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O00505

- IMA4_HUMAN

UniProt

O00505 - IMA4_HUMAN

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Protein

Importin subunit alpha-4

Gene
KPNA3, QIP2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9.

GO - Molecular functioni

  1. nuclear localization sequence binding Source: ProtInc
  2. protein binding Source: IntAct
  3. protein transporter activity Source: InterPro

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: Reactome
  2. NLS-bearing protein import into nucleus Source: ProtInc
  3. protein complex assembly Source: ProtInc
  4. viral entry into host cell Source: UniProtKB-KW
  5. viral penetration into host nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Protein transport, Transport, Viral penetration into host nucleus, Virus entry into host cell

Enzyme and pathway databases

ReactomeiREACT_115831. ISG15 antiviral mechanism.
SignaLinkiO00505.

Names & Taxonomyi

Protein namesi
Recommended name:
Importin subunit alpha-4
Alternative name(s):
Importin alpha Q2
Short name:
Qip2
Karyopherin subunit alpha-3
SRP1-gamma
Gene namesi
Name:KPNA3
Synonyms:QIP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:6396. KPNA3.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. nuclear pore Source: ProtInc
  3. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30187.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 521520Importin subunit alpha-4PRO_0000120724Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei56 – 561Phosphoserine2 Publications
Modified residuei60 – 601Phosphoserine5 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO00505.
PaxDbiO00505.
PeptideAtlasiO00505.
PRIDEiO00505.

PTM databases

PhosphoSiteiO00505.

Expressioni

Tissue specificityi

Ubiquitous. Highest levels in heart and skeletal muscle.

Gene expression databases

BgeeiO00505.
CleanExiHS_KPNA3.
GenevestigatoriO00505.

Organism-specific databases

HPAiHPA046852.

Interactioni

Subunit structurei

Forms a complex with importin subunit beta-1. Interacts with HIV-1 integrase; this interaction might play a role in nuclear import of HIV pre-integration complex. Interacts with influenza virus nucleoprotein; this interaction might play a role in nuclear import of viral genome.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDKN1BP465274EBI-358297,EBI-519280
Mkl1Q8K4J69EBI-358297,EBI-8291665From a different organism.

Protein-protein interaction databases

BioGridi110037. 32 interactions.
DIPiDIP-27586N.
IntActiO00505. 32 interactions.
MINTiMINT-88920.
STRINGi9606.ENSP00000261667.

Structurei

3D structure databases

ProteinModelPortaliO00505.
SMRiO00505. Positions 11-485.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 5857IBBAdd
BLAST
Repeati66 – 10641ARM 1; truncatedAdd
BLAST
Repeati107 – 14943ARM 2Add
BLAST
Repeati150 – 19445ARM 3Add
BLAST
Repeati195 – 23339ARM 4Add
BLAST
Repeati234 – 27845ARM 5Add
BLAST
Repeati279 – 31840ARM 6Add
BLAST
Repeati319 – 36042ARM 7Add
BLAST
Repeati361 – 40040ARM 8Add
BLAST
Repeati401 – 44343ARM 9Add
BLAST
Repeati447 – 48539ARM 10; atypicalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni137 – 22993NLS binding site (major) By similarityAdd
BLAST
Regioni306 – 39489NLS binding site (minor) By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5210Nuclear localization signal By similarity

Domaini

Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.
The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins By similarity.
The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding By similarity.

Sequence similaritiesi

Belongs to the importin alpha family.
Contains 10 ARM repeats.
Contains 1 IBB domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5064.
HOGENOMiHOG000167616.
HOVERGENiHBG001846.
InParanoidiO00505.
OMAiNCDVLSY.
OrthoDBiEOG7VHSWV.
PhylomeDBiO00505.
TreeFamiTF101178.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR002652. Importin-a_IBB.
IPR024931. Importing_su_alpha.
[Graphical view]
PfamiPF00514. Arm. 8 hits.
PF01749. IBB. 1 hit.
[Graphical view]
PIRSFiPIRSF005673. Importin_alpha. 1 hit.
SMARTiSM00185. ARM. 8 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
PS51214. IBB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00505-1 [UniParc]FASTAAdd to Basket

« Hide

MAENPSLENH RIKSFKNKGR DVETMRRHRN EVTVELRKNK RDEHLLKKRN    50
VPQEESLEDS DVDADFKAQN VTLEAILQNA TSDNPVVQLS AVQAARKLLS 100
SDRNPPIDDL IKSGILPILV KCLERDDNPS LQFEAAWALT NIASGTSAQT 150
QAVVQSNAVP LFLRLLRSPH QNVCEQAVWA LGNIIGDGPQ CRDYVISLGV 200
VKPLLSFISP SIPITFLRNV TWVIVNLCRN KDPPPPMETV QEILPALCVL 250
IYHTDINILV DTVWALSYLT DGGNEQIQMV IDSGVVPFLV PLLSHQEVKV 300
QTAALRAVGN IVTGTDEQTQ VVLNCDVLSH FPNLLSHPKE KINKEAVWFL 350
SNITAGNQQQ VQAVIDAGLI PMIIHQLAKG DFGTQKEAAW AISNLTISGR 400
KDQVEYLVQQ NVIPPFCNLL SVKDSQVVQV VLDGLKNILI MAGDEASTIA 450
EIIEECGGLE KIEVLQQHEN EDIYKLAFEI IDQYFSGDDI DEDPCLIPEA 500
TQGGTYNFDP TANLQTKEFN F 521
Length:521
Mass (Da):57,811
Last modified:January 23, 2002 - v2
Checksum:iC4FF132C3F346B7F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti291 – 2911P → S.
Corresponds to variant rs1043015 [ dbSNP | Ensembl ].
VAR_014454

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341V → M in CAA73026. 1 Publication
Sequence conflicti103 – 1031R → Q in BAA20378. 1 Publication
Sequence conflicti154 – 1541V → G in AAB87693. 1 Publication
Sequence conflicti236 – 2361P → T in AAB87693. 1 Publication
Sequence conflicti237 – 2371M → L in CAA73026. 1 Publication
Sequence conflicti256 – 2561I → V in CAA73026. 1 Publication
Sequence conflicti259 – 2591L → V in CAA73026. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D89618 mRNA. Translation: BAA20378.1.
Y12394 mRNA. Translation: CAA73026.1.
AF034756 mRNA. Translation: AAB87693.1.
AF005263 mRNA. Translation: AAQ13404.1.
AK290528 mRNA. Translation: BAF83217.1.
AK291000 mRNA. Translation: BAF83689.1.
AL136301, AL135901 Genomic DNA. Translation: CAH71145.1.
AL135901, AL136301 Genomic DNA. Translation: CAI40716.1.
CH471075 Genomic DNA. Translation: EAX08837.1.
BC017355 mRNA. Translation: AAH17355.1.
BC024202 mRNA. Translation: AAH24202.1.
CCDSiCCDS9421.1.
RefSeqiNP_002258.2. NM_002267.3.
UniGeneiHs.527919.

Genome annotation databases

EnsembliENST00000261667; ENSP00000261667; ENSG00000102753.
GeneIDi3839.
KEGGihsa:3839.
UCSCiuc001vdj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D89618 mRNA. Translation: BAA20378.1 .
Y12394 mRNA. Translation: CAA73026.1 .
AF034756 mRNA. Translation: AAB87693.1 .
AF005263 mRNA. Translation: AAQ13404.1 .
AK290528 mRNA. Translation: BAF83217.1 .
AK291000 mRNA. Translation: BAF83689.1 .
AL136301 , AL135901 Genomic DNA. Translation: CAH71145.1 .
AL135901 , AL136301 Genomic DNA. Translation: CAI40716.1 .
CH471075 Genomic DNA. Translation: EAX08837.1 .
BC017355 mRNA. Translation: AAH17355.1 .
BC024202 mRNA. Translation: AAH24202.1 .
CCDSi CCDS9421.1.
RefSeqi NP_002258.2. NM_002267.3.
UniGenei Hs.527919.

3D structure databases

ProteinModelPortali O00505.
SMRi O00505. Positions 11-485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110037. 32 interactions.
DIPi DIP-27586N.
IntActi O00505. 32 interactions.
MINTi MINT-88920.
STRINGi 9606.ENSP00000261667.

PTM databases

PhosphoSitei O00505.

Proteomic databases

MaxQBi O00505.
PaxDbi O00505.
PeptideAtlasi O00505.
PRIDEi O00505.

Protocols and materials databases

DNASUi 3839.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261667 ; ENSP00000261667 ; ENSG00000102753 .
GeneIDi 3839.
KEGGi hsa:3839.
UCSCi uc001vdj.2. human.

Organism-specific databases

CTDi 3839.
GeneCardsi GC13M050273.
HGNCi HGNC:6396. KPNA3.
HPAi HPA046852.
MIMi 601892. gene.
neXtProti NX_O00505.
PharmGKBi PA30187.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5064.
HOGENOMi HOG000167616.
HOVERGENi HBG001846.
InParanoidi O00505.
OMAi NCDVLSY.
OrthoDBi EOG7VHSWV.
PhylomeDBi O00505.
TreeFami TF101178.

Enzyme and pathway databases

Reactomei REACT_115831. ISG15 antiviral mechanism.
SignaLinki O00505.

Miscellaneous databases

ChiTaRSi KPNA3. human.
GeneWikii KPNA3.
GenomeRNAii 3839.
NextBioi 15107.
PROi O00505.
SOURCEi Search...

Gene expression databases

Bgeei O00505.
CleanExi HS_KPNA3.
Genevestigatori O00505.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR002652. Importin-a_IBB.
IPR024931. Importing_su_alpha.
[Graphical view ]
Pfami PF00514. Arm. 8 hits.
PF01749. IBB. 1 hit.
[Graphical view ]
PIRSFi PIRSF005673. Importin_alpha. 1 hit.
SMARTi SM00185. ARM. 8 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 3 hits.
PS51214. IBB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and mapping of karyopherin alpha 3 (KPNA3), a human gene that is highly homologous to genes encoding Xenopus importin, yeast SRP1 and human RCH1."
    Takeda S., Fujiwara T., Shimizu F., Kawai A., Shinomiya K., Okuno S., Ozaki K., Katagiri T., Shimada Y., Nagata M., Watanabe T., Takaichi A., Kuga Y., Suzuki M., Hishigaki H., Takahashi E., Shin S., Nakamura Y., Hirai Y.
    Cytogenet. Cell Genet. 76:87-93(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. "Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family."
    Koehler M., Ansieau S., Prehn S., Leutz A., Haller H., Hartmann E.
    FEBS Lett. 417:104-108(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  3. "Cloning and characterization of hSRP1 gamma, a tissue-specific nuclear transport factor."
    Nachury M.V., Ryder U.W., Lamond A.I., Weis K.
    Proc. Natl. Acad. Sci. U.S.A. 95:582-587(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Importin alpha-3, a novel variant of the small importin subunit evolutionarily conserved from hydrozoa to man."
    Fischer R.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  9. "Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein."
    Melen K., Fagerlund R., Franke J., Koehler M., Kinnunen L., Julkunen I.
    J. Biol. Chem. 278:28193-28200(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH INFLUENZA VIRUS NP.
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56 AND SER-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  15. "Importin alpha3 interacts with HIV-1 integrase and contributes to HIV-1 nuclear import and replication."
    Ao Z., Danappa Jayappa K., Wang B., Zheng Y., Kung S., Rassart E., Depping R., Kohler M., Cohen E.A., Yao X.
    J. Virol. 84:8650-8663(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HIV-1 INTEGRASE.
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56 AND SER-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIMA4_HUMAN
AccessioniPrimary (citable) accession number: O00505
Secondary accession number(s): O00191
, O43195, Q5JVM9, Q96AA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2002
Last modified: September 3, 2014
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was termed (1 Publication) importin alpha-4.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi