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O00501

- CLD5_HUMAN

UniProt

O00501 - CLD5_HUMAN

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Protein
Claudin-5
Gene
CLDN5, AWAL, TMVCF
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space By similarity.

GO - Molecular functioni

  1. identical protein binding Source: UniProtKB
  2. structural molecule activity Source: InterPro

GO - Biological processi

  1. calcium-independent cell-cell adhesion Source: UniProtKB
  2. myelination Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_19373. Tight junction interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-5
Alternative name(s):
Transmembrane protein deleted in VCFS
Short name:
TMDVCF
Gene namesi
Name:CLDN5
Synonyms:AWAL, TMVCF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:2047. CLDN5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77Cytoplasmic Reviewed prediction
Transmembranei8 – 2821Helical; Reviewed prediction
Add
BLAST
Topological domaini29 – 8153Extracellular Reviewed prediction
Add
BLAST
Transmembranei82 – 10221Helical; Reviewed prediction
Add
BLAST
Topological domaini103 – 12220Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei123 – 14321Helical; Reviewed prediction
Add
BLAST
Topological domaini144 – 15916Extracellular Reviewed prediction
Add
BLAST
Transmembranei160 – 18021Helical; Reviewed prediction
Add
BLAST
Topological domaini181 – 21838Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Schmidt-Lanterman incisure Source: Ensembl
  2. cell-cell junction Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProt
  4. integral component of membrane Source: ProtInc
  5. paranode region of axon Source: Ensembl
  6. plasma membrane Source: UniProtKB-SubCell
  7. tight junction Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26573.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Claudin-5
PRO_0000144745Add
BLAST

Proteomic databases

PaxDbiO00501.
PRIDEiO00501.

PTM databases

PhosphoSiteiO00501.

Expressioni

Gene expression databases

ArrayExpressiO00501.
BgeeiO00501.
CleanExiHS_CLDN5.
GenevestigatoriO00501.

Organism-specific databases

HPAiCAB002607.

Interactioni

Subunit structurei

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ By similarity.

Protein-protein interaction databases

BioGridi112977. 4 interactions.
STRINGi9606.ENSP00000384554.

Structurei

3D structure databases

ProteinModelPortaliO00501.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni217 – 2182Interactions with TJP1, TJP2 and TJP3 By similarity

Sequence similaritiesi

Belongs to the claudin family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43495.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiO00501.
KOiK06087.
OrthoDBiEOG76HQ2T.
PhylomeDBiO00501.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003551. Claudin5.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PR01380. CLAUDIN5.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00501-1 [UniParc]FASTAAdd to Basket

« Hide

MGSAALEILG LVLCLVGWGG LILACGLPMW QVTAFLDHNI VTAQTTWKGL    50
WMSCVVQSTG HMQCKVYDSV LALSTEVQAA RALTVSAVLL AFVALFVTLA 100
GAQCTTCVAP GPAKARVALT GGVLYLFCGL LALVPLCWFA NIVVREFYDP 150
SVPVSQKYEL GAALYIGWAA TALLMVGGCL LCCGAWVCTG RPDLSFPVKY 200
SAPRRPTATG DYDKKNYV 218
Length:218
Mass (Da):23,147
Last modified:July 1, 1997 - v1
Checksum:i9F7F9E194D25425F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF000959 mRNA. Translation: AAC51364.1.
CR456420 mRNA. Translation: CAG30306.1.
AK092561 mRNA. Translation: BAG52573.1.
BT007254 mRNA. Translation: AAP35918.1.
AC000082 Genomic DNA. No translation available.
BC002404 mRNA. Translation: AAH02404.1.
BC019290 mRNA. Translation: AAH19290.2.
BC032363 mRNA. Translation: AAH32363.1.
RefSeqiNP_001124333.1. NM_001130861.1.
NP_003268.2. NM_003277.3.
UniGeneiHs.505337.

Genome annotation databases

EnsembliENST00000403084; ENSP00000384554; ENSG00000184113.
ENST00000406028; ENSP00000385477; ENSG00000184113.
ENST00000413119; ENSP00000400612; ENSG00000184113.
GeneIDi7122.
KEGGihsa:7122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF000959 mRNA. Translation: AAC51364.1 .
CR456420 mRNA. Translation: CAG30306.1 .
AK092561 mRNA. Translation: BAG52573.1 .
BT007254 mRNA. Translation: AAP35918.1 .
AC000082 Genomic DNA. No translation available.
BC002404 mRNA. Translation: AAH02404.1 .
BC019290 mRNA. Translation: AAH19290.2 .
BC032363 mRNA. Translation: AAH32363.1 .
RefSeqi NP_001124333.1. NM_001130861.1.
NP_003268.2. NM_003277.3.
UniGenei Hs.505337.

3D structure databases

ProteinModelPortali O00501.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112977. 4 interactions.
STRINGi 9606.ENSP00000384554.

PTM databases

PhosphoSitei O00501.

Proteomic databases

PaxDbi O00501.
PRIDEi O00501.

Protocols and materials databases

DNASUi 7122.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000403084 ; ENSP00000384554 ; ENSG00000184113 .
ENST00000406028 ; ENSP00000385477 ; ENSG00000184113 .
ENST00000413119 ; ENSP00000400612 ; ENSG00000184113 .
GeneIDi 7122.
KEGGi hsa:7122.

Organism-specific databases

CTDi 7122.
GeneCardsi GC22M019510.
HGNCi HGNC:2047. CLDN5.
HPAi CAB002607.
MIMi 602101. gene.
neXtProti NX_O00501.
PharmGKBi PA26573.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43495.
HOGENOMi HOG000220937.
HOVERGENi HBG000643.
InParanoidi O00501.
KOi K06087.
OrthoDBi EOG76HQ2T.
PhylomeDBi O00501.
TreeFami TF331936.

Enzyme and pathway databases

Reactomei REACT_19373. Tight junction interactions.

Miscellaneous databases

GeneWikii CLDN5.
GenomeRNAii 7122.
NextBioi 27871.
PROi O00501.
SOURCEi Search...

Gene expression databases

ArrayExpressi O00501.
Bgeei O00501.
CleanExi HS_CLDN5.
Genevestigatori O00501.

Family and domain databases

InterProi IPR006187. Claudin.
IPR003551. Claudin5.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view ]
PANTHERi PTHR12002. PTHR12002. 1 hit.
Pfami PF00822. PMP22_Claudin. 1 hit.
[Graphical view ]
PRINTSi PR01077. CLAUDIN.
PR01380. CLAUDIN5.
PROSITEi PS01346. CLAUDIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome."
    Sirotkin H., Morrow B., St Jore B., Puech A., Das Gupta R., Patanjali S., Skoultchi A., Weissman S.M., Kucherlapati R.
    Genomics 42:245-251(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Lung.

Entry informationi

Entry nameiCLD5_HUMAN
AccessioniPrimary (citable) accession number: O00501
Secondary accession number(s): B3KS11, Q53XW2, Q8WUW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: September 3, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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