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Protein

Myc box-dependent-interacting protein 1

Gene

BIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.

GO - Molecular functioni

  • actin filament binding Source: WormBase
  • RNA polymerase binding Source: AgBase
  • tau protein binding Source: Alzheimers_University_of_Toronto

GO - Biological processi

  • cell proliferation Source: ProtInc
  • endocytosis Source: UniProtKB-KW
  • lipid tube assembly Source: Alzheimers_University_of_Toronto
  • muscle cell differentiation Source: Ensembl
  • nucleus localization Source: Ensembl
  • nucleus organization Source: WormBase
  • positive regulation of apoptotic process Source: AgBase
  • positive regulation of astrocyte differentiation Source: Alzheimers_University_of_Toronto
  • regulation of cell cycle arrest Source: Alzheimers_University_of_Toronto
  • regulation of endocytosis Source: InterPro
  • regulation of neuron differentiation Source: Alzheimers_University_of_Toronto
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Endocytosis, Host-virus interaction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136717-MONOMER.
ReactomeiR-HSA-8856828. Clathrin-mediated endocytosis.
SIGNORiO00499.

Names & Taxonomyi

Protein namesi
Recommended name:
Myc box-dependent-interacting protein 1
Alternative name(s):
Amphiphysin II
Amphiphysin-like protein
Box-dependent myc-interacting protein 1
Bridging integrator 1
Gene namesi
Name:BIN1
Synonyms:AMPHL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:1052. BIN1.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: ProtInc
  • axon Source: Alzheimers_University_of_Toronto
  • axon initial segment Source: Alzheimers_University_of_Toronto
  • cytoplasm Source: LIFEdb
  • I band Source: Alzheimers_University_of_Toronto
  • lipid tube Source: Alzheimers_University_of_Toronto
  • membrane Source: AgBase
  • node of Ranvier Source: Alzheimers_University_of_Toronto
  • nuclear envelope Source: Ensembl
  • T-tubule Source: Alzheimers_University_of_Toronto
  • Z disc Source: Alzheimers_University_of_Toronto
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Myopathy, centronuclear, 2 (CNM2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
See also OMIM:255200
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03742535K → N in CNM2; abolishes membrane tubulation. 1 PublicationCorresponds to variant rs121909273dbSNPEnsembl.1
Natural variantiVAR_037426151D → N in CNM2; abolishes membrane tubulation. 1 PublicationCorresponds to variant rs121909274dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Tumor suppressor

Organism-specific databases

DisGeNETi274.
MalaCardsiBIN1.
MIMi255200. phenotype.
OpenTargetsiENSG00000136717.
Orphaneti169189. Autosomal dominant centronuclear myopathy.
169186. Autosomal recessive centronuclear myopathy.
PharmGKBiPA25355.

Polymorphism and mutation databases

BioMutaiBIN1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001929512 – 593Myc box-dependent-interacting protein 1Add BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei296PhosphoserineCombined sources1
Modified residuei298PhosphoserineCombined sources1
Modified residuei303PhosphoserineCombined sources1
Modified residuei307PhosphothreonineCombined sources1
Modified residuei323PhosphothreonineCombined sources1
Modified residuei331PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by protein kinase C.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO00499.
MaxQBiO00499.
PaxDbiO00499.
PeptideAtlasiO00499.
PRIDEiO00499.

2D gel databases

UCD-2DPAGEO00499.

PTM databases

iPTMnetiO00499.
PhosphoSitePlusiO00499.

Expressioni

Tissue specificityi

Ubiquitous. Highest expression in the brain and muscle. Isoform IIA is expressed only in the brain where it is concentrated in axon initial segments and nodes of Ranvier. Isoform BIN1 is widely expressed with highest expression in skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000136717.
ExpressionAtlasiO00499. baseline and differential.
GenevisibleiO00499. HS.

Organism-specific databases

HPAiCAB001945.
HPA003894.
HPA005437.

Interactioni

Subunit structurei

Heterodimer with AMPH. Binds SH3GLB1 (By similarity). Interacts (via SH3 domain) with SYNJ1. Interacts (via SH3 domain) with DNM1. Isoform IIA interacts with CLTC. Isoform IIB does not interact with CLTC. Isoform IIC1 does not interact with CLTC. Isoform IIC2 does not interact with CLTC. Interacts with AP2A2. Interacts with AP2B1. Interacts with MYC (via N-terminal transactivation domain); the interaction requires the integrity of the conserved MYC box regions 1 and 2. Interacts with BIN2. Interacts (SH3 domain) with HCV NS5A.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-719094,EBI-719094
P2795811EBI-719094,EBI-8753518From a different organism.
Q9WMX25EBI-719094,EBI-6863748From a different organism.
BIN2Q9UBW52EBI-719094,EBI-2042570
DLGAP4Q9Y2H04EBI-719094,EBI-722139
FBP1P094674EBI-719094,EBI-712740
MAPTP10636-75EBI-6926280,EBI-6926270
MTM1Q134966EBI-719094,EBI-2864109
MYCP011063EBI-7689134,EBI-447544
REPS2Q8NFH8-26EBI-719094,EBI-8029141
SNX4O952193EBI-719094,EBI-724909
XRCC4Q134264EBI-719094,EBI-717592

GO - Molecular functioni

  • actin filament binding Source: WormBase
  • RNA polymerase binding Source: AgBase
  • tau protein binding Source: Alzheimers_University_of_Toronto

Protein-protein interaction databases

BioGridi106771. 62 interactors.
DIPiDIP-41480N.
IntActiO00499. 22 interactors.
MINTiMINT-258326.
STRINGi9606.ENSP00000316779.

Structurei

Secondary structure

1593
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 33Combined sources26
Helixi43 – 89Combined sources47
Helixi97 – 121Combined sources25
Helixi123 – 131Combined sources9
Helixi133 – 161Combined sources29
Beta strandi163 – 165Combined sources3
Helixi205 – 268Combined sources64
Beta strandi523 – 527Combined sources5
Beta strandi535 – 537Combined sources3
Beta strandi546 – 549Combined sources4
Helixi555 – 557Combined sources3
Beta strandi562 – 567Combined sources6
Helixi568 – 572Combined sources5
Helixi573 – 579Combined sources7
Beta strandi582 – 585Combined sources4
Helixi586 – 588Combined sources3
Beta strandi589 – 591Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MUZNMR-A513-593[»]
1MV0NMR-B513-593[»]
1MV3NMR-A301-593[»]
2FICX-ray1.99A/B1-272[»]
2RMYNMR-A1-33[»]
2RNDNMR-A1-33[»]
5I22NMR-A513-593[»]
ProteinModelPortaliO00499.
SMRiO00499.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00499.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 276BARPROSITE-ProRule annotationAdd BLAST248
Domaini520 – 592SH3PROSITE-ProRule annotationAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 122Interaction with BIN21 PublicationAdd BLAST121
Regioni378 – 421Clathrin-bindingAdd BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili15 – 42Sequence analysisAdd BLAST28
Coiled coili193 – 267Sequence analysisAdd BLAST75

Sequence similaritiesi

Contains 1 BAR domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiENOG410ITR4. Eukaryota.
ENOG410XQXT. LUCA.
GeneTreeiENSGT00390000017588.
HOVERGENiHBG004224.
InParanoidiO00499.
KOiK12562.
OMAiVYEPEWP.
OrthoDBiEOG091G07IE.
PhylomeDBiO00499.
TreeFamiTF313542.

Family and domain databases

Gene3Di1.20.1270.60. 2 hits.
InterProiIPR027267. AH/BAR-dom.
IPR003005. Amphiphysin.
IPR003023. Amphiphysin_2.
IPR004148. BAR_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR01251. AMPHIPHYSIN.
PR01253. AMPHIPHYSIN2.
PR00452. SH3DOMAIN.
SMARTiSM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (11)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 11 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform IIA (identifier: O00499-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEMGSKGVT AGKIASNVQK KLTRAQEKVL QKLGKADETK DEQFEQCVQN
60 70 80 90 100
FNKQLTEGTR LQKDLRTYLA SVKAMHEASK KLNECLQEVY EPDWPGRDEA
110 120 130 140 150
NKIAENNDLL WMDYHQKLVD QALLTMDTYL GQFPDIKSRI AKRGRKLVDY
160 170 180 190 200
DSARHHYESL QTAKKKDEAK IAKPVSLLEK AAPQWCQGKL QAHLVAQTNL
210 220 230 240 250
LRNQAEEELI KAQKVFEEMN VDLQEELPSL WNSRVGFYVN TFQSIAGLEE
260 270 280 290 300
NFHKEMSKLN QNLNDVLVGL EKQHGSNTFT VKAQPSDNAP AKGNKSPSPP
310 320 330 340 350
DGSPAATPEI RVNHEPEPAG GATPGATLPK SPSQLRKGPP VPPPPKHTPS
360 370 380 390 400
KEVKQEQILS LFEDTFVPEI SVTTPSQFEA PGPFSEQASL LDLDFDPLPP
410 420 430 440 450
VTSPVKAPTP SGQSIPWDLW EPTESPAGSL PSGEPSAAEG TFAVSWPSQT
460 470 480 490 500
AEPGPAQPAE ASEVAGGTQP AAGAQEPGET AASEAASSSL PAVVVETFPA
510 520 530 540 550
TVNGTVEGGS GAGRLDLPPG FMFKVQAQHD YTATDTDELQ LKAGDVVLVI
560 570 580 590
PFQNPEEQDE GWLMGVKESD WNQHKELEKC RGVFPENFTE RVP
Length:593
Mass (Da):64,699
Last modified:July 1, 1997 - v1
Checksum:i0FF1956F0C7E3B50
GO
Isoform IIB (identifier: O00499-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-204: Missing.
     378-421: Missing.

Show »
Length:518
Mass (Da):56,499
Checksum:i9BEF82FC2C28C845
GO
Isoform IIC1 (identifier: O00499-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     335-421: Missing.

Show »
Length:506
Mass (Da):55,175
Checksum:iF3EA5A2EF666CE59
GO
Isoform IIC2 (identifier: O00499-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-204: Missing.
     335-421: Missing.

Show »
Length:475
Mass (Da):51,737
Checksum:i876B8A866F96BA14
GO
Isoform IID (identifier: O00499-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     335-377: Missing.

Show »
Length:550
Mass (Da):59,937
Checksum:i99FC3F5471E1926B
GO
Isoform II2 (identifier: O00499-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-204: Missing.
     378-457: Missing.

Show »
Length:482
Mass (Da):53,020
Checksum:iDF00A44348B6F1BF
GO
Isoform II3 (identifier: O00499-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-204: Missing.
     335-457: Missing.

Show »
Length:439
Mass (Da):48,258
Checksum:i350E429F13AF49C6
GO
Isoform BIN1 (identifier: O00499-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-204: Missing.
     285-285: P → PRKKSKLFSRLRRKKN
     335-457: Missing.

Show »
Length:454
Mass (Da):50,185
Checksum:i7E2ADD14E9D56D9E
GO
Isoform BIN1-10-13 (identifier: O00499-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-204: Missing.
     335-487: Missing.

Show »
Length:409
Mass (Da):45,563
Checksum:i08C5B23D79252350
GO
Isoform BIN1-13 (identifier: O00499-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-204: Missing.
     285-285: P → PRKKSKLFSRLRRKKN
     335-487: Missing.

Show »
Length:424
Mass (Da):47,491
Checksum:i1C86B9D4C8C204C6
GO
Isoform BIN1+12A (identifier: O00499-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-204: Missing.
     285-285: P → PRKKSKLFSRLRRKKN
     378-457: Missing.

Show »
Length:497
Mass (Da):54,948
Checksum:i55E3246DD05172AA
GO

Sequence cautioni

The sequence AAC23441 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti474A → P in AAB63263 (PubMed:9182667).Curated1
Sequence conflicti481A → S in AAC24126 (PubMed:15815621).Curated1
Sequence conflicti481A → S in AAC23750 (PubMed:15815621).Curated1
Sequence conflicti481A → S in AAC23751 (PubMed:15815621).Curated1
Sequence conflicti510S → C in AAC23440 (PubMed:9395479).Curated1
Sequence conflicti510S → C in AAC23441 (PubMed:9395479).Curated1
Sequence conflicti528Q → H in AAC23440 (PubMed:9395479).Curated1
Sequence conflicti528Q → H in AAC23441 (PubMed:9395479).Curated1
Sequence conflicti576E → K in AAC23440 (PubMed:9395479).Curated1
Sequence conflicti576E → K in AAC23441 (PubMed:9395479).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03742535K → N in CNM2; abolishes membrane tubulation. 1 PublicationCorresponds to variant rs121909273dbSNPEnsembl.1
Natural variantiVAR_037426151D → N in CNM2; abolishes membrane tubulation. 1 PublicationCorresponds to variant rs121909274dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000246174 – 204Missing in isoform IIB, isoform IIC2, isoform II2, isoform II3, isoform BIN1, isoform BIN1+12A, isoform BIN1-10-13 and isoform BIN1-13. 5 PublicationsAdd BLAST31
Alternative sequenceiVSP_000247285P → PRKKSKLFSRLRRKKN in isoform BIN1, isoform BIN1+12A and isoform BIN1-13. 3 Publications1
Alternative sequenceiVSP_000251335 – 487Missing in isoform BIN1-10-13 and isoform BIN1-13. 1 PublicationAdd BLAST153
Alternative sequenceiVSP_000250335 – 457Missing in isoform II3 and isoform BIN1. 4 PublicationsAdd BLAST123
Alternative sequenceiVSP_000249335 – 421Missing in isoform IIC1 and isoform IIC2. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_000248335 – 377Missing in isoform IID. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_000253378 – 457Missing in isoform II2 and isoform BIN1+12A. 2 PublicationsAdd BLAST80
Alternative sequenceiVSP_000252378 – 421Missing in isoform IIB. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004015 mRNA. Translation: AAC51345.1.
AF070576 mRNA. Translation: AAC28646.1.
AF001383 mRNA. Translation: AAB61363.1.
U68485 mRNA. Translation: AAC17461.1.
AF043898 mRNA. Translation: AAC39710.1.
AF043899 mRNA. Translation: AAC39711.1.
AF043900 mRNA. Translation: AAC39712.1.
AF043901 mRNA. Translation: AAC39713.1.
U87558 mRNA. Translation: AAB63263.1.
AF068914 mRNA. Translation: AAC24126.1.
AF068915 mRNA. Translation: AAC24127.1.
AF068916 mRNA. Translation: AAC24128.1.
AF068917 mRNA. Translation: AAC23750.1.
AF068918 mRNA. Translation: AAC23751.1.
U84004
, U83999, U84001, U84002, U84003 Genomic DNA. Translation: AAC23440.1.
U84004
, U83999, U84001, U84002, U84003 Genomic DNA. Translation: AAC23441.1. Different initiation.
AL713697 mRNA. Translation: CAD28496.1.
AC012508 Genomic DNA. Translation: AAY24328.1.
CH471103 Genomic DNA. Translation: EAW95302.1.
CCDSiCCDS2137.1. [O00499-8]
CCDS2138.1. [O00499-1]
CCDS2139.1. [O00499-5]
CCDS2140.1. [O00499-3]
CCDS2141.1. [O00499-11]
CCDS2142.1. [O00499-2]
CCDS2143.1. [O00499-9]
CCDS42743.1. [O00499-4]
CCDS42744.1. [O00499-6]
CCDS46403.1. [O00499-7]
CCDS82508.1. [O00499-10]
PIRiJC5593.
RefSeqiNP_001307561.1. NM_001320632.1. [O00499-10]
NP_001307562.1. NM_001320633.1.
NP_001307569.1. NM_001320640.1.
NP_001307570.1. NM_001320641.1.
NP_001307571.1. NM_001320642.1.
NP_004296.1. NM_004305.3. [O00499-8]
NP_647593.1. NM_139343.2. [O00499-1]
NP_647594.1. NM_139344.2. [O00499-5]
NP_647595.1. NM_139345.2. [O00499-3]
NP_647596.1. NM_139346.2. [O00499-11]
NP_647597.1. NM_139347.2. [O00499-2]
NP_647598.1. NM_139348.2. [O00499-6]
NP_647599.1. NM_139349.2. [O00499-4]
NP_647600.1. NM_139350.2. [O00499-7]
NP_647601.1. NM_139351.2. [O00499-9]
UniGeneiHs.193163.

Genome annotation databases

EnsembliENST00000259238; ENSP00000259238; ENSG00000136717. [O00499-11]
ENST00000316724; ENSP00000316779; ENSG00000136717. [O00499-1]
ENST00000346226; ENSP00000315411; ENSG00000136717. [O00499-2]
ENST00000348750; ENSP00000259237; ENSG00000136717. [O00499-9]
ENST00000351659; ENSP00000315388; ENSG00000136717. [O00499-3]
ENST00000352848; ENSP00000315284; ENSG00000136717. [O00499-8]
ENST00000357970; ENSP00000350654; ENSG00000136717. [O00499-5]
ENST00000376113; ENSP00000365281; ENSG00000136717. [O00499-10]
ENST00000393040; ENSP00000376760; ENSG00000136717. [O00499-6]
ENST00000393041; ENSP00000376761; ENSG00000136717. [O00499-4]
ENST00000409400; ENSP00000386797; ENSG00000136717. [O00499-7]
GeneIDi274.
KEGGihsa:274.
UCSCiuc002tns.3. human. [O00499-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004015 mRNA. Translation: AAC51345.1.
AF070576 mRNA. Translation: AAC28646.1.
AF001383 mRNA. Translation: AAB61363.1.
U68485 mRNA. Translation: AAC17461.1.
AF043898 mRNA. Translation: AAC39710.1.
AF043899 mRNA. Translation: AAC39711.1.
AF043900 mRNA. Translation: AAC39712.1.
AF043901 mRNA. Translation: AAC39713.1.
U87558 mRNA. Translation: AAB63263.1.
AF068914 mRNA. Translation: AAC24126.1.
AF068915 mRNA. Translation: AAC24127.1.
AF068916 mRNA. Translation: AAC24128.1.
AF068917 mRNA. Translation: AAC23750.1.
AF068918 mRNA. Translation: AAC23751.1.
U84004
, U83999, U84001, U84002, U84003 Genomic DNA. Translation: AAC23440.1.
U84004
, U83999, U84001, U84002, U84003 Genomic DNA. Translation: AAC23441.1. Different initiation.
AL713697 mRNA. Translation: CAD28496.1.
AC012508 Genomic DNA. Translation: AAY24328.1.
CH471103 Genomic DNA. Translation: EAW95302.1.
CCDSiCCDS2137.1. [O00499-8]
CCDS2138.1. [O00499-1]
CCDS2139.1. [O00499-5]
CCDS2140.1. [O00499-3]
CCDS2141.1. [O00499-11]
CCDS2142.1. [O00499-2]
CCDS2143.1. [O00499-9]
CCDS42743.1. [O00499-4]
CCDS42744.1. [O00499-6]
CCDS46403.1. [O00499-7]
CCDS82508.1. [O00499-10]
PIRiJC5593.
RefSeqiNP_001307561.1. NM_001320632.1. [O00499-10]
NP_001307562.1. NM_001320633.1.
NP_001307569.1. NM_001320640.1.
NP_001307570.1. NM_001320641.1.
NP_001307571.1. NM_001320642.1.
NP_004296.1. NM_004305.3. [O00499-8]
NP_647593.1. NM_139343.2. [O00499-1]
NP_647594.1. NM_139344.2. [O00499-5]
NP_647595.1. NM_139345.2. [O00499-3]
NP_647596.1. NM_139346.2. [O00499-11]
NP_647597.1. NM_139347.2. [O00499-2]
NP_647598.1. NM_139348.2. [O00499-6]
NP_647599.1. NM_139349.2. [O00499-4]
NP_647600.1. NM_139350.2. [O00499-7]
NP_647601.1. NM_139351.2. [O00499-9]
UniGeneiHs.193163.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MUZNMR-A513-593[»]
1MV0NMR-B513-593[»]
1MV3NMR-A301-593[»]
2FICX-ray1.99A/B1-272[»]
2RMYNMR-A1-33[»]
2RNDNMR-A1-33[»]
5I22NMR-A513-593[»]
ProteinModelPortaliO00499.
SMRiO00499.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106771. 62 interactors.
DIPiDIP-41480N.
IntActiO00499. 22 interactors.
MINTiMINT-258326.
STRINGi9606.ENSP00000316779.

PTM databases

iPTMnetiO00499.
PhosphoSitePlusiO00499.

Polymorphism and mutation databases

BioMutaiBIN1.

2D gel databases

UCD-2DPAGEO00499.

Proteomic databases

EPDiO00499.
MaxQBiO00499.
PaxDbiO00499.
PeptideAtlasiO00499.
PRIDEiO00499.

Protocols and materials databases

DNASUi274.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259238; ENSP00000259238; ENSG00000136717. [O00499-11]
ENST00000316724; ENSP00000316779; ENSG00000136717. [O00499-1]
ENST00000346226; ENSP00000315411; ENSG00000136717. [O00499-2]
ENST00000348750; ENSP00000259237; ENSG00000136717. [O00499-9]
ENST00000351659; ENSP00000315388; ENSG00000136717. [O00499-3]
ENST00000352848; ENSP00000315284; ENSG00000136717. [O00499-8]
ENST00000357970; ENSP00000350654; ENSG00000136717. [O00499-5]
ENST00000376113; ENSP00000365281; ENSG00000136717. [O00499-10]
ENST00000393040; ENSP00000376760; ENSG00000136717. [O00499-6]
ENST00000393041; ENSP00000376761; ENSG00000136717. [O00499-4]
ENST00000409400; ENSP00000386797; ENSG00000136717. [O00499-7]
GeneIDi274.
KEGGihsa:274.
UCSCiuc002tns.3. human. [O00499-1]

Organism-specific databases

CTDi274.
DisGeNETi274.
GeneCardsiBIN1.
HGNCiHGNC:1052. BIN1.
HPAiCAB001945.
HPA003894.
HPA005437.
MalaCardsiBIN1.
MIMi255200. phenotype.
601248. gene.
neXtProtiNX_O00499.
OpenTargetsiENSG00000136717.
Orphaneti169189. Autosomal dominant centronuclear myopathy.
169186. Autosomal recessive centronuclear myopathy.
PharmGKBiPA25355.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITR4. Eukaryota.
ENOG410XQXT. LUCA.
GeneTreeiENSGT00390000017588.
HOVERGENiHBG004224.
InParanoidiO00499.
KOiK12562.
OMAiVYEPEWP.
OrthoDBiEOG091G07IE.
PhylomeDBiO00499.
TreeFamiTF313542.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136717-MONOMER.
ReactomeiR-HSA-8856828. Clathrin-mediated endocytosis.
SIGNORiO00499.

Miscellaneous databases

ChiTaRSiBIN1. human.
EvolutionaryTraceiO00499.
GeneWikiiBIN1.
GenomeRNAii274.
PROiO00499.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136717.
ExpressionAtlasiO00499. baseline and differential.
GenevisibleiO00499. HS.

Family and domain databases

Gene3Di1.20.1270.60. 2 hits.
InterProiIPR027267. AH/BAR-dom.
IPR003005. Amphiphysin.
IPR003023. Amphiphysin_2.
IPR004148. BAR_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR01251. AMPHIPHYSIN.
PR01253. AMPHIPHYSIN2.
PR00452. SH3DOMAIN.
SMARTiSM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBIN1_HUMAN
AccessioniPrimary (citable) accession number: O00499
Secondary accession number(s): O00297
, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q659B7, Q92944, Q99688
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: July 1, 1997
Last modified: November 30, 2016
This is version 178 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.