Reviewed,
UniProtKB/Swiss-Prot O00501 (CLD5_HUMAN)
Last modified
June 16, 2009.
Version 82.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Claudin-5 Alternative name(s): Transmembrane protein deleted in VCFS Short name=TMDVCF | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 218 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Plays a major role in tight junction-specific obliteration of the intercellular space By similarity. |
| Subunit structure | Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ By similarity. |
| Subcellular location | Cell junction › tight junction. Cell membrane; Multi-pass membrane protein. |
| Sequence similarities | Belongs to the claudin family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell junction Cell membrane Membrane Tight junction |
| Domain | Transmembrane |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | calcium-independent cell-cell adhesion Inferred from sequence or structural similarity. Source: UniProtKB |
| Cellular component | integral to membrane Ref.1 Traceable author statement. Source: ProtInc tight junctionInferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | identical protein binding Inferred from sequence or structural similarity. Source: UniProtKB structural molecule activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 218 | 218 | Claudin-5 | PRO_0000144745 | |||||
Regions | |||||||||
| Topological domain | 1 – 7 | 7 | Cytoplasmic Potential | ||||||
| Transmembrane | 8 – 28 | 21 | Potential | ||||||
| Topological domain | 29 – 81 | 53 | Extracellular Potential | ||||||
| Transmembrane | 82 – 102 | 21 | Potential | ||||||
| Topological domain | 103 – 122 | 20 | Cytoplasmic Potential | ||||||
| Transmembrane | 123 – 143 | 21 | Potential | ||||||
| Topological domain | 144 – 159 | 16 | Extracellular Potential | ||||||
| Transmembrane | 160 – 180 | 21 | Potential | ||||||
| Topological domain | 181 – 218 | 38 | Cytoplasmic Potential | ||||||
| Region | 217 – 218 | 2 | Interactions with TJP1, TJP2 and TJP3 By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 212 | 1 | Phosphotyrosine Ref.6 | ||||||
| Modified residue | 217 | 1 | Phosphotyrosine Ref.6 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome." Sirotkin H., Morrow B., St Jore B., Puech A., Das Gupta R., Patanjali S., Skoultchi A., Weissman S.M., Kucherlapati R. Genomics 42:245-251(1997) [PubMed: 9192844] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate. |
| [4] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Lung. |
| [6] | "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. Comb M.J.Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-212 AND TYR-217, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF000959 mRNA. Translation: AAC51364.1. CR456420 mRNA. Translation: CAG30306.1. AK092561 mRNA. Translation: BAG52573.1. BT007254 mRNA. Translation: AAP35918.1. BC002404 mRNA. Translation: AAH02404.1. BC019290 mRNA. Translation: AAH19290.2. BC032363 mRNA. Translation: AAH32363.1. | |
| IPI | IPI00012089. |
| RefSeq | NP_001124333.1. NP_003268.2. |
| UniGene | Hs.505337 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | O00501. |
Proteomic databases | |
| PRIDE | O00501. |
Genome annotation databases | |
| Ensembl | ENSG00000184113. Homo sapiens. [Contig view] |
| GeneID | 7122. |
Organism-specific databases | |
| GeneCards | GC22M017885. |
| H-InvDB | HIX0016239. |
| HGNC | HGNC:2047. CLDN5. |
| HPA | CAB002607. |
| MIM | 602101. gene. |
| PharmGKB | PA26573. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | O00501. |
| HOVERGEN | O00501. |
| OMA | O00501. GGGLVCC. |
Gene expression databases | |
| ArrayExpress | O00501. |
| Bgee | O00501. |
| CleanEx | HS_CLDN5. |
| GermOnline | ENSG00000184113. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR006187. Claudin. IPR003551. Claudin5. IPR017974. Claudin_CS. IPR004031. PMP22/EMP/MP20/Claudin. [Graphical view] |
| PANTHER | PTHR12002. Claudin. 1 hit. |
| Pfam | PF00822. PMP22_Claudin. 1 hit. [Graphical view] |
| PRINTS | PR01077. CLAUDIN. PR01380. CLAUDIN5. |
| PROSITE | PS01346. CLAUDIN. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 27871. |
| SOURCE | Search... |
Entry information
| Entry name | CLD5_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O00501 Secondary accession number(s): B3KS11, Q53XW2, Q8WUW3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 22 Human chromosome 22: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


