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Protein

Claudin-5

Gene

CLDN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space.By similarity

GO - Molecular functioni

GO - Biological processi

  • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
  • cell-cell junction assembly Source: UniProtKB
  • face morphogenesis Source: UniProtKB
  • learning Source: UniProtKB
  • outflow tract morphogenesis Source: UniProtKB
  • positive regulation of establishment of endothelial barrier Source: UniProtKB
  • regulation of bicellular tight junction assembly Source: Reactome
  • roof of mouth development Source: UniProtKB
  • transforming growth factor beta receptor signaling pathway Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions

Protein family/group databases

TCDBi1.H.1.1.16 the claudin tight junction (claudin1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-5
Alternative name(s):
Transmembrane protein deleted in VCFS
Short name:
TMDVCF
Gene namesi
Name:CLDN5
Synonyms:AWAL, TMVCF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000184113.9
HGNCiHGNC:2047 CLDN5
MIMi602101 gene
neXtProtiNX_O00501

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 122CytoplasmicSequence analysisAdd BLAST20
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 159ExtracellularSequence analysisAdd BLAST16
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 218CytoplasmicSequence analysisAdd BLAST38

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi7122
OpenTargetsiENSG00000184113
PharmGKBiPA26573

Polymorphism and mutation databases

BioMutaiCLDN5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447451 – 218Claudin-5Add BLAST218

Proteomic databases

PaxDbiO00501
PeptideAtlasiO00501
PRIDEiO00501

PTM databases

iPTMnetiO00501
PhosphoSitePlusiO00501
SwissPalmiO00501

Expressioni

Gene expression databases

BgeeiENSG00000184113
CleanExiHS_CLDN5
ExpressionAtlasiO00501 baseline and differential
GenevisibleiO00501 HS

Organism-specific databases

HPAiCAB002607

Interactioni

Subunit structurei

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112977, 2 interactors
STRINGi9606.ENSP00000384554

Structurei

3D structure databases

ProteinModelPortaliO00501
SMRiO00501
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni217 – 218Interactions with TJP1, TJP2 and TJP3By similarity2

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJT1 Eukaryota
ENOG410Y9S8 LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiO00501
KOiK06087
PhylomeDBiO00501
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003551 Claudin5
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01380 CLAUDIN5
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

O00501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSAALEILG LVLCLVGWGG LILACGLPMW QVTAFLDHNI VTAQTTWKGL
60 70 80 90 100
WMSCVVQSTG HMQCKVYDSV LALSTEVQAA RALTVSAVLL AFVALFVTLA
110 120 130 140 150
GAQCTTCVAP GPAKARVALT GGVLYLFCGL LALVPLCWFA NIVVREFYDP
160 170 180 190 200
SVPVSQKYEL GAALYIGWAA TALLMVGGCL LCCGAWVCTG RPDLSFPVKY
210
SAPRRPTATG DYDKKNYV
Length:218
Mass (Da):23,147
Last modified:July 1, 1997 - v1
Checksum:i9F7F9E194D25425F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000959 mRNA Translation: AAC51364.1
CR456420 mRNA Translation: CAG30306.1
AK092561 mRNA Translation: BAG52573.1
BT007254 mRNA Translation: AAP35918.1
AC000082 Genomic DNA No translation available.
BC002404 mRNA Translation: AAH02404.1
BC019290 mRNA Translation: AAH19290.2
BC032363 mRNA Translation: AAH32363.1
RefSeqiNP_001124333.1, NM_001130861.1
NP_003268.2, NM_003277.3
UniGeneiHs.505337

Genome annotation databases

EnsembliENST00000618236; ENSP00000480623; ENSG00000184113
GeneIDi7122
KEGGihsa:7122
UCSCiuc062bmp.1 human

Similar proteinsi

Entry informationi

Entry nameiCLD5_HUMAN
AccessioniPrimary (citable) accession number: O00501
Secondary accession number(s): B3KS11, Q53XW2, Q8WUW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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