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Protein

Claudin-5

Gene

CLDN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space.By similarity

GO - Molecular functioni

GO - Biological processi

  • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
  • cell-cell junction assembly Source: UniProtKB
  • face morphogenesis Source: UniProtKB
  • learning Source: UniProtKB
  • outflow tract morphogenesis Source: UniProtKB
  • palate development Source: UniProtKB
  • positive regulation of establishment of endothelial barrier Source: UniProtKB
  • transforming growth factor beta receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32977-MONOMER.
ReactomeiR-HSA-420029. Tight junction interactions.

Protein family/group databases

TCDBi1.H.1.1.16. the claudin tight junction (claudin1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-5
Alternative name(s):
Transmembrane protein deleted in VCFS
Short name:
TMDVCF
Gene namesi
Name:CLDN5
Synonyms:AWAL, TMVCF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:2047. CLDN5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 122CytoplasmicSequence analysisAdd BLAST20
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 159ExtracellularSequence analysisAdd BLAST16
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 218CytoplasmicSequence analysisAdd BLAST38

GO - Cellular componenti

  • apicolateral plasma membrane Source: UniProtKB
  • bicellular tight junction Source: UniProtKB
  • cell-cell junction Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi7122.
OpenTargetsiENSG00000184113.
PharmGKBiPA26573.

Polymorphism and mutation databases

BioMutaiCLDN5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447451 – 218Claudin-5Add BLAST218

Proteomic databases

PaxDbiO00501.
PeptideAtlasiO00501.
PRIDEiO00501.

PTM databases

iPTMnetiO00501.
PhosphoSitePlusiO00501.
SwissPalmiO00501.

Expressioni

Gene expression databases

BgeeiENSG00000184113.
CleanExiHS_CLDN5.
ExpressionAtlasiO00501. baseline and differential.
GenevisibleiO00501. HS.

Organism-specific databases

HPAiCAB002607.

Interactioni

Subunit structurei

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112977. 2 interactors.
STRINGi9606.ENSP00000384554.

Structurei

3D structure databases

ProteinModelPortaliO00501.
SMRiO00501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni217 – 218Interactions with TJP1, TJP2 and TJP3By similarity2

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJT1. Eukaryota.
ENOG410Y9S8. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiO00501.
KOiK06087.
PhylomeDBiO00501.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003551. Claudin5.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01380. CLAUDIN5.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSAALEILG LVLCLVGWGG LILACGLPMW QVTAFLDHNI VTAQTTWKGL
60 70 80 90 100
WMSCVVQSTG HMQCKVYDSV LALSTEVQAA RALTVSAVLL AFVALFVTLA
110 120 130 140 150
GAQCTTCVAP GPAKARVALT GGVLYLFCGL LALVPLCWFA NIVVREFYDP
160 170 180 190 200
SVPVSQKYEL GAALYIGWAA TALLMVGGCL LCCGAWVCTG RPDLSFPVKY
210
SAPRRPTATG DYDKKNYV
Length:218
Mass (Da):23,147
Last modified:July 1, 1997 - v1
Checksum:i9F7F9E194D25425F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000959 mRNA. Translation: AAC51364.1.
CR456420 mRNA. Translation: CAG30306.1.
AK092561 mRNA. Translation: BAG52573.1.
BT007254 mRNA. Translation: AAP35918.1.
AC000082 Genomic DNA. No translation available.
BC002404 mRNA. Translation: AAH02404.1.
BC019290 mRNA. Translation: AAH19290.2.
BC032363 mRNA. Translation: AAH32363.1.
RefSeqiNP_001124333.1. NM_001130861.1.
NP_003268.2. NM_003277.3.
UniGeneiHs.505337.

Genome annotation databases

EnsembliENST00000618236; ENSP00000480623; ENSG00000184113.
GeneIDi7122.
KEGGihsa:7122.
UCSCiuc062bmp.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000959 mRNA. Translation: AAC51364.1.
CR456420 mRNA. Translation: CAG30306.1.
AK092561 mRNA. Translation: BAG52573.1.
BT007254 mRNA. Translation: AAP35918.1.
AC000082 Genomic DNA. No translation available.
BC002404 mRNA. Translation: AAH02404.1.
BC019290 mRNA. Translation: AAH19290.2.
BC032363 mRNA. Translation: AAH32363.1.
RefSeqiNP_001124333.1. NM_001130861.1.
NP_003268.2. NM_003277.3.
UniGeneiHs.505337.

3D structure databases

ProteinModelPortaliO00501.
SMRiO00501.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112977. 2 interactors.
STRINGi9606.ENSP00000384554.

Protein family/group databases

TCDBi1.H.1.1.16. the claudin tight junction (claudin1) family.

PTM databases

iPTMnetiO00501.
PhosphoSitePlusiO00501.
SwissPalmiO00501.

Polymorphism and mutation databases

BioMutaiCLDN5.

Proteomic databases

PaxDbiO00501.
PeptideAtlasiO00501.
PRIDEiO00501.

Protocols and materials databases

DNASUi7122.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000618236; ENSP00000480623; ENSG00000184113.
GeneIDi7122.
KEGGihsa:7122.
UCSCiuc062bmp.1. human.

Organism-specific databases

CTDi7122.
DisGeNETi7122.
GeneCardsiCLDN5.
HGNCiHGNC:2047. CLDN5.
HPAiCAB002607.
MIMi602101. gene.
neXtProtiNX_O00501.
OpenTargetsiENSG00000184113.
PharmGKBiPA26573.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJT1. Eukaryota.
ENOG410Y9S8. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiO00501.
KOiK06087.
PhylomeDBiO00501.
TreeFamiTF331936.

Enzyme and pathway databases

BioCyciZFISH:G66-32977-MONOMER.
ReactomeiR-HSA-420029. Tight junction interactions.

Miscellaneous databases

ChiTaRSiCLDN5. human.
GeneWikiiCLDN5.
GenomeRNAii7122.
PROiO00501.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184113.
CleanExiHS_CLDN5.
ExpressionAtlasiO00501. baseline and differential.
GenevisibleiO00501. HS.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003551. Claudin5.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01380. CLAUDIN5.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLD5_HUMAN
AccessioniPrimary (citable) accession number: O00501
Secondary accession number(s): B3KS11, Q53XW2, Q8WUW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: November 2, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.