawa M., Saito R., Mizuno K., Suzuki A., Hirai S., Ohno S.
    Oncogene 14:2047-2057(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Amygdala.
  5. NIEHS SNPs program
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis and Uterus.
  9. "YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta."
    Preisinger C., Short B., De Corte V., Bruyneel E., Haas A., Kopajtich R., Gettemans J., Barr F.A.
    J. Cell Biol. 164:1009-1020(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ENZYME REGULATION, PHOSPHORYLATION AT THR-174, SUBCELLULAR LOCATION, INTERACTION WITH GOLGA2, MUTAGENESIS OF LYS-49 AND ASP-158.
  10. "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein."
    Goudreault M., D'Ambrosio L.M., Kean M.J., Mullin M.J., Larsen B.G., Sanchez A., Chaudhry S., Chen G.I., Sicheri F., Nesvizhskii A.I., Aebersold R., Raught B., Gingras A.C.
    Mol. Cell. Proteomics 8:157-171(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CTTNBP2NL.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSTK25_HUMAN
AccessioniPrimary (citable) accession number: O00506
Secondary accession number(s): A8K6Z3
, A8K7D2, B7Z9K1, Q15522, Q5BJF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 1, 1997
Last modified: October 29, 2014
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3