##gff-version 3
O00505	UniProtKB	Initiator methionine	1	1	.	.	.	Note=Removed;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19413330;Dbxref=PMID:19413330	
O00505	UniProtKB	Chain	2	521	.	.	.	ID=PRO_0000120724;Note=Importin subunit alpha-4	
O00505	UniProtKB	Domain	2	58	.	.	.	Note=IBB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00561	
O00505	UniProtKB	Repeat	66	106	.	.	.	Note=ARM 1%3B truncated	
O00505	UniProtKB	Repeat	107	149	.	.	.	Note=ARM 2	
O00505	UniProtKB	Repeat	150	194	.	.	.	Note=ARM 3	
O00505	UniProtKB	Repeat	195	233	.	.	.	Note=ARM 4	
O00505	UniProtKB	Repeat	234	278	.	.	.	Note=ARM 5	
O00505	UniProtKB	Repeat	279	318	.	.	.	Note=ARM 6	
O00505	UniProtKB	Repeat	319	360	.	.	.	Note=ARM 7	
O00505	UniProtKB	Repeat	361	400	.	.	.	Note=ARM 8	
O00505	UniProtKB	Repeat	401	443	.	.	.	Note=ARM 9	
O00505	UniProtKB	Repeat	447	485	.	.	.	Note=ARM 10%3B atypical	
O00505	UniProtKB	Region	1	29	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O00505	UniProtKB	Region	137	229	.	.	.	Note=NLS binding site (major);Ontology_term=ECO:0000250;evidence=ECO:0000250	
O00505	UniProtKB	Region	306	394	.	.	.	Note=NLS binding site (minor);Ontology_term=ECO:0000250;evidence=ECO:0000250	
O00505	UniProtKB	Motif	43	52	.	.	.	Note=Nuclear localization signal;Ontology_term=ECO:0000250;evidence=ECO:0000250	
O00505	UniProtKB	Compositional bias	9	29	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O00505	UniProtKB	Modified residue	2	2	.	.	.	Note=N-acetylalanine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19413330;Dbxref=PMID:19413330	
O00505	UniProtKB	Modified residue	56	56	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:19690332,PMID:20068231,PMID:23186163,PMID:24275569	
O00505	UniProtKB	Modified residue	60	60	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17081983,ECO:0007744|PubMed:18318008,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:17081983,PMID:18318008,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569	
O00505	UniProtKB	Modified residue	484	484	.	.	.	Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569	
O00505	UniProtKB	Natural variant	291	291	.	.	.	ID=VAR_014454;Note=P->S;Dbxref=dbSNP:rs1043015	
O00505	UniProtKB	Natural variant	315	315	.	.	.	ID=VAR_087813;Note=In SPG88%3B decreased interaction with RCC1 and DDX21%3B no effect on interaction with NCBP1 and NCBP2. T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:34564892,ECO:0000269|PubMed:34981581;Dbxref=PMID:34564892,PMID:34981581	
O00505	UniProtKB	Natural variant	328	328	.	.	.	ID=VAR_087814;Note=In SPG88%3B decreased interaction with RCC1 and DDX21%3B no effect on interaction with NCBP1 and NCBP2. L->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34564892;Dbxref=PMID:34564892	
O00505	UniProtKB	Natural variant	328	328	.	.	.	ID=VAR_087815;Note=In SPG88%3B loss of interaction with DDX21 and NCBP1%3B severely decreased interaction with RCC1 and NCBP2%3B compared to the wild type%2C the mutant shows increased cytoplasmic levels. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:34564892,ECO:0000269|PubMed:34825409;Dbxref=PMID:34564892,PMID:34825409	
O00505	UniProtKB	Natural variant	334	334	.	.	.	ID=VAR_087816;Note=In SPG88%3B decreased interaction with RCC1%2C DDX21%2C NCBP1 and NCBP2%3B compared to the wild type%2C the mutant shows increased cytoplasmic levels. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34564892;Dbxref=PMID:34564892	
O00505	UniProtKB	Natural variant	350	350	.	.	.	ID=VAR_087817;Note=In SPG88%3B loss of interaction with RCC1%2C DDX21%2C NCBP1 and NCBP2. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34564892;Dbxref=PMID:34564892	
O00505	UniProtKB	Natural variant	415	415	.	.	.	ID=VAR_087818;Note=In SPG88%3B loss of interaction with RCC1%3B severely decreased interaction with DDX21 and NCBP1%3B no effect on interaction with NCBP2. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34564892;Dbxref=PMID:34564892	
O00505	UniProtKB	Sequence conflict	34	34	.	.	.	Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O00505	UniProtKB	Sequence conflict	103	103	.	.	.	Note=R->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O00505	UniProtKB	Sequence conflict	152	153	.	.	.	Note=AV->DI;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O00505	UniProtKB	Sequence conflict	154	154	.	.	.	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O00505	UniProtKB	Sequence conflict	236	236	.	.	.	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O00505	UniProtKB	Sequence conflict	237	237	.	.	.	Note=M->L;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O00505	UniProtKB	Sequence conflict	256	256	.	.	.	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O00505	UniProtKB	Sequence conflict	259	259	.	.	.	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O00505	UniProtKB	Sequence conflict	332	332	.	.	.	Note=P->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O00505	UniProtKB	Sequence conflict	411	411	.	.	.	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305